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Carbohydrates as Drugs [[electronic resource] /] / edited by Peter H. Seeberger, Christoph Rademacher
| Carbohydrates as Drugs [[electronic resource] /] / edited by Peter H. Seeberger, Christoph Rademacher |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (242 p.) |
| Disciplina | 615.3 |
| Collana | Topics in Medicinal Chemistry |
| Soggetto topico |
Medicinal chemistry
Carbohydrates Molecular biology Medicinal Chemistry Carbohydrate Chemistry Molecular Medicine |
| ISBN | 3-319-08675-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Carbohydrate-Based Synthetic Chemistry in the Context of Drug Design -- Iminosugars: Therapeutic Applications and Synthetic Considerations -- Computational Docking as a Tool for the Rational Design of Carbohydrate-Based Drugs -- Discovery and Development of Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Dapagliflozin for the Treatment of Type 2 Diabetes -- Design, Synthesis, and Applications of Galectin Modulators in Human Health -- Discovery and Application of FimH Antagonists -- Carbohydrate-Based Anti-Virulence Compounds Against Chronic Pseudomonas aeruginosa Infections with a Focus on Small Molecules -- The Evolution of a Glycoconjugate Vaccine for Candida albicans. |
| Record Nr. | UNINA-9910298645503321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Glycoscience : biology and medicine / / editors, Tamao Endo [et al.]
| Glycoscience : biology and medicine / / editors, Tamao Endo [et al.] |
| Pubbl/distr/stampa | Tokyo : , : Springer Japan : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (Approx. 1200 pages, 540 illustrations, 240 illustrations in color) |
| Disciplina | 572 |
| Soggetto topico |
Biochemistry
Cell biology Cancer research Cytology |
| ISBN | 4-431-54836-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | A. Analytical and Structural Approach - Technical Description for Analyzing Glycan Structures (Reviewed by Yoshiki Yamaguchi): Overview -- EMARS -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Automated programmable one-pot synthesis of glycans -- Lectin array -- Lectin-glycan interaction based on glycan array data -- Glycoform-specific protein staining by lectin and antibody -- Glycosaminoglycans analysis -- Mass analysis -- Mass analysis -- IGOT-lectin capture -- Membrane electrophoresis -- HPLC nucleotide-sugar analysis -- Capillary electrophoresis -- HPLC PA-sugar -- Congenital disorders of glycosylation, analytical aspect -- Quality control of pharmaceutical products and biosimilars -- NMR -- NMR -- STD-NMR -- Conformational analysis of glycans and glycoproteins -- Glycolipid LC-MS -- MALDI-MS -- MALDI-MS -- Sulfoglycolipids -- GAG array -- X-ray -- REMD simulation -- MD simulation and computational screening -- B. Glycoinformatics - New Approach for Informatics and Databases for Glycoscience (Reviewed by Kiyoko F. Aoki-Kinoshita): Informatics overview -- MIRAGE project -- RINGS -- JCGGDB -- UniCarb-DB -- CIRES -- GLYCOSCIENCES.de -- CSDB, Plant and Bacterial Carbohydrate Structure Database -- MonosaccharideDB -- GlycomeDB -- GlycoEpitope -- SugarBindDB -- GLYCAM -- CAZy -- 3D Lectines -- C. Chemoenzymatic Synthesis of Glycans - Chemical and Enzymatic Methods of Glycan Synthesis (Reviewed by Yasuhiro Kajihara and Peter Seeberger): Overview -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Glycopeptide/glycoprotein synthesis -- Gangliosides synthesis -- Specific Glycosylation -- Furanoside chemistry -- Glycoside synthesis -- Carbohydrate Library Synthesis -- Development of sugar array -- Development of sugar array -- Development of sugar array -- Automated synthesis -- Automation in glycan synthesis -- GPI chemical synthesis -- Oligosialic acid synthesis -- Synthesis of sulfated glycans -- Synthesis of sulfated glycans -- Synthetic antitumor vaccines -- Synthetic carbohydrate antigens for HIV Vaccine Design -- Chemical approach in biology and disease -- Glycoenzyme inhibitors -- Glycoenzyme inhibitors -- Glycoenzymes in glycan analysis and synthesis -- Endo-enzymes -- Oxazoline derivatives -- Large-scale enzymatic synthesis of glycans with cofactor regeneration -- Large-scale enzymatic synthesis of glycans -- Chemoenzymatic synthesis -- Chemoenzymatic synthesis of heparins -- Chemoenzymatic synthesis of glycoproteins -- Multivalent glycan synthesis -- Biosynthesis of A and B blood group -- Glycosyltransferase structures -- Structural biology of oligosaccharyltransferase (OST) -- Chemoenzymatic synthesis of oligosaccharides and cancer and bacterial vaccines -- Neoglycoprotein and oligosaccharide synthesis -- Chemoenzymatic synthesis of glycoconjugates -- Synthesis of O-glycosylated proteins -- D. Imaging of Glycans - New Techniques for Imaging Glycans (Reviewed by Yasuhiro Kajihara and Chi-Huey Wong): Molecular probes for glycosylation: overview Imaging by Click Chemistry -- Imaging by Click Chemistry -- Imaging by Click Chemistry -- Chemical tools to detect Helicobacter pylori -- Enzymatic imaging -- PET imaging -- Glycoprotein imaging -- E. Neuroglycobiology - The Role of Glycans in Neurobiology and Neuroscience (Reviewed by Kenji Kadomatsu): Neuroglycobiology overview -- Neurochemistry and developmental neurobiology -- Glycans in neurobiology -- Glycosaminoglycans (GAGs) -- GAGs -- Polysialic acid -- Polysialic acid -- Glycolipids sialidase -- HNK-1 -- Ganglioside -- Single molecule imaging -- Glycolipid -- Heparan sulfate proteoglycans (HSPG) -- HSPG -- N-glycans and glial cells. |
| Record Nr. | UNINA-9910349267203321 |
| Tokyo : , : Springer Japan : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Glycoscience: Biology and Medicine [[electronic resource] /] / edited by Naoyuki Taniguchi, Tamao Endo, Gerald W. Hart, Peter H. Seeberger, Chi-Huey Wong
| Glycoscience: Biology and Medicine [[electronic resource] /] / edited by Naoyuki Taniguchi, Tamao Endo, Gerald W. Hart, Peter H. Seeberger, Chi-Huey Wong |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Tokyo : , : Springer Japan : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (LXII, 1568 p. 333 illus., 233 illus. in color. eReference.) : online resource |
| Disciplina | 572.567 |
| Soggetto topico |
Biochemistry
Cell biology Cancer research Biochemistry, general Cell Biology Cancer Research |
| ISBN | 4-431-54841-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | A. Analytical and Structural Approach - Technical Description for Analyzing Glycan Structures (Reviewed by Yoshiki Yamaguchi): Overview -- EMARS -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Automated programmable one-pot synthesis of glycans -- Lectin array -- Lectin-glycan interaction based on glycan array data -- Glycoform-specific protein staining by lectin and antibody -- Glycosaminoglycans analysis -- Mass analysis -- Mass analysis -- IGOT-lectin capture -- Membrane electrophoresis -- HPLC nucleotide-sugar analysis -- Capillary electrophoresis -- HPLC PA-sugar -- Congenital disorders of glycosylation, analytical aspect -- Quality control of pharmaceutical products and biosimilars -- NMR -- NMR -- STD-NMR -- Conformational analysis of glycans and glycoproteins -- Glycolipid LC-MS -- MALDI-MS -- MALDI-MS -- Sulfoglycolipids -- GAG array -- X-ray -- REMD simulation -- MD simulation and computational screening -- B. Glycoinformatics - New Approach for Informatics and Databases for Glycoscience (Reviewed by Kiyoko F. Aoki-Kinoshita): Informatics overview -- MIRAGE project -- RINGS -- JCGGDB -- UniCarb-DB -- CIRES -- GLYCOSCIENCES.de -- CSDB, Plant and Bacterial Carbohydrate Structure Database -- MonosaccharideDB -- Glycome DB -- GlycoEpitope -- Sugar Bind DB -- GLYCAM -- CAZy -- 3D Lectines -- C. Chemoenzymatic Synthesis of Glycans - Chemical and Enzymatic Methods of Glycan Synthesis (Reviewed by Yasuhiro Kajihara and Peter Seeberger): Overview -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Glycopeptide/glycoprotein synthesis -- Gangliosides synthesis -- Specific Glycosylation -- Furanoside chemistry -- Glycoside synthesis -- Carbohydrate Library Synthesis -- Development of sugar array -- Development of sugar array -- Development of sugar array -- Automated synthesis -- Automation in glycan synthesis -- GPI chemical synthesis -- Oligosialic acid synthesis -- Synthesis of sulfated glycans -- Synthesis of sulfated glycans -- Synthetic antitumor vaccines -- Synthetic carbohydrate antigens for HIV Vaccine Design -- Chemical approach in biology and disease -- Glycoenzyme inhibitors -- Glycoenzyme inhibitors -- Glycoenzymes in glycan analysis and synthesis -- Endo-enzymes -- Oxazoline derivatives -- Large-scale enzymatic synthesis of glycans with cofactor regeneration -- Large-scale enzymatic synthesis of glycans -- Chemoenzymatic synthesis -- Chemoenzymatic synthesis of heparins -- Chemoenzymatic synthesis of glycoproteins -- Multivalent glycan synthesis -- Biosynthesis of A and B blood group -- Glycosyltransferase structures -- Structural biology of oligosaccharyltransferase (OST) -- Chemoenzymatic synthesis of oligosaccharides and cancer and bacterial vaccines -- Neoglycoprotein and oligosaccharide synthesis -- Chemoenzymatic synthesis of glycoconjugates -- Synthesis of O-glycosylated proteins -- D. Imaging of Glycans - New Techniques for Imaging Glycans (Reviewed by Yasuhiro Kajihara and Chi-Huey Wong): Molecular probes for glycosylation: overview Imaging by Click Chemistry -- Imaging by Click Chemistry -- Imaging by Click Chemistry -- Chemical tools to detect Helicobacter pylori -- Enzymatic imaging -- PET imaging -- Glycoprotein imaging -- E. Neuroglycobiology - The Role of Glycans in Neurobiology and Neuroscience (Reviewed by Kenji Kadomatsu): Neuroglycobiology overview -- Neurochemistry and developmental neurobiology -- Glycans in neurobiology -- Glycosaminoglycans (GAGs) -- GAGs -- Polysialic acid -- Polysialic acid -- Glycolipids sialidase -- HNK-1 -- Ganglioside -- Single molecule imaging -- Glycolipid -- Heparan sulfate proteoglycans (HSPG) -- HSPG -- N-glycans and glial cells. |
| Record Nr. | UNINA-9910298283503321 |
| Tokyo : , : Springer Japan : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid support oligosaccharide synthesis and combinatorial carbohydrate libraries [[electronic resource] /] / edited by Peter H. Seeberger
| Solid support oligosaccharide synthesis and combinatorial carbohydrate libraries [[electronic resource] /] / edited by Peter H. Seeberger |
| Pubbl/distr/stampa | New York, : Wiley-Interscience, c2001 |
| Descrizione fisica | 1 online resource (321 p.) |
| Disciplina |
547.7815
572/.565 |
| Altri autori (Persone) | SeebergerPeter H. <1966-> |
| Soggetto topico |
Oligosaccharides - Synthesis
Glycoconjugates Combinatorial chemistry Solid-phase synthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-54174-1
9786610541744 0-471-46072-9 0-471-22044-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Contributors; 1 Solid-Phase Carbohydrate Synthesis: The Early Work; 1.1 Introduction; 1.2 Solid-Phase Strategies; 1.3 Oligosaccharide Synthesis on Soluble Polymers; 1.4 The Period of Stagnancy (1976-1991); 2 The Glycal Assembly Method on Solid Supports: Synthesis of Oligosaccharides and Glycoconjugates; 2.1 Introduction; 2.2 Why Glycal Assembly? Strategic Considerations; 2.3 Linker Design; 2.4 Solid Support Glycal Assembly via 1,2-Anhydrosugar Donors; 2.5 Solid-Phase Synthesis of the Blood Group H Determinant; 2.6 Solid Support Glycal Assembly via Thioethyl Glycosyl Donors
2.7 Solid Support Assembly via Thioethyl 2-Amidoglycosyl Donors2.8 Solid-Phase Synthesis of the Lewis[sub(b)] Blood Group Determinant; 2.9 Solid-Phase Synthesis of the Hexasaccharide Globo-H Antigen: Progress and Limitations; 2.10 Solid-Phase Synthesis of N-Linked Glycopeptides; 2.11 Conclusions; 3 The Sulfoxide Glycosylation Method and its Application to Solid-Phase Oligosaccharide Synthesis and the Generation of Combinatorial Libraries; 3.1 Introduction; 3.2 Synthesis of Sulfoxide Donors; 3.3 Mechanism of the Sulfoxide Glycosylation; 3.4 Stereoselectivity 3.5 Solid-Phase Oligosaccharide Synthesis3.6 Libraries of Oligosaccharides; 3.7 Outlook; 4 The Use of O-Glycosyl Trichloroacetimidates for the Polymer-Supported Synthesis of Oligosaccharides; 4.1 Introduction; 4.2 Polystyrene-Based Supports; 4.3 Controlled-Pore Glass as a Solid Support; 4.4 Soluble Polymers as Supports; 4.5 Oligosaccharide Syntheses on Peptides Attached to a Solid Support; 4.6 Conclusions and Outlook; 5 Synthesis of Oligosaccharides on Solid Support Using Thioglycosides and Pentenyl Glycosides; 5.1 Introduction; 5.2 Thioglycosides as Glycosyl Donors 5.3 Pentenyl Glycosides as Glycosyl Donors6 Solid-Phase Oligosaccharide Synthesis Using Glycosyl Phosphates; 6.1 Introduction; 6.2 Glycosyl Phosphate Donors; 6.3 Other Phosphorous(V) Glycosyl Donors; 6.4 Conclusion; 7 Stereoselective β-Mannosylation on Polymer Support; 7.1 p-Methoxybenzyl-Assisted Intramolecular Aglycon Delivery: Highly Efficient β-mannosylation; 7.2 Intramolecular Aglycon Delivery on Polymer Support: Gatekeeper-Controlled Glycosylation; 7.3 Conclusions; 8 Tools for ""On-Bead"" Monitoring and Analysis in Solid-Phase Oligosaccharide Synthesis; 8.1 Introduction 8.2 IR Spectroscopic Methods8.3 NMR Spectroscopic Methods; 9 Polyethyleneglycol ω-Monomethylether (MPEG)-Supported Solution-Phase Synthesis of Oligosaccharides; 9.1 Introduction; 9.2 Polyethyleneglycol ω-Monomethylether (MPEG); 9.3 Linkers; 9.4 MPEG-Supported Syntheses Using Enzymes; 9.5 Use of MPEG in Mechanistic Studies; 9.6 MPEG and Combinatorial Libraries; 9.7 Other Applications; 9.8 Capping; 9.9 Outlook; 10 Two-Direction Glycosylations for the Preparation of Libraries of Oligosaccharides; 10.1 Two-Directional Glycosylations in Solution 10.2 Two-Directional Glycosylations on Solid Support |
| Record Nr. | UNINA-9910143186803321 |
| New York, : Wiley-Interscience, c2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid support oligosaccharide synthesis and combinatorial carbohydrate libraries [[electronic resource] /] / edited by Peter H. Seeberger
| Solid support oligosaccharide synthesis and combinatorial carbohydrate libraries [[electronic resource] /] / edited by Peter H. Seeberger |
| Pubbl/distr/stampa | New York, : Wiley-Interscience, c2001 |
| Descrizione fisica | 1 online resource (321 p.) |
| Disciplina |
547.7815
572/.565 |
| Altri autori (Persone) | SeebergerPeter H. <1966-> |
| Soggetto topico |
Oligosaccharides - Synthesis
Glycoconjugates Combinatorial chemistry Solid-phase synthesis |
| ISBN |
1-280-54174-1
9786610541744 0-471-46072-9 0-471-22044-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Contributors; 1 Solid-Phase Carbohydrate Synthesis: The Early Work; 1.1 Introduction; 1.2 Solid-Phase Strategies; 1.3 Oligosaccharide Synthesis on Soluble Polymers; 1.4 The Period of Stagnancy (1976-1991); 2 The Glycal Assembly Method on Solid Supports: Synthesis of Oligosaccharides and Glycoconjugates; 2.1 Introduction; 2.2 Why Glycal Assembly? Strategic Considerations; 2.3 Linker Design; 2.4 Solid Support Glycal Assembly via 1,2-Anhydrosugar Donors; 2.5 Solid-Phase Synthesis of the Blood Group H Determinant; 2.6 Solid Support Glycal Assembly via Thioethyl Glycosyl Donors
2.7 Solid Support Assembly via Thioethyl 2-Amidoglycosyl Donors2.8 Solid-Phase Synthesis of the Lewis[sub(b)] Blood Group Determinant; 2.9 Solid-Phase Synthesis of the Hexasaccharide Globo-H Antigen: Progress and Limitations; 2.10 Solid-Phase Synthesis of N-Linked Glycopeptides; 2.11 Conclusions; 3 The Sulfoxide Glycosylation Method and its Application to Solid-Phase Oligosaccharide Synthesis and the Generation of Combinatorial Libraries; 3.1 Introduction; 3.2 Synthesis of Sulfoxide Donors; 3.3 Mechanism of the Sulfoxide Glycosylation; 3.4 Stereoselectivity 3.5 Solid-Phase Oligosaccharide Synthesis3.6 Libraries of Oligosaccharides; 3.7 Outlook; 4 The Use of O-Glycosyl Trichloroacetimidates for the Polymer-Supported Synthesis of Oligosaccharides; 4.1 Introduction; 4.2 Polystyrene-Based Supports; 4.3 Controlled-Pore Glass as a Solid Support; 4.4 Soluble Polymers as Supports; 4.5 Oligosaccharide Syntheses on Peptides Attached to a Solid Support; 4.6 Conclusions and Outlook; 5 Synthesis of Oligosaccharides on Solid Support Using Thioglycosides and Pentenyl Glycosides; 5.1 Introduction; 5.2 Thioglycosides as Glycosyl Donors 5.3 Pentenyl Glycosides as Glycosyl Donors6 Solid-Phase Oligosaccharide Synthesis Using Glycosyl Phosphates; 6.1 Introduction; 6.2 Glycosyl Phosphate Donors; 6.3 Other Phosphorous(V) Glycosyl Donors; 6.4 Conclusion; 7 Stereoselective β-Mannosylation on Polymer Support; 7.1 p-Methoxybenzyl-Assisted Intramolecular Aglycon Delivery: Highly Efficient β-mannosylation; 7.2 Intramolecular Aglycon Delivery on Polymer Support: Gatekeeper-Controlled Glycosylation; 7.3 Conclusions; 8 Tools for ""On-Bead"" Monitoring and Analysis in Solid-Phase Oligosaccharide Synthesis; 8.1 Introduction 8.2 IR Spectroscopic Methods8.3 NMR Spectroscopic Methods; 9 Polyethyleneglycol ω-Monomethylether (MPEG)-Supported Solution-Phase Synthesis of Oligosaccharides; 9.1 Introduction; 9.2 Polyethyleneglycol ω-Monomethylether (MPEG); 9.3 Linkers; 9.4 MPEG-Supported Syntheses Using Enzymes; 9.5 Use of MPEG in Mechanistic Studies; 9.6 MPEG and Combinatorial Libraries; 9.7 Other Applications; 9.8 Capping; 9.9 Outlook; 10 Two-Direction Glycosylations for the Preparation of Libraries of Oligosaccharides; 10.1 Two-Directional Glycosylations in Solution 10.2 Two-Directional Glycosylations on Solid Support |
| Record Nr. | UNINA-9910829966203321 |
| New York, : Wiley-Interscience, c2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Solid support oligosaccharide synthesis and combinatorial carbohydrate libraries [[electronic resource] /] / edited by Peter H. Seeberger
| Solid support oligosaccharide synthesis and combinatorial carbohydrate libraries [[electronic resource] /] / edited by Peter H. Seeberger |
| Pubbl/distr/stampa | New York, : Wiley-Interscience, c2001 |
| Descrizione fisica | 1 online resource (321 p.) |
| Disciplina |
547.7815
572/.565 |
| Altri autori (Persone) | SeebergerPeter H. <1966-> |
| Soggetto topico |
Oligosaccharides - Synthesis
Glycoconjugates Combinatorial chemistry Solid-phase synthesis |
| ISBN |
1-280-54174-1
9786610541744 0-471-46072-9 0-471-22044-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Contributors; 1 Solid-Phase Carbohydrate Synthesis: The Early Work; 1.1 Introduction; 1.2 Solid-Phase Strategies; 1.3 Oligosaccharide Synthesis on Soluble Polymers; 1.4 The Period of Stagnancy (1976-1991); 2 The Glycal Assembly Method on Solid Supports: Synthesis of Oligosaccharides and Glycoconjugates; 2.1 Introduction; 2.2 Why Glycal Assembly? Strategic Considerations; 2.3 Linker Design; 2.4 Solid Support Glycal Assembly via 1,2-Anhydrosugar Donors; 2.5 Solid-Phase Synthesis of the Blood Group H Determinant; 2.6 Solid Support Glycal Assembly via Thioethyl Glycosyl Donors
2.7 Solid Support Assembly via Thioethyl 2-Amidoglycosyl Donors2.8 Solid-Phase Synthesis of the Lewis[sub(b)] Blood Group Determinant; 2.9 Solid-Phase Synthesis of the Hexasaccharide Globo-H Antigen: Progress and Limitations; 2.10 Solid-Phase Synthesis of N-Linked Glycopeptides; 2.11 Conclusions; 3 The Sulfoxide Glycosylation Method and its Application to Solid-Phase Oligosaccharide Synthesis and the Generation of Combinatorial Libraries; 3.1 Introduction; 3.2 Synthesis of Sulfoxide Donors; 3.3 Mechanism of the Sulfoxide Glycosylation; 3.4 Stereoselectivity 3.5 Solid-Phase Oligosaccharide Synthesis3.6 Libraries of Oligosaccharides; 3.7 Outlook; 4 The Use of O-Glycosyl Trichloroacetimidates for the Polymer-Supported Synthesis of Oligosaccharides; 4.1 Introduction; 4.2 Polystyrene-Based Supports; 4.3 Controlled-Pore Glass as a Solid Support; 4.4 Soluble Polymers as Supports; 4.5 Oligosaccharide Syntheses on Peptides Attached to a Solid Support; 4.6 Conclusions and Outlook; 5 Synthesis of Oligosaccharides on Solid Support Using Thioglycosides and Pentenyl Glycosides; 5.1 Introduction; 5.2 Thioglycosides as Glycosyl Donors 5.3 Pentenyl Glycosides as Glycosyl Donors6 Solid-Phase Oligosaccharide Synthesis Using Glycosyl Phosphates; 6.1 Introduction; 6.2 Glycosyl Phosphate Donors; 6.3 Other Phosphorous(V) Glycosyl Donors; 6.4 Conclusion; 7 Stereoselective β-Mannosylation on Polymer Support; 7.1 p-Methoxybenzyl-Assisted Intramolecular Aglycon Delivery: Highly Efficient β-mannosylation; 7.2 Intramolecular Aglycon Delivery on Polymer Support: Gatekeeper-Controlled Glycosylation; 7.3 Conclusions; 8 Tools for ""On-Bead"" Monitoring and Analysis in Solid-Phase Oligosaccharide Synthesis; 8.1 Introduction 8.2 IR Spectroscopic Methods8.3 NMR Spectroscopic Methods; 9 Polyethyleneglycol ω-Monomethylether (MPEG)-Supported Solution-Phase Synthesis of Oligosaccharides; 9.1 Introduction; 9.2 Polyethyleneglycol ω-Monomethylether (MPEG); 9.3 Linkers; 9.4 MPEG-Supported Syntheses Using Enzymes; 9.5 Use of MPEG in Mechanistic Studies; 9.6 MPEG and Combinatorial Libraries; 9.7 Other Applications; 9.8 Capping; 9.9 Outlook; 10 Two-Direction Glycosylations for the Preparation of Libraries of Oligosaccharides; 10.1 Two-Directional Glycosylations in Solution 10.2 Two-Directional Glycosylations on Solid Support |
| Record Nr. | UNINA-9910841416003321 |
| New York, : Wiley-Interscience, c2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||