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Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter
| Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 2001 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
540
660.28 |
| Soggetto topico | Chemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-76400-0
9786611764005 3-527-61294-7 3-527-61295-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry for the 21st Century; Contents; 1 Some Reflections on Chemistry - Molecular, Supramolecular and Beyond; 1.1 From Structure to Information. The Challenge of Instructed Chemistry; 1.2 Steps Towards Complexity; 1.3 Chemistry and Biology, Creativity and Art; 2 Chemical Synthesis and Biological Studies of the Epothilones - Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug Resistant Cell Lines and Tumors; 2.1 Introduction; 2.2 Total Synthesis of Epothilones; 2.3 First Generation Syntheses of Epothilones A and B; 2.4 First Generation Synthesis of the Acyl Domain
2.5 Investigation of C9-C10 Bond Construction Through Ring Closing Metathesis2.6 B-Alkyl Suzuki Strategy; 2.7 Macrolactonization and Macroaldolization Approaches; 2.8 A New and More Efficient Synthesis of Epothilone B; 2.9 Dianion Equivalents Corresponding to the Polypropionate Domain of Epothilone B; 2.10 B-Alkyl Suzuki Merger; 2.11 Stereoselective Noyori Reduction; 2.12 Discovery of a Remarkable Long-Range Effect on the Double Diastereoface Selectivity in an Aldol Condensation; 2.13 Preparation of Other Epothilone Analogs; 2.14 Biological Evaluation of Epothilones 2.15 SAR Analysis of Epothilones: The Zone Approach2.16 In Vitro Analysis Comparison to Paclitaxel and Related Agents; 2.17 In Vivo Analysis: Comparisons to Paclitaxel; 2.18 Conclusions; 2.19 Acknowledgements; 3 The Spirotetrahydrofuran Motif: its Role in Enhancing Ligation in Belted lonophores, Biasing Cyclohexane Conformation, and Restricting Nucleoside/Nucleotide Conformation; 3.1 Introduction; 3.2 syn-1,3,5-Orientation on a Cyclohexane Core; 3.3 Maximally Substituted Hexa(spirotetrahydrofuranyl)-cyclohexanes; 3.4 Spirocyclic Restriction of Nucleosides/Nucleotides; 3.5 Acknowledgement 4 Heterogeneous Catalysis: from ""Black Art"" to Atomic Understanding4.1 Introduction; 4.2 A Case Study Ammonia Synthesis; 4.3 The Surface Science Approach; 4.4 The Atomic Mechanism of a Catalytic Reaction: Oxidation of Carbon Monoxide; 4.5 Further Aspects; 5 Drugs for a New Millennium; 5.1 Introduction; 5.2 Cell Death; 5.3 Stroke and Myocardial Infarct; 5.4 Schizophrenia; 5.4.1 Neuroleptic Drug Development; 5.4.2 Drug Psychoses; 5.5 Drugs of Abuse; 5.5.1 Definitions and Varieties; 5.5.2 Approaches to Treatment: Focus on Cocaine; 5.6 Conclusions and New Directions; 5.7 Acknowledgements 6 Protein Folding and Beyond6.1 Introduction; 6.1.1 Computational Protein Folding; 6.1.2 All-atom Simulations of Protein Unfolding and Short Peptide Folding; 6.2 All-Atom Simulations of Folding of Small Proteins; 6.2.1 Concomitant Hydrophobic Collapse and Partial Helix Formation; 6.2.2 A Marginally Stable Intermediate State; 6.3 A Perspective View; 7 The Enzymology of Biological Nitrogen Fixation; 7.1 Early History; 7.2 Practical Applications; 7.3 Biochemistry of N2 Fixation; 7.4 First Product of N2 Fixation; 7.5 Studies with 15N as a Tracer; 7.6 N2 Fixation with Cell-Free Preparations 7.7 Nitrogenase Consists of Two Proteins |
| Record Nr. | UNINA-9910143990503321 |
| Weinheim, [Germany] : , : Wiley-VCH, , 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter
| Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 2001 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
540
660.28 |
| Soggetto topico | Chemistry |
| ISBN |
1-281-76400-0
9786611764005 3-527-61294-7 3-527-61295-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry for the 21st Century; Contents; 1 Some Reflections on Chemistry - Molecular, Supramolecular and Beyond; 1.1 From Structure to Information. The Challenge of Instructed Chemistry; 1.2 Steps Towards Complexity; 1.3 Chemistry and Biology, Creativity and Art; 2 Chemical Synthesis and Biological Studies of the Epothilones - Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug Resistant Cell Lines and Tumors; 2.1 Introduction; 2.2 Total Synthesis of Epothilones; 2.3 First Generation Syntheses of Epothilones A and B; 2.4 First Generation Synthesis of the Acyl Domain
2.5 Investigation of C9-C10 Bond Construction Through Ring Closing Metathesis2.6 B-Alkyl Suzuki Strategy; 2.7 Macrolactonization and Macroaldolization Approaches; 2.8 A New and More Efficient Synthesis of Epothilone B; 2.9 Dianion Equivalents Corresponding to the Polypropionate Domain of Epothilone B; 2.10 B-Alkyl Suzuki Merger; 2.11 Stereoselective Noyori Reduction; 2.12 Discovery of a Remarkable Long-Range Effect on the Double Diastereoface Selectivity in an Aldol Condensation; 2.13 Preparation of Other Epothilone Analogs; 2.14 Biological Evaluation of Epothilones 2.15 SAR Analysis of Epothilones: The Zone Approach2.16 In Vitro Analysis Comparison to Paclitaxel and Related Agents; 2.17 In Vivo Analysis: Comparisons to Paclitaxel; 2.18 Conclusions; 2.19 Acknowledgements; 3 The Spirotetrahydrofuran Motif: its Role in Enhancing Ligation in Belted lonophores, Biasing Cyclohexane Conformation, and Restricting Nucleoside/Nucleotide Conformation; 3.1 Introduction; 3.2 syn-1,3,5-Orientation on a Cyclohexane Core; 3.3 Maximally Substituted Hexa(spirotetrahydrofuranyl)-cyclohexanes; 3.4 Spirocyclic Restriction of Nucleosides/Nucleotides; 3.5 Acknowledgement 4 Heterogeneous Catalysis: from ""Black Art"" to Atomic Understanding4.1 Introduction; 4.2 A Case Study Ammonia Synthesis; 4.3 The Surface Science Approach; 4.4 The Atomic Mechanism of a Catalytic Reaction: Oxidation of Carbon Monoxide; 4.5 Further Aspects; 5 Drugs for a New Millennium; 5.1 Introduction; 5.2 Cell Death; 5.3 Stroke and Myocardial Infarct; 5.4 Schizophrenia; 5.4.1 Neuroleptic Drug Development; 5.4.2 Drug Psychoses; 5.5 Drugs of Abuse; 5.5.1 Definitions and Varieties; 5.5.2 Approaches to Treatment: Focus on Cocaine; 5.6 Conclusions and New Directions; 5.7 Acknowledgements 6 Protein Folding and Beyond6.1 Introduction; 6.1.1 Computational Protein Folding; 6.1.2 All-atom Simulations of Protein Unfolding and Short Peptide Folding; 6.2 All-Atom Simulations of Folding of Small Proteins; 6.2.1 Concomitant Hydrophobic Collapse and Partial Helix Formation; 6.2.2 A Marginally Stable Intermediate State; 6.3 A Perspective View; 7 The Enzymology of Biological Nitrogen Fixation; 7.1 Early History; 7.2 Practical Applications; 7.3 Biochemistry of N2 Fixation; 7.4 First Product of N2 Fixation; 7.5 Studies with 15N as a Tracer; 7.6 N2 Fixation with Cell-Free Preparations 7.7 Nitrogenase Consists of Two Proteins |
| Record Nr. | UNISA-996205069003316 |
| Weinheim, [Germany] : , : Wiley-VCH, , 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter
| Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 2001 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
540
660.28 |
| Soggetto topico | Chemistry |
| ISBN |
1-281-76400-0
9786611764005 3-527-61294-7 3-527-61295-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry for the 21st Century; Contents; 1 Some Reflections on Chemistry - Molecular, Supramolecular and Beyond; 1.1 From Structure to Information. The Challenge of Instructed Chemistry; 1.2 Steps Towards Complexity; 1.3 Chemistry and Biology, Creativity and Art; 2 Chemical Synthesis and Biological Studies of the Epothilones - Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug Resistant Cell Lines and Tumors; 2.1 Introduction; 2.2 Total Synthesis of Epothilones; 2.3 First Generation Syntheses of Epothilones A and B; 2.4 First Generation Synthesis of the Acyl Domain
2.5 Investigation of C9-C10 Bond Construction Through Ring Closing Metathesis2.6 B-Alkyl Suzuki Strategy; 2.7 Macrolactonization and Macroaldolization Approaches; 2.8 A New and More Efficient Synthesis of Epothilone B; 2.9 Dianion Equivalents Corresponding to the Polypropionate Domain of Epothilone B; 2.10 B-Alkyl Suzuki Merger; 2.11 Stereoselective Noyori Reduction; 2.12 Discovery of a Remarkable Long-Range Effect on the Double Diastereoface Selectivity in an Aldol Condensation; 2.13 Preparation of Other Epothilone Analogs; 2.14 Biological Evaluation of Epothilones 2.15 SAR Analysis of Epothilones: The Zone Approach2.16 In Vitro Analysis Comparison to Paclitaxel and Related Agents; 2.17 In Vivo Analysis: Comparisons to Paclitaxel; 2.18 Conclusions; 2.19 Acknowledgements; 3 The Spirotetrahydrofuran Motif: its Role in Enhancing Ligation in Belted lonophores, Biasing Cyclohexane Conformation, and Restricting Nucleoside/Nucleotide Conformation; 3.1 Introduction; 3.2 syn-1,3,5-Orientation on a Cyclohexane Core; 3.3 Maximally Substituted Hexa(spirotetrahydrofuranyl)-cyclohexanes; 3.4 Spirocyclic Restriction of Nucleosides/Nucleotides; 3.5 Acknowledgement 4 Heterogeneous Catalysis: from ""Black Art"" to Atomic Understanding4.1 Introduction; 4.2 A Case Study Ammonia Synthesis; 4.3 The Surface Science Approach; 4.4 The Atomic Mechanism of a Catalytic Reaction: Oxidation of Carbon Monoxide; 4.5 Further Aspects; 5 Drugs for a New Millennium; 5.1 Introduction; 5.2 Cell Death; 5.3 Stroke and Myocardial Infarct; 5.4 Schizophrenia; 5.4.1 Neuroleptic Drug Development; 5.4.2 Drug Psychoses; 5.5 Drugs of Abuse; 5.5.1 Definitions and Varieties; 5.5.2 Approaches to Treatment: Focus on Cocaine; 5.6 Conclusions and New Directions; 5.7 Acknowledgements 6 Protein Folding and Beyond6.1 Introduction; 6.1.1 Computational Protein Folding; 6.1.2 All-atom Simulations of Protein Unfolding and Short Peptide Folding; 6.2 All-Atom Simulations of Folding of Small Proteins; 6.2.1 Concomitant Hydrophobic Collapse and Partial Helix Formation; 6.2.2 A Marginally Stable Intermediate State; 6.3 A Perspective View; 7 The Enzymology of Biological Nitrogen Fixation; 7.1 Early History; 7.2 Practical Applications; 7.3 Biochemistry of N2 Fixation; 7.4 First Product of N2 Fixation; 7.5 Studies with 15N as a Tracer; 7.6 N2 Fixation with Cell-Free Preparations 7.7 Nitrogenase Consists of Two Proteins |
| Record Nr. | UNINA-9910830064003321 |
| Weinheim, [Germany] : , : Wiley-VCH, , 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||