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Cell and Molecular Biology of Ovarian Cancer : Updates, Insights and New Frontiers
| Cell and Molecular Biology of Ovarian Cancer : Updates, Insights and New Frontiers |
| Autore | Schatten Heide |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing AG, , 2024 |
| Descrizione fisica | 1 online resource (133 pages) |
| Collana | Advances in Experimental Medicine and Biology Series |
| Soggetto topico | Ovarian Neoplasms |
| ISBN |
9783031583117
9783031583100 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- 1: Microtubule-Targeting Agents: Disruption of the Cellular Cytoskeleton as a Backbone of Ovarian Cancer Therapy -- 1.1 Microtubules -- 1.1.1 Formation and Features -- 1.1.2 Role in Cellular Function -- 1.2 NCCN-Approved Agents for Use in Ovarian Cancer -- 1.3 Microtubule-Stabilizing Agents -- 1.3.1 Paclitaxel -- 1.3.2 Nab-paclitaxel -- 1.3.3 Docetaxel -- 1.3.4 Ixabepilone -- 1.4 Microtubule-Destabilizing Agents -- 1.4.1 Vincristine -- 1.4.1.1 Vinblastine -- 1.4.2 Vinorelbine -- 1.5 Mechanisms of Resistance -- References -- 2: Tubulin Complexity in Cancer and Metastasis -- 2.1 Tubulin Complexity -- 2.2 Microtubule-Associated Proteins (MAPs) -- 2.3 Tubulin Posttranslational Modifications (PTMs) -- 2.4 Microtentacles -- References -- 3: The Impact of Centrosome Pathologies on Ovarian Cancer Development and Progression with a Focus on Centrosomes as Therapeutic Target -- 3.1 Introduction -- 3.2 Structure, Composition, and Function of Centrosomes and Abnormalities/Dysregulation in Ovarian Cancer -- 3.3 Centrosome Regulation in Normal Cell Cycles -- 3.4 Centrosome Dysregulation, Abnormalities in Ovarian Cancer, and New Research to Correct Centrosome Abnormalities -- 3.4.1 Centrosome Clustering -- 3.5 The Role of Primary Cilia in Ovarian Cancer -- 3.6 Centrosomes as Target for Ovarian Cancer Therapy -- 3.7 Conclusion and Future Directions -- References -- 4: Drug-Resistant Epithelial Ovarian Cancer: Current and Future Perspectives -- 4.1 Introduction to Epithelial Ovarian Cancer and Its Subtypes -- 4.1.1 Type I Neoplasms -- 4.1.1.1 Low-Grade Serous Ovarian Cancer (LGSOC) Subtype -- 4.1.1.2 Sero-mucinous Subtype -- 4.1.1.3 Mucinous Ovarian Carcinomas (MOC) -- 4.1.1.4 Endometrioid Ovarian Carcinomas (EEOC) -- 4.1.1.5 Clear Cell Ovarian Carcinomas (CCOC) -- 4.1.1.6 Brenner Tumours.
4.1.2 Type II Neoplasms -- 4.1.2.1 High-Grade Serous Ovarian Cancer (HGSOC) -- 4.1.2.2 High Grade EEOC -- 4.1.2.3 Undifferentiated Carcinoma -- 4.2 Current Diagnostic Strategies -- 4.3 Current Treatment Modalities -- 4.3.1 Targeted Therapy -- 4.4 Resistance, a Major Limitation Against Currently Available Therapeutics -- 4.5 Elucidating Drug Resistance Mechanisms: Understanding the Molecular Players -- 4.5.1 Decreased Intracellular Drug Accumulation and Increased Drug Export -- 4.5.1.1 Influx Transporters -- 4.5.1.2 Efflux Transporters -- 4.5.2 Increased Drug Inactivation -- 4.5.2.1 CYP System -- 4.5.2.2 Glutathione S-Transferase (GST) -- 4.5.2.3 Uridine Diphospho-glucuronosyltransferase (UGT) Superfamily -- 4.5.3 Resistance to PARP Inhibitors and HR Pathways -- 4.5.4 Deregulated Autophagy -- 4.5.5 Altered Metabolism -- 4.5.5.1 Glucose Metabolism -- 4.5.5.2 Fatty Acid Metabolism -- 4.5.5.3 Altered Glutamine Metabolism -- 4.5.6 Evasion of Apoptosis -- 4.5.7 Cancer Stem Cells -- 4.5.8 Role of miRNAs and lncRNA -- 4.6 An Insight Into the Upcoming Therapies and Clinical Trials -- 4.6.1 Overcoming Bevacizumab Resistance Through Peptide Fusion Protein Trebananib -- 4.6.2 Emerging Targeted Therapies -- 4.6.2.1 Anti-angiogenic agents -- 4.6.2.2 Targeting the DNA Repair Pathway -- 4.6.2.3 Receptor Tyrosine Kinase Inhibitors -- 4.6.2.4 Epidermal Growth Factor Receptor- Family Targeted Inhibitors -- 4.6.2.5 MEK Inhibitors -- 4.6.2.6 PI3K Inhibitors -- 4.6.3 Strategies to Develop Additional Synthetic Lethal Therapies -- 4.6.3.1 Wee1 Inhibition -- 4.6.3.2 CHK1 Inhibitors -- 4.6.4 Sequential and Combinatorial Approaches Using Chemotherapeutics and Molecular Targeted Agents -- 4.6.5 Targeting Immune Evasion Mechanisms -- 4.6.5.1 Adoptive T-Cell Therapies -- 4.6.6 Targeting the Tumour Microenvironment. 4.6.7 Vaccine-Based Therapies -- 4.6.7.1 Cell-Based Vaccine-Cvac -- 4.6.7.2 p53 Vaccine-p53MVA -- 4.6.7.3 Tumour-Associated Antigens-DPX-Survivac -- 4.7 Conclusion -- References -- 5: The Role of the Human Microbiome in Epithelial Ovarian Cancer -- 5.1 Introduction -- 5.2 Human Microbiome -- 5.3 Epithelial Ovarian Cancer and the Human Microbiome -- 5.3.1 Lower Reproductive Tract -- 5.3.2 Upper Reproductive Tract -- 5.3.3 Gastrointestinal Tract -- 5.4 Conclusions and Future Directions -- References -- 6: Insights into the Microbial Composition of Intratumoral, Reproductive Tract, and Gut Microbiota in Ovarian Cancer Patients -- 6.1 Introduction -- 6.2 Overview of Ovarian Cancer Associated Microbiota -- 6.2.1 Ovarian Cancer Tissue Microbial Composition and Origin -- 6.2.2 Reproductive Tract Microbial Composition -- 6.2.3 The Relationship Between Reproductive Tract Microbiota and Ovarian Cancer -- 6.2.4 Gut Microbiota in Ovarian Cancer Patients and Animal Models -- 6.3 Functions of Ovarian Cancer-Associated Microbiota Metabolites -- 6.3.1 Microbial Metabolites Affect Ovarian Cancer Development -- 6.3.2 Microbiota Affect Hormone Regulation and Carcinogenesis -- 6.3.3 Microbiota Regulate Inflammatory and Immune Regulation -- 6.4 Bacteria in Therapeutics and Diagnostics of Ovarian Cancer -- 6.4.1 The Role of Microbiota in Therapeutic Effects in Ovarian Cancer -- 6.4.1.1 The Potential Role of Microbiota in Ovarian Cancer Therapy Drug Resistance -- 6.4.1.2 A Dual Role of Antibiotic Therapy for Ovarian Cancer -- 6.4.2 Nutrient and Diet Modify Microbiome and Help Prevent Ovarian Cancer -- 6.5 Conclusion and Future Perspectives -- References -- 7: The Impact of Mitochondria in Ovarian Cancer Cell Metabolism, Proliferation, and Metastasis -- 7.1 Introduction -- 7.1.1 Mitochondrial Vulnerabilities Underlying Dysfunction and Disease. 7.1.2 Mitochondrial Dysfunction in Ovarian Cancer -- 7.1.3 Present Treatment Difficulties for Ovarian Cancer and New Potential Treatment Strategies to Target Ovarian Cancer Mitochondrial Metabolism -- 7.1.4 Biobehavioral Factors Influencing Ovarian Cancer Development -- 7.2 Conclusions and Future Perspectives -- References -- Index. |
| Record Nr. | UNINA-9910865232203321 |
Schatten Heide
|
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| Cham : , : Springer International Publishing AG, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Centrosome and its Functions and Dysfunctions / / by Heide Schatten
| The Centrosome and its Functions and Dysfunctions / / by Heide Schatten |
| Autore | Schatten Heide |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (115 pages) |
| Disciplina | 574.3 |
| Collana | Advances in Anatomy, Embryology and Cell Biology |
| Soggetto topico |
Cytology
Reproduction Physiology Medicine - Research Biology - Research Cancer Developmental biology Cell Biology Reproductive Physiology Biomedical Research Cancer Biology Developmental Biology and Stem Cells Centrosomes Citologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN |
9783031208485
9783031208478 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cell and Molecular Biology of Centrosome Structure and Function -- The centrosome Cycle within the cell cycle -- Centrosome as center for proteolytic activity and dysfunctions associated with pathogenesis of human disease -- Centrosome dysfunctions in cancer -- Virus exploitation of centrosomes -- Centrosomes in reproduction -- Transition from centrosomal to non-centrosomal microtubule organization during cellular polarization -- External and environmental effects on Centrosomes -- Centrosomes and centrosome equivalents in other systems -- Non-centrosomal microtubule organization in plant cells. |
| Record Nr. | UNINA-9910635397603321 |
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Schatten Heide
|
||
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Scanning electron microscopy for the life sciences / / Heide Schatten [[electronic resource]]
| Scanning electron microscopy for the life sciences / / Heide Schatten [[electronic resource]] |
| Autore | Schatten Heide |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2013 |
| Descrizione fisica | 1 online resource (xi, 261 pages) : digital, PDF file(s) |
| Disciplina | 570.28/25 |
| Collana | Advances in microscopy and microanalysis |
| Soggetto topico |
Biology - Methodology
Scanning electron microscopy |
| ISBN |
1-107-23287-2
1-139-85343-0 1-139-01817-5 1-139-84549-7 1-139-83960-8 1-139-84198-X 1-139-84434-2 1-283-81251-7 1-139-84079-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. The role of scanning electron microscopy in cell and molecular biology: SEM basics, past accomplishments and new frontiers / Heide Schatten -- 2. Corrosion casting technique / Jerzy Walocha, Jan A. Litwin and Adam J. Miodoński -- 3. Revealing the internal structure of cells in three dimensions with scanning electron microscopy / Sol Sepsenwol -- 4. Mitochondria form continuous intracellular network-structures visualized with high-resolution field-emission scanning electron microscopy / T. Naguro, H. Nakane and S. Inaga -- 5. Is the scanning mode the future of electron microscopy in cell biology? / Paul Walther, Christopher Schmid, Michaela Sailer, and Katherine Höhn -- 6. High resolution labeling for correlative microscopy / Ralph Albrecht, Daryl A. Meyer and O.E. Olorundare -- 7. The use of SEM to explore virus structure and trafficking / Jens M. Holl and Elizabeth R. Wright -- 8. High resolution scanning electron microscopy of the nuclear surface in Herpes Simplex Virus 1 infected cells / Peter Wild, Andres Kaech and Miriam S. Lucas -- 9. Scanning electron microscopy of chromosomes: structural and analytical investigations / Elizabeth Schroeder-Reiter and Gerhard Wanner -- 10. A method to visualize the microarchitecture of glycoprotein matrices with scanning electron microscopy / Giuseppe Familiari, Rosemarie Heyn, Luciano Petruzziello and Michela Relucenti -- 11. Scanning electron microscopy of cerebellar intrinsic circuits / Orlando J. Castejón -- 12. Application of in vivo cryotechnique to living animal organs examined by scanning electron microscopy / Shinichi Ohno, Nobuo Terada, Nobuhiko Ohno and Yasuhisa Fujii -- 13. SEM in dental research / Vladimir Dusevich, Jennifer R. Melander and J. David Eick -- 14. SEM, teeth and palaeoanthropology: the secret of ancient human diets / Alejandro Romero and Joaquín De Juan. |
| Record Nr. | UNINA-9910453005703321 |
|
Schatten Heide
|
||
| Cambridge : , : Cambridge University Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Scanning electron microscopy for the life sciences / / Heide Schatten [[electronic resource]]
| Scanning electron microscopy for the life sciences / / Heide Schatten [[electronic resource]] |
| Autore | Schatten Heide |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2013 |
| Descrizione fisica | 1 online resource (xi, 261 pages) : digital, PDF file(s) |
| Disciplina | 570.28/25 |
| Collana | Advances in microscopy and microanalysis |
| Soggetto topico |
Biology - Methodology
Scanning electron microscopy |
| ISBN |
1-107-23287-2
1-139-85343-0 1-139-01817-5 1-139-84549-7 1-139-83960-8 1-139-84198-X 1-139-84434-2 1-283-81251-7 1-139-84079-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. The role of scanning electron microscopy in cell and molecular biology: SEM basics, past accomplishments and new frontiers / Heide Schatten -- 2. Corrosion casting technique / Jerzy Walocha, Jan A. Litwin and Adam J. Miodoński -- 3. Revealing the internal structure of cells in three dimensions with scanning electron microscopy / Sol Sepsenwol -- 4. Mitochondria form continuous intracellular network-structures visualized with high-resolution field-emission scanning electron microscopy / T. Naguro, H. Nakane and S. Inaga -- 5. Is the scanning mode the future of electron microscopy in cell biology? / Paul Walther, Christopher Schmid, Michaela Sailer, and Katherine Höhn -- 6. High resolution labeling for correlative microscopy / Ralph Albrecht, Daryl A. Meyer and O.E. Olorundare -- 7. The use of SEM to explore virus structure and trafficking / Jens M. Holl and Elizabeth R. Wright -- 8. High resolution scanning electron microscopy of the nuclear surface in Herpes Simplex Virus 1 infected cells / Peter Wild, Andres Kaech and Miriam S. Lucas -- 9. Scanning electron microscopy of chromosomes: structural and analytical investigations / Elizabeth Schroeder-Reiter and Gerhard Wanner -- 10. A method to visualize the microarchitecture of glycoprotein matrices with scanning electron microscopy / Giuseppe Familiari, Rosemarie Heyn, Luciano Petruzziello and Michela Relucenti -- 11. Scanning electron microscopy of cerebellar intrinsic circuits / Orlando J. Castejón -- 12. Application of in vivo cryotechnique to living animal organs examined by scanning electron microscopy / Shinichi Ohno, Nobuo Terada, Nobuhiko Ohno and Yasuhisa Fujii -- 13. SEM in dental research / Vladimir Dusevich, Jennifer R. Melander and J. David Eick -- 14. SEM, teeth and palaeoanthropology: the secret of ancient human diets / Alejandro Romero and Joaquín De Juan. |
| Record Nr. | UNINA-9910779340903321 |
|
Schatten Heide
|
||
| Cambridge : , : Cambridge University Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Scanning electron microscopy for the life sciences / / Heide Schatten [[electronic resource]]
| Scanning electron microscopy for the life sciences / / Heide Schatten [[electronic resource]] |
| Autore | Schatten Heide |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2013 |
| Descrizione fisica | 1 online resource (xi, 261 pages) : digital, PDF file(s) |
| Disciplina | 570.28/25 |
| Collana | Advances in microscopy and microanalysis |
| Soggetto topico |
Biology - Methodology
Scanning electron microscopy |
| ISBN |
1-107-23287-2
1-139-85343-0 1-139-01817-5 1-139-84549-7 1-139-83960-8 1-139-84198-X 1-139-84434-2 1-283-81251-7 1-139-84079-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. The role of scanning electron microscopy in cell and molecular biology: SEM basics, past accomplishments and new frontiers / Heide Schatten -- 2. Corrosion casting technique / Jerzy Walocha, Jan A. Litwin and Adam J. Miodoński -- 3. Revealing the internal structure of cells in three dimensions with scanning electron microscopy / Sol Sepsenwol -- 4. Mitochondria form continuous intracellular network-structures visualized with high-resolution field-emission scanning electron microscopy / T. Naguro, H. Nakane and S. Inaga -- 5. Is the scanning mode the future of electron microscopy in cell biology? / Paul Walther, Christopher Schmid, Michaela Sailer, and Katherine Höhn -- 6. High resolution labeling for correlative microscopy / Ralph Albrecht, Daryl A. Meyer and O.E. Olorundare -- 7. The use of SEM to explore virus structure and trafficking / Jens M. Holl and Elizabeth R. Wright -- 8. High resolution scanning electron microscopy of the nuclear surface in Herpes Simplex Virus 1 infected cells / Peter Wild, Andres Kaech and Miriam S. Lucas -- 9. Scanning electron microscopy of chromosomes: structural and analytical investigations / Elizabeth Schroeder-Reiter and Gerhard Wanner -- 10. A method to visualize the microarchitecture of glycoprotein matrices with scanning electron microscopy / Giuseppe Familiari, Rosemarie Heyn, Luciano Petruzziello and Michela Relucenti -- 11. Scanning electron microscopy of cerebellar intrinsic circuits / Orlando J. Castejón -- 12. Application of in vivo cryotechnique to living animal organs examined by scanning electron microscopy / Shinichi Ohno, Nobuo Terada, Nobuhiko Ohno and Yasuhisa Fujii -- 13. SEM in dental research / Vladimir Dusevich, Jennifer R. Melander and J. David Eick -- 14. SEM, teeth and palaeoanthropology: the secret of ancient human diets / Alejandro Romero and Joaquín De Juan. |
| Record Nr. | UNINA-9910828651903321 |
|
Schatten Heide
|
||
| Cambridge : , : Cambridge University Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||