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Asteroseismology and Exoplanets: Listening to the Stars and Searching for New Worlds : IVth Azores International Advanced School in Space Sciences / / edited by Tiago L. Campante, Nuno C. Santos, Mário J. P. F. G. Monteiro
| Asteroseismology and Exoplanets: Listening to the Stars and Searching for New Worlds : IVth Azores International Advanced School in Space Sciences / / edited by Tiago L. Campante, Nuno C. Santos, Mário J. P. F. G. Monteiro |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (XVI, 282 p. 74 illus., 53 illus. in color.) |
| Disciplina | 523.7 |
| Collana | Astrophysics and Space Science Proceedings |
| Soggetto topico |
Observations, Astronomical
Astronomy—Observations Astrophysics Space sciences Astronomy, Observations and Techniques Astrophysics and Astroparticles Space Sciences (including Extraterrestrial Physics, Space Exploration and Astronautics) |
| ISBN | 3-319-59315-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910300538403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Membrane–Peptide Interactions : From Basics to Current Applications
| Membrane–Peptide Interactions : From Basics to Current Applications |
| Autore | Santos Nuno C |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (302 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
tachyplesin
host defense peptide anticancer antimicrobial antibiofilm peptide-membrane interaction structure-activity model membranes nuclear magnetic resonance solution structure accelerated molecular dynamics alamethicin membrane peptaibol cell-penetrating peptide peptide–lipid interaction lipid model systems molecular dynamics NMR membrane biophysics antimicrobial peptides non-lytic peptides bacterial membranes calcium hydroxide chemokine human beta defensin-3-C15 human dental pulp cell Streptococcus gordonii lipoprotein luffa sponge phosphopeptide mass spectrometry Matrix-assisted laser desorption ionization solid-phase extraction surface plasmon resonance melittin liposomes peptide–lipid interactions anti-microbial peptides pore-forming peptides ESKAPE pathogens Staphylococcus aureus KR12 LL-37 lipopeptide critical aggregation concentration CD spectroscopy biofilm cytotoxicity organisms sequence analysis machine learning feature selection sesame protein ACE inhibitory peptides simulated gastrointestinal digestion amino acid sequence molecular docking chionodracines circular dichroism membrane affinity cell-penetrating peptides circular dichroism spectroscopy atomic force microscopy mycolic acid Langmuir monolayer drug–peptide conjugates metastasis model of B16F10 melanoma Pisum sativum defensin 1 (Psd1) anti-metastatic activity glucosylceramide (GlcCer) cyclin F anti-inflammatory peptide cell permeable peptide heparin-binding peptide collagen-induced arthritis inducible nitric oxide interferon gamma interleukin-6 Enbrel |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
MembraneâPeptide Interactions
Membrane–Peptide Interactions |
| Record Nr. | UNINA-9910557551603321 |
Santos Nuno C
|
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptide drug discovery and development [[electronic resource] ] : translational research in academia and industry / / edited by Miguel Castanho and Nuno C. Santos
| Peptide drug discovery and development [[electronic resource] ] : translational research in academia and industry / / edited by Miguel Castanho and Nuno C. Santos |
| Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2011 |
| Descrizione fisica | 1 online resource (392 p.) |
| Disciplina |
572.65
615.19 |
| Altri autori (Persone) |
CastanhoMiguel
SantosNuno C |
| Soggetto topico |
Peptide drugs
Drugs - Design Pharmacology |
| ISBN |
3-527-63674-9
1-283-30251-9 9786613302519 3-527-63673-0 3-527-63675-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Peptide Drug Discovery and Development: Translational Research in Academia and Industry; Contents; Preface; List of Contributors; Part I: The Academia - Market Bouncing of Peptide Drugs - Challenges and Strategies in Translational Research with Peptide Drugs; 1: Peptides as Leads for Drug Discovery; 1.1: Introduction; 1.2: Overview of Process for Transforming Peptides to Peptidomimetics; 1.3: HCMV Protease; 1.3.1: HCMV Protease: Identification and Characterization of Antiviral Inhibitors Targeting the Serine Protease Domain of the Human Cytomegalovirus (HCMV Protease)
1.3.2: Mapping Essential Elements of the Substrate Peptides and Determining Structures of Ligands Bound to HCMV1.3.3: Improving Peptide Activity to Allow SAR Studies; 1.3.4: Elucidation of the Binding Mode of the Optimized Peptidyl Segment; 1.3.5: Ligand Adaptations upon Binding; 1.3.6: Strategic Summary for HCMV Peptide Mimic Design Process; 1.4: HCV Protease; 1.4.1: HCV Protease as an Antiviral Target; 1.4.2: NS3 Serine Protease Possesses a Chymotrypsin-Like Fold; 1.4.3: Discovery of the Peptide DDIVPC as an Inhibitor of NS3 Protease 1.4.4: ''Sensemaking'' and Knowledge Building: Mapping of the Critical Binding Residues of the Peptide and Creation of an Inhibitor-Protease Model1.4.5: Knowledge Building: Monitoring Ligand Flexibility in the Free-State and Changes Upon Binding - P3 Rigidification; 1.4.6: N-Terminal Truncation and Improved P1, P2 and P5 Substituents; 1.4.7: Macrocyclization: Linking the Flexible P1 Side-Chain to P3; 1.4.8: HCV Protease Inhibitor BI00201335; 1.5: Herpes Simplex Virus; 1.5.1: Herpes Simplex Virus-Encoded Ribonucleotide Reductase Inhibitors; 1.6: Renin 1.6.1: Aspartyl Protease Renin as a Target1.7: HIV; 1.7.1: HIV Protease Inhibitors; 1.8: Conclusions; 2: Marketing Antimicrobial Peptides: A Critical Academic Point of View; 2.1: Introduction; 2.2: Basic Research: Antimicrobial Peptides; 2.3: Patents; 2.4: Potential Applications of AMPs; 2.5: Technology Transfer: Valorization, Licensing, or Spin-Off Creation; 2.6: Spin-Off Creation: An Academic Point of View; 3: Oral Peptide Drug Delivery: Strategies to Overcome Challenges; 3.1: Introduction; 3.2: Challenges Associated with Oral Peptide Delivery 3.2.1: Transport Pathways Across the Intestinal Epithelium3.2.2: Unfavorable Physicochemical Properties of Peptide Drugs; 3.2.2.1: Molecular Size, Hydrophilicity, and Physical Stability; 3.2.3: Physical Barriers of the Gastrointestinal Tract; 3.2.3.1: Transcellular Pathway; 3.2.3.2: Paracellular Pathway; 3.2.4: Biochemical Barriers of the Gastrointestinal Tract; 3.2.4.1: Luminal Enzymes; 3.2.4.2: Brush Border Membrane Bound Enzymes and Intracellular Enzymes; 3.2.5: Efflux Transport Systems; 3.2.6: Gastrointestinal Transit Time and Site-Specific Absorption 3.3: Strategies to Overcome the Barriers of the Gastrointestinal Tract |
| Record Nr. | UNINA-9910139579303321 |
| Weinheim, Germany, : Wiley-VCH, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptide drug discovery and development : translational research in academia and industry / / edited by Miguel Castanho and Nuno C. Santos
| Peptide drug discovery and development : translational research in academia and industry / / edited by Miguel Castanho and Nuno C. Santos |
| Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2011 |
| Descrizione fisica | 1 online resource (xix, 370 pages) : illustrations |
| Disciplina |
572.65
615.19 |
| Altri autori (Persone) |
CastanhoMiguel A. R. B
SantosNuno C |
| Soggetto topico |
Peptide drugs
Drugs - Design Pharmacology |
| ISBN |
3-527-63674-9
1-283-30251-9 9786613302519 3-527-63673-0 3-527-63675-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Peptide Drug Discovery and Development: Translational Research in Academia and Industry; Contents; Preface; List of Contributors; Part I: The Academia - Market Bouncing of Peptide Drugs - Challenges and Strategies in Translational Research with Peptide Drugs; 1: Peptides as Leads for Drug Discovery; 1.1: Introduction; 1.2: Overview of Process for Transforming Peptides to Peptidomimetics; 1.3: HCMV Protease; 1.3.1: HCMV Protease: Identification and Characterization of Antiviral Inhibitors Targeting the Serine Protease Domain of the Human Cytomegalovirus (HCMV Protease)
1.3.2: Mapping Essential Elements of the Substrate Peptides and Determining Structures of Ligands Bound to HCMV1.3.3: Improving Peptide Activity to Allow SAR Studies; 1.3.4: Elucidation of the Binding Mode of the Optimized Peptidyl Segment; 1.3.5: Ligand Adaptations upon Binding; 1.3.6: Strategic Summary for HCMV Peptide Mimic Design Process; 1.4: HCV Protease; 1.4.1: HCV Protease as an Antiviral Target; 1.4.2: NS3 Serine Protease Possesses a Chymotrypsin-Like Fold; 1.4.3: Discovery of the Peptide DDIVPC as an Inhibitor of NS3 Protease 1.4.4: ''Sensemaking'' and Knowledge Building: Mapping of the Critical Binding Residues of the Peptide and Creation of an Inhibitor-Protease Model1.4.5: Knowledge Building: Monitoring Ligand Flexibility in the Free-State and Changes Upon Binding - P3 Rigidification; 1.4.6: N-Terminal Truncation and Improved P1, P2 and P5 Substituents; 1.4.7: Macrocyclization: Linking the Flexible P1 Side-Chain to P3; 1.4.8: HCV Protease Inhibitor BI00201335; 1.5: Herpes Simplex Virus; 1.5.1: Herpes Simplex Virus-Encoded Ribonucleotide Reductase Inhibitors; 1.6: Renin 1.6.1: Aspartyl Protease Renin as a Target1.7: HIV; 1.7.1: HIV Protease Inhibitors; 1.8: Conclusions; 2: Marketing Antimicrobial Peptides: A Critical Academic Point of View; 2.1: Introduction; 2.2: Basic Research: Antimicrobial Peptides; 2.3: Patents; 2.4: Potential Applications of AMPs; 2.5: Technology Transfer: Valorization, Licensing, or Spin-Off Creation; 2.6: Spin-Off Creation: An Academic Point of View; 3: Oral Peptide Drug Delivery: Strategies to Overcome Challenges; 3.1: Introduction; 3.2: Challenges Associated with Oral Peptide Delivery 3.2.1: Transport Pathways Across the Intestinal Epithelium3.2.2: Unfavorable Physicochemical Properties of Peptide Drugs; 3.2.2.1: Molecular Size, Hydrophilicity, and Physical Stability; 3.2.3: Physical Barriers of the Gastrointestinal Tract; 3.2.3.1: Transcellular Pathway; 3.2.3.2: Paracellular Pathway; 3.2.4: Biochemical Barriers of the Gastrointestinal Tract; 3.2.4.1: Luminal Enzymes; 3.2.4.2: Brush Border Membrane Bound Enzymes and Intracellular Enzymes; 3.2.5: Efflux Transport Systems; 3.2.6: Gastrointestinal Transit Time and Site-Specific Absorption; 3.3: Strategies to Overcome the Barriers of the Gastrointestinal Tract |
| Record Nr. | UNINA-9910829074503321 |
| Weinheim, Germany, : Wiley-VCH, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||