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Hepatotoxicity [[electronic resource] ] : from genomics to in vitro and in vivo models / / editor, Saura C. Sahu
| Hepatotoxicity [[electronic resource] ] : from genomics to in vitro and in vivo models / / editor, Saura C. Sahu |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 |
| Descrizione fisica | 1 online resource (704 p.) |
| Disciplina |
616.3
616.3/623071 616.3623071 |
| Altri autori (Persone) | SahuSaura C |
| Soggetto topico | Hepatotoxicology |
| ISBN |
1-281-31820-5
9786611318208 0-470-51675-5 0-470-51674-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Current in vitro models to study drug-induced liver injury / Julio C. Davila ... [et al.] -- Utilization of an in vitro hepatotoxicity test in the early stage of drug discovery / Ikuo Horii ... [et al.] -- Use of hepatocytes for characterizing a candidate drug's metabolism and drug interaction potential / Srikanth C. Nallani, John M. Strong, and Shiew Mei Huang -- Human-based in vitro experimental systems for the evaluation of human drug safety / Albert P. Li -- Hepatocytes as a model for screening food-related hepatotoxins and studying mechanisms of their toxicity / Saura C. Sahu -- Some experimental models of liver damage / Pablo Muriel -- Application of short- and long-term hepatocyte cultures to predict toxicities / Gregor Tuschl ... [et al.] -- Biomarkers of mycotoxin exposure in liver toxicity / Angela J. Harris -- Mechanisms of toxic liver injury / Nora Anderson and Jurgen Borlak -- A role of cytochrome P450 in quinone-induced hepatotoxicity / Yasuhiro Ishihara and Norio Shimamoto -- A mechanistic view of troglitazone hepatotoxicity / Rawiwan Maniratanachote and Tsuyoshi Yokoi -- Role of the Kupffer cell in hepatotoxicity and hepatocarcinogenesis / James E. Klaunig ... [et al.] -- Sinusoidal cells in liver injury and repair / Carol C. Gardner and Debra L. Laskin -- Cytokines in liver diseases / Pablo Muriel -- Bile acids as modulators of apoptosis / Rui E. Castro ... [et al.] --
Drug-induced intrahepatic cholestasis by interaction with the hepatic bile salt export pump (BSEP) / Christoph Funk ... [et al.] -- Application of toxicogenomics in predicting hepatotoxicity: potentials and challenges / Wen Lin ... [et al.] -- Genomic profiling of liver injury / Kevin Gerrish and David E. Malarkey -- Use of DNA arrays in understanding hepatic test systems / Angela J. Harris and Daniel A. Casciano -- Prediction of hepatotoxicity based on the toxicogenomics database / Tetsuro Urushidani -- Relationship between N-acetyltransferase-2 gene polymorphism and isoniazid-induced hepatotoxicity / Yasuo Shimazu, Kunio Dobashi, and Masatomo Mori -- Human and animal-based differences in hepatic xenobiotic metabolism and toxicity / Peter J. O'Brien, Katie Chan, and Raymond J. Poon -- Hepatotoxicity in oncology drug development / Wei Chen, Kenneth Hastings, and John K. Leighton -- The potent rat hepatocarcinogen methapyrilene: an hypothesis regarding its hepatotoxicology / Daniel A. Casciano -- Botanical supplements and hepatotoxicity / Shabana Khan, Ikhlas Khan, and Larry Walker -- Physiologically based pharmokinetic modeling and risk assessment of hepatotoxicants / Kannan Krishnan. |
| Record Nr. | UNINA-9910145702203321 |
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hepatotoxicity : from genomics to in vitro and in vivo models / / editor, Saura C. Sahu
| Hepatotoxicity : from genomics to in vitro and in vivo models / / editor, Saura C. Sahu |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 |
| Descrizione fisica | 1 online resource (704 p.) |
| Disciplina | 616.3/623071 |
| Altri autori (Persone) | SahuSaura C |
| Soggetto topico | Hepatotoxicology |
| ISBN |
1-281-31820-5
9786611318208 0-470-51675-5 0-470-51674-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Current in vitro models to study drug-induced liver injury / Julio C. Davila ... [et al.] -- Utilization of an in vitro hepatotoxicity test in the early stage of drug discovery / Ikuo Horii ... [et al.] -- Use of hepatocytes for characterizing a candidate drug's metabolism and drug interaction potential / Srikanth C. Nallani, John M. Strong, and Shiew Mei Huang -- Human-based in vitro experimental systems for the evaluation of human drug safety / Albert P. Li -- Hepatocytes as a model for screening food-related hepatotoxins and studying mechanisms of their toxicity / Saura C. Sahu -- Some experimental models of liver damage / Pablo Muriel -- Application of short- and long-term hepatocyte cultures to predict toxicities / Gregor Tuschl ... [et al.] -- Biomarkers of mycotoxin exposure in liver toxicity / Angela J. Harris -- Mechanisms of toxic liver injury / Nora Anderson and Jurgen Borlak -- A role of cytochrome P450 in quinone-induced hepatotoxicity / Yasuhiro Ishihara and Norio Shimamoto -- A mechanistic view of troglitazone hepatotoxicity / Rawiwan Maniratanachote and Tsuyoshi Yokoi -- Role of the Kupffer cell in hepatotoxicity and hepatocarcinogenesis / James E. Klaunig ... [et al.] -- Sinusoidal cells in liver injury and repair / Carol C. Gardner and Debra L. Laskin -- Cytokines in liver diseases / Pablo Muriel -- Bile acids as modulators of apoptosis / Rui E. Castro ... [et al.] --
Drug-induced intrahepatic cholestasis by interaction with the hepatic bile salt export pump (BSEP) / Christoph Funk ... [et al.] -- Application of toxicogenomics in predicting hepatotoxicity: potentials and challenges / Wen Lin ... [et al.] -- Genomic profiling of liver injury / Kevin Gerrish and David E. Malarkey -- Use of DNA arrays in understanding hepatic test systems / Angela J. Harris and Daniel A. Casciano -- Prediction of hepatotoxicity based on the toxicogenomics database / Tetsuro Urushidani -- Relationship between N-acetyltransferase-2 gene polymorphism and isoniazid-induced hepatotoxicity / Yasuo Shimazu, Kunio Dobashi, and Masatomo Mori -- Human and animal-based differences in hepatic xenobiotic metabolism and toxicity / Peter J. O'Brien, Katie Chan, and Raymond J. Poon -- Hepatotoxicity in oncology drug development / Wei Chen, Kenneth Hastings, and John K. Leighton -- The potent rat hepatocarcinogen methapyrilene: an hypothesis regarding its hepatotoxicology / Daniel A. Casciano -- Botanical supplements and hepatotoxicity / Shabana Khan, Ikhlas Khan, and Larry Walker -- Physiologically based pharmokinetic modeling and risk assessment of hepatotoxicants / Kannan Krishnan. |
| Record Nr. | UNINA-9910677552403321 |
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
MicroRNAs in toxicology and medicine [[electronic resource] /] / editor, Saura C. Sahu
| MicroRNAs in toxicology and medicine [[electronic resource] /] / editor, Saura C. Sahu |
| Pubbl/distr/stampa | Chichester, West Sussex, U.K., : John Wiley & Sons Inc., 2014 |
| Descrizione fisica | 1 online resource (499 p.) |
| Disciplina | 572.8/8 |
| Altri autori (Persone) | SahuSaura C |
| Soggetto topico |
Small interfering RNA
Small interfering RNA - Therapeutic use Genetic regulation |
| ISBN |
1-118-69603-4
1-118-69599-2 1-118-69601-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. MicroRNAs and toxicology -- pt. II. MicroRNAs and disease states -- pt. III. MicroRNAs and stem cells -- pt. IV. MicroRNAs and genomics -- pt. V. MicroRNAs and epigenomics -- pt. VI. MicroRNAs and biomarkers. |
| Record Nr. | UNINA-9910139025203321 |
| Chichester, West Sussex, U.K., : John Wiley & Sons Inc., 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
MicroRNAs in toxicology and medicine / / editor, Saura C. Sahu
| MicroRNAs in toxicology and medicine / / editor, Saura C. Sahu |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, U.K., : John Wiley & Sons Inc., 2014 |
| Descrizione fisica | 1 online resource (499 p.) |
| Disciplina | 572.8/8 |
| Altri autori (Persone) | SahuSaura C |
| Soggetto topico |
Small interfering RNA
Small interfering RNA - Therapeutic use Genetic regulation |
| ISBN |
1-118-69603-4
1-118-69599-2 1-118-69601-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. MicroRNAs and toxicology -- pt. II. MicroRNAs and disease states -- pt. III. MicroRNAs and stem cells -- pt. IV. MicroRNAs and genomics -- pt. V. MicroRNAs and epigenomics -- pt. VI. MicroRNAs and biomarkers. |
| Record Nr. | UNINA-9910816166603321 |
| Chichester, West Sussex, U.K., : John Wiley & Sons Inc., 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nanotoxicity [[electronic resource] ] : in vivo and in vitro models to health risks / / editors, Saura C. Sahu and Daniel Casciano
| Nanotoxicity [[electronic resource] ] : in vivo and in vitro models to health risks / / editors, Saura C. Sahu and Daniel Casciano |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2009 |
| Descrizione fisica | 1 online resource (636 p.) |
| Disciplina |
338.4/76205
338.476205 615.902 |
| Altri autori (Persone) |
SahuSaura C
CascianoDaniel A |
| Soggetto topico |
Nanostructured materials - Toxicology
Toxicity testing |
| ISBN |
1-282-34956-2
9786612349560 0-470-74780-3 0-470-74779-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nanotoxicity; Contents; Preface; List of Contributors; Acknowledgments; 1 Characterization of Nanomaterials for Toxicological Evaluation; 2 Criteria and Implementation of Physical and Chemical Characteristics of Nanomaterials for Human Health Effects and Ecological Toxicity Studies; 3 Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines; 4 High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm; 5 Application of Zinc Oxide Quantum Dots in Food Safety
6 Evaluation of Nanotoxicity of Foods and Drugs: Biological Properties of Red Elemental Selenium at Nano Size (Nano-Se) In Vitro and In Vivo7 Evaluation of Toxicity of Nanostructures in Biological Systems; 8 Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials; 9 Nanoparticles: Is Neurotoxicity a Concern?; 10 Hepatotoxic Potential of Nanomaterials; 11 Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets; 12 Sources, Fate and Effects of Engineered Nanomaterials in the Aquatic Environment 13 Nanotoxicity of Metal Oxide Nanoparticles in Vivo14 In Vivo Hypersensitive Pulmonary Disease Models for Nanotoxicity; 15 In Vivo and In Vitro Models for Nanotoxicology Testing; 16 In Vitro and In Vivo Toxicity Study of Nanoparticles; 17 In Vitro and In Vivo Models for Nanotoxicity Testing; 18 In Vitro Models for Nanotoxicity Testing; 19 In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles; 20 Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms; 21 Toxicity Testing and Evaluation of Nanoparticles: Challenges in Risk Assessment 22 Evaluating Strategies For Risk Assessment of Nanomaterials23 Strategies for Risk Assessment of Nanomaterials; 24 Metal Nanoparticle Health Risk Assessment; 25 Application of Toxicology Studies in Assessing the Health Risks of Nanomaterials in Consumer Products; 26 Safety Assessment of Engineered Nanomaterials in Direct Food Additives and Food Contact Materials; Index; Color Plate |
| Record Nr. | UNINA-9910139773303321 |
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nanotoxicity [[electronic resource] ] : in vivo and in vitro models to health risks / / editors, Saura C. Sahu and Daniel Casciano
| Nanotoxicity [[electronic resource] ] : in vivo and in vitro models to health risks / / editors, Saura C. Sahu and Daniel Casciano |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2009 |
| Descrizione fisica | 1 online resource (636 p.) |
| Disciplina |
338.4/76205
338.476205 615.902 |
| Altri autori (Persone) |
SahuSaura C
CascianoDaniel A |
| Soggetto topico |
Nanostructured materials - Toxicology
Toxicity testing |
| ISBN |
1-282-34956-2
9786612349560 0-470-74780-3 0-470-74779-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nanotoxicity; Contents; Preface; List of Contributors; Acknowledgments; 1 Characterization of Nanomaterials for Toxicological Evaluation; 2 Criteria and Implementation of Physical and Chemical Characteristics of Nanomaterials for Human Health Effects and Ecological Toxicity Studies; 3 Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines; 4 High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm; 5 Application of Zinc Oxide Quantum Dots in Food Safety
6 Evaluation of Nanotoxicity of Foods and Drugs: Biological Properties of Red Elemental Selenium at Nano Size (Nano-Se) In Vitro and In Vivo7 Evaluation of Toxicity of Nanostructures in Biological Systems; 8 Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials; 9 Nanoparticles: Is Neurotoxicity a Concern?; 10 Hepatotoxic Potential of Nanomaterials; 11 Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets; 12 Sources, Fate and Effects of Engineered Nanomaterials in the Aquatic Environment 13 Nanotoxicity of Metal Oxide Nanoparticles in Vivo14 In Vivo Hypersensitive Pulmonary Disease Models for Nanotoxicity; 15 In Vivo and In Vitro Models for Nanotoxicology Testing; 16 In Vitro and In Vivo Toxicity Study of Nanoparticles; 17 In Vitro and In Vivo Models for Nanotoxicity Testing; 18 In Vitro Models for Nanotoxicity Testing; 19 In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles; 20 Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms; 21 Toxicity Testing and Evaluation of Nanoparticles: Challenges in Risk Assessment 22 Evaluating Strategies For Risk Assessment of Nanomaterials23 Strategies for Risk Assessment of Nanomaterials; 24 Metal Nanoparticle Health Risk Assessment; 25 Application of Toxicology Studies in Assessing the Health Risks of Nanomaterials in Consumer Products; 26 Safety Assessment of Engineered Nanomaterials in Direct Food Additives and Food Contact Materials; Index; Color Plate |
| Record Nr. | UNINA-9910830307103321 |
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nanotoxicity : in vivo and in vitro models to health risks / / editors, Saura C. Sahu and Daniel Casciano
| Nanotoxicity : in vivo and in vitro models to health risks / / editors, Saura C. Sahu and Daniel Casciano |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2009 |
| Descrizione fisica | 1 online resource (636 p.) |
| Disciplina |
338.4/76205
338.476205 615.902 |
| Altri autori (Persone) |
SahuSaura C
CascianoDaniel A |
| Soggetto topico |
Nanostructured materials - Toxicology
Toxicity testing |
| ISBN |
1-282-34956-2
9786612349560 0-470-74780-3 0-470-74779-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nanotoxicity; Contents; Preface; List of Contributors; Acknowledgments; 1 Characterization of Nanomaterials for Toxicological Evaluation; 2 Criteria and Implementation of Physical and Chemical Characteristics of Nanomaterials for Human Health Effects and Ecological Toxicity Studies; 3 Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines; 4 High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm; 5 Application of Zinc Oxide Quantum Dots in Food Safety
6 Evaluation of Nanotoxicity of Foods and Drugs: Biological Properties of Red Elemental Selenium at Nano Size (Nano-Se) In Vitro and In Vivo7 Evaluation of Toxicity of Nanostructures in Biological Systems; 8 Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials; 9 Nanoparticles: Is Neurotoxicity a Concern?; 10 Hepatotoxic Potential of Nanomaterials; 11 Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets; 12 Sources, Fate and Effects of Engineered Nanomaterials in the Aquatic Environment 13 Nanotoxicity of Metal Oxide Nanoparticles in Vivo14 In Vivo Hypersensitive Pulmonary Disease Models for Nanotoxicity; 15 In Vivo and In Vitro Models for Nanotoxicology Testing; 16 In Vitro and In Vivo Toxicity Study of Nanoparticles; 17 In Vitro and In Vivo Models for Nanotoxicity Testing; 18 In Vitro Models for Nanotoxicity Testing; 19 In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles; 20 Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms; 21 Toxicity Testing and Evaluation of Nanoparticles: Challenges in Risk Assessment 22 Evaluating Strategies For Risk Assessment of Nanomaterials23 Strategies for Risk Assessment of Nanomaterials; 24 Metal Nanoparticle Health Risk Assessment; 25 Application of Toxicology Studies in Assessing the Health Risks of Nanomaterials in Consumer Products; 26 Safety Assessment of Engineered Nanomaterials in Direct Food Additives and Food Contact Materials; Index; Color Plate |
| Record Nr. | UNINA-9910877088903321 |
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Toxicogenomics [[electronic resource] ] : a powerful tool for toxicity assessment / / editor, Saura C. Sahu
| Toxicogenomics [[electronic resource] ] : a powerful tool for toxicity assessment / / editor, Saura C. Sahu |
| Pubbl/distr/stampa | Chichester, UK, : John Wiley & Sons, 2008 |
| Descrizione fisica | 1 online resource (439 p.) |
| Disciplina |
616.042
616/.042 |
| Altri autori (Persone) | SahuSaura C |
| Soggetto topico |
Genetic toxicology
Genomics Proteomics |
| ISBN |
1-282-34264-9
9786612342646 0-470-69963-9 0-470-69964-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Toxicogenomics; Contents; Preface; List of Contributors; Acknowledgments; SECTION 1 DESIGN, ANALYSIS AND INTERPRETATION OF TOXICOGENOMICS; 1 Mechanistic Toxicogenomics: Design and Analysis of Microarray Experiments; 2 A New Approach to Analysis and Interpretation of Toxicogenomic Gene Expression Data and its Importance in Examining Biological Responses to Low, Environmentally Relevant Doses of Toxicants; 3 Principles of Data Mining in Toxicogenomics; 4 Design Issues in Toxicogenomics: The Application of Genomic Technologies for Mechanistic and Predictive Research
5 Sources of Variability in Toxicogenomic Assays6 Key Aspects of Toxicogenomic Data Analysis and Interpretation as a Safety Assessment Tool to Identify and Understand Drug-Induced Toxicity; SECTION 2 APPLICATIONS OF TOXICOGENOMICS; 7 Toxicogenomics as a Tool to Assess Immunotoxicity; 8 Toxicogenomics and Ecotoxicogenomics: Studying Chemical Effects and Basic Biology in Vertebrates and Invertebrates; 9 Gene Expression Profiling of Transplacental Arsenic Carcinogenesis in Mice; 10 Characterization of Estrogen-active Compounds and Estrogenic Signaling by Global Gene Expression Profiling In Vitro 11 Escherichia coli Stress Response as a Tool for Detection of Toxicity12 Toxicogenomics In Vitro: A Powerful Tool for Screening Hepatotoxic Potential of Food-related Products; 13 Toxicogenomics Approach to Drug-induced Phospholipidosis; 14 Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity; 15 Nutrigenomics: The Application of Genomics Signatures in Nutrition-related Research; 16 Application of Toxicogenomics in Drug Discovery; SECTION 3 TOXICOGENOMICS AND RISK ASSESSMENT; 17 Natural Products from Medicinal Plants and Risk Assessment 18 The Development of a Metabonomic-based Drug Safety Testing Paradigm19 Potential Uses of Toxicogenomic Biomarkers in Occupational Health and Risk Assessment; SECTION 4 TOXICOGENOMICS FOR REGULATORY USE; 20 Toxicogenomics: A Regulatory Perspective; 21 Toxicogenomics for Regulatory Use: The View from the Bench; 22 Perspectives on Toxicogenomics Activities at the US Environmental Protection Agency; Index; Color Plate |
| Record Nr. | UNINA-9910144382703321 |
| Chichester, UK, : John Wiley & Sons, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Toxicogenomics [[electronic resource] ] : a powerful tool for toxicity assessment / / editor, Saura C. Sahu
| Toxicogenomics [[electronic resource] ] : a powerful tool for toxicity assessment / / editor, Saura C. Sahu |
| Pubbl/distr/stampa | Chichester, UK, : John Wiley & Sons, 2008 |
| Descrizione fisica | 1 online resource (439 p.) |
| Disciplina |
616.042
616/.042 |
| Altri autori (Persone) | SahuSaura C |
| Soggetto topico |
Genetic toxicology
Genomics Proteomics |
| ISBN |
1-282-34264-9
9786612342646 0-470-69963-9 0-470-69964-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Toxicogenomics; Contents; Preface; List of Contributors; Acknowledgments; SECTION 1 DESIGN, ANALYSIS AND INTERPRETATION OF TOXICOGENOMICS; 1 Mechanistic Toxicogenomics: Design and Analysis of Microarray Experiments; 2 A New Approach to Analysis and Interpretation of Toxicogenomic Gene Expression Data and its Importance in Examining Biological Responses to Low, Environmentally Relevant Doses of Toxicants; 3 Principles of Data Mining in Toxicogenomics; 4 Design Issues in Toxicogenomics: The Application of Genomic Technologies for Mechanistic and Predictive Research
5 Sources of Variability in Toxicogenomic Assays6 Key Aspects of Toxicogenomic Data Analysis and Interpretation as a Safety Assessment Tool to Identify and Understand Drug-Induced Toxicity; SECTION 2 APPLICATIONS OF TOXICOGENOMICS; 7 Toxicogenomics as a Tool to Assess Immunotoxicity; 8 Toxicogenomics and Ecotoxicogenomics: Studying Chemical Effects and Basic Biology in Vertebrates and Invertebrates; 9 Gene Expression Profiling of Transplacental Arsenic Carcinogenesis in Mice; 10 Characterization of Estrogen-active Compounds and Estrogenic Signaling by Global Gene Expression Profiling In Vitro 11 Escherichia coli Stress Response as a Tool for Detection of Toxicity12 Toxicogenomics In Vitro: A Powerful Tool for Screening Hepatotoxic Potential of Food-related Products; 13 Toxicogenomics Approach to Drug-induced Phospholipidosis; 14 Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity; 15 Nutrigenomics: The Application of Genomics Signatures in Nutrition-related Research; 16 Application of Toxicogenomics in Drug Discovery; SECTION 3 TOXICOGENOMICS AND RISK ASSESSMENT; 17 Natural Products from Medicinal Plants and Risk Assessment 18 The Development of a Metabonomic-based Drug Safety Testing Paradigm19 Potential Uses of Toxicogenomic Biomarkers in Occupational Health and Risk Assessment; SECTION 4 TOXICOGENOMICS FOR REGULATORY USE; 20 Toxicogenomics: A Regulatory Perspective; 21 Toxicogenomics for Regulatory Use: The View from the Bench; 22 Perspectives on Toxicogenomics Activities at the US Environmental Protection Agency; Index; Color Plate |
| Record Nr. | UNINA-9910830300803321 |
| Chichester, UK, : John Wiley & Sons, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Toxicogenomics : a powerful tool for toxicity assessment / / editor, Saura C. Sahu
| Toxicogenomics : a powerful tool for toxicity assessment / / editor, Saura C. Sahu |
| Pubbl/distr/stampa | Chichester, UK, : John Wiley & Sons, 2008 |
| Descrizione fisica | 1 online resource (439 p.) |
| Disciplina |
616.042
616/.042 |
| Altri autori (Persone) | SahuSaura C |
| Soggetto topico |
Genetic toxicology
Genomics Proteomics |
| ISBN |
1-282-34264-9
9786612342646 0-470-69963-9 0-470-69964-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Toxicogenomics; Contents; Preface; List of Contributors; Acknowledgments; SECTION 1 DESIGN, ANALYSIS AND INTERPRETATION OF TOXICOGENOMICS; 1 Mechanistic Toxicogenomics: Design and Analysis of Microarray Experiments; 2 A New Approach to Analysis and Interpretation of Toxicogenomic Gene Expression Data and its Importance in Examining Biological Responses to Low, Environmentally Relevant Doses of Toxicants; 3 Principles of Data Mining in Toxicogenomics; 4 Design Issues in Toxicogenomics: The Application of Genomic Technologies for Mechanistic and Predictive Research
5 Sources of Variability in Toxicogenomic Assays6 Key Aspects of Toxicogenomic Data Analysis and Interpretation as a Safety Assessment Tool to Identify and Understand Drug-Induced Toxicity; SECTION 2 APPLICATIONS OF TOXICOGENOMICS; 7 Toxicogenomics as a Tool to Assess Immunotoxicity; 8 Toxicogenomics and Ecotoxicogenomics: Studying Chemical Effects and Basic Biology in Vertebrates and Invertebrates; 9 Gene Expression Profiling of Transplacental Arsenic Carcinogenesis in Mice; 10 Characterization of Estrogen-active Compounds and Estrogenic Signaling by Global Gene Expression Profiling In Vitro 11 Escherichia coli Stress Response as a Tool for Detection of Toxicity12 Toxicogenomics In Vitro: A Powerful Tool for Screening Hepatotoxic Potential of Food-related Products; 13 Toxicogenomics Approach to Drug-induced Phospholipidosis; 14 Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity; 15 Nutrigenomics: The Application of Genomics Signatures in Nutrition-related Research; 16 Application of Toxicogenomics in Drug Discovery; SECTION 3 TOXICOGENOMICS AND RISK ASSESSMENT; 17 Natural Products from Medicinal Plants and Risk Assessment 18 The Development of a Metabonomic-based Drug Safety Testing Paradigm19 Potential Uses of Toxicogenomic Biomarkers in Occupational Health and Risk Assessment; SECTION 4 TOXICOGENOMICS FOR REGULATORY USE; 20 Toxicogenomics: A Regulatory Perspective; 21 Toxicogenomics for Regulatory Use: The View from the Bench; 22 Perspectives on Toxicogenomics Activities at the US Environmental Protection Agency; Index; Color Plate |
| Record Nr. | UNINA-9910876751703321 |
| Chichester, UK, : John Wiley & Sons, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
