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Mechanisms of synaptic transmission [[electronic resource] ] : bridging the gaps (1890-1990) / / Joseph D. Robinson
| Mechanisms of synaptic transmission [[electronic resource] ] : bridging the gaps (1890-1990) / / Joseph D. Robinson |
| Autore | Robinson Joseph D |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2001 |
| Descrizione fisica | 1 online resource (468 p.) |
| Disciplina |
573.809
573.85 612.8 |
| Soggetto topico |
Neural transmission - Research - History - 20th century
Synapses - Research - History - 20th century |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-803145-9
9786610834624 1-280-83462-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; 1. Beginnings: Cajal and the Neuron Theory (1889-1909); Cajal at Berlin; Background: Cells, Nerve Cells, and Nerve Impulses; Proclamation of the Neuron Theory; Cajal's Contributions; Confirmations, Criticisms, and Responses; Conclusions; 2. Beginnings: Sherrington and the Synapse (1890-1913); Sherrington, Reflexes, and the Synapse; Background: Reflexes; Sherrington's Achievements; Synapses and the Reflex Arc; Conclusions; 3. Chemical Transmission at Synapses (1895-1945); Nerve Impulse Conduction and Synapse Structure; Background: The Autonomic Nervous System
Chemical Transmission in the Autonomic Nervous SystemChemical Transmission at Neuromuscular Junctions; Chemical Transmission in the Central Nervous System; Electrical Transmission; Conclusions; 4. Chemical Transmission at Synapses (1945-1965); Postwar Progress; Identifying Chemical Transmission; Visualizing Synaptic Gaps and Synaptic Vesicles; Identifying Electrical Transmission; Conclusions; 5. Identifying Neurotransmitters (1946-1976); Scope and Criteria; Acetylcholine; Noradrenaline; Dopamine; Serotonin; GABA; Glutamate; Glycine; Neuropeptides: Substance P and Enkephalins; Conclusions 6. Characterizing Receptors (1905-1983)Essential Issues; Drug-Receptor Interactions; Receptor Classification; Structure-Activity Relationships; Receptor Identification and Purification; Responses of Individual Receptor Molecules; Conclusions; 7. Second Messengers (1951-1990); Cyclic AMP; Protein Kinases and Phosphatases; G-Proteins; Ca[sup(2+)]; Inositol-trisphosphate and Diacylglycerol; Conclusions; 8. Receptor Structures and Receptor Families (1983-1990); Molecular Biology and Recombinant DNA Techniques; Nicotinic Cholinergic Receptors; Ligand-Gated Ion Channels; Adrenergic Receptors G-Protein Coupled ReceptorsReceptor Regulation; Conclusions; 9. Synthesis, Storage, Transport, and Metabolic Degradation of Neurotransmitters; Steps in Chemical Transmission; Synthesis; Storage; Degradation; Transport (""Reuptake""); Conclusions; 10. Neurotransmitter Release; Proposals; Evidence for Exocytotic Release; Triggering of Release; Mechanism of Release; Endocytotic Retrieval of Vesicles; Ca[sup(2+)]-Independent Non-Exocytotic Release; Conclusions; 11. Formation of Specific Synapses; Embryonic Development of Synaptic Connections; Approaches and Possible Mechanisms Early Arguments Concerning Chemotaxis (1890-1963)Cell Death and Neurotrophic Factors; Chemical Guidance (1963-1990); Growth Cone Motility; Synapse Formation; Conclusions; 12. Learning; Background; Chemical Representations; Learning in Aplysia; Learning in Drosophila; Learning in Mammals: The Hippocampus and Long-Term Potentiation (LTP); Conclusions; 13. Diseases and Therapies; Defining and Developing; Parkinson's Disease; Schizophrenia; Depression and Manic-Depressive Illness; Conclusions; 14. Epilogue; Progress; Historical Accounts and Conclusions; Assumptions; Approaches; Goals Generalities and Exceptions |
| Record Nr. | UNINA-9910465825203321 |
Robinson Joseph D
|
||
| Oxford ; ; New York, : Oxford University Press, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mechanisms of synaptic transmission [[electronic resource] ] : bridging the gaps (1890-1990) / / Joseph D. Robinson
| Mechanisms of synaptic transmission [[electronic resource] ] : bridging the gaps (1890-1990) / / Joseph D. Robinson |
| Autore | Robinson Joseph D |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2001 |
| Descrizione fisica | 1 online resource (468 p.) |
| Disciplina |
573.809
573.85 612.8 |
| Soggetto topico |
Neural transmission - Research - History - 20th century
Synapses - Research - History - 20th century |
| ISBN |
0-19-803145-9
9786610834624 1-280-83462-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; 1. Beginnings: Cajal and the Neuron Theory (1889-1909); Cajal at Berlin; Background: Cells, Nerve Cells, and Nerve Impulses; Proclamation of the Neuron Theory; Cajal's Contributions; Confirmations, Criticisms, and Responses; Conclusions; 2. Beginnings: Sherrington and the Synapse (1890-1913); Sherrington, Reflexes, and the Synapse; Background: Reflexes; Sherrington's Achievements; Synapses and the Reflex Arc; Conclusions; 3. Chemical Transmission at Synapses (1895-1945); Nerve Impulse Conduction and Synapse Structure; Background: The Autonomic Nervous System
Chemical Transmission in the Autonomic Nervous SystemChemical Transmission at Neuromuscular Junctions; Chemical Transmission in the Central Nervous System; Electrical Transmission; Conclusions; 4. Chemical Transmission at Synapses (1945-1965); Postwar Progress; Identifying Chemical Transmission; Visualizing Synaptic Gaps and Synaptic Vesicles; Identifying Electrical Transmission; Conclusions; 5. Identifying Neurotransmitters (1946-1976); Scope and Criteria; Acetylcholine; Noradrenaline; Dopamine; Serotonin; GABA; Glutamate; Glycine; Neuropeptides: Substance P and Enkephalins; Conclusions 6. Characterizing Receptors (1905-1983)Essential Issues; Drug-Receptor Interactions; Receptor Classification; Structure-Activity Relationships; Receptor Identification and Purification; Responses of Individual Receptor Molecules; Conclusions; 7. Second Messengers (1951-1990); Cyclic AMP; Protein Kinases and Phosphatases; G-Proteins; Ca[sup(2+)]; Inositol-trisphosphate and Diacylglycerol; Conclusions; 8. Receptor Structures and Receptor Families (1983-1990); Molecular Biology and Recombinant DNA Techniques; Nicotinic Cholinergic Receptors; Ligand-Gated Ion Channels; Adrenergic Receptors G-Protein Coupled ReceptorsReceptor Regulation; Conclusions; 9. Synthesis, Storage, Transport, and Metabolic Degradation of Neurotransmitters; Steps in Chemical Transmission; Synthesis; Storage; Degradation; Transport (""Reuptake""); Conclusions; 10. Neurotransmitter Release; Proposals; Evidence for Exocytotic Release; Triggering of Release; Mechanism of Release; Endocytotic Retrieval of Vesicles; Ca[sup(2+)]-Independent Non-Exocytotic Release; Conclusions; 11. Formation of Specific Synapses; Embryonic Development of Synaptic Connections; Approaches and Possible Mechanisms Early Arguments Concerning Chemotaxis (1890-1963)Cell Death and Neurotrophic Factors; Chemical Guidance (1963-1990); Growth Cone Motility; Synapse Formation; Conclusions; 12. Learning; Background; Chemical Representations; Learning in Aplysia; Learning in Drosophila; Learning in Mammals: The Hippocampus and Long-Term Potentiation (LTP); Conclusions; 13. Diseases and Therapies; Defining and Developing; Parkinson's Disease; Schizophrenia; Depression and Manic-Depressive Illness; Conclusions; 14. Epilogue; Progress; Historical Accounts and Conclusions; Assumptions; Approaches; Goals Generalities and Exceptions |
| Record Nr. | UNINA-9910792253003321 |
|
Robinson Joseph D
|
||
| Oxford ; ; New York, : Oxford University Press, 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||