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Principles and practice of skin toxicology [[electronic resource] /] / editors, Robert P. Chilcott and Shirley Price
| Principles and practice of skin toxicology [[electronic resource] /] / editors, Robert P. Chilcott and Shirley Price |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, NJ, : John Wiley & Sons, c2008 |
| Descrizione fisica | 1 online resource (402 p.) |
| Disciplina |
615.778
616.5 |
| Altri autori (Persone) |
ChilcottRobert P
PriceShirley, Dr. |
| Soggetto topico |
Dermatotoxicology
Skin - Diseases |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-84110-2
9786611841102 0-470-77309-X 0-470-77308-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Principles and Practice of Skin Toxicology; Contents; Foreword; Preface; Acknowledgements; List of contributors; PART I Introduction; 1 Cutaneous anatomy and function; 1.1 Introduction and scope; 1.2 Surface features; 1.3 Functional histology of the epidermis and associated structures; 1.4 Species differences; Summary; References; 2 Biochemistry of the skin; 2.1 Introduction and scope; 2.2 Protein synthesis and organisation during epidermal differentiation; 2.3 Lipid synthesis and organisation during epidermal differentiation; 2.4 Lipid classes in the stratum corneum
2.5 Stratum corneum turnover2.6 Biotransformations in skin; Summary; References; 3 Skin photobiology; 3.1 Introduction and scope; 3.2 Photoprotection and melanogenesis; 3.3 Increased environmental ultraviolet radiation exposure and its link with photoageing and skin cancer; 3.4 Mitochondrial DNA as a biomarker of sun exposure in human skin; 3.5 Apoptosis; 3.6 Sun protection; Summary; References; PART II Skin Absorption; 4 Skin as a route of entry; 4.1 Salient anatomical features of the stratum corneum - the 'brick and mortar model'; 4.2 Species and regional variation in skin structure 4.3 Species and regional variation in skin permeability4.4 Intra- and inter-individual variation in percutaneous absorption; 4.5 Effect of age on skin barrier function; 4.6 Role of skin appendages; 4.7 The in vitro skin sandwich model; 4.8 Penetration of particles through appendages; Summary; References; 5 Physicochemical Factors Affecting Skin Absorption; 5.1 Introduction; 5.2 Physicochemical properties; 5.3 Exposure considerations; Summary; References; 6 Principles of Diffusion and Thermodynamics; 6.1 Introduction and scope; 6.2 Some definitions pertaining to skin absorption kinetics 6.3 Basic concepts of diffusion6.4 Fick's Laws of diffusion; 6.5 Thermodynamic activity; 6.6 Skin absorption of a substance from two different vehicles; 6.7 Partitioning; 6.8 Diffusivity; 6.9 Skin absorption data and risk assessments; Summary; References; 7 In vivo measurements of skin absorption; 7.1 Introduction and scope; 7.2 Why conduct in vivo studies?; 7.3 Ethics and legislation; 7.4 Standard methodology: OECD Guideline 427; 7.5 Alternative in vivo methods; Summary; References; 8 In vitro percutaneous absorption measurements; 8.1 Introduction and scope; 8.2 Regulatory guidelines 8.3 Why assess percutaneous absorption in vitro?8.4 Basic principle of in vitro percutaneous absorption measurements; 8.5 Choice of diffusion cell; 8.6 Skin membrane considerations; 8.7 Integrity measurements; 8.8 Choice of receptor fluid and sampling considerations; 8.9 Test material considerations; 8.10 Application of test preparation to the skin; 8.11 Examples of results from in vitro skin absorption studies; 8.12 What is considered to be absorbed?; 8.13 Micro-autoradiography; Summary; References; PART III Toxicological Assessment; 9 Skin immunology and sensitisation; 9.1 Introduction 9.2 Definitions |
| Record Nr. | UNINA-9910144096203321 |
| Chichester, West Sussex, England ; ; Hoboken, NJ, : John Wiley & Sons, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Principles and practice of skin toxicology [[electronic resource] /] / editors, Robert P. Chilcott and Shirley Price
| Principles and practice of skin toxicology [[electronic resource] /] / editors, Robert P. Chilcott and Shirley Price |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, NJ, : John Wiley & Sons, c2008 |
| Descrizione fisica | 1 online resource (402 p.) |
| Disciplina |
615.778
616.5 |
| Altri autori (Persone) |
ChilcottRobert P
PriceShirley, Dr. |
| Soggetto topico |
Dermatotoxicology
Skin - Diseases |
| ISBN |
1-281-84110-2
9786611841102 0-470-77309-X 0-470-77308-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Principles and Practice of Skin Toxicology; Contents; Foreword; Preface; Acknowledgements; List of contributors; PART I Introduction; 1 Cutaneous anatomy and function; 1.1 Introduction and scope; 1.2 Surface features; 1.3 Functional histology of the epidermis and associated structures; 1.4 Species differences; Summary; References; 2 Biochemistry of the skin; 2.1 Introduction and scope; 2.2 Protein synthesis and organisation during epidermal differentiation; 2.3 Lipid synthesis and organisation during epidermal differentiation; 2.4 Lipid classes in the stratum corneum
2.5 Stratum corneum turnover2.6 Biotransformations in skin; Summary; References; 3 Skin photobiology; 3.1 Introduction and scope; 3.2 Photoprotection and melanogenesis; 3.3 Increased environmental ultraviolet radiation exposure and its link with photoageing and skin cancer; 3.4 Mitochondrial DNA as a biomarker of sun exposure in human skin; 3.5 Apoptosis; 3.6 Sun protection; Summary; References; PART II Skin Absorption; 4 Skin as a route of entry; 4.1 Salient anatomical features of the stratum corneum - the 'brick and mortar model'; 4.2 Species and regional variation in skin structure 4.3 Species and regional variation in skin permeability4.4 Intra- and inter-individual variation in percutaneous absorption; 4.5 Effect of age on skin barrier function; 4.6 Role of skin appendages; 4.7 The in vitro skin sandwich model; 4.8 Penetration of particles through appendages; Summary; References; 5 Physicochemical Factors Affecting Skin Absorption; 5.1 Introduction; 5.2 Physicochemical properties; 5.3 Exposure considerations; Summary; References; 6 Principles of Diffusion and Thermodynamics; 6.1 Introduction and scope; 6.2 Some definitions pertaining to skin absorption kinetics 6.3 Basic concepts of diffusion6.4 Fick's Laws of diffusion; 6.5 Thermodynamic activity; 6.6 Skin absorption of a substance from two different vehicles; 6.7 Partitioning; 6.8 Diffusivity; 6.9 Skin absorption data and risk assessments; Summary; References; 7 In vivo measurements of skin absorption; 7.1 Introduction and scope; 7.2 Why conduct in vivo studies?; 7.3 Ethics and legislation; 7.4 Standard methodology: OECD Guideline 427; 7.5 Alternative in vivo methods; Summary; References; 8 In vitro percutaneous absorption measurements; 8.1 Introduction and scope; 8.2 Regulatory guidelines 8.3 Why assess percutaneous absorption in vitro?8.4 Basic principle of in vitro percutaneous absorption measurements; 8.5 Choice of diffusion cell; 8.6 Skin membrane considerations; 8.7 Integrity measurements; 8.8 Choice of receptor fluid and sampling considerations; 8.9 Test material considerations; 8.10 Application of test preparation to the skin; 8.11 Examples of results from in vitro skin absorption studies; 8.12 What is considered to be absorbed?; 8.13 Micro-autoradiography; Summary; References; PART III Toxicological Assessment; 9 Skin immunology and sensitisation; 9.1 Introduction 9.2 Definitions |
| Record Nr. | UNINA-9910830426403321 |
| Chichester, West Sussex, England ; ; Hoboken, NJ, : John Wiley & Sons, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Principles and practice of skin toxicology [[electronic resource] /] / editors, Robert P. Chilcott and Shirley Price
| Principles and practice of skin toxicology [[electronic resource] /] / editors, Robert P. Chilcott and Shirley Price |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, NJ, : John Wiley & Sons, c2008 |
| Descrizione fisica | 1 online resource (402 p.) |
| Disciplina |
615.778
616.5 |
| Altri autori (Persone) |
ChilcottRobert P
PriceShirley, Dr. |
| Soggetto topico |
Dermatotoxicology
Skin - Diseases |
| ISBN |
1-281-84110-2
9786611841102 0-470-77309-X 0-470-77308-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Principles and Practice of Skin Toxicology; Contents; Foreword; Preface; Acknowledgements; List of contributors; PART I Introduction; 1 Cutaneous anatomy and function; 1.1 Introduction and scope; 1.2 Surface features; 1.3 Functional histology of the epidermis and associated structures; 1.4 Species differences; Summary; References; 2 Biochemistry of the skin; 2.1 Introduction and scope; 2.2 Protein synthesis and organisation during epidermal differentiation; 2.3 Lipid synthesis and organisation during epidermal differentiation; 2.4 Lipid classes in the stratum corneum
2.5 Stratum corneum turnover2.6 Biotransformations in skin; Summary; References; 3 Skin photobiology; 3.1 Introduction and scope; 3.2 Photoprotection and melanogenesis; 3.3 Increased environmental ultraviolet radiation exposure and its link with photoageing and skin cancer; 3.4 Mitochondrial DNA as a biomarker of sun exposure in human skin; 3.5 Apoptosis; 3.6 Sun protection; Summary; References; PART II Skin Absorption; 4 Skin as a route of entry; 4.1 Salient anatomical features of the stratum corneum - the 'brick and mortar model'; 4.2 Species and regional variation in skin structure 4.3 Species and regional variation in skin permeability4.4 Intra- and inter-individual variation in percutaneous absorption; 4.5 Effect of age on skin barrier function; 4.6 Role of skin appendages; 4.7 The in vitro skin sandwich model; 4.8 Penetration of particles through appendages; Summary; References; 5 Physicochemical Factors Affecting Skin Absorption; 5.1 Introduction; 5.2 Physicochemical properties; 5.3 Exposure considerations; Summary; References; 6 Principles of Diffusion and Thermodynamics; 6.1 Introduction and scope; 6.2 Some definitions pertaining to skin absorption kinetics 6.3 Basic concepts of diffusion6.4 Fick's Laws of diffusion; 6.5 Thermodynamic activity; 6.6 Skin absorption of a substance from two different vehicles; 6.7 Partitioning; 6.8 Diffusivity; 6.9 Skin absorption data and risk assessments; Summary; References; 7 In vivo measurements of skin absorption; 7.1 Introduction and scope; 7.2 Why conduct in vivo studies?; 7.3 Ethics and legislation; 7.4 Standard methodology: OECD Guideline 427; 7.5 Alternative in vivo methods; Summary; References; 8 In vitro percutaneous absorption measurements; 8.1 Introduction and scope; 8.2 Regulatory guidelines 8.3 Why assess percutaneous absorption in vitro?8.4 Basic principle of in vitro percutaneous absorption measurements; 8.5 Choice of diffusion cell; 8.6 Skin membrane considerations; 8.7 Integrity measurements; 8.8 Choice of receptor fluid and sampling considerations; 8.9 Test material considerations; 8.10 Application of test preparation to the skin; 8.11 Examples of results from in vitro skin absorption studies; 8.12 What is considered to be absorbed?; 8.13 Micro-autoradiography; Summary; References; PART III Toxicological Assessment; 9 Skin immunology and sensitisation; 9.1 Introduction 9.2 Definitions |
| Record Nr. | UNINA-9910840533503321 |
| Chichester, West Sussex, England ; ; Hoboken, NJ, : John Wiley & Sons, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||