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The biliary system / / David Q.-H. Wang, Brent A. Neuschwander-Tetri, Piero Portincasa
| The biliary system / / David Q.-H. Wang, Brent A. Neuschwander-Tetri, Piero Portincasa |
| Autore | Wang David Q.-H. |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | [San Rafael, California] : , : Morgan & Claypool Life Sciences, , 2017 |
| Descrizione fisica | 1 online resource (192 pages) |
| Disciplina | 616.36 |
| Collana | Colloquium Series on Integrated Systems Physiology : From Molecule to Function |
| Soggetto topico | Biliary tract - Diseases |
| ISBN | 1-61504-738-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
1. Introduction --
2. Anatomy of the liver, biliary tract, and gallbladder -- 2.1 The liver -- 2.1.1 Gross and surface anatomy -- 2.1.2 Structural concepts of liver lobes and segmentation -- 2.1.3 Large vessels of the liver -- 2.1.3.1 Portal veins -- 2.1.3.2 Hepatic arteries -- 2.1.3.3 Hepatic veins -- 2.1.4 Lymphatic drainage -- 2.2 The biliary tract and gallbladder -- 2.2.1 Intrahepatic bile ducts -- 2.2.2 Extrahepatic bile ducts -- 2.2.3 Gallbladder -- 2.3 Liver, gallbladder, and bile duct cell types -- 2.3.1 Parenchymal cells -- 2.3.1.1 Hepatocytes -- 2.3.2 Sinusoidal nonparenchymal cells -- 2.3.2.1 Hepatic sinusoidal endothelial cells -- 2.3.2.2 Kupffer cells -- 2.3.3 Perisinusoidal nonparenchymal cells -- 2.3.3.1 Hepatic stellate cells -- 2.3.3.2 Pit cells -- 2.3.4 Gallbladder cells -- 2.3.5 Bile duct epithelial cells -- 3. Physical chemistry of bile -- 3.1 Chemical composition of bile -- 3.2 Biliary cholesterol -- 3.3 Biliary bile acids -- 3.4 Biliary phospholipids -- 3.5 Bile pigments -- 4. Hepatic cholesterol metabolism -- 4.1 Physical chemistry of cholesterol -- 4.2 Features of cholesterol balance in the body -- 4.3 Cholesterol synthesis rates -- 4.4 Cholesterol biosynthesis pathways -- 4.4.1 The conversion of three acetyl CoA molecules to mevalonate -- 4.4.2 Synthesis of two activated isoprenes from mevalonate -- 4.4.3 Synthesis of the 30-carbon squalene from six activated isoprenes -- 4.4.4 Cholesterol is synthesized from squalene via lanosterol -- 4.5 Regulation of hepatic cholesterol biosynthesis -- 5. Physical chemistry and hepatic metabolism of bile acids -- 5.1 Chemical structure and physical-chemical properties of bile acids -- 5.2 Hydrophilic-hydrophobic balance of bile acids -- 5.3 Bile acid biosynthesis pathways -- 5.4 Regulation of bile acid biosynthesis -- 5.5 Inhibitory mechanisms of FXR signaling on CYP7A1 -- 5.5.1 The FXR/SHP pathway -- 5.5.2 The FXR/FGF19/FGFR4 pathway -- 5.6 FXR-independent bile acid inhibition of CYP7A1 -- 6. The enterohepatic circulation of bile acids -- 6.1 Physiology of the enterohepatic circulation -- 6.2 Bile acid pool and kinetics -- 6.3 Driving forces of the enterohepatic circulation -- 6.4 Kinetics and regulation of the enterohepatic circulation -- 6.4.1 The hepatic uptake of bile acids -- 6.4.1.1 Hepatic sinusoidal sodium-dependent bile acid uptake -- 6.4.1.2 Hepatic sinusoidal sodium-independent bile acid uptake -- 6.4.2 The canalicular transport of bile acids -- 6.4.3 The role of gallbladder in the enterohepatic circulation -- 6.4.4 The role of the intestine in the maintenance of the enterohepatic circulation -- 6.4.4.1 Ileal sodium-dependent bile acid uptake -- 6.4.5 The role of kidneys in the enterohepatic circulation -- 6.4.5.1 Renal sodium-dependent bile acid uptake -- 7. Hepatic secretion of biliary lipids and bile formation -- 7.1 Structure of the bile secretory apparatus -- 7.2 Source of lipids secreted in bile -- 7.3 Biliary lipid secretion -- 7.4 Canalicular bile flow -- 7.4.1 Bile acid-dependent bile flow -- 7.4.2 Bile acid-independent bile flow -- 7.5 Physical states of biliary lipids -- 7.6 Biliary micelles -- 7.7 Biliary vesicles, nonmicellar carriers of cholesterol in bile -- 7.8 Co-existence and interconversion of micelles and vesicles in bile -- 8. Cholesterol crystallization and gallstone formation -- 8.1 Introduction -- 8.2 Five primary defects in the pathogenesis of cholesterol gallstone disease -- 8.3 Pathophysiology of cholesterol gallstone formation -- 8.3.1 Phase diagrams and cholesterol solubility in bile -- 8.3.2 Cholesterol nucleation and crystallization in supersaturated bile -- 8.3.3 Cholesterol crystal detection time -- 8.3.4 Agents influencing cholesterol nucleation and crystallization -- 8.3.5 Pro-nucleating agents -- 8.3.6 Anti-nucleating agents -- 8.3.7 Solid cholesterol crystal growth -- 8.4 Future directions -- 9. Summary -- Acknowledgments -- References -- Author biographies. |
| Record Nr. | UNINA-9910156411403321 |
Wang David Q.-H.
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| [San Rafael, California] : , : Morgan & Claypool Life Sciences, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Endocrinology and Systemic Diseases [[electronic resource] /] / edited by Piero Portincasa, Gema Frühbeck, Hendrik M. Nathoe
| Endocrinology and Systemic Diseases [[electronic resource] /] / edited by Piero Portincasa, Gema Frühbeck, Hendrik M. Nathoe |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (X, 400 p.) |
| Disciplina | 616.4 |
| Collana | Endocrinology |
| Soggetto topico |
Endocrinology
Cardiology Gastroenterology Nephrology Critical care medicine Geriatrics Endocrinology Gastroenterology Intensive / Critical Care Medicine Geriatrics/Gerontology |
| ISBN | 3-319-66362-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Impact of endocrine disorders on typical and atypical cardiovascular risk factors -- Impact of endocrine disorders on blood pressure -- Impact of endocrine disorders on the heart -- Impact of endocrine disorders on vasculature -- Impact of endocrine disorders on the kidney -- Impact of endocrine disorders on the liver -- Impact of endocrine disorders on gastro-intestinal diseases -- Impact of endocrine disorders on autoimmune diseases -- Neuroendocrine involvement in immune mediated rheumatic diseases -- Impact of endocrine disorders on hematologic diseases -- Impact of endocrine disorders on skin disorders -- Endocrine disorders and neurologic manifestations -- Endocrine disorders and psychiatric manifestations -- Impact of endocrine disorders in the critically ill -- Impact of endocrine disorders in the elderly. |
| Record Nr. | UNINA-9910349373603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Gallstones : recent advances in epidemiology, pathogenesis, diagnosis and management / / David Q.H. Wang and Piero Portincasa, editors
| Gallstones : recent advances in epidemiology, pathogenesis, diagnosis and management / / David Q.H. Wang and Piero Portincasa, editors |
| Pubbl/distr/stampa | Hauppauge, NY : , : Nova Science Publishers, Incorporated, , [2017] |
| Descrizione fisica | 1 online resource (700 pages) : illustrations (some color) |
| Disciplina | 616.365 |
| Collana | Hepatology research and clinical developments |
| Soggetto topico |
Gallstones
Gallstones - Diseases |
| ISBN | 1-5361-0018-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910159435303321 |
| Hauppauge, NY : , : Nova Science Publishers, Incorporated, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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