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Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing
| Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing |
| Autore | Pörtner Ralf |
| Descrizione fisica | 1 online resource (226 p.) |
| Soggetto topico |
History of engineering and technology
Technology: general issues |
| Soggetto non controllato |
Adeno-associated virus
Bayes optimization biopharmaceutical manufacturing bioprocess bioreactor bioreactor characterization biosensor biotherapeutics production cell culture cell culture model Chinese hamster ovary cells CHO DP-12 clonal cell population computational fluid dynamics continuous critical shear stress cryopreservation diabetes Escherichia coli Gaussian processes gene therapy hybrid modeling hydrodynamic gradients hydrodynamic stress inoculum train Kolmogorov length scale machine learning microcarriers model-assisted DoE monitoring monoclonal antibodies multi-objective n/a N−1 perfusion operational space Pareto optimization PAT PEI phenotypic diversity process analytical technology (PAT) process development process intensification quality by design quality by design (QbD) seed train sensors shear stress-guided production smart biomanufacturing soft-sensor spectroscopy spheroid strength surface plasmon resonance (SPR) transfection transient expression uncertainty-based upstream bioprocessing upstream processing vaccines production β-cells |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595072803321 |
Pörtner Ralf
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| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Digital Twins : Tools and Concepts for Smart Biomanufacturing / / edited by Christoph Herwig, Ralf Pörtner, Johannes Möller
| Digital Twins : Tools and Concepts for Smart Biomanufacturing / / edited by Christoph Herwig, Ralf Pörtner, Johannes Möller |
| Edizione | [1st ed. 2021.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 |
| Descrizione fisica | 1 online resource (267 pages) |
| Disciplina |
660.63
338.476606 |
| Collana | Advances in Biochemical Engineering/Biotechnology |
| Soggetto topico |
Biochemical engineering
Biotechnology Computational intelligence Manufactures Bioprocess Engineering Computational Intelligence Machines, Tools, Processes |
| ISBN | 3-030-71660-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Towards the development of digital twins for the biomanufacturing industry -- When is an In silico representation a digital twin? A biopharmaceutical industry approach to the digital twin concept -- Digitalization and bioprocessing, regulatory aspects -- Usage of Digital Twins along a typical process development cycle -- Mechanistic Mathematical Models as a Basis for Process Optimization and Digital Twins -- Digital Seed Train Twins and Statistical Methods -- Digital Twins in Biomanufacturing. |
| Record Nr. | UNINA-9910483653803321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Digital Twins : Applications to the Design and Optimization of Bioprocesses / / edited by Christoph Herwig, Ralf Pörtner, Johannes Möller
| Digital Twins : Applications to the Design and Optimization of Bioprocesses / / edited by Christoph Herwig, Ralf Pörtner, Johannes Möller |
| Edizione | [1st ed. 2021.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 |
| Descrizione fisica | 1 online resource (260 pages) |
| Disciplina |
660.63
338.476606 |
| Collana | Advances in Biochemical Engineering/Biotechnology |
| Soggetto topico |
Biotechnology
Computational intelligence Manufactures Chemical Bioengineering Computational Intelligence Machines, Tools, Processes |
| ISBN | 3-030-71656-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Potential of model-based design of experiments approaches for bioprocess scale-down -- Digital Twins and Their Role in Model-Assisted Design of Experiments -- Digital twins for bioprocess control strategy development and realization -- The Kalman filter for the supervision of cultivation processes.-The challenge of implementing digital twins in operating value chains -- Digital twins in the (bio)pharma industry -- Numerical methods for the design and description of in vitro expansion processes of human mesenchymal stem cells -- Euler-Lagrangian Simulations: A Proper Tool for Predicting Cellular Performance in Industrial Scale Bioreactors. |
| Record Nr. | UNINA-9910484863603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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