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Biopharmaceutical Applied Statistics Symposium : Volume 3 Pharmaceutical Applications / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon
| Biopharmaceutical Applied Statistics Symposium : Volume 3 Pharmaceutical Applications / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (426 pages) |
| Disciplina | 615.10727 |
| Collana | ICSA Book Series in Statistics |
| Soggetto topico |
Biometry
Biostatistics |
| ISBN | 981-10-7820-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I: Personalized Medicine -- 1 Targeted Learning of Optimal Individualized Treatment Rules under Cost Constraints -- 2 Uses of Mixture Normal Distribution in Genomics and Otherwise -- 3 Personalized Medicine – Design Considerations -- 4 Adaptive Biomarker Subpopulation and Tumor Type Selection in Phase III Oncology Trials -- 5 High Dimensional Data in Genomics -- Part II: Novel Applications -- 6 Synergy or Additivity - The Importance of Defining the Primary Endpoint -- 7 Full Bayesian Adaptive Dose Finding using Toxicity Probability Interval (TPI) -- 8 Alpha-recycling for the Analyses of Primary and Secondary Endpoints of Clinical Trials -- 9 Expanded Interpretations of Results of Carcinogenicity Studies of Pharmaceuticals -- 1 Clinical Trials in Orphan Drug Development -- 11 Mediation Modeling in Randomized Trials with Non-normal Outcome Variables -- 12 Statistical Considerations in Using Images in Clinical Trials -- 13 Interesting Applications over 30 Years of Consulting -- 14 Uncovering Fraud, Misconduct and Other Data Quality Issues in Clinical Trials -- 15 Development and Evaluation of High Dimensional Prognostic Models -- 16 Design and Analysis of Biosimilar Studies. |
| Record Nr. | UNINA-9910300121003321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biopharmaceutical Applied Statistics Symposium : Volume 1 Design of Clinical Trials / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon
| Biopharmaceutical Applied Statistics Symposium : Volume 1 Design of Clinical Trials / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (XIV, 409 p. 54 illus., 28 illus. in color.) |
| Disciplina | 615.10727 |
| Collana | ICSA Book Series in Statistics |
| Soggetto topico |
Biometry
Biostatistics |
| ISBN | 981-10-7829-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. A Statistical Approach to Clinical Trial Simulations -- 2. Comparison of Statistical Analysis Methods Using Modeling and Simulation for Optimal Protocol Design -- 3. Adaptive Trial Design in Clinical Research -- 4. Best Practices and Recommendations for Trial Simulations Within the Context of Designing Adaptive Clinical Trials -- 5. Designing and Analyzing Recurrent Event Data Trials -- 6. Bayesian Methodologies for Response-Adaptive Allocation -- 7. Addressing High Placebo Response in Neuroscience Clinical Trials -- 8. Phase I Cancer Clinical Trial Design: Single and Combination Agents -- 9. Sample Size and Power for the Mixed Linear Model -- 10. Crossover Designs -- 11. Data monitoring: Structure for Clinical Trials and Sequential Monitoring Procedures -- 12. Design and Data Analysis of Multiregional Clinical Trials (MRCT) – Theory and Practice -- 13. Multiregional Clinical Trials (MRCT) -- 14. Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines -- 15. Development and validation of Patient-reported Outcomes -- 16. Interim Analysis of Survival Trials: Group Sequential Analyses and Conditional Power. |
| Record Nr. | UNINA-9910300110403321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biopharmaceutical Applied Statistics Symposium : Volume 2 Biostatistical Analysis of Clinical Trials / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon
| Biopharmaceutical Applied Statistics Symposium : Volume 2 Biostatistical Analysis of Clinical Trials / / edited by Karl E. Peace, Ding-Geng Chen, Sandeep Menon |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (251 pages) |
| Disciplina | 614.35 |
| Collana | ICSA Book Series in Statistics |
| Soggetto topico |
Biometry
Biostatistics |
| ISBN | 981-10-7826-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | On Statistical Approaches to Meta-analysis of Randomized Clinical Trials -- Collaborative Targeted Maximum Likelihood Estimation to Assess Causal Effects in Observational Studies -- Generalized Tests in Clinical Trials -- Discrete Time-to-event and Score-based Methods with Application to Composite Endpoint for Assessing Evidence of Disease Activity-Free -- Imputing Missing Data Using a Surrogate Biomarker: Analyzing the Incidence of Endometrial Hyperplasia -- Some Statistical Issues in Patient-reported Outcomes -- Network Meta-analysis -- Detecting Safety Signals Among Adverse Events in Clinical Trials -- Applied Meta-analysis using R -- Treatment of Missing Data in Comparative Effectiveness Research -- Missing Data -- Bayesian Subgroup Analysis with Examples -- Statistical Methods in Diagnostic Devices -- A Question-Based Approach to the Analysis of Safety Data -- Analysis of Two-stage Adaptive Seamless Trial Design -- Multiplicity Problems in Clinical Trials – A Regulatory Perspective. |
| Record Nr. | UNINA-9910300111803321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||