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Dynamic combinatorial chemistry [[electronic resource] /] / edited by Joost N. H. Reek and Sijbren Otto
| Dynamic combinatorial chemistry [[electronic resource] /] / edited by Joost N. H. Reek and Sijbren Otto |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH Verlag GmbH & Co., c2010 |
| Descrizione fisica | 1 online resource (213 p.) |
| Disciplina |
547.2
615/.19 |
| Altri autori (Persone) |
ReekJoost N. H
OttoSijbren |
| Soggetto topico |
Combinatorial chemistry
Chemistry, Organic |
| ISBN |
1-282-48273-4
9786612482731 3-527-62970-X 3-527-62971-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Dynamic Combinatorial Chemistry; Contents; List of Contributors; 1: History and Principles of Dynamic Combinatorial Chemistry; 1.1 Introduction; 1.2 History; 1.2.1 Thermodynamically Controlled Templated Synthesis; 1.2.2 Early DCLs; 1.3 Exercising Control over a DCL to Influence Species Distribution; 1.3.1 Selection through Molecular Recognition of an External Template; 1.3.2 Selection through Self-Templating; 1.3.3 Selection Directed by External Physical Stimuli; 1.3.4 Selection Through a Stabilizing Phase Change; 1.4 Designing a Dynamic Combinatorial System; 1.4.1 Building Block Design
1.4.2 Exchange Reactions1.4.3 Exchange Reactions Currently in Use; 1.4.3.1 Reversible Benzylic Nucleophilic Substitution; 1.4.3.2 Nitrone Exchange; 1.4.3.3 Reversible Nitroaldol Reaction; 1.4.3.4 Reversible Resorcinol and Alkanedial Condensation; 1.4.3.5 Reversible Boroxine Formation; 1.4.3.6 Phosphazide Exchange; 1.4.3.7 Transboroxoaromatic Esterification; 1.4.3.8 Future Reactions; 1.5 Conclusions; References; 2: The Practice of Dynamic Combinatorial Libraries: Analytical Chemistry, Experimental Design, and Data Analysis; 2.1 Introduction; 2.2 Analytical Methods; 2.2.1 MS Analysis 2.2.2 LC-MS Analysis2.2.3 Analysis by NMR; 2.2.4 Resin-Bound DCC; 2.3 Experimental Design; 2.3.1 Importance of Template Concentration; 2.3.2 Library Size; 2.4 Data Analysis; 2.4.1 Quantifying Equilibrium Constants; 2.4.2 DCLs as Sensors; 2.5 Conclusions; Acknowledgments; References; 3: Development of Synthetic Receptors using Dynamic Combinatorial Chemistry; 3.1 Introduction; 3.2 Experimental Considerations; 3.2.1 Preparation of DCLs; 3.2.1.1 Reversible Chemistry; 3.2.1.2 Building Block Design; 3.2.1.3 Building Block Concentration; 3.2.1.4 Assessing Equilibrium 3.2.2 Templating of the Library3.2.2.1 Ensuring Meaningful Amplifications; 3.2.2.2 Identification of Amplified Compounds; 3.2.3 Isolation of Amplified Receptors; 3.2.3.1 Biased Libraries; 3.2.3.2 Solid Supported Templates; 3.3 Selected Examples; 3.3.1 Synthetic Receptors for Metal Cations; 3.3.2 Synthetic Receptors for Anions; 3.3.3 Synthetic Receptors for Organic Guests; 3.4 Conclusions; References; 4: Dynamic Combinatorial Chemistry for Catalytic Applications; 4.1 Introduction; 4.2 Dynamic Combinatorial Approaches to Cage Catalysts 4.2.1 Libraries of Cage Molecules and Dynamic Selection of Hosts/Guests4.2.2 Catalysis with Cage Compounds and Possible Selection Procedures; 4.3 Dynamic Combinatorial Approaches to Transition Metal Catalysts; 4.3.1 Dynamic Libraries of Transition Metal Catalysts; 4.3.1.1 Library of Monodentate and Covalent Bidentate Ligands; 4.3.1.2 Library of Supramolecular Bidentate Ligands; 4.3.1.3 Library of Dynamic Supramolecular Templates; 4.3.1.4 Library of Dynamic Covalent Linkers; 4.3.2 Selection Procedures via Intermediates and TSAs; 4.3.2.1 TSA Approach 4.3.2.2 Selection of Catalyst Based on Intermediate Stability |
| Record Nr. | UNINA-9910139499903321 |
| Weinheim, : Wiley-VCH Verlag GmbH & Co., c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Dynamic combinatorial chemistry [[electronic resource] /] / edited by Joost N. H. Reek and Sijbren Otto
| Dynamic combinatorial chemistry [[electronic resource] /] / edited by Joost N. H. Reek and Sijbren Otto |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH Verlag GmbH & Co., c2010 |
| Descrizione fisica | 1 online resource (213 p.) |
| Disciplina |
547.2
615/.19 |
| Altri autori (Persone) |
ReekJoost N. H
OttoSijbren |
| Soggetto topico |
Combinatorial chemistry
Chemistry, Organic |
| ISBN |
1-282-48273-4
9786612482731 3-527-62970-X 3-527-62971-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Dynamic Combinatorial Chemistry; Contents; List of Contributors; 1: History and Principles of Dynamic Combinatorial Chemistry; 1.1 Introduction; 1.2 History; 1.2.1 Thermodynamically Controlled Templated Synthesis; 1.2.2 Early DCLs; 1.3 Exercising Control over a DCL to Influence Species Distribution; 1.3.1 Selection through Molecular Recognition of an External Template; 1.3.2 Selection through Self-Templating; 1.3.3 Selection Directed by External Physical Stimuli; 1.3.4 Selection Through a Stabilizing Phase Change; 1.4 Designing a Dynamic Combinatorial System; 1.4.1 Building Block Design
1.4.2 Exchange Reactions1.4.3 Exchange Reactions Currently in Use; 1.4.3.1 Reversible Benzylic Nucleophilic Substitution; 1.4.3.2 Nitrone Exchange; 1.4.3.3 Reversible Nitroaldol Reaction; 1.4.3.4 Reversible Resorcinol and Alkanedial Condensation; 1.4.3.5 Reversible Boroxine Formation; 1.4.3.6 Phosphazide Exchange; 1.4.3.7 Transboroxoaromatic Esterification; 1.4.3.8 Future Reactions; 1.5 Conclusions; References; 2: The Practice of Dynamic Combinatorial Libraries: Analytical Chemistry, Experimental Design, and Data Analysis; 2.1 Introduction; 2.2 Analytical Methods; 2.2.1 MS Analysis 2.2.2 LC-MS Analysis2.2.3 Analysis by NMR; 2.2.4 Resin-Bound DCC; 2.3 Experimental Design; 2.3.1 Importance of Template Concentration; 2.3.2 Library Size; 2.4 Data Analysis; 2.4.1 Quantifying Equilibrium Constants; 2.4.2 DCLs as Sensors; 2.5 Conclusions; Acknowledgments; References; 3: Development of Synthetic Receptors using Dynamic Combinatorial Chemistry; 3.1 Introduction; 3.2 Experimental Considerations; 3.2.1 Preparation of DCLs; 3.2.1.1 Reversible Chemistry; 3.2.1.2 Building Block Design; 3.2.1.3 Building Block Concentration; 3.2.1.4 Assessing Equilibrium 3.2.2 Templating of the Library3.2.2.1 Ensuring Meaningful Amplifications; 3.2.2.2 Identification of Amplified Compounds; 3.2.3 Isolation of Amplified Receptors; 3.2.3.1 Biased Libraries; 3.2.3.2 Solid Supported Templates; 3.3 Selected Examples; 3.3.1 Synthetic Receptors for Metal Cations; 3.3.2 Synthetic Receptors for Anions; 3.3.3 Synthetic Receptors for Organic Guests; 3.4 Conclusions; References; 4: Dynamic Combinatorial Chemistry for Catalytic Applications; 4.1 Introduction; 4.2 Dynamic Combinatorial Approaches to Cage Catalysts 4.2.1 Libraries of Cage Molecules and Dynamic Selection of Hosts/Guests4.2.2 Catalysis with Cage Compounds and Possible Selection Procedures; 4.3 Dynamic Combinatorial Approaches to Transition Metal Catalysts; 4.3.1 Dynamic Libraries of Transition Metal Catalysts; 4.3.1.1 Library of Monodentate and Covalent Bidentate Ligands; 4.3.1.2 Library of Supramolecular Bidentate Ligands; 4.3.1.3 Library of Dynamic Supramolecular Templates; 4.3.1.4 Library of Dynamic Covalent Linkers; 4.3.2 Selection Procedures via Intermediates and TSAs; 4.3.2.1 TSA Approach 4.3.2.2 Selection of Catalyst Based on Intermediate Stability |
| Record Nr. | UNINA-9910829903603321 |
| Weinheim, : Wiley-VCH Verlag GmbH & Co., c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Dynamic combinatorial chemistry / / edited by Joost N. H. Reek and Sijbren Otto
| Dynamic combinatorial chemistry / / edited by Joost N. H. Reek and Sijbren Otto |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH Verlag GmbH & Co., c2010 |
| Descrizione fisica | 1 online resource (213 p.) |
| Disciplina |
547.2
615/.19 |
| Altri autori (Persone) |
ReekJoost N. H
OttoSijbren |
| Soggetto topico |
Combinatorial chemistry
Chemistry, Organic |
| ISBN |
1-282-48273-4
9786612482731 3-527-62970-X 3-527-62971-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Dynamic Combinatorial Chemistry; Contents; List of Contributors; 1: History and Principles of Dynamic Combinatorial Chemistry; 1.1 Introduction; 1.2 History; 1.2.1 Thermodynamically Controlled Templated Synthesis; 1.2.2 Early DCLs; 1.3 Exercising Control over a DCL to Influence Species Distribution; 1.3.1 Selection through Molecular Recognition of an External Template; 1.3.2 Selection through Self-Templating; 1.3.3 Selection Directed by External Physical Stimuli; 1.3.4 Selection Through a Stabilizing Phase Change; 1.4 Designing a Dynamic Combinatorial System; 1.4.1 Building Block Design
1.4.2 Exchange Reactions1.4.3 Exchange Reactions Currently in Use; 1.4.3.1 Reversible Benzylic Nucleophilic Substitution; 1.4.3.2 Nitrone Exchange; 1.4.3.3 Reversible Nitroaldol Reaction; 1.4.3.4 Reversible Resorcinol and Alkanedial Condensation; 1.4.3.5 Reversible Boroxine Formation; 1.4.3.6 Phosphazide Exchange; 1.4.3.7 Transboroxoaromatic Esterification; 1.4.3.8 Future Reactions; 1.5 Conclusions; References; 2: The Practice of Dynamic Combinatorial Libraries: Analytical Chemistry, Experimental Design, and Data Analysis; 2.1 Introduction; 2.2 Analytical Methods; 2.2.1 MS Analysis 2.2.2 LC-MS Analysis2.2.3 Analysis by NMR; 2.2.4 Resin-Bound DCC; 2.3 Experimental Design; 2.3.1 Importance of Template Concentration; 2.3.2 Library Size; 2.4 Data Analysis; 2.4.1 Quantifying Equilibrium Constants; 2.4.2 DCLs as Sensors; 2.5 Conclusions; Acknowledgments; References; 3: Development of Synthetic Receptors using Dynamic Combinatorial Chemistry; 3.1 Introduction; 3.2 Experimental Considerations; 3.2.1 Preparation of DCLs; 3.2.1.1 Reversible Chemistry; 3.2.1.2 Building Block Design; 3.2.1.3 Building Block Concentration; 3.2.1.4 Assessing Equilibrium 3.2.2 Templating of the Library3.2.2.1 Ensuring Meaningful Amplifications; 3.2.2.2 Identification of Amplified Compounds; 3.2.3 Isolation of Amplified Receptors; 3.2.3.1 Biased Libraries; 3.2.3.2 Solid Supported Templates; 3.3 Selected Examples; 3.3.1 Synthetic Receptors for Metal Cations; 3.3.2 Synthetic Receptors for Anions; 3.3.3 Synthetic Receptors for Organic Guests; 3.4 Conclusions; References; 4: Dynamic Combinatorial Chemistry for Catalytic Applications; 4.1 Introduction; 4.2 Dynamic Combinatorial Approaches to Cage Catalysts 4.2.1 Libraries of Cage Molecules and Dynamic Selection of Hosts/Guests4.2.2 Catalysis with Cage Compounds and Possible Selection Procedures; 4.3 Dynamic Combinatorial Approaches to Transition Metal Catalysts; 4.3.1 Dynamic Libraries of Transition Metal Catalysts; 4.3.1.1 Library of Monodentate and Covalent Bidentate Ligands; 4.3.1.2 Library of Supramolecular Bidentate Ligands; 4.3.1.3 Library of Dynamic Supramolecular Templates; 4.3.1.4 Library of Dynamic Covalent Linkers; 4.3.2 Selection Procedures via Intermediates and TSAs; 4.3.2.1 TSA Approach 4.3.2.2 Selection of Catalyst Based on Intermediate Stability |
| Record Nr. | UNINA-9910876512703321 |
| Weinheim, : Wiley-VCH Verlag GmbH & Co., c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||