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Insulin resistance [[electronic resource] ] : insulin action and its disturbances in disease / / editors, Sudhesh Kumar, Stephen O'Rahilly
| Insulin resistance [[electronic resource] ] : insulin action and its disturbances in disease / / editors, Sudhesh Kumar, Stephen O'Rahilly |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, N.J., : J. Wiley, c2005 |
| Descrizione fisica | 1 online resource (617 p.) |
| Disciplina |
612.34
616.4/6207 616.46207 |
| Altri autori (Persone) |
KumarSudhesh
O'RahillyS (Stephen) |
| Soggetto topico | Insulin resistance |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-27609-6
9786610276097 0-470-01126-2 0-470-01132-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Insulin Resistance; Contents; Preface; List of Contributors; 1 The Insulin Receptor and Downstream Signalling; 1.1 Introduction; 1.2 Insulin receptor structure and function; 1.3 Insulin receptor substrates; 1.4 Downstream signalling pathways; 1.5 The basis of insulin's signalling specificity; 1.6 Conclusion; References; 2 Insulin-mediated Regulation of Glucose Metabolism; 2.1 Introduction; 2.2 Insulin as a master regulator of whole body glucose disposal; 2.3 Insulin-mediated regulation of glucose metabolic pathways
2.4 Glucose uptake into skeletal muscle - the rate-limiting step in glucose metabolismAcknowledgements; References; 3 Insulin Action on Lipid Metabolism; 3.1 Introduction: does insulin affect lipid metabolism?; 3.2 Molecular mechanisms by which insulin regulates lipid metabolism; 3.3 Insulin and lipolysis; 3.4 Insulin, lipoprotein lipase and cellular fatty acid uptake; 3.5 Co-ordinated regulation of fatty acid synthesis and ketogenesis; 3.6 Insulin and cholesterol synthesis; 3.7 Insulin effects on lipoprotein metabolism; Acknowledgement; References 4 The Effect of Insulin on Protein Metabolism4.1 Introduction; 4.2 Molecular mechanisms of insulin's effect on protein turnover; 4.3 Measurement of protein metabolism (synthesis and breakdown or turnover) in human subjects; 4.4 Whole body and regional protein turnover; Acknowledgements; References; 5 Genetically Modified Mouse Models of Insulin Resistance; 5.1 Introduction; 5.2 Genetic modification as a tool to dissect the mechanisms leading to insulin resistance; 5.3 Candidate genes involved in the mechanisms of insulin resistance; 5.4 Insulin signalling network 5.5 Factors leading to insulin resistance5.6 Defining the function of the insulin cascade molecules through global knockouts; 5.7 Double heterozygous mice as models of polygenic forms of diabetes; 5.8 Defining tissue and/or organ relevance for the maintenance of insulin sensitivity; 5.9 Genetically modified mice to study modulators of insulin sensitivity; 5.10 Lipodystrophy versus obesity, the insulin resistance paradox; 5.11 Excess of nutrients as a cause of insulin resistance; 5.12 PPARs, key mediators of nutritional-regulated gene expression and insulin sensitivity; References 6 Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes6.1 Introduction; 6.2 Measurement of insulin resistance; 6.3 Insulin-resistant states; 6.4 Conclusion and perspectives; References; 7 Central Regulation of Peripheral Glucose Metabolism; 7.1 Introduction; 7.2 Counter-regulation of hypoglycaemia - role of the CNS; 7.3 Brain regions involved in counter-regulation; 7.4 Glucosensing neurons; 7.5 Central control of peripheral organs involved in glucoregulation 7.6 Additional afferent signals to the CNS regulating peripheral glucose metabolism |
| Record Nr. | UNINA-9910144640103321 |
| Chichester, West Sussex, England ; ; Hoboken, N.J., : J. Wiley, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Insulin resistance : insulin action and its disturbances in disease / / editors, Sudhesh Kumar, Stephen O'Rahilly
| Insulin resistance : insulin action and its disturbances in disease / / editors, Sudhesh Kumar, Stephen O'Rahilly |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, N.J., : J. Wiley, c2005 |
| Descrizione fisica | 1 online resource (617 p.) |
| Disciplina | 616.4/6207 |
| Altri autori (Persone) |
KumarSudhesh
O'RahillyS (Stephen) |
| Soggetto topico | Insulin resistance |
| ISBN |
1-280-27609-6
9786610276097 0-470-01126-2 0-470-01132-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Insulin Resistance; Contents; Preface; List of Contributors; 1 The Insulin Receptor and Downstream Signalling; 1.1 Introduction; 1.2 Insulin receptor structure and function; 1.3 Insulin receptor substrates; 1.4 Downstream signalling pathways; 1.5 The basis of insulin's signalling specificity; 1.6 Conclusion; References; 2 Insulin-mediated Regulation of Glucose Metabolism; 2.1 Introduction; 2.2 Insulin as a master regulator of whole body glucose disposal; 2.3 Insulin-mediated regulation of glucose metabolic pathways
2.4 Glucose uptake into skeletal muscle - the rate-limiting step in glucose metabolismAcknowledgements; References; 3 Insulin Action on Lipid Metabolism; 3.1 Introduction: does insulin affect lipid metabolism?; 3.2 Molecular mechanisms by which insulin regulates lipid metabolism; 3.3 Insulin and lipolysis; 3.4 Insulin, lipoprotein lipase and cellular fatty acid uptake; 3.5 Co-ordinated regulation of fatty acid synthesis and ketogenesis; 3.6 Insulin and cholesterol synthesis; 3.7 Insulin effects on lipoprotein metabolism; Acknowledgement; References 4 The Effect of Insulin on Protein Metabolism4.1 Introduction; 4.2 Molecular mechanisms of insulin's effect on protein turnover; 4.3 Measurement of protein metabolism (synthesis and breakdown or turnover) in human subjects; 4.4 Whole body and regional protein turnover; Acknowledgements; References; 5 Genetically Modified Mouse Models of Insulin Resistance; 5.1 Introduction; 5.2 Genetic modification as a tool to dissect the mechanisms leading to insulin resistance; 5.3 Candidate genes involved in the mechanisms of insulin resistance; 5.4 Insulin signalling network 5.5 Factors leading to insulin resistance5.6 Defining the function of the insulin cascade molecules through global knockouts; 5.7 Double heterozygous mice as models of polygenic forms of diabetes; 5.8 Defining tissue and/or organ relevance for the maintenance of insulin sensitivity; 5.9 Genetically modified mice to study modulators of insulin sensitivity; 5.10 Lipodystrophy versus obesity, the insulin resistance paradox; 5.11 Excess of nutrients as a cause of insulin resistance; 5.12 PPARs, key mediators of nutritional-regulated gene expression and insulin sensitivity; References 6 Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes6.1 Introduction; 6.2 Measurement of insulin resistance; 6.3 Insulin-resistant states; 6.4 Conclusion and perspectives; References; 7 Central Regulation of Peripheral Glucose Metabolism; 7.1 Introduction; 7.2 Counter-regulation of hypoglycaemia - role of the CNS; 7.3 Brain regions involved in counter-regulation; 7.4 Glucosensing neurons; 7.5 Central control of peripheral organs involved in glucoregulation 7.6 Additional afferent signals to the CNS regulating peripheral glucose metabolism |
| Record Nr. | UNINA-9910677482003321 |
| Chichester, West Sussex, England ; ; Hoboken, N.J., : J. Wiley, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||