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Antibody fc [[electronic resource]] : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn
| Antibody fc [[electronic resource]] : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn |
| Autore | Ackerman Margaret E |
| Pubbl/distr/stampa | London, : Academic Press, c2014 |
| Descrizione fisica | 1 online resource (376 p.) |
| Disciplina | 616.07/93 |
| Altri autori (Persone) | NimmerjahnFalk |
| Soggetto topico |
Fc receptors
Immune response Anti-antibodies |
| Soggetto genere / forma | Electronic books. |
| ISBN | 0-12-394818-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Antibody Fc: Linking Adaptive and Innate Immunity; Copyright Page; Contents; List of Contributors; 1. EFFECTOR MECHANISMS; 1 Antibody-Dependent Cellular Cytotoxicity (ADCC); Brief History of ADCC; Effector Cells; Receptors Involved; Mechanisms of ADCC; Recognition of the Target Cell and Cross-Linking of the Fc Receptor on the Effector Cell; Downstream Signals in the Effector Cell; Mechanisms of Killing; The Perforin/Granzyme Cell Death Pathway; The FAS-L Pathway; The ROS/ROI Pathway; ADCC Assays in Relation to Killing Mechanisms; ADCC in Monoclonal Antibody Therapy of Cancer
Versatility of Monoclonal Antibodies as Platforms for Cancer TherapyEvidence for ADCC in Cancer Therapy; ADCC in Infectious Disease: A Correlate of Protection?; Studies of Herpes Simplex Virus; Studies of Human and Simian Immunodeficiency Virus; Ongoing Debate and a Possible Consensus; Rational Modification of ADCC Activity; Enhancing the Link between ADCC and Adaptive Immunity; Perspectives: Future Directions; Acknowledgments; References; 2 Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control; Introduction; Phagocytic Cells and Their Fcγ Receptors Various Receptors for IgGDifferential Expression of Fcγ Receptors on Phagocytic Cells; Fcγ Receptor-Mediated Phagocytosis by Phagocytes; Signaling by Activating FcγRs; Regulation of FcR Signals; Phagosome Maturation; Role of FcγR-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control; Bacteria; Avoiding Uptake into Phagocytes; Establishing an Intracellular Niche; Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies; Viruses; Targeting of Viruses to FcRs; Antibody-Dependent Enhancement of Infection; FcR-Mediated Uptake of Parasites and Fungi Leishmania-Specific Antibodies Can Shift the Balance between Th1 and Th2 ResponsesToxoplasma is Targeted to Lysosomes in the Presence of Specific Antibody; Antibody-Mediated Phagocytosis of Invasive Fungi; Concluding Remarks; References; 3 Interactions Between the Complement System and Fcγ Receptors; Preliminary Comments; Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence; Historical Perspective; Modern Times and Mechanisms: CR1 is Removed from Erythrocytes Complement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and Its Significance in HIV D...Similarities and Differences between CR1 and CR2; The Shuttle Mechanism: CR2 and Antigen Presentation; CR1, CR2, and AIDS; A Clue to a Mechanism: Lessons Learned from Dendritic Cells; Cooperation/Synergy between Fcγ Receptors and Complement Receptors on Effector Cells; In Vivo Studies of the Clearance of Opsonized Erythrocytes; In Vitro Evidence for Synergy between Fcγ Receptors and Complement Receptors; Interaction between FcγRIII and CR3; C3b-IgG as a Superopsonin Interaction between FcγR and Complement: Cancer Models |
| Record Nr. | UNINA-9910452543403321 |
Ackerman Margaret E
|
||
| London, : Academic Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn
| Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn |
| Autore | Ackerman Margaret E |
| Pubbl/distr/stampa | London, : Academic Press, c2014 |
| Descrizione fisica | 1 online resource (xii, 363 pages) : illustrations (some color) |
| Disciplina | 616.07/93 |
| Collana | Gale eBooks |
| Soggetto topico |
Immunoglobulins
Antibody diversity |
| ISBN | 0-12-394818-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Antibody Fc: Linking Adaptive and Innate Immunity; Copyright Page; Contents; List of Contributors; 1. EFFECTOR MECHANISMS; 1 Antibody-Dependent Cellular Cytotoxicity (ADCC); Brief History of ADCC; Effector Cells; Receptors Involved; Mechanisms of ADCC; Recognition of the Target Cell and Cross-Linking of the Fc Receptor on the Effector Cell; Downstream Signals in the Effector Cell; Mechanisms of Killing; The Perforin/Granzyme Cell Death Pathway; The FAS-L Pathway; The ROS/ROI Pathway; ADCC Assays in Relation to Killing Mechanisms; ADCC in Monoclonal Antibody Therapy of Cancer
Versatility of Monoclonal Antibodies as Platforms for Cancer TherapyEvidence for ADCC in Cancer Therapy; ADCC in Infectious Disease: A Correlate of Protection?; Studies of Herpes Simplex Virus; Studies of Human and Simian Immunodeficiency Virus; Ongoing Debate and a Possible Consensus; Rational Modification of ADCC Activity; Enhancing the Link between ADCC and Adaptive Immunity; Perspectives: Future Directions; Acknowledgments; References; 2 Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control; Introduction; Phagocytic Cells and Their Fcγ Receptors Various Receptors for IgGDifferential Expression of Fcγ Receptors on Phagocytic Cells; Fcγ Receptor-Mediated Phagocytosis by Phagocytes; Signaling by Activating FcγRs; Regulation of FcR Signals; Phagosome Maturation; Role of FcγR-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control; Bacteria; Avoiding Uptake into Phagocytes; Establishing an Intracellular Niche; Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies; Viruses; Targeting of Viruses to FcRs; Antibody-Dependent Enhancement of Infection; FcR-Mediated Uptake of Parasites and Fungi Leishmania-Specific Antibodies Can Shift the Balance between Th1 and Th2 ResponsesToxoplasma is Targeted to Lysosomes in the Presence of Specific Antibody; Antibody-Mediated Phagocytosis of Invasive Fungi; Concluding Remarks; References; 3 Interactions Between the Complement System and Fcγ Receptors; Preliminary Comments; Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence; Historical Perspective; Modern Times and Mechanisms: CR1 is Removed from Erythrocytes Complement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and Its Significance in HIV D...Similarities and Differences between CR1 and CR2; The Shuttle Mechanism: CR2 and Antigen Presentation; CR1, CR2, and AIDS; A Clue to a Mechanism: Lessons Learned from Dendritic Cells; Cooperation/Synergy between Fcγ Receptors and Complement Receptors on Effector Cells; In Vivo Studies of the Clearance of Opsonized Erythrocytes; In Vitro Evidence for Synergy between Fcγ Receptors and Complement Receptors; Interaction between FcγRIII and CR3; C3b-IgG as a Superopsonin Interaction between FcγR and Complement: Cancer Models |
| Record Nr. | UNINA-9910779973903321 |
|
Ackerman Margaret E
|
||
| London, : Academic Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn
| Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn |
| Autore | Ackerman Margaret E |
| Pubbl/distr/stampa | London, : Academic Press, c2014 |
| Descrizione fisica | 1 online resource (xii, 363 pages) : illustrations (some color) |
| Disciplina | 616.07/93 |
| Collana | Gale eBooks |
| Soggetto topico |
Immunoglobulins
Antibody diversity |
| ISBN | 0-12-394818-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Antibody Fc: Linking Adaptive and Innate Immunity; Copyright Page; Contents; List of Contributors; 1. EFFECTOR MECHANISMS; 1 Antibody-Dependent Cellular Cytotoxicity (ADCC); Brief History of ADCC; Effector Cells; Receptors Involved; Mechanisms of ADCC; Recognition of the Target Cell and Cross-Linking of the Fc Receptor on the Effector Cell; Downstream Signals in the Effector Cell; Mechanisms of Killing; The Perforin/Granzyme Cell Death Pathway; The FAS-L Pathway; The ROS/ROI Pathway; ADCC Assays in Relation to Killing Mechanisms; ADCC in Monoclonal Antibody Therapy of Cancer
Versatility of Monoclonal Antibodies as Platforms for Cancer TherapyEvidence for ADCC in Cancer Therapy; ADCC in Infectious Disease: A Correlate of Protection?; Studies of Herpes Simplex Virus; Studies of Human and Simian Immunodeficiency Virus; Ongoing Debate and a Possible Consensus; Rational Modification of ADCC Activity; Enhancing the Link between ADCC and Adaptive Immunity; Perspectives: Future Directions; Acknowledgments; References; 2 Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control; Introduction; Phagocytic Cells and Their Fcγ Receptors Various Receptors for IgGDifferential Expression of Fcγ Receptors on Phagocytic Cells; Fcγ Receptor-Mediated Phagocytosis by Phagocytes; Signaling by Activating FcγRs; Regulation of FcR Signals; Phagosome Maturation; Role of FcγR-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control; Bacteria; Avoiding Uptake into Phagocytes; Establishing an Intracellular Niche; Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies; Viruses; Targeting of Viruses to FcRs; Antibody-Dependent Enhancement of Infection; FcR-Mediated Uptake of Parasites and Fungi Leishmania-Specific Antibodies Can Shift the Balance between Th1 and Th2 ResponsesToxoplasma is Targeted to Lysosomes in the Presence of Specific Antibody; Antibody-Mediated Phagocytosis of Invasive Fungi; Concluding Remarks; References; 3 Interactions Between the Complement System and Fcγ Receptors; Preliminary Comments; Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence; Historical Perspective; Modern Times and Mechanisms: CR1 is Removed from Erythrocytes Complement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and Its Significance in HIV D...Similarities and Differences between CR1 and CR2; The Shuttle Mechanism: CR2 and Antigen Presentation; CR1, CR2, and AIDS; A Clue to a Mechanism: Lessons Learned from Dendritic Cells; Cooperation/Synergy between Fcγ Receptors and Complement Receptors on Effector Cells; In Vivo Studies of the Clearance of Opsonized Erythrocytes; In Vitro Evidence for Synergy between Fcγ Receptors and Complement Receptors; Interaction between FcγRIII and CR3; C3b-IgG as a Superopsonin Interaction between FcγR and Complement: Cancer Models |
| Record Nr. | UNINA-9910820381203321 |
|
Ackerman Margaret E
|
||
| London, : Academic Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Autoantibodies
| Autoantibodies |
| Autore | Holmdahl Rikard |
| Pubbl/distr/stampa | Frontiers Media SA, 2019 |
| Descrizione fisica | 1 electronic resource (1038 p.) |
| Soggetto topico |
Medicine
Immunology |
| Soggetto non controllato |
Autoantibody
Pemphigus Pemphigoid Arthritis systemic lupus erythematosus autoimmune neurological disease Pathogenesis Biomarker. Diagnosis Treatment |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557241403321 |
|
Holmdahl Rikard
|
||
| Frontiers Media SA, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Fc Mediated Activity of Antibodies : Structural and Functional Diversity / / edited by Jeffrey V. Ravetch, Falk Nimmerjahn
| Fc Mediated Activity of Antibodies : Structural and Functional Diversity / / edited by Jeffrey V. Ravetch, Falk Nimmerjahn |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (VII, 150 p. 14 illus., 12 illus. in color.) |
| Disciplina | 616.079 |
| Collana | Current Topics in Microbiology and Immunology |
| Soggetto topico |
Immunology
Cancer research Infectious diseases Cancer Research Infectious Diseases |
| ISBN | 3-030-31053-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | IgG Fc receptors: evolutionary considerations -- Role of FcgRs in Antibody Based Cancer Therapy -- Anti-inflammatory Activity of IgG-Fc -- IgG Fc glycosylation in human immunity -- IgE Glycosylation in Health and Disease -- Immune Complex Vaccination -- Fc receptors in anti-microbial protection. |
| Record Nr. | UNINA-9910349284103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Fc Receptors / / edited by Marc Daeron, Falk Nimmerjahn
| Fc Receptors / / edited by Marc Daeron, Falk Nimmerjahn |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (426 p.) |
| Disciplina | 574.87 |
| Collana | Current Topics in Microbiology and Immunology |
| Soggetto topico |
Immunology
Proteins Medicine - Research Biology - Research Biomedical Research |
| ISBN | 3-319-07911-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The Old but New IgM Fc Receptor (FcμR) -- Emerging Roles for FCRL Family Members in Lymphocyte Biology and Disease -- Intracellular antibody immunity and the cytosolic Fc receptor TRIM21 -- Computational modeling of the main signaling pathways involved in mast cell activation -- Calcium channels in FcR signaling -- Regulation of FcεRI signaling by lipid phosphatases -- Fc Receptors as Adaptive Immunoreceptors -- Glycosylation and Fc Receptors -- Antibodies as natural adjuvants -- IgA, IgA receptors and their anti-inflammatory properties -- Humanized mice to study FcγR function -- FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions -- Human FcR polymorphism and disease -- Bridging auto-antibodies and arthritis; the role of Fc Receptors -- The FcγR of humans and non-human primates and their interaction with IgG: Implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies -- FcgRIIB as a key determinant of agonistic antibody efficacy -- Fc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work -- Sweet and Sour: The role of glycosylation for the anti-inflammatory activity of immunoglobulin G. |
| Record Nr. | UNINA-9910298337003321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular and cellular mechanisms of antibody activity / / Falk Nimmerjahn, editor
| Molecular and cellular mechanisms of antibody activity / / Falk Nimmerjahn, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Springer, 2013 |
| Descrizione fisica | 1 online resource (300 p.) |
| Disciplina | 616.0798 |
| Altri autori (Persone) | NimmerjahnFalk |
| Soggetto topico |
Antigen-antibody reactions
Immunospecificity Binding sites (Biochemistry) |
| ISBN | 1-4614-7107-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | IgM and IgD in infection and inflammatory diseases -- Immunoglobulin A – molecular mechanisms of function and role in immune defense -- Crystal structures of human IgG Fc-fragments and their complexes with Fc Receptors -- The role of IgG in immune responses -- Molecular and cellular pathways involved in the anti-inflammatory activity of IgG -- Example of the Pathogenic Potential of Two Sets of Autoantibodies: Anti-RBC and IgG3 RF Cryoglobulins -- Cross-talk between antibodies, IgG Fc receptors and the complement system -- Regulation of immunological responses by the neonatal Fc receptor for IgG, FcRn -- Antibody mediated regulation of humoral immunity -- Engineered antibody derivatives in preclinical and clinical development. |
| Record Nr. | UNINA-9910437843403321 |
| New York, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||