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Bifurcations and chaos in piecewise-smooth dynamical systems [[electronic resource] /] / Zhanybai T. Zhusubaliyev, Erik Mosekilde
| Bifurcations and chaos in piecewise-smooth dynamical systems [[electronic resource] /] / Zhanybai T. Zhusubaliyev, Erik Mosekilde |
| Autore | Zhusubaliyev Zhanybai T |
| Pubbl/distr/stampa | River Edge, N.J., : World Scientific, c2003 |
| Descrizione fisica | 1 online resource (377 p.) |
| Disciplina | 515/.392 |
| Altri autori (Persone) | MosekildeErik |
| Collana | World Scientific series on nonlinear science. Series A |
| Soggetto topico |
Bifurcation theory
Chaotic behavior in systems Differentiable dynamical systems |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-87682-8
9786611876821 981-256-443-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | PREFACE; CONTENTS; Chapter 1 ON THE DYNAMICS OF NONLINEAR SYSTEMS; Chapter 2 BASIC CONCEPTS AND METHODS; Chapter 3 RELAY CONTROL SYSTEMS; Chapter 4 BIFURCATIONS AND CHAOTIC OSCILLATIONS IN RELAY SYSTEMS; Chapter 5 CHAOTIC OSCILLATIONS IN PULSE-WIDTH MODULATED SYSTEMS; Chapter 6 BORDER-COLLISION BIFURCATIONS ON A TWO-DIMENSIONAL TORUS; Chapter 7 BORDER-COLLISION BIFURCATIONS IN A MANAGEMENT SYSTEM; INDEX |
| Record Nr. | UNINA-9910449886603321 |
Zhusubaliyev Zhanybai T
|
||
| River Edge, N.J., : World Scientific, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bifurcations and chaos in piecewise-smooth dynamical systems [[electronic resource] /] / Zhanybai T. Zhusubaliyev, Erik Mosekilde
| Bifurcations and chaos in piecewise-smooth dynamical systems [[electronic resource] /] / Zhanybai T. Zhusubaliyev, Erik Mosekilde |
| Autore | Zhusubaliyev Zhanybai T |
| Pubbl/distr/stampa | River Edge, N.J., : World Scientific, c2003 |
| Descrizione fisica | 1 online resource (377 p.) |
| Disciplina | 515/.392 |
| Altri autori (Persone) | MosekildeErik |
| Collana | World Scientific series on nonlinear science. Series A |
| Soggetto topico |
Bifurcation theory
Chaotic behavior in systems Differentiable dynamical systems |
| ISBN |
1-281-87682-8
9786611876821 981-256-443-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | PREFACE; CONTENTS; Chapter 1 ON THE DYNAMICS OF NONLINEAR SYSTEMS; Chapter 2 BASIC CONCEPTS AND METHODS; Chapter 3 RELAY CONTROL SYSTEMS; Chapter 4 BIFURCATIONS AND CHAOTIC OSCILLATIONS IN RELAY SYSTEMS; Chapter 5 CHAOTIC OSCILLATIONS IN PULSE-WIDTH MODULATED SYSTEMS; Chapter 6 BORDER-COLLISION BIFURCATIONS ON A TWO-DIMENSIONAL TORUS; Chapter 7 BORDER-COLLISION BIFURCATIONS IN A MANAGEMENT SYSTEM; INDEX |
| Record Nr. | UNINA-9910783224803321 |
|
Zhusubaliyev Zhanybai T
|
||
| River Edge, N.J., : World Scientific, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bifurcations and chaos in piecewise-smooth dynamical systems [[electronic resource] /] / Zhanybai T. Zhusubaliyev, Erik Mosekilde
| Bifurcations and chaos in piecewise-smooth dynamical systems [[electronic resource] /] / Zhanybai T. Zhusubaliyev, Erik Mosekilde |
| Autore | Zhusubaliyev Zhanybai T |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | River Edge, N.J., : World Scientific, c2003 |
| Descrizione fisica | 1 online resource (377 p.) |
| Disciplina | 515/.392 |
| Altri autori (Persone) | MosekildeErik |
| Collana | World Scientific series on nonlinear science. Series A |
| Soggetto topico |
Bifurcation theory
Chaotic behavior in systems Differentiable dynamical systems |
| ISBN |
1-281-87682-8
9786611876821 981-256-443-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | PREFACE; CONTENTS; Chapter 1 ON THE DYNAMICS OF NONLINEAR SYSTEMS; Chapter 2 BASIC CONCEPTS AND METHODS; Chapter 3 RELAY CONTROL SYSTEMS; Chapter 4 BIFURCATIONS AND CHAOTIC OSCILLATIONS IN RELAY SYSTEMS; Chapter 5 CHAOTIC OSCILLATIONS IN PULSE-WIDTH MODULATED SYSTEMS; Chapter 6 BORDER-COLLISION BIFURCATIONS ON A TWO-DIMENSIONAL TORUS; Chapter 7 BORDER-COLLISION BIFURCATIONS IN A MANAGEMENT SYSTEM; INDEX |
| Record Nr. | UNINA-9910822690603321 |
|
Zhusubaliyev Zhanybai T
|
||
| River Edge, N.J., : World Scientific, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff
| Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (542 p.) |
| Disciplina | 615.580724 |
| Soggetto topico |
Drug development
Drug development - Simulation methods |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-94698-2
9786611946982 3-527-62267-5 3-527-62268-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biosimulation in Drug Development; Contents; Preface; List of Contributors; Part I Introduction; 1 Simulation in Clinical Drug Development; 1.1 Introduction; 1.2 Models for Simulations; 1.3 Simulations in Clinical Drug Development: Practical Examples; 1.3.1 Predicting the Outcome of Phase I Studies of Erythropoietin Receptor Agonists; 1.3.2 Simulations for Antimicrobial Dose Selection; 1.3.3 Optimizing the Design of Phase II Dose Finding Studies; 1.3.4 Predicting the Outcome of Phase III Trials Using Phase II Data; 1.4 Conclusions; 2 Modeling of Complex Biomedical Systems; 2.1 Introduction
2.2 Pulsatile Secretion of Insulin2.3 Subcutaneous Absorption of Insulin; 2.4 Bursting Pancreatic β-Cells; 2.5 Conclusions; 3 Biosimulation of Drug Metabolism; 3.1 Introduction; 3.2 Experimental Approaches; 3.2.1 Animal Test Models; 3.2.2 Microbial Models; 3.3 The Biosimulation Approach; 3.4 Ethical Issues; 3.5 PharmBiosim - a Computer Model of Drug Metabolism in Yeast; 3.5.1 General Concept; 3.5.1.1 Chemical Abstraction; 3.5.1.2 Biological Abstraction; 3.5.2 Initial Steps - Experimental Results; 3.5.2.1 Dehalogenation (Pathways II and III); 3.5.2.2 Retro-Claisen Condensation (Pathway IV) 3.5.2.3 Ester Hydrolysis (Pathway VI)3.5.2.4 Competing Pathways and Stereoselectivity; 3.6 Computational Modeling; 3.6.1 Selection of the Modeling Software; 3.6.2 SBML-compatible Software; 3.6.2.1 Cellware; 3.6.2.2 Copasi; 3.6.2.3 Ecell; 3.6.2.4 JigCell; 3.6.2.5 JSim; 3.6.2.6 Systems Biology Workbench; 3.6.2.7 Virtual Cell; 3.6.2.8 XPPAUT; 3.6.3 CellML-compatible Software; 3.6.4 Kinetic Model; 3.6.4.1 Methods; 3.6.4.2 Model Derivation; 3.6.4.3 Results; 3.6.5 Stoichiometric Model; 3.6.5.1 Methods; 3.6.5.2 Model Derivation; 3.6.5.3 Results 3.7 Application of the Model to Predict Drug Metabolism3.8 Conclusions; Part II Simulating Cells and Tissues; 4 Correlation Between In Vitro, In Situ, and In Vivo Models; 4.1 Introduction; 4.2 Biophysical Models of Intestinal Absorption; 4.2.1 Colon; 4.2.2 Small Intestine; 4.2.3 Stomach; 4.3 Influence of Surfactants on Intestinal Permeability; 4.3.1 Absorption Experiments in Presence of Surfactants; 4.3.1.1 Colon; 4.3.1.2 Intestine; 4.3.1.3 Stomach; 4.4 Modeling and Predicting Fraction Absorbed from Permeability Values; 4.4.1 Mass Balance, Time-independent Models 4.4.2 Prediction of the Fraction of Dose Absorbed from In Vitro and In Situ Data4.4.3 Prediction from In Situ Absorption Rate Constant Determined with Closed Loop Techniques; 4.4.4 Prediction from Permeabilities Through Caco-2 Cell Lines; 4.4.5 Prediction from the PAMPA In Vitro System; 4.5 Characterization of Active Transport Parameters; 4.5.1 In Situ Parameter Estimation; 4.5.2 In Vitro-In Situ Correlation; 5 Core-Box Modeling in the Biosimulation of Drug Action; 5.1 Introduction; 5.2 Core-Box Modeling; 5.2.1 Shortcomings of Gray-Box and Minimal Modeling 5.2.1.1 Full-Scale Mechanistic Gray-Box Modeling |
| Record Nr. | UNINA-9910144228403321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff
| Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (542 p.) |
| Disciplina | 615.580724 |
| Soggetto topico |
Drug development
Drug development - Simulation methods |
| ISBN |
1-281-94698-2
9786611946982 3-527-62267-5 3-527-62268-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biosimulation in Drug Development; Contents; Preface; List of Contributors; Part I Introduction; 1 Simulation in Clinical Drug Development; 1.1 Introduction; 1.2 Models for Simulations; 1.3 Simulations in Clinical Drug Development: Practical Examples; 1.3.1 Predicting the Outcome of Phase I Studies of Erythropoietin Receptor Agonists; 1.3.2 Simulations for Antimicrobial Dose Selection; 1.3.3 Optimizing the Design of Phase II Dose Finding Studies; 1.3.4 Predicting the Outcome of Phase III Trials Using Phase II Data; 1.4 Conclusions; 2 Modeling of Complex Biomedical Systems; 2.1 Introduction
2.2 Pulsatile Secretion of Insulin2.3 Subcutaneous Absorption of Insulin; 2.4 Bursting Pancreatic β-Cells; 2.5 Conclusions; 3 Biosimulation of Drug Metabolism; 3.1 Introduction; 3.2 Experimental Approaches; 3.2.1 Animal Test Models; 3.2.2 Microbial Models; 3.3 The Biosimulation Approach; 3.4 Ethical Issues; 3.5 PharmBiosim - a Computer Model of Drug Metabolism in Yeast; 3.5.1 General Concept; 3.5.1.1 Chemical Abstraction; 3.5.1.2 Biological Abstraction; 3.5.2 Initial Steps - Experimental Results; 3.5.2.1 Dehalogenation (Pathways II and III); 3.5.2.2 Retro-Claisen Condensation (Pathway IV) 3.5.2.3 Ester Hydrolysis (Pathway VI)3.5.2.4 Competing Pathways and Stereoselectivity; 3.6 Computational Modeling; 3.6.1 Selection of the Modeling Software; 3.6.2 SBML-compatible Software; 3.6.2.1 Cellware; 3.6.2.2 Copasi; 3.6.2.3 Ecell; 3.6.2.4 JigCell; 3.6.2.5 JSim; 3.6.2.6 Systems Biology Workbench; 3.6.2.7 Virtual Cell; 3.6.2.8 XPPAUT; 3.6.3 CellML-compatible Software; 3.6.4 Kinetic Model; 3.6.4.1 Methods; 3.6.4.2 Model Derivation; 3.6.4.3 Results; 3.6.5 Stoichiometric Model; 3.6.5.1 Methods; 3.6.5.2 Model Derivation; 3.6.5.3 Results 3.7 Application of the Model to Predict Drug Metabolism3.8 Conclusions; Part II Simulating Cells and Tissues; 4 Correlation Between In Vitro, In Situ, and In Vivo Models; 4.1 Introduction; 4.2 Biophysical Models of Intestinal Absorption; 4.2.1 Colon; 4.2.2 Small Intestine; 4.2.3 Stomach; 4.3 Influence of Surfactants on Intestinal Permeability; 4.3.1 Absorption Experiments in Presence of Surfactants; 4.3.1.1 Colon; 4.3.1.2 Intestine; 4.3.1.3 Stomach; 4.4 Modeling and Predicting Fraction Absorbed from Permeability Values; 4.4.1 Mass Balance, Time-independent Models 4.4.2 Prediction of the Fraction of Dose Absorbed from In Vitro and In Situ Data4.4.3 Prediction from In Situ Absorption Rate Constant Determined with Closed Loop Techniques; 4.4.4 Prediction from Permeabilities Through Caco-2 Cell Lines; 4.4.5 Prediction from the PAMPA In Vitro System; 4.5 Characterization of Active Transport Parameters; 4.5.1 In Situ Parameter Estimation; 4.5.2 In Vitro-In Situ Correlation; 5 Core-Box Modeling in the Biosimulation of Drug Action; 5.1 Introduction; 5.2 Core-Box Modeling; 5.2.1 Shortcomings of Gray-Box and Minimal Modeling 5.2.1.1 Full-Scale Mechanistic Gray-Box Modeling |
| Record Nr. | UNINA-9910830717703321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||