| Autore |
Mirzayans Razmik
|
| Edizione | [1st ed.] |
| Pubbl/distr/stampa |
New York, : Nova Biomedical Books, c2009
|
| Descrizione fisica |
113 p. : ill. (some col.)
|
| Altri autori (Persone) |
MurrayDavid, Ph. D.
|
| Soggetto topico |
Cells - Aging
Cancer - Treatment
|
| ISBN |
1-61728-173-5
|
| Formato |
Materiale a stampa  |
| Livello bibliografico |
Monografia |
| Lingua di pubblicazione |
eng
|
| Nota di contenuto |
Intro -- CELLULAR SENESCENCE: IMPLICATIONS FOR CANCER THERAPY -- CELLULAR SENESCENCE: IMPLICATIONS FOR CANCER THERAPY -- CONTENTS -- PREFACE -- Chapter 1 INTRODUCTION -- Chapter 2 TELOMERASE-BASED SENESCENCE -- Chapter 3 STRESS-TRIGGERED PREMATURE SENESCENCE -- Chapter 4 FEATURES OF PREMATURE SENESCENCE -- CELL MORPHOLOGY -- SENESCENCE-ASSOCIATED β-GALACTOSIDASE EXPRESSION -- SUSTAINED P21 UP-REGULATION -- INHIBITION OF CELL GROWTH -- NUCLEAR ACCUMULATION OF ACTIN -- STRESS-ASSOCIATED NUCLEAR FOCI -- Chapter 5 DIFFERENT MODES OF GROWTH ARREST ARE TRIGGERED BY GENOTOXIC STRESS -- Chapter 6 CLASSIFICATION OF CDK INHIBITORS -- Chapter 7 ROLES OF P21, P53 AND P16 IN SENESCENCE -- Chapter 8 REGULATION OF P21WAF1 TRANSCRIPT AND P21 PROTEIN LEVELS -- Chapter 9 MODE OF ACTION OF P21 -- Chapter 10 P53 SIGNALING AND CELLULAR RESPONSE TO DNA-DAMAGING AGENTS -- IONIZING RADIATION-TRIGGERED RESPONSES -- UV-TRIGGERED RESPONSES -- APOPTOTIC THRESHOLD IN CANCER CELLS EXPOSED TO DNA-DAMAGING AGENTS -- WHAT FACTORS MIGHT CONTRIBUTE TO THE APOPTOTIC THRESHOLD? -- Chapter 11 CELL-TO-CELL COMMUNICATION TRIGGERED BY DNA-DAMAGING AGENTS -- ROS-ASSOCIATED BYSTANDER EFFECT OF RADIATION -- P53-MEDIATED BYSTANDER EFFECT OF RADIATION -- DIFFUSIBLE "AT-CORRECTING" FACTORS -- Chapter 12 MODULATING SENESCENCE IN THE CONTEXT OF CANCER THERAPY -- PROS AND CONS OF ACTIVATING SENESCENCE IN CANCER CELLS -- ASSAYS FOR PRECLINICAL TESTING OF ANTICANCER AGENTS -- Chapter 13 AGING, SENESCENCE, AND "HORMESIS" -- Chapter 14 HUMAN GENETIC DISORDERS ASSOCIATED WITH GENOMIC INSTABILITY AND CANCER PREDISPOSITION -- WERNER SYNDROME -- HUTCHINSON-GILFORD'S PROGERIA SYNDROME -- BLOOM SYNDROME -- ROTHMUND-THOMPSON SYNDROME -- COCKAYNE SYNDROME -- XERODERMA PIGMENTOSUM -- FANCONI ANEMIA -- ATAXIA TELANGIECTASIA -- LI-FRAUMENI SYNDROME.
Chapter 15 BIOLOGICAL CONSEQUENCES OF THE FAILURE OF CELLS TO UNDERGO SENESCENCE/APOPTOSIS FOLLOWING GENOTOXIC STRESS: BASIS FOR THE EMERGENCE OF HIGHLY METASTATIC AND THERAPY-RESISTANT DISEASE? -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- INDEX -- Blank Page.
|
| Record Nr. | UNINA-9910817000303321 |
Info
Cellular senescence [[electronic resource] ] : implications for cancer therapy / / Razmik Mirzayans and David Murray
