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Females are mosaics : X inactivation and sex differences in disease / / Barbara R. Migeon
| Females are mosaics : X inactivation and sex differences in disease / / Barbara R. Migeon |
| Autore | Migeon Barbara R |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Oxford : , : Oxford University Press, , [2014] |
| Descrizione fisica | 1 online resource (328 p.) |
| Disciplina | 616/.042 |
| Soggetto topico |
Mosaicism
X chromosome - Abnormalities Genetic disorders Sex factors in disease |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-934366-7
0-19-992754-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Sex differences in disease -- Evolution of the human sex chromosomes and a portrait of the human X -- X chromosome dosage compensation : an overview -- The discovery of X chromosome inactivation -- Experimental models for X inactivation studies -- Theme 1 : the initial step : creating the active and inactive X -- Theme 2 : subsequent steps : spreading and maintaining inactivation -- Variations 1 : evolution of the X inactivation center -- Variations 2 : stability of the inactive X -- Variations 3 : choice of active X -- The single active X -- Mosaicism -- Epimutations, chromatin disorders and sex differences in phenotype -- Determinants of female phenotypes. |
| Record Nr. | UNINA-9910452506403321 |
Migeon Barbara R
|
||
| Oxford : , : Oxford University Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Females are mosaics : X inactivation and sex differences in disease / / Barbara R. Migeon
| Females are mosaics : X inactivation and sex differences in disease / / Barbara R. Migeon |
| Autore | Migeon Barbara R |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Oxford : , : Oxford University Press, , [2014] |
| Descrizione fisica | 1 online resource (328 p.) |
| Disciplina | 616/.042 |
| Soggetto topico |
Mosaicism
X chromosome - Abnormalities Genetic disorders Sex factors in disease |
| ISBN |
0-19-934366-7
0-19-992754-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Sex differences in disease -- Evolution of the human sex chromosomes and a portrait of the human X -- X chromosome dosage compensation : an overview -- The discovery of X chromosome inactivation -- Experimental models for X inactivation studies -- Theme 1 : the initial step : creating the active and inactive X -- Theme 2 : subsequent steps : spreading and maintaining inactivation -- Variations 1 : evolution of the X inactivation center -- Variations 2 : stability of the inactive X -- Variations 3 : choice of active X -- The single active X -- Mosaicism -- Epimutations, chromatin disorders and sex differences in phenotype -- Determinants of female phenotypes. |
| Record Nr. | UNINA-9910790682503321 |
|
Migeon Barbara R
|
||
| Oxford : , : Oxford University Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Females are mosaics : X inactivation and sex differences in disease / / Barbara R. Migeon
| Females are mosaics : X inactivation and sex differences in disease / / Barbara R. Migeon |
| Autore | Migeon Barbara R |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Oxford : , : Oxford University Press, , [2014] |
| Descrizione fisica | 1 online resource (328 p.) |
| Disciplina | 616/.042 |
| Soggetto topico |
Mosaicism
X chromosome - Abnormalities Genetic disorders Sex factors in disease |
| ISBN |
0-19-934366-7
0-19-992754-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Sex differences in disease -- Evolution of the human sex chromosomes and a portrait of the human X -- X chromosome dosage compensation : an overview -- The discovery of X chromosome inactivation -- Experimental models for X inactivation studies -- Theme 1 : the initial step : creating the active and inactive X -- Theme 2 : subsequent steps : spreading and maintaining inactivation -- Variations 1 : evolution of the X inactivation center -- Variations 2 : stability of the inactive X -- Variations 3 : choice of active X -- The single active X -- Mosaicism -- Epimutations, chromatin disorders and sex differences in phenotype -- Determinants of female phenotypes. |
| Record Nr. | UNINA-9910822425603321 |
|
Migeon Barbara R
|
||
| Oxford : , : Oxford University Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Females are mosaics [[electronic resource] ] : X inactivation and sex differences in disease / / Barbara R. Migeon
| Females are mosaics [[electronic resource] ] : X inactivation and sex differences in disease / / Barbara R. Migeon |
| Autore | Migeon Barbara R |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (xi, 271 p., [8] p. of plates ) : ill. (some col.) |
| Disciplina | 616/.042 |
| Soggetto topico |
X chromosome
Mosaicism Sex determination, Genetic Sex-linkage (Genetics) |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-16268-X
0-19-972006-1 1-4294-8700-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910451721103321 |
|
Migeon Barbara R
|
||
| Oxford ; ; New York, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Females are mosaics [[electronic resource] ] : X inactivation and sex differences in disease / / Barbara R. Migeon
| Females are mosaics [[electronic resource] ] : X inactivation and sex differences in disease / / Barbara R. Migeon |
| Autore | Migeon Barbara R |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (xi, 271 p., [8] p. of plates ) : ill. (some col.) |
| Disciplina | 616/.042 |
| Soggetto topico |
X chromosome
Mosaicism Sex determination, Genetic Sex-linkage (Genetics) |
| ISBN |
0-19-770667-3
1-281-16268-X 0-19-972006-1 1-4294-8700-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910777823503321 |
|
Migeon Barbara R
|
||
| Oxford ; ; New York, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Females are mosaics : X inactivation and sex differences in disease / / Barbara R. Migeon
| Females are mosaics : X inactivation and sex differences in disease / / Barbara R. Migeon |
| Autore | Migeon Barbara R |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (xi, 271 p., [8] p. of plates ) : ill. (some col.) |
| Disciplina | 616/.042 |
| Collana | Oxford scholarship online |
| Soggetto topico |
X chromosome
Mosaicism Sex determination, Genetic Sex-linkage (Genetics) |
| ISBN |
0-19-020847-3
0-19-770667-3 1-281-16268-X 0-19-972006-1 1-4294-8700-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Contents -- Introduction -- PART I. BACKGROUND -- Chapter 1 Sex Differences in Disease -- 1.1. Males More Vulnerable at Every Age -- 1.2. Vulnerability of Males Leads to Sex-Specific Disease -- 1.3. Summary and Speculations -- Chapter 2 Evolution of the Human Sex Chromosomes and a Portrait of the Human X -- 2.1. Chromosomal Basis of Sex Determination -- 2.2. The Human Sex Chromosomes Evolved from Reptilian Autosomes -- 2.3. Degeneration of the Y Chromosome -- 2.4. Ohno's Law and the Conservation of the Original X -- 2.5. Residual Homology and the Pseudoautosomal Regions -- 2.6. Genetic Portrait of the Human X -- 2.7. Summary and Speculations -- Chapter 3 X Chromosome Dosage Compensation: An Overview -- 3.1. X Chromosome Dosage Compensation -- 3.2. Heterochromatin and Chromosome Silencing -- 3.3. Role in Sex Determination -- 3.4. Mechanisms of Dosage Compensation in Other Organisms -- 3.5. Mechanisms of Dosage Compensation in Mammals -- 3.6. Summary and Speculations -- Chapter 4 The Discovery of X Chromosome Inactivation -- 4.1. The Lyon Hypothesis -- 4.2. General Scheme of Mammalian Dosage Compensation -- 4.3. Summary and Speculations -- Chapter 5 Experimental Models for X Inactivation Studies -- 5.1. Spontaneous Human Mutations that Interfere with Inactivation -- 5.2. X-Linked Protein Variants Distinguish Parental Origin of X Chromosomes -- 5.3. Characterizing the Inactive X in Human Cell Cultures and Clones -- 5.4. Mouse-Human Hybrids Separate Inactive from Active X -- 5.5. Mouse Embryonic Stem Cells for Manipulating the Early Steps in X Inactivation -- 5.6. Transgenic Mice as a Functional Assay -- 5.7. Assays for X Inactivation Patterns in Heterozygotes -- 5.8. Summary and Speculations -- PART II. THEMES AND VARIATIONS OF X INACTIVATION -- Chapter 6 Theme 1: The Initial Steps-Creating the Active and Inactive X.
6.1. Characteristics of the Inactive X Chromosome -- 6.2. Time of Initiation in the Embryo -- 6.3. Cis Inactivation -- 6.4. The Master Control Region: XIC and Xist -- 6.5. Silencing the Inactive X Chromosome -- 6.6. Choosing the Active X Chromosome -- 6.7. Summary and Speculations -- Chapter 7 Theme 2: Subsequent Steps-Spreading and Maintaining Inactivation -- 7.1. Spreading Inactivation by Modifying Chromatin -- 7.2. Maintaining Inactivation by DNA Methylation of CpG Islands -- 7.3. Escape from Inactivation -- 7.4. Transient X Inactivation in Germ Cells -- 7.5. Induced X Reactivation in Placental Cells -- 7.6. Role of DNA Replication in X Inactivation -- 7. 7. Summary and Speculations -- Chapter 8 Variations 1: Stability of the Inactive X -- 8.1. Variations on the Themes of X Inactivation -- 8.2. Divergence in the Physical Map -- 8.3. Stability of X Inactivation -- 8.4. Summary and Speculations -- Chapter 9 Variations 2: Choice of Active X -- 9.1. Primary Nonrandom X Inactivation -- 9.2. Paternal X Inactivation -- 9.3. Relationship of Paternal X Inactivation to Genomic Imprinting -- 9.4. Does Antisense Transcription Have a Role? -- 9.5. Evolution and Tinkering -- 9.6. Effect of Inactivation Timing -- 9.7. Summary and Speculations -- PART III. MEDICAL CONSEQUENCE OF X INACTIVATION -- Chapter 10 The Single Active X -- 10.1. Coping with a Monosomy X -- 10.2. Sex Differences in Susceptibility to Disease -- 10.3. Viability of Turner Syndrome, Klinefelter Syndrome, and X Chromosome Aneuploidy -- 10.4. X Deletions, Ring X Chromosomes, X Duplications, and Functional Disomy -- 10.5. X/Autosome Translocations and Spreading of Inactivation -- 10.6. Polyploidy and the Choice of Active X -- 10.7. Summary and Speculations -- Chapter 11 Mosaicism -- 11.1. The X-Linked Phenotype Is Dominant at the Cellular Level -- 11.2. Females Are Mosaics. 11.3. Interaction between Mosaic Cell Populations -- 11.4. Skewing of X Inactivation Patterns -- 11.5. Effect of X Inactivation on Clinical Phenotype -- 11.6. "Manifesting" Heterozygotes -- 11.7. Summary and Speculations -- Chapter 12 Determinants of Female Phenotypes -- 12.1. The Dynamic Effect of Interacting Cell Populations on the Health of Females -- 12.2. The Effect of X Inactivation on Normal Female Phenotype and Cell Diversity -- 12.3. Epilogue -- Appendix A: Descriptions of Model X-linked and Other Relevant Diseases -- Appendix B: Sex Chromosome Aneuploidy, Polyploidy, and Parthenogenetic Conceptuses -- Glossary -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- R -- S -- T -- X -- References -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- W -- X -- Y -- Z. |
| Altri titoli varianti | X inactivation and sex differences in disease |
| Record Nr. | UNINA-9910813270003321 |
|
Migeon Barbara R
|
||
| Oxford ; ; New York, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||