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Target validation in drug discovery [[electronic resource] /] / Brian W. Metcalf and Susan Dillon, editors
| Target validation in drug discovery [[electronic resource] /] / Brian W. Metcalf and Susan Dillon, editors |
| Pubbl/distr/stampa | Boston, MA, : Academic Press, 2006 |
| Descrizione fisica | 1 online resource (293 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
MetcalfBrian W
DillonSusan <1952-> |
| Soggetto topico |
Drug development
Drugs - Testing High throughput screening (Drug development) |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-70760-7
9786610707607 0-08-046597-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Title Page; Copyright Page; Table of Contents; Preface; Contributors; PART I PHARMACEUTICAL BIOTECHNOLOGY FOR TARGET VALIDATION; Chapter 1 Generation of Transgenic Animals; I. INTRODUCTION; II. GENERATION OF TRANSGENIC ANIMALS FOR TARGET VALIDATION; III. CONCLUSION; ACKNOWLEDGMENTS; RECOMMENDED RESOURCES; REFERENCES; Chapter 2 Target Validation in Chemogenomics; I. INTRODUCTION; II. REVERSE CHEMOGENOMICS: TARGET VALIDATION USING COMPOUNDS WITH KNOWN MOLECULAR TARGET (AND/OR MECHANISM OF ACTION)
III. FORWARD CHEMOGENOMICS: TARGET IDENTIFICATION/VALIDATION USING COMPOUNDS WITH UNKNOWN MECHANISM OF ACTIONIV. CONCLUSION; REFERENCES; PART II TARGET VALIDATION FOR BIOPHARMACEUTICAL DRUG DISCOVERY; Chapter 3 Cetuximab (Erbitux®), An Anti-Epidermal Growth Factor Receptor Antibody for the Treatment of Metastatic Colorectal Cancer; I. INTRODUCTION; II. EPIDERMAL GROWTH FACTOR RECEPTOR AND ITS ROLE IN HUMAN CANCER; III. CETUXIMAB (ERBITUX®, IMC-C225); IV. CETUXIMAB IN CLINICAL STUDIES IN PATIENTS WITH mCRC; V. MECHANISMS OF ACTION OF CETUXIMAB; VI. CONCLUSIONS AND PERSPECTIVES RECOMMENDED RESOURCESREFERENCES; Chapter 4 Monoclonal Antibody to HER-2 in Breast Cancer; I. INTRODUCTION; II. MECHANISM OF ACTION OF TRASTUZUMAB; III. MOLECULAR MECHANISMS OF TRASTUZUMAB RESISTANCE; IV. ASSESSMENT OF HER-2 STATUS; V. CLINICAL TRIALS WITH TRASTUZUMAB; CONCLUSION; ACKNOWLEDGMENTS; USEFUL WEBSITES; REFERENCES; Chapter 5 Validation of TNF as a Drug Target in Inflammatory Bowel Disease; I. INTRODUCTION; II. TUMOR NECROSIS FACTOR; III. INFLAMMATORY BOWEL DISEASE; IV. PATHOPHYSIOLOGY OF IBD AND THE PUTATIVE ROLE OF TNF; V. CLINICAL EXPERIENCE WITH TNF-BLOCKING THERAPY IN IBD CONCLUSIONACKNOWLEDGMENTS; REFERENCES; Chapter 6 Anti-CCL-2/MCP-1: Directed Biologicals for Inflammatory and Malignant Diseases; I. INTRODUCTION; II. IN VITRO ASSAYS TO ESTABLISH THE PRO-INFLAMMATORY ACTIVITIES OF CCL-2; III. IN VIVO VALIDATION STUDIES; IV. SUMMARY; ACKNOWLEDGMENTS; REFERENCES; Chapter 7 Targeting IL-12p40 for Immune-Mediated Disease; I. INTRODUCTION; II. IN VITRO TARGET VALIDATION OF IL-12p40; III. IN VIVO PROOF-OF-CONCEPT FOR IL-12p40 INHIBITION; IV. CONCLUSION; RECOMMENDED RESOURCES; REFERENCES Chapter 8 The GPIIb/IIIa Antagonist Abciximab for Acute Percutaneous Coronary InterventionI. INTRODUCTION; II. RATIONALE FOR GPIIb/IIIa AS A TARGET IN CORONARY ARTERIAL DISEASE; III. GENERATION OF THE 7E3 MONOCLONAL ANTIBODY AGAINST GPIIb/IIIa; IV. IN VITRO STUDIES; V. ANIMAL STUDIES; VI. PLATELET PHARMACODYNAMIC PHENOMENA RECOGNIZED LATER; VII. CROSS REACTIVITY WITH OTHER INTEGRINS; VIII. INTEGRATION OF CLINICAL PHARMACOLOGY AND PRECLINICAL STUDIES; IX. CLINICAL STUDIES; X. CONCLUSION; RECOMMENDED RESOURCES; REFERENCES; PART III VALIDATING TARGETS OF SMALL MOLECULE APPROACHES Chapter 9 Epidermal Growth Factor Receptor (EGFR) Inhibitor for Oncology: Discovery and Development of Erlotinib |
| Record Nr. | UNINA-9910458639003321 |
| Boston, MA, : Academic Press, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Target validation in drug discovery [[electronic resource] /] / Brian W. Metcalf and Susan Dillon, editors
| Target validation in drug discovery [[electronic resource] /] / Brian W. Metcalf and Susan Dillon, editors |
| Pubbl/distr/stampa | Boston, MA, : Academic Press, 2006 |
| Descrizione fisica | 1 online resource (293 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
MetcalfBrian W
DillonSusan <1952-> |
| Soggetto topico |
Drug development
Drugs - Testing High throughput screening (Drug development) |
| ISBN |
1-280-70760-7
9786610707607 0-08-046597-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Title Page; Copyright Page; Table of Contents; Preface; Contributors; PART I PHARMACEUTICAL BIOTECHNOLOGY FOR TARGET VALIDATION; Chapter 1 Generation of Transgenic Animals; I. INTRODUCTION; II. GENERATION OF TRANSGENIC ANIMALS FOR TARGET VALIDATION; III. CONCLUSION; ACKNOWLEDGMENTS; RECOMMENDED RESOURCES; REFERENCES; Chapter 2 Target Validation in Chemogenomics; I. INTRODUCTION; II. REVERSE CHEMOGENOMICS: TARGET VALIDATION USING COMPOUNDS WITH KNOWN MOLECULAR TARGET (AND/OR MECHANISM OF ACTION)
III. FORWARD CHEMOGENOMICS: TARGET IDENTIFICATION/VALIDATION USING COMPOUNDS WITH UNKNOWN MECHANISM OF ACTIONIV. CONCLUSION; REFERENCES; PART II TARGET VALIDATION FOR BIOPHARMACEUTICAL DRUG DISCOVERY; Chapter 3 Cetuximab (Erbitux®), An Anti-Epidermal Growth Factor Receptor Antibody for the Treatment of Metastatic Colorectal Cancer; I. INTRODUCTION; II. EPIDERMAL GROWTH FACTOR RECEPTOR AND ITS ROLE IN HUMAN CANCER; III. CETUXIMAB (ERBITUX®, IMC-C225); IV. CETUXIMAB IN CLINICAL STUDIES IN PATIENTS WITH mCRC; V. MECHANISMS OF ACTION OF CETUXIMAB; VI. CONCLUSIONS AND PERSPECTIVES RECOMMENDED RESOURCESREFERENCES; Chapter 4 Monoclonal Antibody to HER-2 in Breast Cancer; I. INTRODUCTION; II. MECHANISM OF ACTION OF TRASTUZUMAB; III. MOLECULAR MECHANISMS OF TRASTUZUMAB RESISTANCE; IV. ASSESSMENT OF HER-2 STATUS; V. CLINICAL TRIALS WITH TRASTUZUMAB; CONCLUSION; ACKNOWLEDGMENTS; USEFUL WEBSITES; REFERENCES; Chapter 5 Validation of TNF as a Drug Target in Inflammatory Bowel Disease; I. INTRODUCTION; II. TUMOR NECROSIS FACTOR; III. INFLAMMATORY BOWEL DISEASE; IV. PATHOPHYSIOLOGY OF IBD AND THE PUTATIVE ROLE OF TNF; V. CLINICAL EXPERIENCE WITH TNF-BLOCKING THERAPY IN IBD CONCLUSIONACKNOWLEDGMENTS; REFERENCES; Chapter 6 Anti-CCL-2/MCP-1: Directed Biologicals for Inflammatory and Malignant Diseases; I. INTRODUCTION; II. IN VITRO ASSAYS TO ESTABLISH THE PRO-INFLAMMATORY ACTIVITIES OF CCL-2; III. IN VIVO VALIDATION STUDIES; IV. SUMMARY; ACKNOWLEDGMENTS; REFERENCES; Chapter 7 Targeting IL-12p40 for Immune-Mediated Disease; I. INTRODUCTION; II. IN VITRO TARGET VALIDATION OF IL-12p40; III. IN VIVO PROOF-OF-CONCEPT FOR IL-12p40 INHIBITION; IV. CONCLUSION; RECOMMENDED RESOURCES; REFERENCES Chapter 8 The GPIIb/IIIa Antagonist Abciximab for Acute Percutaneous Coronary InterventionI. INTRODUCTION; II. RATIONALE FOR GPIIb/IIIa AS A TARGET IN CORONARY ARTERIAL DISEASE; III. GENERATION OF THE 7E3 MONOCLONAL ANTIBODY AGAINST GPIIb/IIIa; IV. IN VITRO STUDIES; V. ANIMAL STUDIES; VI. PLATELET PHARMACODYNAMIC PHENOMENA RECOGNIZED LATER; VII. CROSS REACTIVITY WITH OTHER INTEGRINS; VIII. INTEGRATION OF CLINICAL PHARMACOLOGY AND PRECLINICAL STUDIES; IX. CLINICAL STUDIES; X. CONCLUSION; RECOMMENDED RESOURCES; REFERENCES; PART III VALIDATING TARGETS OF SMALL MOLECULE APPROACHES Chapter 9 Epidermal Growth Factor Receptor (EGFR) Inhibitor for Oncology: Discovery and Development of Erlotinib |
| Record Nr. | UNINA-9910784646803321 |
| Boston, MA, : Academic Press, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Target validation in drug discovery / / Brian W. Metcalf and Susan Dillon, editors
| Target validation in drug discovery / / Brian W. Metcalf and Susan Dillon, editors |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Boston, MA, : Academic Press, 2006 |
| Descrizione fisica | 1 online resource (293 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
MetcalfBrian W
DillonSusan <1952-> |
| Soggetto topico |
Drug development
Drugs - Testing High throughput screening (Drug development) |
| ISBN |
1-280-70760-7
9786610707607 0-08-046597-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Title Page; Copyright Page; Table of Contents; Preface; Contributors; PART I PHARMACEUTICAL BIOTECHNOLOGY FOR TARGET VALIDATION; Chapter 1 Generation of Transgenic Animals; I. INTRODUCTION; II. GENERATION OF TRANSGENIC ANIMALS FOR TARGET VALIDATION; III. CONCLUSION; ACKNOWLEDGMENTS; RECOMMENDED RESOURCES; REFERENCES; Chapter 2 Target Validation in Chemogenomics; I. INTRODUCTION; II. REVERSE CHEMOGENOMICS: TARGET VALIDATION USING COMPOUNDS WITH KNOWN MOLECULAR TARGET (AND/OR MECHANISM OF ACTION)
III. FORWARD CHEMOGENOMICS: TARGET IDENTIFICATION/VALIDATION USING COMPOUNDS WITH UNKNOWN MECHANISM OF ACTIONIV. CONCLUSION; REFERENCES; PART II TARGET VALIDATION FOR BIOPHARMACEUTICAL DRUG DISCOVERY; Chapter 3 Cetuximab (Erbitux®), An Anti-Epidermal Growth Factor Receptor Antibody for the Treatment of Metastatic Colorectal Cancer; I. INTRODUCTION; II. EPIDERMAL GROWTH FACTOR RECEPTOR AND ITS ROLE IN HUMAN CANCER; III. CETUXIMAB (ERBITUX®, IMC-C225); IV. CETUXIMAB IN CLINICAL STUDIES IN PATIENTS WITH mCRC; V. MECHANISMS OF ACTION OF CETUXIMAB; VI. CONCLUSIONS AND PERSPECTIVES RECOMMENDED RESOURCESREFERENCES; Chapter 4 Monoclonal Antibody to HER-2 in Breast Cancer; I. INTRODUCTION; II. MECHANISM OF ACTION OF TRASTUZUMAB; III. MOLECULAR MECHANISMS OF TRASTUZUMAB RESISTANCE; IV. ASSESSMENT OF HER-2 STATUS; V. CLINICAL TRIALS WITH TRASTUZUMAB; CONCLUSION; ACKNOWLEDGMENTS; USEFUL WEBSITES; REFERENCES; Chapter 5 Validation of TNF as a Drug Target in Inflammatory Bowel Disease; I. INTRODUCTION; II. TUMOR NECROSIS FACTOR; III. INFLAMMATORY BOWEL DISEASE; IV. PATHOPHYSIOLOGY OF IBD AND THE PUTATIVE ROLE OF TNF; V. CLINICAL EXPERIENCE WITH TNF-BLOCKING THERAPY IN IBD CONCLUSIONACKNOWLEDGMENTS; REFERENCES; Chapter 6 Anti-CCL-2/MCP-1: Directed Biologicals for Inflammatory and Malignant Diseases; I. INTRODUCTION; II. IN VITRO ASSAYS TO ESTABLISH THE PRO-INFLAMMATORY ACTIVITIES OF CCL-2; III. IN VIVO VALIDATION STUDIES; IV. SUMMARY; ACKNOWLEDGMENTS; REFERENCES; Chapter 7 Targeting IL-12p40 for Immune-Mediated Disease; I. INTRODUCTION; II. IN VITRO TARGET VALIDATION OF IL-12p40; III. IN VIVO PROOF-OF-CONCEPT FOR IL-12p40 INHIBITION; IV. CONCLUSION; RECOMMENDED RESOURCES; REFERENCES Chapter 8 The GPIIb/IIIa Antagonist Abciximab for Acute Percutaneous Coronary InterventionI. INTRODUCTION; II. RATIONALE FOR GPIIb/IIIa AS A TARGET IN CORONARY ARTERIAL DISEASE; III. GENERATION OF THE 7E3 MONOCLONAL ANTIBODY AGAINST GPIIb/IIIa; IV. IN VITRO STUDIES; V. ANIMAL STUDIES; VI. PLATELET PHARMACODYNAMIC PHENOMENA RECOGNIZED LATER; VII. CROSS REACTIVITY WITH OTHER INTEGRINS; VIII. INTEGRATION OF CLINICAL PHARMACOLOGY AND PRECLINICAL STUDIES; IX. CLINICAL STUDIES; X. CONCLUSION; RECOMMENDED RESOURCES; REFERENCES; PART III VALIDATING TARGETS OF SMALL MOLECULE APPROACHES Chapter 9 Epidermal Growth Factor Receptor (EGFR) Inhibitor for Oncology: Discovery and Development of Erlotinib |
| Record Nr. | UNINA-9910819756903321 |
| Boston, MA, : Academic Press, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||