Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Gene therapy technologies, applications, and regulations : from laboratory to clinic / / edited by Anthony Meager
| Gene therapy technologies, applications, and regulations : from laboratory to clinic / / edited by Anthony Meager |
| Pubbl/distr/stampa | Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , 1999 |
| Descrizione fisica | 1 online resource (439 p.) |
| Disciplina |
616.042
616/.042 |
| Soggetto topico | Gene therapy |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-55444-4
9786610554447 0-470-35936-6 0-470-84238-5 0-470-85368-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Gene Therapy Technologies, Applications and Regulations; Contents; List of contributors; Preface; 1 Cationic Liposomes for Gene Therapy Applications; 2 DNA Condensation and Receptor-mediated Gene Transfer; 3 Retroviral Vectors; 4 Lentiviral Vectors; 5 Adenoviral Vectors; 6 Adeno-associated Viral Vectors; 7 Advances in Engineering HSV Vectors for Gene Transfer to the Nervous System; 8 Mammalian Artificial Chromosomes: Prospects for Gene Therapy; 9 Gene Therapy for Severe Combined Immunodeficiency; 10 Gene Therapy for Haemophilia; 11 Cystic Fibrosis: Gene Therapy Approaches
12 Therapeutic Approaches to Haemoglobinopathies13 Gene Therapy Approaches to Duchenne Muscular Dystrophy; 14 Lysosomal Storage Diseases; 15 Prospects for Gene Therapy of HIV Infections and AIDS; 16 The Development of the Regulatory Process in Europe for Biological Medicines: how it Affects Gene Therapy Products; 17 Development and Regulation of Gene Therapy Drugs in Germany; 18 The Transfer of Technology from the Laboratory to the Clinic: In process Controls and Final Product Testing; 19 Good Laboratory Practice in the Research and Development Laboratory 20 Facilities for Large-scale Production of Vectors Under GMP ConditionsAddendum; Index |
| Record Nr. | UNINA-9910142484203321 |
| Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Gene therapy technologies, applications, and regulations : from laboratory to clinic / / edited by Anthony Meager
| Gene therapy technologies, applications, and regulations : from laboratory to clinic / / edited by Anthony Meager |
| Pubbl/distr/stampa | Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , 1999 |
| Descrizione fisica | 1 online resource (439 p.) |
| Disciplina |
616.042
616/.042 |
| Soggetto topico | Gene therapy |
| ISBN |
1-280-55444-4
9786610554447 0-470-35936-6 0-470-84238-5 0-470-85368-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Gene Therapy Technologies, Applications and Regulations; Contents; List of contributors; Preface; 1 Cationic Liposomes for Gene Therapy Applications; 2 DNA Condensation and Receptor-mediated Gene Transfer; 3 Retroviral Vectors; 4 Lentiviral Vectors; 5 Adenoviral Vectors; 6 Adeno-associated Viral Vectors; 7 Advances in Engineering HSV Vectors for Gene Transfer to the Nervous System; 8 Mammalian Artificial Chromosomes: Prospects for Gene Therapy; 9 Gene Therapy for Severe Combined Immunodeficiency; 10 Gene Therapy for Haemophilia; 11 Cystic Fibrosis: Gene Therapy Approaches
12 Therapeutic Approaches to Haemoglobinopathies13 Gene Therapy Approaches to Duchenne Muscular Dystrophy; 14 Lysosomal Storage Diseases; 15 Prospects for Gene Therapy of HIV Infections and AIDS; 16 The Development of the Regulatory Process in Europe for Biological Medicines: how it Affects Gene Therapy Products; 17 Development and Regulation of Gene Therapy Drugs in Germany; 18 The Transfer of Technology from the Laboratory to the Clinic: In process Controls and Final Product Testing; 19 Good Laboratory Practice in the Research and Development Laboratory 20 Facilities for Large-scale Production of Vectors Under GMP ConditionsAddendum; Index |
| Record Nr. | UNINA-9910830956003321 |
| Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The interferons [[electronic resource] ] : characterization and application / / edited by Anthony Meager
| The interferons [[electronic resource] ] : characterization and application / / edited by Anthony Meager |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (462 p.) |
| Disciplina | 616.0791 |
| Altri autori (Persone) | MeagerAnthony |
| Soggetto topico |
Interferon
Interferon - Testing |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-72341-6
9786610723416 3-527-60820-6 3-527-60792-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Interferons; Contents; Preface; List of Contributors; Color Plates; Section A Molecular Aspects, Introduction and Purification; 1 Type I Interferons: Genetics and Structure; 1.1 Introduction; 1.2 The Type I IFN Genetic Locus; 1.3 Type I IFN Genes; 1.3.1 IFN-α; 1.3.2 IFN-β; 1.3.3 IFN-ω; 1.3.4 IFN-κ; 1.3.5 IFN-ε; 1.3.6 IFN-ζ (Limitin); 1.3.7 IFN-τ; 1.3.8 IFN-δ; 1.3.9 IFN-ν; 1.4 Type I IFN Gene-regulatory Regions; 1.5 Evolution of the Type I IFNs; 1.5.1 Vertebrate IFN Genes; 1.5.2 The Expansion and Divergence of the IFN Genes; 1.6 Natural and Induced Mutations in IFN Genes
1.7 Secondary Structural Features of Type I IFNs1.7.1 Conserved Amino Acid Residues; 1.7.2 Post-translational Modifications of Type I IFNs; 1.7.3 Conserved Cysteine Residues and Disulfide Bond Formation; 1.8 The Structure of Type I IFNs; References; 2 Activation of Interferon Gene Expression Through Toll-like Receptor-dependent and -independent Pathways; 2.1 Introduction; 2.2 IFN-β Gene Transcription; 2.3 IRF Family Members; 2.4 Role of IRFs in Virus-mediated IFN Activation; 2.4.1 IRF-3; 2.4.2 IRF-5; 2.4.3 IRF-7; 2.5 IFN Signaling Pathways; 2.5.1 TLR-dependent Signaling to IFN Activation 2.5.1.1 TLR Overview2.5.1.2 TLR-3 Signaling; 2.5.1.3 TLR-4 Signaling; 2.5.1.4 TLR-7 Signaling; 2.5.1.5 TLR-9 Signaling; 2.5.2 TLR-independent Signaling; 2.5.2.1 Retinoic Acid Inducible Gene (RIG)-I Signaling; 2.5.2.2 Melanoma Differentiation-associated Gene-5 (mda-5); 2.6 Conclusions; References; 3 Interferon Proteins: Structure, Production and Purification; 3.1 Introduction; 3.2 The Structure of Type I IFNs; 3.3 Production and Purification of Type I IFNs; 3.3.1 Leukocyte-derived IFN - First Steps in Producing Commercial IFN; 3.3.2 Lymphoblastoid IFN - Towards more Reliable Supplies of IFN 3.3.3 Cloned Type I IFNs - An Inexhaustible Supply of Therapeutic Material3.4 Long-acting IFNs; 3.5 Summary; References; 4 Interferon-γ: Gene and Protein Structure, Transcription Regulation, and Actions; 4.1 Introduction; 4.2 IFN-γ Gene Structure and Regulation; 4.2.1 Transcriptional Regulation; 4.2.2 Epigenetic Regulation; 4.2.3 Post-transcriptional Regulation; 4.3 IFN-γ Signal Transduction; 4.3.1 The JAK-STAT Signaling Pathway; 4.3.2 Activation of Alternate Signaling Pathways; 4.3.3 Regulation of IFN-γ Signaling; 4.4 IFN-γ in T(h) Cell Development 4.4.1 Signaling Pathways Involved in T Cell Development4.5 IFN-γ and DCs; 4.5.1 IFN-γ and T Cell-DC Crosstalk; 4.5.2 Signals through Toll-like Receptors (TLRs) Activate DCs and Influence IFN-γ Expression; 4.6 IFN-γ - Role in Tumor Development and Growth; 4.6.1 IFN-γ in Tumor Growth and Survival; 4.6.2 Inhibition of Angiogenesis by IFN-γ; 4.6.3 Role of IFN-γ in Promoting Immune Responses against Tumors; 4.7 Summary; References; 5 Interferon and Related Receptors; 5.1 Introduction; 5.2 IFNs and IFN-like Molecules in Brief; 5.3 The Receptors; 5.3.1 Receptor Nomenclature 5.4 The Type I IFN Receptor |
| Record Nr. | UNINA-9910144556603321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The interferons [[electronic resource] ] : characterization and application / / edited by Anthony Meager
| The interferons [[electronic resource] ] : characterization and application / / edited by Anthony Meager |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (462 p.) |
| Disciplina | 616.0791 |
| Altri autori (Persone) | MeagerAnthony |
| Soggetto topico |
Interferon
Interferon - Testing |
| ISBN |
1-280-72341-6
9786610723416 3-527-60820-6 3-527-60792-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Interferons; Contents; Preface; List of Contributors; Color Plates; Section A Molecular Aspects, Introduction and Purification; 1 Type I Interferons: Genetics and Structure; 1.1 Introduction; 1.2 The Type I IFN Genetic Locus; 1.3 Type I IFN Genes; 1.3.1 IFN-α; 1.3.2 IFN-β; 1.3.3 IFN-ω; 1.3.4 IFN-κ; 1.3.5 IFN-ε; 1.3.6 IFN-ζ (Limitin); 1.3.7 IFN-τ; 1.3.8 IFN-δ; 1.3.9 IFN-ν; 1.4 Type I IFN Gene-regulatory Regions; 1.5 Evolution of the Type I IFNs; 1.5.1 Vertebrate IFN Genes; 1.5.2 The Expansion and Divergence of the IFN Genes; 1.6 Natural and Induced Mutations in IFN Genes
1.7 Secondary Structural Features of Type I IFNs1.7.1 Conserved Amino Acid Residues; 1.7.2 Post-translational Modifications of Type I IFNs; 1.7.3 Conserved Cysteine Residues and Disulfide Bond Formation; 1.8 The Structure of Type I IFNs; References; 2 Activation of Interferon Gene Expression Through Toll-like Receptor-dependent and -independent Pathways; 2.1 Introduction; 2.2 IFN-β Gene Transcription; 2.3 IRF Family Members; 2.4 Role of IRFs in Virus-mediated IFN Activation; 2.4.1 IRF-3; 2.4.2 IRF-5; 2.4.3 IRF-7; 2.5 IFN Signaling Pathways; 2.5.1 TLR-dependent Signaling to IFN Activation 2.5.1.1 TLR Overview2.5.1.2 TLR-3 Signaling; 2.5.1.3 TLR-4 Signaling; 2.5.1.4 TLR-7 Signaling; 2.5.1.5 TLR-9 Signaling; 2.5.2 TLR-independent Signaling; 2.5.2.1 Retinoic Acid Inducible Gene (RIG)-I Signaling; 2.5.2.2 Melanoma Differentiation-associated Gene-5 (mda-5); 2.6 Conclusions; References; 3 Interferon Proteins: Structure, Production and Purification; 3.1 Introduction; 3.2 The Structure of Type I IFNs; 3.3 Production and Purification of Type I IFNs; 3.3.1 Leukocyte-derived IFN - First Steps in Producing Commercial IFN; 3.3.2 Lymphoblastoid IFN - Towards more Reliable Supplies of IFN 3.3.3 Cloned Type I IFNs - An Inexhaustible Supply of Therapeutic Material3.4 Long-acting IFNs; 3.5 Summary; References; 4 Interferon-γ: Gene and Protein Structure, Transcription Regulation, and Actions; 4.1 Introduction; 4.2 IFN-γ Gene Structure and Regulation; 4.2.1 Transcriptional Regulation; 4.2.2 Epigenetic Regulation; 4.2.3 Post-transcriptional Regulation; 4.3 IFN-γ Signal Transduction; 4.3.1 The JAK-STAT Signaling Pathway; 4.3.2 Activation of Alternate Signaling Pathways; 4.3.3 Regulation of IFN-γ Signaling; 4.4 IFN-γ in T(h) Cell Development 4.4.1 Signaling Pathways Involved in T Cell Development4.5 IFN-γ and DCs; 4.5.1 IFN-γ and T Cell-DC Crosstalk; 4.5.2 Signals through Toll-like Receptors (TLRs) Activate DCs and Influence IFN-γ Expression; 4.6 IFN-γ - Role in Tumor Development and Growth; 4.6.1 IFN-γ in Tumor Growth and Survival; 4.6.2 Inhibition of Angiogenesis by IFN-γ; 4.6.3 Role of IFN-γ in Promoting Immune Responses against Tumors; 4.7 Summary; References; 5 Interferon and Related Receptors; 5.1 Introduction; 5.2 IFNs and IFN-like Molecules in Brief; 5.3 The Receptors; 5.3.1 Receptor Nomenclature 5.4 The Type I IFN Receptor |
| Record Nr. | UNINA-9910830440003321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The interferons : characterization and application / / edited by Anthony Meager
| The interferons : characterization and application / / edited by Anthony Meager |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (462 p.) |
| Disciplina | 616.0791 |
| Altri autori (Persone) | MeagerAnthony |
| Soggetto topico |
Interferon
Interferon - Testing |
| ISBN |
1-280-72341-6
9786610723416 3-527-60820-6 3-527-60792-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Interferons; Contents; Preface; List of Contributors; Color Plates; Section A Molecular Aspects, Introduction and Purification; 1 Type I Interferons: Genetics and Structure; 1.1 Introduction; 1.2 The Type I IFN Genetic Locus; 1.3 Type I IFN Genes; 1.3.1 IFN-α; 1.3.2 IFN-β; 1.3.3 IFN-ω; 1.3.4 IFN-κ; 1.3.5 IFN-ε; 1.3.6 IFN-ζ (Limitin); 1.3.7 IFN-τ; 1.3.8 IFN-δ; 1.3.9 IFN-ν; 1.4 Type I IFN Gene-regulatory Regions; 1.5 Evolution of the Type I IFNs; 1.5.1 Vertebrate IFN Genes; 1.5.2 The Expansion and Divergence of the IFN Genes; 1.6 Natural and Induced Mutations in IFN Genes
1.7 Secondary Structural Features of Type I IFNs1.7.1 Conserved Amino Acid Residues; 1.7.2 Post-translational Modifications of Type I IFNs; 1.7.3 Conserved Cysteine Residues and Disulfide Bond Formation; 1.8 The Structure of Type I IFNs; References; 2 Activation of Interferon Gene Expression Through Toll-like Receptor-dependent and -independent Pathways; 2.1 Introduction; 2.2 IFN-β Gene Transcription; 2.3 IRF Family Members; 2.4 Role of IRFs in Virus-mediated IFN Activation; 2.4.1 IRF-3; 2.4.2 IRF-5; 2.4.3 IRF-7; 2.5 IFN Signaling Pathways; 2.5.1 TLR-dependent Signaling to IFN Activation 2.5.1.1 TLR Overview2.5.1.2 TLR-3 Signaling; 2.5.1.3 TLR-4 Signaling; 2.5.1.4 TLR-7 Signaling; 2.5.1.5 TLR-9 Signaling; 2.5.2 TLR-independent Signaling; 2.5.2.1 Retinoic Acid Inducible Gene (RIG)-I Signaling; 2.5.2.2 Melanoma Differentiation-associated Gene-5 (mda-5); 2.6 Conclusions; References; 3 Interferon Proteins: Structure, Production and Purification; 3.1 Introduction; 3.2 The Structure of Type I IFNs; 3.3 Production and Purification of Type I IFNs; 3.3.1 Leukocyte-derived IFN - First Steps in Producing Commercial IFN; 3.3.2 Lymphoblastoid IFN - Towards more Reliable Supplies of IFN 3.3.3 Cloned Type I IFNs - An Inexhaustible Supply of Therapeutic Material3.4 Long-acting IFNs; 3.5 Summary; References; 4 Interferon-γ: Gene and Protein Structure, Transcription Regulation, and Actions; 4.1 Introduction; 4.2 IFN-γ Gene Structure and Regulation; 4.2.1 Transcriptional Regulation; 4.2.2 Epigenetic Regulation; 4.2.3 Post-transcriptional Regulation; 4.3 IFN-γ Signal Transduction; 4.3.1 The JAK-STAT Signaling Pathway; 4.3.2 Activation of Alternate Signaling Pathways; 4.3.3 Regulation of IFN-γ Signaling; 4.4 IFN-γ in T(h) Cell Development 4.4.1 Signaling Pathways Involved in T Cell Development4.5 IFN-γ and DCs; 4.5.1 IFN-γ and T Cell-DC Crosstalk; 4.5.2 Signals through Toll-like Receptors (TLRs) Activate DCs and Influence IFN-γ Expression; 4.6 IFN-γ - Role in Tumor Development and Growth; 4.6.1 IFN-γ in Tumor Growth and Survival; 4.6.2 Inhibition of Angiogenesis by IFN-γ; 4.6.3 Role of IFN-γ in Promoting Immune Responses against Tumors; 4.7 Summary; References; 5 Interferon and Related Receptors; 5.1 Introduction; 5.2 IFNs and IFN-like Molecules in Brief; 5.3 The Receptors; 5.3.1 Receptor Nomenclature 5.4 The Type I IFN Receptor |
| Record Nr. | UNINA-9910877171203321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||