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Nuclear Receptors: From Structure to the Clinic / / edited by Iain J. McEwan, Raj Kumar
| Nuclear Receptors: From Structure to the Clinic / / edited by Iain J. McEwan, Raj Kumar |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (236 p.) |
| Disciplina | 610 |
| Soggetto topico |
Human genetics
Endocrinology Human physiology Human Genetics Endocrinology Human Physiology |
| ISBN | 3-319-18729-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic -- Part A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. Corticosteroid Receptors -- 3. Glucocorticoid Receptor Structure and Function -- 4. What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors? -- 5. Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors -- 6. Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor -- 7. Structural Analysis of Heterodimeric Nuclear Receptors -- Part B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS -- 8. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11) -- 9. Assembly and Regulation of Nuclear Receptor Corepressor Complexes -- Part C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC -- 10. Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors -- 11. Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs). |
| Record Nr. | UNINA-9910298445703321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Testosterone: From Basic Research to Clinical Applications / / by Lee B. Smith, Rod T. Mitchell, Iain J. McEwan
| Testosterone: From Basic Research to Clinical Applications / / by Lee B. Smith, Rod T. Mitchell, Iain J. McEwan |
| Autore | Smith Lee B |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
| Descrizione fisica | 1 online resource (78 p.) |
| Disciplina | 615.366 |
| Collana | SpringerBriefs in Reproductive Biology |
| Soggetto topico |
Reproductive medicine
Endocrinology Cell biology Reproductive Medicine Endocrinology Cell Biology |
| ISBN | 1-4614-8978-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Preface""; ""Contents""; ""Abstract""; ""1 History of Masculinization""; ""1.1�From the Ancient World to the Nineteenth Century""; ""1.2��Cell Therapy� or the Search for �The Fountain of Youth�""; ""1.3�Steroid Hunters""; ""1.4�Dihydrotestosterone a Potent Androgen""; ""1.5�Receptor Model for Steroid Hormone Action""; ""1.6�Key Points-Summary""; ""References""; ""2 Recent Understanding of Masculinization""; ""2.1�The History of Masculinization""; ""2.2�The Ontogeny of Testicular Development""
""2.3�Human Conditions Associated with Androgen Disruption During Development""""2.4�The Universal Male Programming Window""; ""2.5�Key Points-Summary""; ""References""; ""3 Where Does Testosterone Come from and How Does It Act?""; ""3.1�Testes-Cellular Morphology""; ""3.2�Steroidogenesis""; ""3.3�Adrenal Gland""; ""3.4�Ovary""; ""3.5�The Androgen Receptor (NR3C4)""; ""3.5.1 Ligand Binding Domain""; ""3.5.2 DNA Binding Domain/Hinge Region""; ""3.5.3 N-Terminal Domain""; ""3.6�Rapid Signaling by Testosterone""; ""3.7�Key Points-Summary""; ""References"" ""4 Androgen Receptor Signaling in the Testis""""4.1�Introduction""; ""4.2�Tfm ARKO Mouse""; ""4.3�The Cre/Lox System""; ""4.4�Cell-Specific KO""; ""4.5�AR in Sertoli Cells""; ""4.6�AR in Peritubular Myoid Cells""; ""4.7�AR in Leydig Cells""; ""4.8�Key Points-Summary""; ""References""; ""5 Androgen Signaling in Other Body Systems""; ""5.1�Seminal Vesicles""; ""5.2�Epididymis""; ""5.3�Prostate""; ""5.3.1 Androgens and Prostate Gland Development""; ""5.3.2 Prostate Cancer""; ""5.4�Muscle and Bone""; ""5.4.1 Bone""; ""5.4.2 Muscle Cells"" ""5.4.3 Spinal Bulbular Muscular Dystrophy (SBMA Kennedy�s Disease)""; ""5.5�Cardiovascular Role of Testosterone""; ""5.6�Female Reproductive System""; ""5.6.1 Breast""; ""5.6.2 Endometrium""; ""5.7�Key Points-Summary""; ""References""; ""6 Manipulating Androgens for Therapy""; ""6.1�Management of DSD""; ""6.1.1 Congenital Adrenal Hyperplasia""; ""6.1.2 Androgen Insensitivity Syndrome""; ""6.1.3 5 alpha -Reductase Deficiency""; ""6.2�Delayed Puberty and Pubertal Induction""; ""6.3�Fertility Induction""; ""6.4�Erectile Dysfunction"" ""6.5�Testosterone in the Aging Male: The �Andropause�""""6.6�Polycystic Ovarian Syndrome (PCOS)""; ""6.7�Key Points""; ""References""; ""Epilogue Future Perspectives "" |
| Record Nr. | UNINA-9910437837103321 |
Smith Lee B
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| New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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