Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Molecular drug properties [[electronic resource] ] : measurement and prediction / / edited by Raimund Mannhold
| Molecular drug properties [[electronic resource] ] : measurement and prediction / / edited by Raimund Mannhold |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2008 |
| Descrizione fisica | 1 online resource (503 p.) |
| Disciplina | 615.7 |
| Altri autori (Persone) | MannholdRaimund <1948-> |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug development
Drugs - Design |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-01059-X
9786612010590 3-527-62128-8 3-527-62129-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Molecular Drug Properties; Contents; List of Contributors; Preface; A Personal Foreword; Part I Introduction; 1 A Fresh Look at Molecular Structure and Properties; 1.1 Introduction; 1.2 Core Features: The Molecular "Genotype"; 1.2.1 The Argument; 1.2.2 Encoding the Molecular "Genotype"; 1.3 Observable and Computable Properties: The Molecular "Phenotype"; 1.3.1 Overview; 1.3.2 Equilibria; 1.3.3 Stereoelectronic Features; 1.3.4 Recognition Forces and Molecular Interaction Fields (MIFs); 1.3.5 Macroscopic Properties
1.4 Molecular Properties and their Adaptability: The Property Space of Molecular Entities1.4.1 Overview; 1.4.2 The Versatile Behavior of Acetylcholine; 1.4.3 The Carnosine-Carnosinase Complex; 1.4.4 Property Space and Dynamic QSAR Analyses; 1.5 Conclusions; 2 Physicochemical Properties in Drug Profiling; 2.1 Introduction; 2.2 Physicochemical Properties and Pharmacokinetics; 2.2.1 DMPK; 2.2.2 Lipophilicity - Permeability - Absorption; 2.2.3 Estimation of Volume of Distribution from Physical Chemistry; 2.2.4 PPB and Physicochemical Properties; 2.3 Dissolution and Solubility 2.3.1 Calculated Solubility2.4 Ionization (pK(a)); 2.4.1 Calculated pK(a); 2.5 Molecular Size and Shape; 2.5.1 Calculated Size Descriptors; 2.6 H-bonding; 2.6.1 Calculated H-bonding descriptors; 2.7 Lipophilicity; 2.7.1 Calculated log P and log D; 2.8 Permeability; 2.8.1 Artificial Membranes and PAMPA; 2.8.1.1 In Silico PAMPA; 2.8.2 IAM, Immobilized Liposome Chromatography (ILC), Micellar Electrokinetic Chromatography (MEKC) and Biopartitioning Micellar Chromatography (BMC); 2.8.3 Liposome Partitioning; 2.8.4 Biosensors; 2.9 Amphiphilicity; 2.10 Drug-like Properties 2.11 Computation versus Measurement of Physicochemical Properties2.11.1 QSAR Modeling; 2.11.2 In Combo: Using the Best of two Worlds; 2.12 Outlook; Part II Electronic Properties and H-Bonding; 3 Drug Ionization and Physicochemical Profiling; 3.1 Introduction; 3.1.1 Absorption, the Henderson-Hasselbalch Equation and the pH-partition Hypothesis; 3.1.2 "Shift-in-the-pK(a)"; 3.2 Accurate Determination of Ionization Constants; 3.2.1 Definitions - Activity versus Concentration Thermodynamic Scales; 3.2.2 Potentiometric Method; 3.2.3 pH Scales; 3.2.4 Cosolvent Methods 3.2.5 Recent Improvements in the Potentiometric Method Applied to Sparingly Soluble Drugs3.2.6 Spectrophotometric Measurements; 3.2.7 Use of Buffers in UV Spectrophotometry; 3.2.8 pK(a) Prediction Methods and Software; 3.2.9 Tabulations of Ionization Constants; 3.3 "Octanol" and "Membrane" pK(a) in Partition Coefficients Measurement; 3.3.1 Definitions; 3.3.2 Shape of the Log D(oct)-pH Lipophilicity Profiles; 3.3.3 The "diff 3-4" Approximation in log D(oct)-pH Profiles for Monoprotic Molecules 3.3.4 Liposome-Water Partitioning and the "diff 1-2" Approximation in log D(MEM)-pH Profiles for Monoprotic Molecules |
| Record Nr. | UNINA-9910144390803321 |
| Weinheim, : Wiley-VCH, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular drug properties [[electronic resource] ] : measurement and prediction / / edited by Raimund Mannhold
| Molecular drug properties [[electronic resource] ] : measurement and prediction / / edited by Raimund Mannhold |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2008 |
| Descrizione fisica | 1 online resource (503 p.) |
| Disciplina | 615.7 |
| Altri autori (Persone) | MannholdRaimund <1948-> |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug development
Drugs - Design |
| ISBN |
1-282-01059-X
9786612010590 3-527-62128-8 3-527-62129-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Molecular Drug Properties; Contents; List of Contributors; Preface; A Personal Foreword; Part I Introduction; 1 A Fresh Look at Molecular Structure and Properties; 1.1 Introduction; 1.2 Core Features: The Molecular "Genotype"; 1.2.1 The Argument; 1.2.2 Encoding the Molecular "Genotype"; 1.3 Observable and Computable Properties: The Molecular "Phenotype"; 1.3.1 Overview; 1.3.2 Equilibria; 1.3.3 Stereoelectronic Features; 1.3.4 Recognition Forces and Molecular Interaction Fields (MIFs); 1.3.5 Macroscopic Properties
1.4 Molecular Properties and their Adaptability: The Property Space of Molecular Entities1.4.1 Overview; 1.4.2 The Versatile Behavior of Acetylcholine; 1.4.3 The Carnosine-Carnosinase Complex; 1.4.4 Property Space and Dynamic QSAR Analyses; 1.5 Conclusions; 2 Physicochemical Properties in Drug Profiling; 2.1 Introduction; 2.2 Physicochemical Properties and Pharmacokinetics; 2.2.1 DMPK; 2.2.2 Lipophilicity - Permeability - Absorption; 2.2.3 Estimation of Volume of Distribution from Physical Chemistry; 2.2.4 PPB and Physicochemical Properties; 2.3 Dissolution and Solubility 2.3.1 Calculated Solubility2.4 Ionization (pK(a)); 2.4.1 Calculated pK(a); 2.5 Molecular Size and Shape; 2.5.1 Calculated Size Descriptors; 2.6 H-bonding; 2.6.1 Calculated H-bonding descriptors; 2.7 Lipophilicity; 2.7.1 Calculated log P and log D; 2.8 Permeability; 2.8.1 Artificial Membranes and PAMPA; 2.8.1.1 In Silico PAMPA; 2.8.2 IAM, Immobilized Liposome Chromatography (ILC), Micellar Electrokinetic Chromatography (MEKC) and Biopartitioning Micellar Chromatography (BMC); 2.8.3 Liposome Partitioning; 2.8.4 Biosensors; 2.9 Amphiphilicity; 2.10 Drug-like Properties 2.11 Computation versus Measurement of Physicochemical Properties2.11.1 QSAR Modeling; 2.11.2 In Combo: Using the Best of two Worlds; 2.12 Outlook; Part II Electronic Properties and H-Bonding; 3 Drug Ionization and Physicochemical Profiling; 3.1 Introduction; 3.1.1 Absorption, the Henderson-Hasselbalch Equation and the pH-partition Hypothesis; 3.1.2 "Shift-in-the-pK(a)"; 3.2 Accurate Determination of Ionization Constants; 3.2.1 Definitions - Activity versus Concentration Thermodynamic Scales; 3.2.2 Potentiometric Method; 3.2.3 pH Scales; 3.2.4 Cosolvent Methods 3.2.5 Recent Improvements in the Potentiometric Method Applied to Sparingly Soluble Drugs3.2.6 Spectrophotometric Measurements; 3.2.7 Use of Buffers in UV Spectrophotometry; 3.2.8 pK(a) Prediction Methods and Software; 3.2.9 Tabulations of Ionization Constants; 3.3 "Octanol" and "Membrane" pK(a) in Partition Coefficients Measurement; 3.3.1 Definitions; 3.3.2 Shape of the Log D(oct)-pH Lipophilicity Profiles; 3.3.3 The "diff 3-4" Approximation in log D(oct)-pH Profiles for Monoprotic Molecules 3.3.4 Liposome-Water Partitioning and the "diff 1-2" Approximation in log D(MEM)-pH Profiles for Monoprotic Molecules |
| Record Nr. | UNINA-9910829855203321 |
| Weinheim, : Wiley-VCH, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular drug properties : measurement and prediction / / edited by Raimund Mannhold
| Molecular drug properties : measurement and prediction / / edited by Raimund Mannhold |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2008 |
| Descrizione fisica | 1 online resource (503 p.) |
| Disciplina | 615.7 |
| Altri autori (Persone) | MannholdRaimund <1948-> |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug development
Drugs - Design |
| ISBN |
1-282-01059-X
9786612010590 3-527-62128-8 3-527-62129-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Molecular Drug Properties; Contents; List of Contributors; Preface; A Personal Foreword; Part I Introduction; 1 A Fresh Look at Molecular Structure and Properties; 1.1 Introduction; 1.2 Core Features: The Molecular "Genotype"; 1.2.1 The Argument; 1.2.2 Encoding the Molecular "Genotype"; 1.3 Observable and Computable Properties: The Molecular "Phenotype"; 1.3.1 Overview; 1.3.2 Equilibria; 1.3.3 Stereoelectronic Features; 1.3.4 Recognition Forces and Molecular Interaction Fields (MIFs); 1.3.5 Macroscopic Properties
1.4 Molecular Properties and their Adaptability: The Property Space of Molecular Entities1.4.1 Overview; 1.4.2 The Versatile Behavior of Acetylcholine; 1.4.3 The Carnosine-Carnosinase Complex; 1.4.4 Property Space and Dynamic QSAR Analyses; 1.5 Conclusions; 2 Physicochemical Properties in Drug Profiling; 2.1 Introduction; 2.2 Physicochemical Properties and Pharmacokinetics; 2.2.1 DMPK; 2.2.2 Lipophilicity - Permeability - Absorption; 2.2.3 Estimation of Volume of Distribution from Physical Chemistry; 2.2.4 PPB and Physicochemical Properties; 2.3 Dissolution and Solubility 2.3.1 Calculated Solubility2.4 Ionization (pK(a)); 2.4.1 Calculated pK(a); 2.5 Molecular Size and Shape; 2.5.1 Calculated Size Descriptors; 2.6 H-bonding; 2.6.1 Calculated H-bonding descriptors; 2.7 Lipophilicity; 2.7.1 Calculated log P and log D; 2.8 Permeability; 2.8.1 Artificial Membranes and PAMPA; 2.8.1.1 In Silico PAMPA; 2.8.2 IAM, Immobilized Liposome Chromatography (ILC), Micellar Electrokinetic Chromatography (MEKC) and Biopartitioning Micellar Chromatography (BMC); 2.8.3 Liposome Partitioning; 2.8.4 Biosensors; 2.9 Amphiphilicity; 2.10 Drug-like Properties 2.11 Computation versus Measurement of Physicochemical Properties2.11.1 QSAR Modeling; 2.11.2 In Combo: Using the Best of two Worlds; 2.12 Outlook; Part II Electronic Properties and H-Bonding; 3 Drug Ionization and Physicochemical Profiling; 3.1 Introduction; 3.1.1 Absorption, the Henderson-Hasselbalch Equation and the pH-partition Hypothesis; 3.1.2 "Shift-in-the-pK(a)"; 3.2 Accurate Determination of Ionization Constants; 3.2.1 Definitions - Activity versus Concentration Thermodynamic Scales; 3.2.2 Potentiometric Method; 3.2.3 pH Scales; 3.2.4 Cosolvent Methods 3.2.5 Recent Improvements in the Potentiometric Method Applied to Sparingly Soluble Drugs3.2.6 Spectrophotometric Measurements; 3.2.7 Use of Buffers in UV Spectrophotometry; 3.2.8 pK(a) Prediction Methods and Software; 3.2.9 Tabulations of Ionization Constants; 3.3 "Octanol" and "Membrane" pK(a) in Partition Coefficients Measurement; 3.3.1 Definitions; 3.3.2 Shape of the Log D(oct)-pH Lipophilicity Profiles; 3.3.3 The "diff 3-4" Approximation in log D(oct)-pH Profiles for Monoprotic Molecules 3.3.4 Liposome-Water Partitioning and the "diff 1-2" Approximation in log D(MEM)-pH Profiles for Monoprotic Molecules |
| Record Nr. | UNINA-9910876995303321 |
| Weinheim, : Wiley-VCH, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Targeted Drug Delivery / / Raimund Mannhold, Helmut Buschmann, Yogeshwar Bachhav, and Jörg Holenz
| Targeted Drug Delivery / / Raimund Mannhold, Helmut Buschmann, Yogeshwar Bachhav, and Jörg Holenz |
| Pubbl/distr/stampa | Newark : , : John Wiley & Sons, Incorporated, , 2023 |
| Descrizione fisica | 1 online resource (459 pages) |
| Disciplina | 615.7 |
| Collana | Methods and Principles in Medicinal Chemistry Ser. |
| Soggetto topico |
Drug targeting
Drug delivery systems |
| ISBN |
3-527-82785-4
3-527-82786-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910643086703321 |
| Newark : , : John Wiley & Sons, Incorporated, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||