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An introduction to statistics in early phase trials [[electronic resource] /] / Steven Julious, Say-Beng Tan, David Machin
| An introduction to statistics in early phase trials [[electronic resource] /] / Steven Julious, Say-Beng Tan, David Machin |
| Autore | Julious Steven A |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley, 2010 |
| Descrizione fisica | 1 online resource (271 p.) |
| Disciplina |
610.15195
615/.19012 |
| Altri autori (Persone) |
MachinDavid <1939->
TanSay Beng |
| Soggetto topico |
Drugs - Testing - Statistical methods
Clinical trials - Statistical methods |
| ISBN |
1-282-48277-7
9786612482779 0-470-68616-2 0-470-31917-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
An Introduction to Statistics in Early Phase Trials; Contents; Chapter 1 Early phase trials; Chapter 2 Introduction to pharmacokinetics; Chapter 3 Sample size calculations for clinical trials; Chapter 4 Crossover trial basics; Chapter 5 Multi-period crossover trials; Chapter 6 First time into man; Chapter 7 Bayesian and frequentist methods; Chapter 8 First-time-into-new-population studies; Chapter 9 Bioequivalence studies; Chapter 10 Other Phase I trials; Chapter 11 Phase II trials: general issues; Chapter 12 Dose-response studies; Chapter 13 Phase II trials with toxic therapies
Chapter 14 Interpreting and applying early phase trial resultsChapter 15 Go/No-Go criteria; Appendix; References; Index |
| Record Nr. | UNINA-9910139509803321 |
Julious Steven A
|
||
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
An introduction to statistics in early phase trials / / Steven Julious, Say-Beng Tan, David Machin
| An introduction to statistics in early phase trials / / Steven Julious, Say-Beng Tan, David Machin |
| Autore | Julious Steven A |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley, 2010 |
| Descrizione fisica | 1 online resource (271 p.) |
| Disciplina |
610.15195
615/.19012 |
| Altri autori (Persone) |
MachinDavid <1939->
TanSay Beng |
| Soggetto topico |
Drugs - Testing - Statistical methods
Clinical trials - Statistical methods |
| ISBN |
1-282-48277-7
9786612482779 0-470-68616-2 0-470-31917-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
An Introduction to Statistics in Early Phase Trials; Contents; Chapter 1 Early phase trials; Chapter 2 Introduction to pharmacokinetics; Chapter 3 Sample size calculations for clinical trials; Chapter 4 Crossover trial basics; Chapter 5 Multi-period crossover trials; Chapter 6 First time into man; Chapter 7 Bayesian and frequentist methods; Chapter 8 First-time-into-new-population studies; Chapter 9 Bioequivalence studies; Chapter 10 Other Phase I trials; Chapter 11 Phase II trials: general issues; Chapter 12 Dose-response studies; Chapter 13 Phase II trials with toxic therapies
Chapter 14 Interpreting and applying early phase trial resultsChapter 15 Go/No-Go criteria; Appendix; References; Index |
| Record Nr. | UNINA-9910816269003321 |
|
Julious Steven A
|
||
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Quality of life [[electronic resource] ] : the assessment, analysis and interpretation of patient-reported outcomes / / Peter M. Fayers and David Machin
| Quality of life [[electronic resource] ] : the assessment, analysis and interpretation of patient-reported outcomes / / Peter M. Fayers and David Machin |
| Autore | Fayers Peter M |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons Ltd., c2007 |
| Descrizione fisica | 1 online resource (568 p.) |
| Disciplina | 362.1072 |
| Altri autori (Persone) | MachinDavid <1939-> |
| Soggetto topico |
Quality of life - Research
Outcome assessment (Medical care) |
| Soggetto genere / forma | Electronic books. |
| ISBN |
9786610554843
0-471-96861-7 0-470-84628-3 1-280-55484-3 1-280-83895-7 9786610838950 0-470-02452-6 0-470-02451-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Quality of Life; Contents; Preface to the second edition; Preface to the first edition; List of abbreviations; Part A Introduction; 1 Introduction; 1.1 Patient-reported outcomes; 1.2 What is quality of life?; 1.3 Historical development; 1.4 Why measure quality of life?; 1.5 Which clinical trials should assess quality of life?; 1.6 How to measure quality of life; 1.7 Instruments; 1.8 Conclusions; 2 Principles of measurement scales; 2.1 Introduction; 2.2 Scales and items; 2.3 Constructs and latent variables; 2.4 Indicator variables and causal variables
2.5 Single global questions versus multi-item scales2.6 Single-item versus multi-item scales; 2.7 Psychometrics and item response theory; 2.8 Psychometric versus clinimetric scales; 2.9 Sufficient causes and necessary causes; 2.10 Discriminative, evaluative and predictive instruments; 2.11 Measuring quality of life: indicator or causal items?; 2.12 Conclusions; Part B Developing and Testing Questionnaires; 3 Developing a questionnaire; 3.1 Introduction; 3.2 General issues; 3.3 Defining the target population; 3.4 Item generation; 3.5 Qualitative methods; 3.6 Forming scales 3.7 Multi-item scales3.8 Wording of questions; 3.9 Face and content validity of the proposed questionnaire; 3.10 Pre-testing the questionnaire; 3.11 Strategies for validation; 3.12 Translation; 3.13 Field-testing; 3.14 Conclusions; 3.15 Further reading; 4 Scores and measurements: validity, reliability, sensitivity; 4.1 Introduction; 4.2 Content validity; 4.3 Criterion validity; 4.4 Construct validity; 4.5 Reliability; 4.6 Sensitivity and responsiveness; 4.7 Conclusions; 5 Multi-item scales; 5.1 Introduction; 5.2 Significance tests; 5.3 Correlations; 5.4 Construct validity 5.5 Cronbach's α and internal consistency5.6 Implications for causal items; 5.7 Conclusions; 6 Factor analysis and structural equation modelling; 6.1 Introduction; 6.2 Correlation patterns; 6.3 Path diagrams; 6.4 Factor analysis; 6.5 Factor analysis of the HADS questionnaire; 6.6 Uses of factor analysis; 6.7 Applying factor analysis: choices and decisions; 6.8 Assumptions for factor analysis; 6.9 Factor analysis in QoL research; 6.10 Limitations of correlation-based analysis; 6.11 Causal models; 6.12 Confirmatory factor analysis and structural equation modelling; 6.13 Conclusions 6.14 Further reading, and software7 Item response theory and differential item functioning; 7.1 Introduction; 7.2 Item characteristic curves; 7.3 Logistic models; 7.4 Fitting item response theory models: tips; 7.5 Test design; 7.6 IRT versus traditional and Guttman scales; 7.7 Polytomous item response theory models; 7.8 Differential item functioning; 7.9 Quantifying differential item functioning; 7.10 Exploring differential item functioning: tips; 7.11 Conclusions; 7.12 Further reading, and software; 8 Item banks, item linking and computer-adaptive tests; 8.1 Introduction; 8.2 Item bank 8.3 Item calibration |
| Record Nr. | UNINA-9910143583103321 |
|
Fayers Peter M
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||
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons Ltd., c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Regression methods for medical research / / Bee Choo Tai, David Machin
| Regression methods for medical research / / Bee Choo Tai, David Machin |
| Autore | Tai Bee-Choo |
| Pubbl/distr/stampa | Chichester, West Sussex, UK : , : John Wiley and Sons, , 2014 |
| Descrizione fisica | 1 online resource (313 p.) |
| Disciplina | 610.72/4 |
| Altri autori (Persone) | MachinDavid <1939-> |
| Soggetto topico |
Regression analysis
Medicine - Research |
| ISBN |
1-118-72198-5
1-118-72195-0 1-118-72196-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Regression Methods for Medical Research; Copyright; Contents; Preface; 1 Introduction; Introduction; Statistical models; Comparing two means; Linear regression; Types of dependent variables (y-variables); Some completed studies; Further reading; Technical details; Student's t-test; Linear regression; Predicting a mean value of y for a particular x; Predicting an individual's value of y for a particular x; Analysis of Variance (ANOVA); Coefficient of determination; Extending the simple linear model; Correlation; Logarithms and the exponential constant, e
2 Linear Regression: Practical IssuesTypes of covariates (independent variables); Ordered categorical covariates; Numerically discrete covariates; Unordered categorical covariates; Verifying the assumptions; Ordered categorical covariate; Continuous covariate; Do the assumptions matter?; Precautions; Computation; Simple models; Study design; Clinical and statistical significance; Reporting; Technical details; Global tests; Ordered Normal scores; 3 Multiple Linear Regression; Linear regression: two covariates; How good is the fitted model?; Quadratic models; Multiple linear regression Extending the 2-covariate modelNotation; Interactions; Non-nested models; Precautions; Nested models; Collinearity; Parsimonious models; Verifying assumptions; Technical details; Nested models; Akaike's criterion; 4 Logistic Regression; The logit transformation; Odds ratio; The logit transformation; Logistic regression; Categorical and continuous covariates; Unordered categorical covariate; Ordered categorical covariate; Continuous covariate; Multiple logistic regression; Interactions; Model checking; Tabulations; Lack of an important covariate; Outlying or influential observations Goodness-of-fitConditional logistic regression; Ordered logistic regression; Technical details; Odds ratio (OR) and relative risk (RR); Binomial distribution; Maximum likelihood estimation (MLE); Likelihood ratio (LR) test; The empirical logit transformation; 5 Poisson Regression; Introduction; Poisson or Binomial models; Unknown population size at risk; Over-dispersion and robust estimates; Over-dispersion; Robust procedures; Known population size at risk; Known cumulative exposure; Zero-inflated models; Residuals; Technical details; Poisson distribution; Maximum Likelihood Estimation (MLE) Relationship between Poisson and logit models6 Time-to-Event Regression; Time-to-event data; Kaplan-Meier survival curve; The hazard rate and hazard ratio; Hazard ratio; The Cox regression model; Single covariate; Two covariates; More than two covariates; Verifying proportional hazards; Complementary log-log plot; Observed and predicted K-M plots; Schoenfeld residuals; What if the proportional hazards assumption is wrong?; Stratified Cox; Technical details; Calculating a Kaplan-Meier survival curve; The hazard function; The complementary log-log transformation; Residuals; 7 Model Building Introduction |
| Record Nr. | UNINA-9910138997503321 |
|
Tai Bee-Choo
|
||
| Chichester, West Sussex, UK : , : John Wiley and Sons, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Regression methods for medical research / / Bee Choo Tai, David Machin
| Regression methods for medical research / / Bee Choo Tai, David Machin |
| Autore | Tai Bee-Choo |
| Pubbl/distr/stampa | Chichester, West Sussex, UK : , : John Wiley and Sons, , 2014 |
| Descrizione fisica | 1 online resource (313 p.) |
| Disciplina | 610.72/4 |
| Altri autori (Persone) | MachinDavid <1939-> |
| Soggetto topico |
Regression analysis
Medicine - Research |
| ISBN |
1-118-72198-5
1-118-72195-0 1-118-72196-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Regression Methods for Medical Research; Copyright; Contents; Preface; 1 Introduction; Introduction; Statistical models; Comparing two means; Linear regression; Types of dependent variables (y-variables); Some completed studies; Further reading; Technical details; Student's t-test; Linear regression; Predicting a mean value of y for a particular x; Predicting an individual's value of y for a particular x; Analysis of Variance (ANOVA); Coefficient of determination; Extending the simple linear model; Correlation; Logarithms and the exponential constant, e
2 Linear Regression: Practical IssuesTypes of covariates (independent variables); Ordered categorical covariates; Numerically discrete covariates; Unordered categorical covariates; Verifying the assumptions; Ordered categorical covariate; Continuous covariate; Do the assumptions matter?; Precautions; Computation; Simple models; Study design; Clinical and statistical significance; Reporting; Technical details; Global tests; Ordered Normal scores; 3 Multiple Linear Regression; Linear regression: two covariates; How good is the fitted model?; Quadratic models; Multiple linear regression Extending the 2-covariate modelNotation; Interactions; Non-nested models; Precautions; Nested models; Collinearity; Parsimonious models; Verifying assumptions; Technical details; Nested models; Akaike's criterion; 4 Logistic Regression; The logit transformation; Odds ratio; The logit transformation; Logistic regression; Categorical and continuous covariates; Unordered categorical covariate; Ordered categorical covariate; Continuous covariate; Multiple logistic regression; Interactions; Model checking; Tabulations; Lack of an important covariate; Outlying or influential observations Goodness-of-fitConditional logistic regression; Ordered logistic regression; Technical details; Odds ratio (OR) and relative risk (RR); Binomial distribution; Maximum likelihood estimation (MLE); Likelihood ratio (LR) test; The empirical logit transformation; 5 Poisson Regression; Introduction; Poisson or Binomial models; Unknown population size at risk; Over-dispersion and robust estimates; Over-dispersion; Robust procedures; Known population size at risk; Known cumulative exposure; Zero-inflated models; Residuals; Technical details; Poisson distribution; Maximum Likelihood Estimation (MLE) Relationship between Poisson and logit models6 Time-to-Event Regression; Time-to-event data; Kaplan-Meier survival curve; The hazard rate and hazard ratio; Hazard ratio; The Cox regression model; Single covariate; Two covariates; More than two covariates; Verifying proportional hazards; Complementary log-log plot; Observed and predicted K-M plots; Schoenfeld residuals; What if the proportional hazards assumption is wrong?; Stratified Cox; Technical details; Calculating a Kaplan-Meier survival curve; The hazard function; The complementary log-log transformation; Residuals; 7 Model Building Introduction |
| Record Nr. | UNINA-9910811547103321 |
|
Tai Bee-Choo
|
||
| Chichester, West Sussex, UK : , : John Wiley and Sons, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Sample size tables for clinical studies [[electronic resource] /] / David Machin ... [et al.]
| Sample size tables for clinical studies [[electronic resource] /] / David Machin ... [et al.] |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Chichester, UK ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 |
| Descrizione fisica | 1 online resource (264 p.) |
| Disciplina | 615.5072/4 |
| Altri autori (Persone) | MachinDavid <1939-> |
| Soggetto topico |
Clinical trials - Statistical methods
Medicine |
| ISBN |
1-282-68987-8
9786612689871 1-4443-0071-7 1-4443-0072-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Preface; 1 Basic design considerations; 2 Distributions and confidence intervals; 3 Comparing two independent groups for binary data; 4 Comparing two independent groups for ordered categorical data; 5 Comparing two independent groups for continuous data; 6 Cluster designs, repeated measures data and more than two groups; 7 Comparing paired groups for binary, ordered categorical and continuous outcomes; 8 Comparing survival curves; 9 Equivalence; 10 Confidence intervals; 11 Post-marketing surveillance; 12 The correlation coefficient; 13 Reference intervals and receiver operating curves
14 Observer agreement studies15 Dose finding studies; 16 Phase II trials; 17 Sample size software S SS; Cumulative references; Author index; Subject index |
| Record Nr. | UNINA-9910145819403321 |
| Chichester, UK ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Sample size tables for clinical studies / / David Machin ... [et al.]
| Sample size tables for clinical studies / / David Machin ... [et al.] |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Chichester, UK ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 |
| Descrizione fisica | 1 online resource (264 p.) |
| Disciplina | 615.5072/4 |
| Altri autori (Persone) | MachinDavid <1939-> |
| Soggetto topico |
Clinical trials - Statistical methods
Medicine |
| ISBN |
1-282-68987-8
9786612689871 1-4443-0071-7 1-4443-0072-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Preface; 1 Basic design considerations; 2 Distributions and confidence intervals; 3 Comparing two independent groups for binary data; 4 Comparing two independent groups for ordered categorical data; 5 Comparing two independent groups for continuous data; 6 Cluster designs, repeated measures data and more than two groups; 7 Comparing paired groups for binary, ordered categorical and continuous outcomes; 8 Comparing survival curves; 9 Equivalence; 10 Confidence intervals; 11 Post-marketing surveillance; 12 The correlation coefficient; 13 Reference intervals and receiver operating curves
14 Observer agreement studies15 Dose finding studies; 16 Phase II trials; 17 Sample size software S SS; Cumulative references; Author index; Subject index |
| Record Nr. | UNINA-9910806132303321 |
| Chichester, UK ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Statistics with confidence : confidence intervals and statistical guidelines / / Douglas Altman
| Statistics with confidence : confidence intervals and statistical guidelines / / Douglas Altman |
| Autore | Altman Douglas G |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2013 |
| Descrizione fisica | 1 online resource (254 pages) |
| Disciplina |
362.102
610.727 |
| Altri autori (Persone) |
MachinDavid <1939->
BryantT. N GardnerM. J (Martin J.) |
| Soggetto topico |
Analysis of variance
Confidence intervals Statistics as topic -- Methods Statistics as Topic Confidence Intervals Epidemiologic Methods Health Care Evaluation Mechanisms Mathematics Quality of Health Care Investigative Techniques Natural Science Disciplines Public Health Health Care Quality, Access, and Evaluation Environment and Public Health Health Care |
| ISBN |
1-118-70250-6
1-118-70251-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Contents; Contributors; Source of contents; Introduction; PART I ESTIMATION AND CONFIDENCE INTERVALS; 1 Estimating with confidence; 2 Confidence intervals in practice; 3 Confidence intervals rather than P values; 4 Means and their differences; 5 Medians and their differences; 6 Proportions and their differences; 7 Epidemiological studies; 8 Regression and correlation; 9 Time to event studies; 10 Diagnostic tests; 11 Clinical trials and meta-analyses; 12 Confidence intervals and sample sizes; 13 Special topics; PART II STATISTICAL GUIDELINES AND CHECKLISTS
14 Statistical guidelines for contributors to medical journals 15 Statistical checklists; PART III NOTATION, SOFTWARE, AND TABLES; 16 Notation; 17 Computer software for calculating confidence intervals (CIA); 18 Tables for the calculation of confidence intervals; Index |
| Record Nr. | UNINA-9910787933803321 |
|
Altman Douglas G
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| Hoboken, : Wiley, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Textbook of clinical trials / / edited by David Machin [and four others]
| Textbook of clinical trials / / edited by David Machin [and four others] |
| Pubbl/distr/stampa | Chichester, England : , : John Wiley & Sons Ltd, , 2004 |
| Descrizione fisica | 1 online resource (430 p.) |
| Disciplina | 610/.72/4 |
| Soggetto topico | Clinical trials |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-54156-3
1-280-73871-5 0-470-01015-0 9786610541560 0-470-01014-2 9786610738717 0-470-01016-9 0-470-02024-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Textbook of Clinical Trials; Contents; Contributors; Preface; INTRODUCTION; CANCER; CARDIOVASCULAR; DENTISTRY AND MAXILLO-FACIAL; DERMATOLOGY; PSYCHIATRY; REPRODUCTIVE HEALTH; RESPIRATORY; Index |
| Record Nr. | UNINA-9910143642203321 |
| Chichester, England : , : John Wiley & Sons Ltd, , 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Textbook of clinical trials / / edited by David Machin [and four others]
| Textbook of clinical trials / / edited by David Machin [and four others] |
| Pubbl/distr/stampa | Chichester, England : , : John Wiley & Sons Ltd, , 2004 |
| Descrizione fisica | 1 online resource (430 p.) |
| Disciplina | 610/.72/4 |
| Soggetto topico | Clinical trials |
| ISBN |
1-280-54156-3
1-280-73871-5 0-470-01015-0 0-470-01014-2 0-470-01016-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Textbook of Clinical Trials; Contents; Contributors; Preface; INTRODUCTION; CANCER; CARDIOVASCULAR; DENTISTRY AND MAXILLO-FACIAL; DERMATOLOGY; PSYCHIATRY; REPRODUCTIVE HEALTH; RESPIRATORY; Index |
| Record Nr. | UNINA-9910831030703321 |
| Chichester, England : , : John Wiley & Sons Ltd, , 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
