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Design of studies for medical research [[electronic resource] /] / David Machlin, Michael J. Campbell
| Design of studies for medical research [[electronic resource] /] / David Machlin, Michael J. Campbell |
| Autore | Machin David <1939-> |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2005 |
| Descrizione fisica | 1 online resource (286 p.) |
| Disciplina |
610.72
610/.72 |
| Altri autori (Persone) | CampbellMichael J |
| Soggetto topico | Medicine - Research - Methodology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-27566-9
9786610275663 0-470-01299-4 0-470-01298-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Design of Studies for Medical Research; Contents; Preface; Chapter 1 What is Evidence?; Chapter 2 Measurement, Forms and Questionnaires; Chapter 3 Principles of Study Size Calculation; Chapter 4 Randomisation; Chapter 5 Cross-sectional and Longitudinal Studies; Chapter 6 Surveys, Cohort and Case-Control Studies; Chapter 7 Clinical Trials - General Issues; Chapter 8 Early Clinical Trials; Chapter 9 Phase III Trials; Chapter 10 Diagnosis; Chapter 11 Prognostic Factor Studies; References; Tables; Index |
| Record Nr. | UNINA-9910145043303321 |
Machin David <1939->
|
||
| Hoboken, NJ, : Wiley, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Design of studies for medical research [[electronic resource] /] / David Machlin, Michael J. Campbell
| Design of studies for medical research [[electronic resource] /] / David Machlin, Michael J. Campbell |
| Autore | Machin David <1939-> |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2005 |
| Descrizione fisica | 1 online resource (286 p.) |
| Disciplina |
610.72
610/.72 |
| Altri autori (Persone) | CampbellMichael J |
| Soggetto topico | Medicine - Research - Methodology |
| ISBN |
1-280-27566-9
9786610275663 0-470-01299-4 0-470-01298-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Design of Studies for Medical Research; Contents; Preface; Chapter 1 What is Evidence?; Chapter 2 Measurement, Forms and Questionnaires; Chapter 3 Principles of Study Size Calculation; Chapter 4 Randomisation; Chapter 5 Cross-sectional and Longitudinal Studies; Chapter 6 Surveys, Cohort and Case-Control Studies; Chapter 7 Clinical Trials - General Issues; Chapter 8 Early Clinical Trials; Chapter 9 Phase III Trials; Chapter 10 Diagnosis; Chapter 11 Prognostic Factor Studies; References; Tables; Index |
| Record Nr. | UNINA-9910831050803321 |
|
Machin David <1939->
|
||
| Hoboken, NJ, : Wiley, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Design of studies for medical research / / David Machlin, Michael J. Campbell
| Design of studies for medical research / / David Machlin, Michael J. Campbell |
| Autore | Machin David <1939-> |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2005 |
| Descrizione fisica | 1 online resource (286 p.) |
| Disciplina | 610/.72 |
| Altri autori (Persone) | CampbellMichael J |
| Soggetto topico | Medicine - Research - Methodology |
| ISBN |
1-280-27566-9
9786610275663 0-470-01299-4 0-470-01298-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Design of Studies for Medical Research; Contents; Preface; Chapter 1 What is Evidence?; Chapter 2 Measurement, Forms and Questionnaires; Chapter 3 Principles of Study Size Calculation; Chapter 4 Randomisation; Chapter 5 Cross-sectional and Longitudinal Studies; Chapter 6 Surveys, Cohort and Case-Control Studies; Chapter 7 Clinical Trials - General Issues; Chapter 8 Early Clinical Trials; Chapter 9 Phase III Trials; Chapter 10 Diagnosis; Chapter 11 Prognostic Factor Studies; References; Tables; Index |
| Record Nr. | UNINA-9910877825203321 |
|
Machin David <1939->
|
||
| Hoboken, NJ, : Wiley, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Randomized clinical trials : design, practice and reporting / / David Machin, Peter M. Fayers, Bee Choo Tai
| Randomized clinical trials : design, practice and reporting / / David Machin, Peter M. Fayers, Bee Choo Tai |
| Autore | Machin David <1939-> |
| Edizione | [2nd edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2021] |
| Descrizione fisica | 1 online resource (553 pages) |
| Disciplina | 610.724 |
| Soggetto topico |
Clinical trials
Clinical trials - Statistical methods |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-119-52467-9
1-119-52468-7 1-119-52465-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910554883203321 |
|
Machin David <1939->
|
||
| Hoboken, New Jersey : , : Wiley, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Randomized clinical trials : design, practice and reporting / / David Machin, Peter M. Fayers, Bee Choo Tai
| Randomized clinical trials : design, practice and reporting / / David Machin, Peter M. Fayers, Bee Choo Tai |
| Autore | Machin David <1939-> |
| Edizione | [2nd edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2021] |
| Descrizione fisica | 1 online resource (553 pages) |
| Disciplina | 610.724 |
| Soggetto topico |
Clinical trials
Clinical trials - Statistical methods |
| ISBN |
1-119-52467-9
1-119-52468-7 1-119-52465-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Design Features -- The Trial Protocol -- Measurement and Data Capture -- Randomisation -- Trial Initiation -- Trial Conduct and Completion -- Basics for Analysis -- Trial Size -- Data and Safety Monitoring -- Reporting -- More than Two Interventions -- Paired and Matched Designs -- Repeated Measures Design -- Non-Inferiority and Equivalence Trials -- Cluster Designs -- Stepped Wedge Designs -- Genomic Targets -- Feasibility and Pilot Studies -- Further Topics. |
| Record Nr. | UNINA-9910830483703321 |
|
Machin David <1939->
|
||
| Hoboken, New Jersey : , : Wiley, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Randomized clinical trials : design, practice and reporting / / David Machin, Peter M. Fayers, Bee Choo Tai
| Randomized clinical trials : design, practice and reporting / / David Machin, Peter M. Fayers, Bee Choo Tai |
| Autore | Machin David <1939-> |
| Edizione | [2nd edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2021] |
| Descrizione fisica | 1 online resource (553 pages) |
| Disciplina | 610.724 |
| Soggetto topico |
Clinical trials
Clinical trials - Statistical methods |
| ISBN |
1-119-52467-9
1-119-52468-7 1-119-52465-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Design Features -- The Trial Protocol -- Measurement and Data Capture -- Randomisation -- Trial Initiation -- Trial Conduct and Completion -- Basics for Analysis -- Trial Size -- Data and Safety Monitoring -- Reporting -- More than Two Interventions -- Paired and Matched Designs -- Repeated Measures Design -- Non-Inferiority and Equivalence Trials -- Cluster Designs -- Stepped Wedge Designs -- Genomic Targets -- Feasibility and Pilot Studies -- Further Topics. |
| Record Nr. | UNINA-9910877072403321 |
|
Machin David <1939->
|
||
| Hoboken, New Jersey : , : Wiley, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Randomized clinical trials : design, practice, and reporting / / David Machin, Michael J. Campbell
| Randomized clinical trials : design, practice, and reporting / / David Machin, Michael J. Campbell |
| Autore | Machin David <1939-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (375 p.) |
| Disciplina | 610.72/4 |
| Altri autori (Persone) | CampbellMichael J., PhD. |
| Soggetto topico |
Clinical trials
Clinical trials - Statistical methods |
| ISBN |
1-282-68961-4
9786612689611 0-470-68623-5 0-471-49779-7 0-470-31922-4 |
| Classificazione | XF 3400 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Randomized Clinical Trials; Contents; Preface; 1 Introduction; 1.1 Introduction; 1.2 Some completed trials; 1.3 Choice of design; 1.4 Practical constraints; 1.5 Influencing clinical practice; 1.6 History; 1.7 How trials arise; 1.8 Ethical considerations; 1.9 Regulatory requirements; 1.10 Focus; 1.11 Further reading; 2 Design Features; 2.1 Introduction; 2.2 The research question; 2.3 Patient selection; 2.4 The consent process; 2.5 Choice of interventions; 2.6 Choice of design; 2.7 Assigning the interventions; 2.8 Making the assessments; 2.9 Analysis and reporting; 2.10 Technical details
2.11 Guidelines2.12 Further reading; 3 The Trial Protocol; 3.1 Introduction; 3.2 Protocol - abstract; 3.3 Protocol - background; 3.4 Protocol - research objectives; 3.5 Protocol - design; 3.6 Protocol - intervention details; 3.7 Protocol - eligibility; 3.8 Protocol - randomization; 3.9 Protocol - assessment and data collection; 3.10 Protocol - statistical considerations; 3.11 Protocol - ethical issues; 3.12 Protocol - organizational structure; 3.13 Protocol - publication policy; 3.14 Protocol - trial forms; 3.15 Protocol - appendices; 3.16 Regulatory requirements; 3.17 Guidelines 3.18 Protocols4 Measurement and Data Capture; 4.1 Introduction; 4.2 Measures and endpoints; 4.3 Making the observations; 4.4 Baseline measures; 4.5 Types of measures; 4.6 Data recording; 4.7 Technical notes; 4.8 Guidelines; 5 Randomization; 5.1 Introduction; 5.2 Rationale; 5.3 Mechanics; 5.4 Application; 5.5 Carrying out randomization; 5.6 Documentation; 5.7 Unacceptable methods; 5.8 Software; 5.9 Guidelines; 6 Trial Initiation; 6.1 Introduction; 6.2 Trial organization; 6.3 Data collection and processing; 6.4 Data monitoring; 6.5 Ethical and regulatory requirements; 6.6 Launching the trial 6.7 Trial registries6.8 Guidelines; 7 Trial Conduct; 7.1 Introduction; 7.2 Regular feedback; 7.3 Publicity; 7.4 Data monitoring committees; 7.5 Protocol modifications; 7.6 Preparing the publication(s); 7.7 The next trial?; 7.8 Protocols; 8 Basics of Analysis; 8.1 Introduction; 8.2 Confidence intervals; 8.3 Statistical tests; 8.4 Examples of analysis; 8.5 Other issues; 8.6 Practice; 8.7 Technical details; 9 Trial Size; 9.1 Introduction; 9.2 Significance level and power; 9.3 The fundamental equation; 9.4 Specific situations; 9.5 Practical considerations; 9.6 Further topics 9.7 Other methods and software9.8 Guideline; 10 Reporting; 10.1 Introduction; 10.2 Publication guidelines; 10.3 Responsibilities; 10.4 Background; 10.5 Methods; 10.6 Findings; 10.7 When things go wrong; 10.8 Conclusions; 10.9 Guidelines; 11 Adaptations of the Basic Design; 11.1 Introduction; 11.2 Repeated measures; 11.3 Cluster-randomized trials; 11.4 Non-inferiority trials; 11.5 Guidelines; 12 Paired Designs; 12.1 Cross-over trials; 12.2 Split-mouth designs; 12.3 Paired organs; 13 More Than Two Interventions; 13.1 Introduction; 13.2 Unstructured comparisons 13.3 Comparisons with placebo (or standard) |
| Record Nr. | UNINA-9910139209603321 |
|
Machin David <1939->
|
||
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Sample sizes for clinical, laboratory and epidemiology studies / / David Machin, [and three others]
| Sample sizes for clinical, laboratory and epidemiology studies / / David Machin, [and three others] |
| Autore | Machin David <1939-> |
| Edizione | [Fourth edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2018] |
| Descrizione fisica | 1 online resource (409 pages) |
| Disciplina | 615.5072/4 |
| Collana | THEi Wiley ebooks. |
| Soggetto topico | Clinical trials |
| Soggetto non controllato |
Research
Statistics Reference Mathematics |
| ISBN |
1-118-87493-5
1-118-87492-7 1-118-87490-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Ranking the Multiple Endpoints2.5 Repeated Significance Tests; Bonferroni Correction; 2.6 Epidemiological Studies; 2.7 The Protocol and Publication; 2.8 Ethical Issues and Sample Size; References; Chapter 3 Binary Outcomes; 3.1 Introduction; 3.2 Comparing Proportions; Effect Size; Analysis; χ2 Test; Fisher's Exact Test; 3.3 One Proportion Known; χ2 Test; 3.4 Bibliography; 3.5 Examples and Use of the Tables; Table 3.1 and Equations 3.2 and 3.3; Table 3.1 and Equations 3.2, 3.3, 3.4 and 3.5; Equations 3.2 and 3.5; Table 3.2 and Equations 3.1, 3.2, 3.3 and 3.4; Equations 3.1, 3.3 and 3.4. |
| Record Nr. | UNINA-9910555074303321 |
|
Machin David <1939->
|
||
| Hoboken, New Jersey : , : Wiley, , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Sample sizes for clinical, laboratory and epidemiology studies / / David Machin, [and three others]
| Sample sizes for clinical, laboratory and epidemiology studies / / David Machin, [and three others] |
| Autore | Machin David <1939-> |
| Edizione | [Fourth edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2018] |
| Descrizione fisica | 1 online resource (409 pages) |
| Disciplina | 615.5072/4 |
| Collana | THEi Wiley ebooks. |
| Soggetto topico | Clinical trials |
| Soggetto non controllato |
Research
Statistics Reference Mathematics |
| ISBN |
1-118-87493-5
1-118-87492-7 1-118-87490-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Ranking the Multiple Endpoints2.5 Repeated Significance Tests; Bonferroni Correction; 2.6 Epidemiological Studies; 2.7 The Protocol and Publication; 2.8 Ethical Issues and Sample Size; References; Chapter 3 Binary Outcomes; 3.1 Introduction; 3.2 Comparing Proportions; Effect Size; Analysis; χ2 Test; Fisher's Exact Test; 3.3 One Proportion Known; χ2 Test; 3.4 Bibliography; 3.5 Examples and Use of the Tables; Table 3.1 and Equations 3.2 and 3.3; Table 3.1 and Equations 3.2, 3.3, 3.4 and 3.5; Equations 3.2 and 3.5; Table 3.2 and Equations 3.1, 3.2, 3.3 and 3.4; Equations 3.1, 3.3 and 3.4. |
| Record Nr. | UNINA-9910815883603321 |
|
Machin David <1939->
|
||
| Hoboken, New Jersey : , : Wiley, , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Survival analysis [[electronic resource] ] : a practical approach / / David Machin, Yin Bun Cheung, Mahesh K.B. Parmar
| Survival analysis [[electronic resource] ] : a practical approach / / David Machin, Yin Bun Cheung, Mahesh K.B. Parmar |
| Autore | Machin David <1939-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : Wiley, c2006 |
| Descrizione fisica | 1 online resource (280 p.) |
| Disciplina | 610.72 |
| Altri autori (Persone) |
CheungYin Bun
ParmarMahesh K. B |
| Soggetto topico | Survival analysis (Biometry) |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-41121-X
9786610411214 0-470-34053-3 0-470-03457-2 0-470-87041-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction and review of statistical concepts -- Survival curves -- Comparison of survival curves -- Parametric modelling -- Cox's proportional hazards model -- Selecting variables within a Cox model -- Extensions of the Cox model -- Prognostic indices -- Sample sizes -- Further topics. |
| Record Nr. | UNINA-9910143557003321 |
|
Machin David <1939->
|
||
| Chichester, England ; ; Hoboken, NJ, : Wiley, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
