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Cover -- Title Page -- Copyright Page -- Dedication Page -- Contents -- Preface -- Chapter 1 Introduction -- Drug Stability and Regulatory Requirements -- Brief Overview of Drug Degradation Chemistry -- Types of Functional Groups or Structural Moieties Susceptible to -- Hydrolytic Degradation -- Carboxylic Esters and Lactones -- Carboxylic Amides and Lactams -- Carbamates -- Phosphoryl Esters and Phosphoramidates -- Sulfonamides and Urea Derivatives -- Imides and Sulfonylureas -- Epoxides and Ethers -- Oligosaccharides/Polysaccharides and Nucleoside Analogs -- Types of Functional Groups or Structural Moieties That Are -- Susceptible to Different Types of Oxidative Degradation -- Nucleophilic Oxidation -- Free- Radical- Mediated Oxidation -- Base- Catalyzed Oxidation -- Oxidation Via the Udenfriend Reaction -- Types of Functional Groups or Structural Moieties That Are -- Susceptible to Photochemical Degradation -- Degradation Due to API- Excipient Interactions -- The Maillard Reaction -- Degradation Due to Impurities in Excipients - Formaldehyde, -- Peroxides, Formic Acid, etc. -- Formation of N- nitrosamines Due to the Reaction of Secondary Amine -- APIs or API- Related Fragments with Residual Nitrites in Excipients -- Forced Degradation Study and Prediction of Real- Life Degradation -- Pathways -- Concluding Remarks -- References -- Chapter 2 Abacavir to Azithromycin -- 1: Abacavir -- References -- 2: Acetaminophen (Paracetamol) -- References -- 3: Acetazolamide -- References -- 4: Acetylcysteine -- References -- 5: Acyclovir -- References -- 6- 8: Albendazole, Fenbendazole, Mebendazole -- 6: Albendazole -- 7: Fenbendazole -- 8: Mebendazole -- References -- 9: Allopurinol [WHO List of Essential Medicines] -- References -- 10- 11: Amantadine, Memantine -- 10: Amantadine -- 11: Memantine -- References -- 12- 13: Ambroxol, Bromhexine.
12: Ambroxol -- 13: Bromhexine -- References -- 14- 16: Aminoglycoside Antibiotics -- 14: Amikacin [WHO Essential List of Medicines] -- 15: Gentamicin -- 15a: Gentamicin C1 -- 15b: Gentamicin C1a -- 15c: Gentamicin C2 -- 15d: Gentamicin C2a -- 15e: Gentamicin C2b (Micronomicin) -- 16: Tobramycin [WHO List of Essential Medicines] -- References -- 17: Amiloride -- References -- 18- 19: 4- Aminosalicylic Acid, 5- Aminosalicyclic Acid -- 18: 4- Aminosalicylic Acid -- 19: 5- Aminosalicyclic Acid (Mesalamine) -- References -- 20: Amiodarone -- References -- 21: Aripiprazole -- References -- 22: Atazanavir -- Reference -- 23: Atenolol -- References -- 24- 25: Amitriptyline, Nortriptyline -- 24: Amitriptyline -- 25: Nortriptyline -- References -- 26: Amlodipine -- References -- 27- 29: Artemisinin, Artemether, Artesunate -- 27: Artemisinin -- 28: Artemether -- 29: Artesunate -- References -- 30: Ascorbic Acid [Vitamin C] -- References -- 31: Aspirin -- References -- 32: Atorvastatin -- References -- 33: Atracurium -- References -- 34- 35: Atropine, Scopolamine -- 34: Atropine -- 35: Scopolamine -- References -- 36: Azathioprine -- References -- 37: Azithromycin -- References -- Chapter 3 Baclofen to Butalbital and Related Barbiturates -- 38: Baclofen -- References -- 39: Benznidazole [WHO List of Essential Medicines] -- Reference -- 40: Benzocaine -- References -- 41- 50: Benzodiazepines -- 41: Alprazolam -- 42: Clonazepam -- 43: Diazepam [WHO Lists of Essential Medicines] -- 44: Flunitrazepam -- 45: Lorazepam -- 46: Midazolam [WHO Lists of Essential Medicines] -- 47: Nitrazepam -- 48: Oxazepam -- 49: Temazepam -- 50: Triazolam -- References -- 51: Benzoyl peroxide -- References -- 52- 54: Bisoprolol, Metoprolol, Propranolol -- 52: Bisoprolol -- 53: Metoprolol -- 54: Propranolol [WHO List of Essential Medicines] -- References.
55: Bleomycin [WHO List of Essential Medicines] -- 55a: Bleomycin A2 -- 55b: Bleomycin B2 -- References -- 56: Beclometasone Dipropionate -- References -- 57- 61: Betamethasone, Dexamethasone, Prednisolone, Methylprednisolone, Prednisone -- 57: Betamethasone -- 58: Dexamethasone -- 59: Prednisolone -- 60: Methylprednisolone -- 61: Prednisone -- References -- 62- 65: Betamethasone 21- Acetate, Betamethasone 17- Valerate, Betamethasone 17,21- Dipropionate, Betamethasone 21- Phosphate -- 62: Betamethasone 21- Acetate (also Known as Betamethasone Acetate) -- 63: Betamethasone 17- Valerate (also Known as Betamethasone Valerate) -- 64: Betamethasone 17,21- Dipropionate (also Known as Betamethasone Dipropionate) -- 65: Betamethasone 21- Phosphate (also Known as Betamethasone Phosphate) -- References -- 66- 69: Brompheniramine, Dexbrompheniramine, Chlorpheniramine, Pheniramine -- 66: Brompheniramine -- 67: Dexbrompheniramine -- 68: Chlorpheniramine -- 69: Pheniramine -- References -- 70- 71: Budesonide, Desonide -- 70: Budesonide -- 71: Desonide -- References -- 72: Bupropion -- References -- 73: Buspirone -- References -- 74- 78: Butalbital and Related Barbiturates -- 74: Butalbital -- 75: Pentobarbital -- 76: Phenobarbital [WHO List of Essential Medicines] -- 77: Secobarbital -- 78: Talbutal -- References -- Chapter 4 Carbamazepine to Decitabine -- 79: Carbamazepine [WHO List of Essential Medicines] -- References -- 80: Cabergoline -- References -- 81: Captopril -- References -- 82-83: Carboplatin, Cisplatin -- 82: Carboplatin -- 83: Cisplatin -- References -- 84: Carisoprodol -- References -- 85-93: Cephalosporin Antibiotics -- 85: Cefalexin [Cephalexin] -- 86: Cefadroxil [Cephadroxil] -- 87: Cefaclor -- 88: Cephazolin [Cefazolin] -- 89: Cefuroxime -- 90: Cefotaxime -- 91: Ceftriaxone -- 92: Cefixime -- 93: Ceftazidime -- References -- 94: Celecoxib.
References -- 95-100: Cetirizine and Structurally Related Drugs -- 95: Cetirizine -- 96: Levocetirizine -- 97: Hydroxyzine -- 98: Cyclizine -- 99: Chlorcyclizine -- 100: Meclizine -- References -- 101: Chlorhexidine [WHO Essential List of Medicines] -- References -- 102: Chlorambucil -- References -- 103: Citicoline -- References -- 104-116: Chlorpromazine and Structurally Analogous Drugs -- 104: Chlorpromazine [List of WHO Essential Medicines] -- 105: Acepromazine -- 106: Carphenazine (Carfenazine) -- 107: Fluphenazine -- 108: Levomepromazine (Methotrimeprazine) -- 109: Perphenazine -- 110: Prochlorperazine -- 111: Promazine -- 112: Thiethylperazine -- 113: Thioproperazine -- 114: Trifluoperazine -- 115: Triflupromazine -- 116: Trimeprazine -- References -- 117: Chlorzoxazone -- References -- 118: Cholecalciferol -- References -- 119: Cyclosporin A [Ciclosporin] -- References -- 120-123: Ciprofloxacin, Norfloxacin, Ofloxacin, Levofloxacin -- 120: Ciprofloxacin -- 121: Levofloxacin -- 122: Ofloxacin -- 123: Norfloxacin -- References -- 124-125: Citalopram, Escitalopram -- 124: Citalopram -- 125: Escitalopram -- References -- 126-127: Clindamycin, Clindamycin Phosphate -- 126: Clindamycin -- 127: Clindamycin Phosphate (Clindamycin- 2- Phosphate -- Injectable Version of Clindamycin) -- References -- 128-129: Clobetasol Propionate, Halobetasol Propionate -- 128: Clobetasol Propionate (Clobetasol 17- Propionate) -- 129: Halobetasol Propionate -- References -- 130: Clomipramine -- References -- 131: Clopidogrel -- References -- 132: Clotrimazole -- References -- 133: Cocaine -- References -- 134: Colchicine -- References -- 135-136: Cyclobenzaprine, Cyproheptadine -- 135: Cyclobenzaprine -- 136: Cyproheptadine -- References -- 137: Cyclophosphamide [WHO List of Essential Medicines] -- References -- 138-140: Cytarabine, Azacitadine, Decitabine.
138: Cytarabine [WHO List of Essential Medicines] -- 139: Azacitidine (Azacytidine) -- 140: Decitabine -- References -- Chapter 5 Dabigatran Etexilate to Duloxetine -- 141: Dabigatran Etexilate -- References -- 142: Dacarbazine [WHO List of Essential Medicines] -- References -- 143: Dapsone [WHO List of Essential Medicines] -- References -- 144-146: Daunorubicin, Doxorubicin, Idarubicin -- 144: Daunorubicin -- 145: Doxorubicin [WHO List of Essential Medicines] -- 146: Idarubicin -- References -- 147-148: Desvenlafaxine, Venlafaxine -- 147: Desvenlafaxine -- 148: Venlafaxine -- References -- 149: Dextromethorphan -- References -- 150-152: Diclofenac, Aceclofenac, Meclofenamic Acid -- 150: Diclofenac -- 151: Aceclofenac -- 152: Meclofenamic Acid -- References -- 153: Dicyclomine (Dicycloverine) -- Reference -- 154: Didanosine [WHO List of Essential Medicines] -- References -- 155-157: Digoxin, Digitoxin, Deslanoside -- 155: Digoxin [WHO List of Essential Medicines] -- 156: Digitoxin -- 157: Deslanoside -- References -- 158: Diltiazem -- References -- 159: Diphenhydramine -- References -- 160: Dipyridamole -- References -- 161-164: Dopamine and related catecholamines, Dobutamine, Norepinephrine, Epinephrine -- 161: Dopamine [WHO List of Essential Medicines] -- 162: Dobutamine -- 163: Norepinephrine -- 164: Epinephrine -- References -- 165: Domperidone -- References -- 166: Donepezil -- References -- 167-168: l- Dopa [Levodopa], Methyldopa -- 167: l- Dopa [Levodopa] -- 168: Methyldopa -- Reference -- 169-170: Doxepin, Dothiepin -- 169: Doxepin -- 170: Dothiepin (Dosulepin) -- References -- 171-175: Doxycycline, Chlortetracycline, Oxytetracycline, Tetracycline, Minocycline -- 171: Doxycycline [WHO List of Essential Medicines] -- 172: Chlortetracycline [WHO List of Essential Medicines] -- 173: Oxytetracycline [WHO List of Essential Medicines].
174: Tetracycline [WHO List of Essential Medicines].
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Compendium of Drug Degradation Pathways
