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Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen
| Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen |
| Pubbl/distr/stampa | Hoboken : , : Wiley, , 2011 |
| Descrizione fisica | 1 online resource (xxii, 462 pages) : illustrations |
| Disciplina |
615.1
615/.1 |
| Altri autori (Persone) |
PramanikBirendra N. <1944->
LeeMike S. <1960-> ChenGuodong |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
| Soggetto topico |
Drugs - Analysis
Drugs - Spectra Mass spectrometry Contamination (Technology) Public Health Chemistry Techniques, Analytical Investigative Techniques Environment and Public Health Health Care Pharmaceutical Preparations Mass Spectrometry Drug Contamination Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-283-23943-4
9786613239433 0-470-92136-6 0-470-92137-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CHARACTERIZATION OF IMPURITIES AND DEGRADANTS USING MASS SPECTROMETRY; CONTENTS; PREFACE; CONTRIBUTORS; ACRONYMS; PART I: METHODOLOGY; 1. Introduction to Mass Spectrometry; 1.1. History; 1.1.1. Atomic Physics; 1.1.2. Early Applications; 1.1.3. Organic Structural Analysis; 1.1.4. The Biological Mass Spectrometry Revolution; 1.2. Ionization Methods; 1.3. Mass Spectrometer Types; 1.3.1. Magnetic Sector Mass Spectrometers; 1.3.2. Quadrupole Mass Filter and Quadrupole Ion Trap Mass Spectrometers; 1.3.3. Time-of-Flight Mass Spectrometers
1.3.4. Fourier Transform Ion Cyclotron Resonance Mass Spectrometers; 1.3.5. Orbitrap Mass Spectrometers; 1.4. Tandem Mass Spectrometry; 1.4.1. Ion Isolation; 1.4.2. Ion-Molecule Collisions and Collision-Induced Dissociation; 1.4.3. Electron Capture Dissociation and Electron Transfer Dissociation; 1.5. Separation Techniques Coupled to Mass Spectrometry; 1.5.1. Gas Chromatography-Mass Spectrometry; 1.5.2. Liquid Chromatography-Mass Spectrometry; 1.5.3. Capillary Electrophoresis-Mass Spectrometry; 1.5.4. Ion Mobility Spectrometry-Mass Spectrometry; 1.6. Prospects for Mass Spectrometry; References 2. LC Method Development and Strategies; 2.1. Introduction; 2.2. Column, pH, and Solvent Screening; 2.2.1. Resolution: Goal of Separation; 2.2.2. Screening: Systematic Approach to Seeking Selectivity; 2.2.3. Screening Instrumentation and Controlling Software; 2.3. Gradient and Temperature Optimization; 2.4. Orthogonal Screening; 2.4.1. Method Orthogonality; 2.4.2. Selection of Orthogonal Methods; 2.4.3. Impurity Orthogonal Screening; 2.5. High-Efficiency Separation; 2.6. Conclusions; References 3. Rapid Analysis of Drug-Related Substances using Desorption Electrospray Ionization and Direct Analysis in Real Time Ionization Mass Spectrometry; 3.1. Introduction; 3.2. Ionization Apparatus, Mechanisms, and General Performance; 3.2.1. Desorption Electrospray Ionization (DESI); 3.2.2. Direct Analysis in Real Time (DART); 3.3. Drug Analysis in Biological Matrices using DESI and DART; 3.3.1. DESI Application; 3.3.2. DART Application; 3.4. High-Throughput Analysis; 3.5. Chemical Imaging and Profiling; 3.6. Future Perspectives; References; 4. Orbitrap High-Resolution Applications 4.1. Historical Anecdote; 4.2. General Description of Orbitrap Operating Principles; 4.3. The Orbitrap is a "Fourier Transform" Device; 4.4. Performing Experiments in Trapping Devices; 4.4.1. "Raw" HPLC Data Look Like Infusion Data; 4.4.2. How Much Mass Resolution Should Be Used During HPLC; 4.5. Determining Elemental Compositions of "Unknowns" Using an Orbitrap; 4.6. Orbitrap Figures of Merit in Mass Measurement; 4.6.1. Accuracy; 4.6.2. Precision; 4.6.3. Discussion; 4.7. HPLC Orbitrap MS: Accurate Mass Demonstration and Differentiation of Small Molecule Formulas Very Proximate in Mass/Charge Ratio Space |
| Record Nr. | UNINA-9910132377503321 |
| Hoboken : , : Wiley, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen
| Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen |
| Pubbl/distr/stampa | Hoboken : , : Wiley, , 2011 |
| Descrizione fisica | 1 online resource (xxii, 462 pages) : illustrations |
| Disciplina |
615.1
615/.1 |
| Altri autori (Persone) |
PramanikBirendra N. <1944->
LeeMike S. <1960-> ChenGuodong |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
| Soggetto topico |
Drugs - Analysis
Drugs - Spectra Mass spectrometry Contamination (Technology) Public Health Chemistry Techniques, Analytical Investigative Techniques Environment and Public Health Health Care Pharmaceutical Preparations Mass Spectrometry Drug Contamination Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-283-23943-4
9786613239433 0-470-92136-6 0-470-92137-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CHARACTERIZATION OF IMPURITIES AND DEGRADANTS USING MASS SPECTROMETRY; CONTENTS; PREFACE; CONTRIBUTORS; ACRONYMS; PART I: METHODOLOGY; 1. Introduction to Mass Spectrometry; 1.1. History; 1.1.1. Atomic Physics; 1.1.2. Early Applications; 1.1.3. Organic Structural Analysis; 1.1.4. The Biological Mass Spectrometry Revolution; 1.2. Ionization Methods; 1.3. Mass Spectrometer Types; 1.3.1. Magnetic Sector Mass Spectrometers; 1.3.2. Quadrupole Mass Filter and Quadrupole Ion Trap Mass Spectrometers; 1.3.3. Time-of-Flight Mass Spectrometers
1.3.4. Fourier Transform Ion Cyclotron Resonance Mass Spectrometers; 1.3.5. Orbitrap Mass Spectrometers; 1.4. Tandem Mass Spectrometry; 1.4.1. Ion Isolation; 1.4.2. Ion-Molecule Collisions and Collision-Induced Dissociation; 1.4.3. Electron Capture Dissociation and Electron Transfer Dissociation; 1.5. Separation Techniques Coupled to Mass Spectrometry; 1.5.1. Gas Chromatography-Mass Spectrometry; 1.5.2. Liquid Chromatography-Mass Spectrometry; 1.5.3. Capillary Electrophoresis-Mass Spectrometry; 1.5.4. Ion Mobility Spectrometry-Mass Spectrometry; 1.6. Prospects for Mass Spectrometry; References 2. LC Method Development and Strategies; 2.1. Introduction; 2.2. Column, pH, and Solvent Screening; 2.2.1. Resolution: Goal of Separation; 2.2.2. Screening: Systematic Approach to Seeking Selectivity; 2.2.3. Screening Instrumentation and Controlling Software; 2.3. Gradient and Temperature Optimization; 2.4. Orthogonal Screening; 2.4.1. Method Orthogonality; 2.4.2. Selection of Orthogonal Methods; 2.4.3. Impurity Orthogonal Screening; 2.5. High-Efficiency Separation; 2.6. Conclusions; References 3. Rapid Analysis of Drug-Related Substances using Desorption Electrospray Ionization and Direct Analysis in Real Time Ionization Mass Spectrometry; 3.1. Introduction; 3.2. Ionization Apparatus, Mechanisms, and General Performance; 3.2.1. Desorption Electrospray Ionization (DESI); 3.2.2. Direct Analysis in Real Time (DART); 3.3. Drug Analysis in Biological Matrices using DESI and DART; 3.3.1. DESI Application; 3.3.2. DART Application; 3.4. High-Throughput Analysis; 3.5. Chemical Imaging and Profiling; 3.6. Future Perspectives; References; 4. Orbitrap High-Resolution Applications 4.1. Historical Anecdote; 4.2. General Description of Orbitrap Operating Principles; 4.3. The Orbitrap is a "Fourier Transform" Device; 4.4. Performing Experiments in Trapping Devices; 4.4.1. "Raw" HPLC Data Look Like Infusion Data; 4.4.2. How Much Mass Resolution Should Be Used During HPLC; 4.5. Determining Elemental Compositions of "Unknowns" Using an Orbitrap; 4.6. Orbitrap Figures of Merit in Mass Measurement; 4.6.1. Accuracy; 4.6.2. Precision; 4.6.3. Discussion; 4.7. HPLC Orbitrap MS: Accurate Mass Demonstration and Differentiation of Small Molecule Formulas Very Proximate in Mass/Charge Ratio Space |
| Record Nr. | UNINA-9910810569103321 |
| Hoboken : , : Wiley, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Dried blood spots : applications and techniques / / edited by Wenkui Li, Mike S. Lee
| Dried blood spots : applications and techniques / / edited by Wenkui Li, Mike S. Lee |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (377 p.) |
| Disciplina | 616.07/561 |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology : Practices, Applications and Methods |
| Soggetto topico |
Blood - Collection and preservation
Phlebotomy Forensic hematology Forensic serology |
| ISBN |
1-118-89089-2
1-118-89083-3 1-118-89090-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Dried Blood Spots; Contents; Preface; Contributors; PART I History, Applications, and Healthcare; 1 Overview of the History and Applications of Dried Blood Samples; 1.1 History; 1.2 Historical Applications; 1.3 Overall Advantages and Disadvantages of Dried-Blood Spot Sampling; 1.3.1 Advantages; 1.3.2 Disadvantages; 1.4 Conclusion; References; 2 Dried Blood Spot Cards; 2.1 Introduction; 2.2 Filter Paper; 2.3 Filter Paper Sources; 2.4 Guidelines and Printing; 2.5 Printing Adaptations; 2.6 Further Innovations in Manufacturing; 2.7 Filter Paper Cards Construction
2.8 Wraparound Cover and Cassette Construction 2.9 Filter Paper Pre-Treatment; 2.10 The Future of the Filter Paper Card; References; 3 Dried Blood Spot Sample Collection, Storage, and Transportation; 3.1 Introduction; 3.2 General Procedures and Precautions for DBS Sample Collection; 3.2.1 Reagents and Materials; 3.2.2 Biosafety and Infection Control; 3.2.3 Specimen Collection; 3.2.4 DBS Prepared by Other Collection Methods; 3.2.5 Labeling of DBS; 3.2.6 Drying; 3.3 Sample Storage and Transportation; 3.3.1 Packaging and Storage; 3.3.2 Transportation 3.4 Common Errors in Sample Collection, Storage, and Shipment 3.5 Conclusions; Disclaimer; References; 4 Dried Blood Spot Specimens for Polymerase Chain Reaction in Molecular Diagnostics and Public Health Surveillance; 4.1 Introduction; 4.2 Pioneering DBS Nucleic Acid Extraction Methods for PCR; 4.3 Direct PCR Amplification of Targeted Genomic DNA from DBS; 4.4 Expansion of DBS-PCR from Newborn Screening to Diagnosis of Infectious and other Diseases; 4.5 Application of DBS-PCR in Sequencing-Based Molecular Epidemiology Analyses 4.6 Application of DBS-PCR for HIV Drug Resistance Surveillance and Monitoring in Resource-Limited Settings4.7 Quantitation of Infectious Agent Particles with DBS-PCR; 4.8 Conclusions; References; 5 Application of Enzyme Immunoassay Methods Using Dried Blood Spot Specimens; 5.1 Introduction; 5.2 Overview of Basic ELISA Systems; 5.2.1 Antibody Detection; 5.2.2 Variation of ELISA Method for Antibody Detection; 5.2.3 Variations of ELISA for Antigen Detection; 5.3 Applications of ELISA Methods Using DBS; 5.4 Optimization and ELISA Methods Validation Using DBS Specimens; 5.4.1 DBS Elution Protocol 5.4.2 Defining Cutoff Values5.5 Factors Influencing the Performance of DBS-based ELISA Methods; 5.5.1 DBS Preparation; 5.5.2 Anticoagulant; 5.5.3 Punching; 5.5.4 Cross-Contamination; 5.6 Conclusions; Disclaimer; References; 6 Applications of Dried Blood Spots in Newborn and Metabolic Screening; 6.1 Introduction; 6.1.1 History and Chronology in the Use of DBS in NBS; 6.1.2 Chapter Organization and Perspectives; 6.2 Fundamentals of Dried Blood Spots; 6.2.1 A Class II Medical Device; 6.2.2 Liquid versus Dried Blood Specimens; 6.2.3 Interaction of Paper with Biological Matrix and Substrates 6.2.4 Sample Collection and DBS |
| Record Nr. | UNINA-9910132219103321 |
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Dried blood spots : applications and techniques / / edited by Wenkui Li, Mike S. Lee
| Dried blood spots : applications and techniques / / edited by Wenkui Li, Mike S. Lee |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (377 p.) |
| Disciplina | 616.07/561 |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology : Practices, Applications and Methods |
| Soggetto topico |
Blood - Collection and preservation
Phlebotomy Forensic hematology Forensic serology |
| ISBN |
1-118-89089-2
1-118-89083-3 1-118-89090-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Dried Blood Spots; Contents; Preface; Contributors; PART I History, Applications, and Healthcare; 1 Overview of the History and Applications of Dried Blood Samples; 1.1 History; 1.2 Historical Applications; 1.3 Overall Advantages and Disadvantages of Dried-Blood Spot Sampling; 1.3.1 Advantages; 1.3.2 Disadvantages; 1.4 Conclusion; References; 2 Dried Blood Spot Cards; 2.1 Introduction; 2.2 Filter Paper; 2.3 Filter Paper Sources; 2.4 Guidelines and Printing; 2.5 Printing Adaptations; 2.6 Further Innovations in Manufacturing; 2.7 Filter Paper Cards Construction
2.8 Wraparound Cover and Cassette Construction 2.9 Filter Paper Pre-Treatment; 2.10 The Future of the Filter Paper Card; References; 3 Dried Blood Spot Sample Collection, Storage, and Transportation; 3.1 Introduction; 3.2 General Procedures and Precautions for DBS Sample Collection; 3.2.1 Reagents and Materials; 3.2.2 Biosafety and Infection Control; 3.2.3 Specimen Collection; 3.2.4 DBS Prepared by Other Collection Methods; 3.2.5 Labeling of DBS; 3.2.6 Drying; 3.3 Sample Storage and Transportation; 3.3.1 Packaging and Storage; 3.3.2 Transportation 3.4 Common Errors in Sample Collection, Storage, and Shipment 3.5 Conclusions; Disclaimer; References; 4 Dried Blood Spot Specimens for Polymerase Chain Reaction in Molecular Diagnostics and Public Health Surveillance; 4.1 Introduction; 4.2 Pioneering DBS Nucleic Acid Extraction Methods for PCR; 4.3 Direct PCR Amplification of Targeted Genomic DNA from DBS; 4.4 Expansion of DBS-PCR from Newborn Screening to Diagnosis of Infectious and other Diseases; 4.5 Application of DBS-PCR in Sequencing-Based Molecular Epidemiology Analyses 4.6 Application of DBS-PCR for HIV Drug Resistance Surveillance and Monitoring in Resource-Limited Settings4.7 Quantitation of Infectious Agent Particles with DBS-PCR; 4.8 Conclusions; References; 5 Application of Enzyme Immunoassay Methods Using Dried Blood Spot Specimens; 5.1 Introduction; 5.2 Overview of Basic ELISA Systems; 5.2.1 Antibody Detection; 5.2.2 Variation of ELISA Method for Antibody Detection; 5.2.3 Variations of ELISA for Antigen Detection; 5.3 Applications of ELISA Methods Using DBS; 5.4 Optimization and ELISA Methods Validation Using DBS Specimens; 5.4.1 DBS Elution Protocol 5.4.2 Defining Cutoff Values5.5 Factors Influencing the Performance of DBS-based ELISA Methods; 5.5.1 DBS Preparation; 5.5.2 Anticoagulant; 5.5.3 Punching; 5.5.4 Cross-Contamination; 5.6 Conclusions; Disclaimer; References; 6 Applications of Dried Blood Spots in Newborn and Metabolic Screening; 6.1 Introduction; 6.1.1 History and Chronology in the Use of DBS in NBS; 6.1.2 Chapter Organization and Perspectives; 6.2 Fundamentals of Dried Blood Spots; 6.2.1 A Class II Medical Device; 6.2.2 Liquid versus Dried Blood Specimens; 6.2.3 Interaction of Paper with Biological Matrix and Substrates 6.2.4 Sample Collection and DBS |
| Record Nr. | UNINA-9910823859903321 |
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Integrated strategies for drug discovery using mass spectrometry [[electronic resource] /] / [edited by] Mike S. Lee
| Integrated strategies for drug discovery using mass spectrometry [[electronic resource] /] / [edited by] Mike S. Lee |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
| Descrizione fisica | 1 online resource (570 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | LeeMike S. <1960-> |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
| Soggetto topico |
Mass spectrometry
Drugs - Analysis High throughput screening (Drug development) |
| ISBN |
1-280-27658-4
9786610276585 0-470-24248-5 0-471-72103-4 0-471-72102-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic -- Mass spectrometry based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery -- Mass spectrometry based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert -- Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng -- A Combinatorial process for drug discovery / David S. Wagner -- Application of technological advances in biotransformation studies / Carmen L. Fernandez-Metzler -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang -- Advances in high-throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann -- New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC/MS strategy for preclinical candidate optimization / Jonathan L. Josephs -- New approaches for method development and purification in lead optimization / Yining Zhao -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns -- Organ perfusion and mass spectrometry / C. Gerald Curtis -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock. |
| Record Nr. | UNINA-9910143579703321 |
| Hoboken, N.J., : Wiley-Interscience, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Integrated strategies for drug discovery using mass spectrometry [[electronic resource] /] / [edited by] Mike S. Lee
| Integrated strategies for drug discovery using mass spectrometry [[electronic resource] /] / [edited by] Mike S. Lee |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
| Descrizione fisica | 1 online resource (570 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | LeeMike S. <1960-> |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
| Soggetto topico |
Mass spectrometry
Drugs - Analysis High throughput screening (Drug development) |
| ISBN |
1-280-27658-4
9786610276585 0-470-24248-5 0-471-72103-4 0-471-72102-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic -- Mass spectrometry based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery -- Mass spectrometry based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert -- Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng -- A Combinatorial process for drug discovery / David S. Wagner -- Application of technological advances in biotransformation studies / Carmen L. Fernandez-Metzler -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang -- Advances in high-throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann -- New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC/MS strategy for preclinical candidate optimization / Jonathan L. Josephs -- New approaches for method development and purification in lead optimization / Yining Zhao -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns -- Organ perfusion and mass spectrometry / C. Gerald Curtis -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock. |
| Record Nr. | UNINA-9910830715203321 |
| Hoboken, N.J., : Wiley-Interscience, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Integrated strategies for drug discovery using mass spectrometry [[electronic resource] /] / [edited by] Mike S. Lee
| Integrated strategies for drug discovery using mass spectrometry [[electronic resource] /] / [edited by] Mike S. Lee |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
| Descrizione fisica | 1 online resource (570 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | LeeMike S. <1960-> |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
| Soggetto topico |
Mass spectrometry
Drugs - Analysis High throughput screening (Drug development) |
| ISBN |
1-280-27658-4
9786610276585 0-470-24248-5 0-471-72103-4 0-471-72102-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic -- Mass spectrometry based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery -- Mass spectrometry based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert -- Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng -- A Combinatorial process for drug discovery / David S. Wagner -- Application of technological advances in biotransformation studies / Carmen L. Fernandez-Metzler -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang -- Advances in high-throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann -- New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC/MS strategy for preclinical candidate optimization / Jonathan L. Josephs -- New approaches for method development and purification in lead optimization / Yining Zhao -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns -- Organ perfusion and mass spectrometry / C. Gerald Curtis -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock. |
| Record Nr. | UNINA-9910841232003321 |
| Hoboken, N.J., : Wiley-Interscience, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mass spectrometry handbook [[electronic resource] /] / edited by Mike S. Lee
| Mass spectrometry handbook [[electronic resource] /] / edited by Mike S. Lee |
| Pubbl/distr/stampa | Hoboken, NJ, : J. Wiley & Sons, c2012 |
| Descrizione fisica | 1 online resource (1340 p.) |
| Disciplina | 543/.65 |
| Altri autori (Persone) | LeeMike S. <1960-> |
| Collana | Wiley series on pharmaceutical science and biotechnology: practices, applications and methods |
| Soggetto topico |
Mass spectrometry
Spectrum analysis |
| ISBN |
1-280-59259-1
9786613622426 1-118-18072-0 1-118-18073-9 1-118-18070-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910141254403321 |
| Hoboken, NJ, : J. Wiley & Sons, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mass spectrometry handbook [[electronic resource] /] / edited by Mike S. Lee
| Mass spectrometry handbook [[electronic resource] /] / edited by Mike S. Lee |
| Pubbl/distr/stampa | Hoboken, NJ, : J. Wiley & Sons, c2012 |
| Descrizione fisica | 1 online resource (1340 p.) |
| Disciplina | 543/.65 |
| Altri autori (Persone) | LeeMike S. <1960-> |
| Collana | Wiley series on pharmaceutical science and biotechnology: practices, applications and methods |
| Soggetto topico |
Mass spectrometry
Spectrum analysis |
| ISBN |
1-280-59259-1
9786613622426 1-118-18072-0 1-118-18073-9 1-118-18070-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910825483203321 |
| Hoboken, NJ, : J. Wiley & Sons, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mass spectrometry in drug metabolism and disposition [[electronic resource] ] : basic principles and applications / / edited by Mike S. Lee, Mingshe Zhu
| Mass spectrometry in drug metabolism and disposition [[electronic resource] ] : basic principles and applications / / edited by Mike S. Lee, Mingshe Zhu |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2011 |
| Descrizione fisica | 1 online resource (776 p.) |
| Disciplina | 615/.7 |
| Altri autori (Persone) |
LeeMike S. <1960->
ZhuMingshe |
| Collana | Wiley series on pharmaceutical science and biotechnology: practices, applications and methods |
| Soggetto topico |
Drugs - Metabolism - Analysis
Metabolites - Spectra Mass spectrometry |
| ISBN |
0-470-93469-7
1-283-05232-6 9786613052322 0-470-92926-X 0-470-92927-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | (Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition -- The Progression of Drug Metabolism -- Common Biotransformation Reactions -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry -- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions -- Experimental Models of Drug Metabolism and Disposition -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics -- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes -- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice -- Theory and Instrumentation of Mass Spectrometry -- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification -- Mass Spectral Interpretation -- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection -- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition -- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening -- High Resolution Mass Spectrometry and Drug Metabolite Identification -- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging -- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies -- Quantitative Drug Metabolism with Accelerator Mass Spectrometry -- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions -- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS -- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices -- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress -- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery. |
| Record Nr. | UNINA-9910133582603321 |
| Hoboken, N.J., : John Wiley & Sons, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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