Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Blood Cells : A Practical Guide
| Blood Cells : A Practical Guide |
| Autore | Bain Barbara J |
| Edizione | [7th ed.] |
| Pubbl/distr/stampa | Newark : , : John Wiley & Sons, Incorporated, , 2025 |
| Descrizione fisica | 1 online resource (605 pages) |
| Disciplina | 612.1/1 |
| Altri autori (Persone) | LeachMike |
| Soggetto topico |
Blood cells
Blood cell count Blood - Analysis |
| ISBN |
1-394-33208-4
1-394-33207-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright Page -- Contents -- Preface -- Acknowledgements -- List of abbreviations -- About the companion website -- CHAPTER 1 Blood sampling and blood film preparation and examination -- Obtaining a blood specimen -- Peripheral venous blood -- 'Capillary' blood -- Cord blood -- Fetal blood -- Blood specimens from other sites -- Anticoagulants and specimen containers -- Guidelines -- Needle-stick injury -- Specimen mixing -- Making a blood film -- Manual spreading of a blood film on a glass slide (wedge-spread film) -- Other methods of spreading thin films -- Thick films -- Unstained wet preparations -- Fixation, staining and mounting -- Fixation -- Staining -- Mounting -- Storage of slides -- Setting up and using a microscope -- Identifying the source of a problem and preventing problems -- Examining a blood film -- References -- CHAPTER 2 Performing a blood count -- Basic techniques -- Haemoglobin concentration -- Packed cell volume -- The red cell count -- Derived red cell variables - the red cell indices -- The white cell count -- The platelet count -- The differential white cell count -- The reticulocyte count -- Units and approved abbreviations -- Automated image analysis -- Pattern-recognition automated differential counters -- Automated blood cell counters -- Principles of operation of automated haematology counters -- Beckman Coulter instruments -- Sysmex and other instruments incorporating impedance measurements -- Siemens instruments (previously Technicon then Bayer instruments) -- Abbott Cell-Dyn and Alinity instruments -- HORIBA Medical -- Nihon Kohden instruments -- Mindray instruments -- Automated reticulocyte count and reticulated platelet count -- Selection of an automated instrument -- Near-patient/point-of-care testing -- Non-invasive methods -- Storage of blood specimens prior to testing -- References.
CHAPTER 3 Morphology of blood cells -- Examining the blood film -- Storage-induced and other artefacts -- Erythrocytes -- Anisocytosis -- Microcytosis -- Macrocytosis -- Hypochromia -- Hyperchromia -- Anisochromasia -- Dimorphism -- Polychromasia -- Poikilocytosis -- Inclusions in erythrocytes -- Circulating nucleated red blood cells -- Red cell agglutination, rouleaux formation and red cell rosetting -- Leucocytes -- Granulocytes -- The neutrophil -- The eosinophil -- The basophil -- Lymphocytes and plasma cells -- The lymphocyte -- The plasma cell -- Cells of monocyte lineage -- The monocyte -- Monocyte precursors -- The macrophage -- Granulocyte precursors -- The myeloblast -- The promyelocyte -- The myelocyte -- The metamyelocyte -- Leucoerythroblastic blood films -- The mast cell -- Disintegrated cells -- Necrotic bone marrow cells -- Platelets and circulating megakaryocytes -- Platelets -- Abnormalities of platelet size -- Other abnormalities of platelet morphology and distribution including platelet aggregation and satellism and phagocytosis of platelets -- Megakaryocytes -- Abnormal megakaryocytes and megakaryoblasts -- Blood film in healthy subjects -- Healthy adult -- Infancy and childhood -- Neonate -- Hyposplenism -- Non-haemopoietic cells -- Endothelial cells -- Epithelial cells -- Fat cells -- Mesothelial cells -- Amniotic fluid cells -- Non-haemopoietic malignant cells and mucin -- Micro-organisms in blood films -- Bacteria -- Fungi -- Parasites -- Malaria -- Babesiosis -- Toxoplasmosis -- Infection by haemoflagellates -- Filariasis -- Further learning resources -- References -- CHAPTER 4 Detecting erroneous blood counts -- The sources of errors in blood counts -- The detection of errors in automated blood counts -- Errors in automated white cell counts -- Errors in haemoglobin concentration and red cell indices. Haemoglobin concentration -- Red blood cell count, mean cell volume and haematocrit -- Mean cell haemoglobin, mean cell haemoglobin concentration and red cell distribution width -- Factitious erythroblastaemia -- Errors in platelet counts -- Errors in automated differential counts -- Five- to seven-part differential counts -- Errors in automated reticulocyte counts and other reticulocyte measurements -- References -- CHAPTER 5 Normal ranges -- Normal ranges for adults -- Normal ranges for neonates and fetuses -- Normal ranges in infants and children -- Normal ranges in pregnancy -- Normal ranges for platelet counts and other platelet variables -- Normal ranges for reticulocyte counts -- References -- CHAPTER 6 Quantitative changes in blood cells -- Polycythaemia -- Reticulocytosis -- Leucocytosis -- Neutrophil leucocytosis - neutrophilia -- Eosinophil leucocytosis - eosinophilia -- Basophil leucocytosis - basophilia -- Lymphocytosis -- Monocytosis -- Plasmacytosis -- Thrombocytosis -- Blood film and count -- Further tests -- Anaemia -- Blood film and count -- Further tests -- Reticulocytopenia -- Leucopenia -- Neutropenia -- Eosinopenia -- Basopenia -- Monocytopenia -- Lymphocytopenia (lymphopenia) -- Thrombocytopenia -- Blood film and count -- Other tests -- Pancytopenia -- Blood film and count -- Differential diagnosis -- Further tests -- References -- CHAPTER 7 Important supplementary tests -- Cytochemical techniques for investigation of erythrocyte disorders -- Heinz bodies -- Haemoglobin H inclusions -- Haemoglobin F-containing cells -- Perls reaction for iron -- Glucose-6-phosphate dehydrogenase -- Cytochemical stains used in the diagnosis and classification of leukaemias -- Neutrophil alkaline phosphatase -- Myeloperoxidase -- Sudan black B -- Naphthol AS-D chloroacetate esterase -- Non-specific esterases -- Combined esterase. Periodic acid-Schiff reaction -- Acid phosphatase -- Flow cytometric immunophenotyping -- Immunocytochemistry -- Cytogenetic analysis -- Fluorescence in situ hybridisation -- Molecular genetic analysis -- Ultrastructural examination -- References -- Further reading -- CHAPTER 8 Disorders of red cells and platelets -- Disorders of red cells -- Hypochromic and microcytic anaemias and thalassaemias -- Disorders resulting from a defect in haem synthesis -- Disorders resulting from a defect in globin chain synthesis -- Disorders resulting from a defect in globin chain synthesis -- Haemoglobinopathies -- Macrocytic anaemias -- Megaloblastic anaemia -- Macrocytic anaemia associated with excess alcohol intake and liver disease -- Macrocytic anaemia due to a myelodysplastic syndrome -- Other rare macrocytic anaemias -- Congenital haemolytic anaemias -- Hereditary spherocytosis and variants -- Hereditary elliptocytosis and ovalocytosis -- Hereditary pyropoikilocytosis -- Southeast Asian ovalocytosis -- Hereditary stomatocytosis and related conditions -- Other defects involving the erythrocyte membrane -- Red cell enzyme abnormalities -- Acquired haemolytic anaemias -- Acquired haemolytic anaemias with an immune mechanism -- Non-immune acquired haemolytic anaemias -- Miscellaneous causes of acquired haemolytic anaemia -- Haemolysis as a contributing factor to anaemia -- Dyserythropoietic anaemias -- Congenital dyserythropoietic anaemias -- Acquired dyserythropoietic anaemias -- Aplastic anaemia and red cell aplasia -- Aplastic anaemia -- Pure red cell aplasia -- Red cell effects of bacterial, viral and parasitic infections and vaccinations -- Bacterial infection -- Viral infection -- Parasitic infections -- Polycythaemia -- Relative polycythaemia -- True polycythaemia -- Disorders of platelets -- Thrombocytopenia. Autoimmune ('idiopathic') thrombocytopenic purpura (ITP) -- Thrombotic thrombocytopenic purpura -- Platelet effects of bacterial, viral and parasitic infections and vaccinations -- Infection- and vaccine-related thrombocytopenia and thrombocytosis -- Thrombocytosis -- Familial thrombocytosis -- Essential thrombocythaemia -- Leucoerythroblastic blood films -- Primary myelofibrosis -- References -- CHAPTER 9 Disorders of white cells -- Reactive changes in white cells -- Bacterial infection -- Viral infections -- Infectious mononucleosis -- Other reactive changes in leucocytes -- Vaccination effects on leucocytes -- Persistent polyclonal B-cell lymphocytosis -- Reactive eosinophilia -- T-cell-mediated hypereosinophilia -- Idiopathic hypereosinophilic syndrome -- Leukaemoid reactions -- Cytopenias -- Severe congenital neutropenia -- Cyclical neutropenia -- Autoimmune neutropenia -- Chronic idiopathic neutropenia -- Haematological neoplasms -- Acute myeloid leukaemia and related conditions -- The myelodysplastic neoplasms/syndromes -- Myeloproliferative and myelodysplastic/myeloproliferative neoplasms -- Myeloproliferative neoplasms -- Myelodysplastic/myeloproliferative neoplasms -- Acute lymphoblastic leukaemia/lymphoma -- Blood film and count -- Differential diagnosis -- Further tests -- Chronic lymphoid leukaemias and lymphomas -- B-lineage lymphoproliferative disorders -- T-lineage and NK-lineage lymphoproliferative disorders -- T-cell prolymphocytic leukaemia -- Hodgkin lymphoma -- References -- Further reading -- Index -- EULA. |
| Record Nr. | UNINA-9911019516303321 |
Bain Barbara J
|
||
| Newark : , : John Wiley & Sons, Incorporated, , 2025 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Leukaemia Diagnosis
| Leukaemia Diagnosis |
| Autore | Bain Barbara J |
| Edizione | [6th ed.] |
| Pubbl/distr/stampa | Newark : , : John Wiley & Sons, Incorporated, , 2024 |
| Descrizione fisica | 1 online resource (653 pages) |
| Disciplina | 616.99/419075 |
| Altri autori (Persone) | LeachMike |
| ISBN |
1-394-21860-5
1-394-21861-3 1-394-21859-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright Page -- Contents -- Preface -- Acknowledgements -- Commonly Used Abbreviations -- Chapter 1 The Nature of Leukaemia, Cytology, Cytochemistry and the Morphological Classification of Acute Leukaemia -- The nature of leukaemia -- The aetiology of leukaemia -- The importance of classification -- The nature and classification of acute leukaemia -- The nature and classification of the myelodysplastic syndromes -- The nature and classification of chronic myeloid leukaemias and myelodysplastic/myeloproliferative neoplasms -- The nature and classification of lymphoid neoplasms -- Defining a blast cell, a promyelocyte and a promonocyte -- The FAB classification of acute leukaemia -- Diagnosing acute leukaemia -- Distinguishing between acute myeloid and acute lymphoblastic leukaemias -- Defining remission -- The incidence of acute leukaemia -- The FAB categories and other morphological categories of acute myeloid leukaemia -- Acute myeloid leukaemia with minimal evidence of myeloid differentiation: M0 acute myeloid leukaemia -- Acute myeloid leukaemia without maturation: M1 acute myeloid leukaemia -- Acute myeloid leukaemia with maturation: M2 acute myeloid leukaemia -- Acute hypergranular promyelocytic leukaemia: M3 acute myeloid leukaemia -- The variant form of acute promyelocytic leukaemia: M3 variant acute myeloid leukaemia -- Acute myelomonocytic leukaemia: M4 acute myeloid leukaemia -- Acute monocytic/monoblastic leukaemia: M5 acute myeloid leukaemia -- Acute myeloid leukaemia with predominant erythroid differentiation: M6 acute myeloid leukaemia -- Acute megakaryoblastic leukaemia: M7 acute myeloid leukaemia -- Acute eosinophilic leukaemia -- Acute basophilic leukaemia -- Acute mast cell leukaemia -- Langerhans cell leukaemia -- Hypoplastic or hypocellular acute myeloid leukaemia.
Clinical correlates of FAB categories of acute myeloid leukaemia -- The FAB classification of acute lymphoblastic leukaemia -- 'Acute lymphoblastic leukaemia' of L3 subtype -- Automated full blood counts in acute leukaemia -- References -- Chapter 2 Immunophenotyping and Cytogenetic/Molecular Genetic Analyis -- Introduction -- Immunophenotyping -- Problems and pitfalls in immunophenotyping -- Immunophenotype of normal haemopoietic cells -- Immunophenotyping in acute leukaemia -- Immunophenotyping in acute myeloid leukaemia -- Immunophenotyping in acute lymphoblastic leukaemia -- Immunophenotyping in mixed phenotype acute leukaemia -- Immunophenotyping in myelodysplastic syndromes, myeloproliferative neoplasms and overlap syndromes -- Immunophenotyping in myelodysplastic syndromes -- Immunophenotyping in myelodysplastic/myeloproliferative neoplasms -- Immunophenotyping in myeloproliferative neoplasms -- Immunophenotyping in suspected B-lineage lymphoproliferative disorders -- Immunophenotyping in suspected T-lineage lymphoproliferative disorders -- Immunophenotyping in suspected natural killer-lineage lymphoproliferative disorders -- Genetic analysis -- Cytogenetic analysis -- Problems and pitfalls in cytogenetic analysis -- FISH and comparative genomic hybridisation -- Problems and pitfalls in FISH analysis -- Molecular genetic analysis -- Problems and pitfalls in molecular genetic analysis -- The role of cytogenetic and molecular genetic analysis in haematological neoplasms -- Problems and pitfalls in cytogenetic and molecular genetic analysis -- Cytogenetic and molecular genetic analysis in acute leukaemia -- Measurable residual disease in acute leukaemia -- Cytogenetic and molecular genetic analysis in acute myeloid leukaemia -- Cytogenetic and molecular genetic analysis in acute lymphoblastic leukaemia -- Conclusions -- References. Chapter 3 Acute Myeloid Leukaemia: Integration of Morphological, Immunophenotypic and Genetic Information: the WHO and International Consensus Classifications -- Introduction -- The WHO classification of acute myeloid leukaemia -- Acute myeloid leukaemia with defining genetic abnormalities -- Acute myeloid leukaemia with RUNX1::RUNX1T1 fusion -- Acute myeloid leukaemia with other RUNX1 rearrangement -- Acute promyelocytic leukaemia with PML::RARA fusion -- Acute myeloid leukaemia with t(11 -- 17)(q23.2 -- q21.2) -- ZBTB16::RARA or other RARA rearrangements -- Acute myeloid leukaemia with CBFB::MYH11 fusion -- Acute myeloid leukaemia with KMT2A rearrangement, particularly KMT2A::MLLT3 associated with t(9 -- 11) (p21.3 -- q23.3) -- Acute myeloid leukaemia with other KMT2A rearrangement -- Acute myeloid leukaemia with DEK::NUP214 fusion -- Acute myeloid leukaemia with MECOM rearrangement -- Acute myeloid leukaemia with other 3q21 or 3q26 rearrangements -- Acute myeloid leukaemia with RBM15::MRTFA fusion -- Acute myeloid leukaemia with BCR::ABL1 fusion -- Acute myeloid leukaemia with NPM1 mutation -- Acute myeloid leukaemia with CEBPA mutation -- Acute myeloid leukaemia with NUP98 rearrangement -- Acute myeloid leukaemia with RUNX1 mutation -- Acute myeloid leukaemia, myelodysplasia-related -- Acute myeloid leukaemia with other defined genetic alterations -- Acute myeloid leukaemia with KAT6A::CREBBP -- Acute myeloid leukaemia with FUS::ERG -- Acute myeloid leukaemia, defined by differentiation -- Acute myeloid leukaemia with minimal differentiation -- Acute myeloid leukaemia without maturation -- Acute myeloid leukaemia with maturation -- Acute basophilic leukaemia -- Acute myelomonocytic leukaemia -- Acute monocytic leukaemia -- Acute erythroid leukaemia -- Acute megakaryoblastic leukaemia -- Myeloid sarcoma. Acute myeloid leukaemia associated with antecedent and predisposing conditions -- Therapy-related acute myeloid leukaemia/acute myeloid leukaemia post cytotoxic therapy -- Acute myeloid leukaemia with germline predisposition -- Myeloid proliferation related to Down syndrome -- Transient abnormal myelopoiesis -- Acute myeloid leukaemia associated with Down syndrome -- The International Consensus Classification of acute myeloid leukaemia -- Other acute myeloid leukaemias and related conditions -- Acute myeloid leukaemia arising in a germ cell tumour with i(12p) -- Mast cell leukaemia -- Blastic plasmacytoid dendritic cell neoplasm -- Prognostic significance of cytogenetic and genetic abnormalities in acute myeloid leukaemia -- The role of immunophenotyping -- The diagnostic pathway -- Conclusions -- References -- Chapter 4 Acute Lymphoblastic Leukaemia and Acute Leukaemia of Mixed or Ambiguous Lineage -- Introduction -- The WHO classification of acute lymphoblastic leukaemia/lymphoblastic lymphoma of B lineage -- B lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities -- B lymphoblastic leukaemia/lymphoma with high hyperdiploidy -- B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion -- B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1-like features -- B lymphoblastic leukaemia/lymphoma with BCR::ABL1 fusion -- B lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features -- B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement -- B lymphoblastic leukaemia/lymphoma with TCF3::PBX1 fusion -- B lymphoblastic leukaemia/lymphoma with TCF3::HLF fusion -- B lymphoblastic leukaemia/lymphoma with t(5 -- 14)(q31.1 -- q32.1) -- IGH::IL3 -- B lymphoblastic leukaemia/lymphoma with hypodiploidy -- B lymphoblastic leukaemia/lymphoma with iAMP21 -- B lymphoblastic leukaemia/lymphoma with other defined genetic alterations. B lymphoblastic leukaemia/lymphoma, not otherwise specified -- B lymphoblastic leukaemia/lymphoma in Down syndrome -- The International Consensus Classification of acute lymphoblastic leukaemia/lymphoblastic lymphoma of B lineage -- The WHO classification of acute lymphoblastic leukaemia/lymphoblastic lymphoma of T lineage -- T lymphoblastic leukaemia/lymphoma, not otherwise specified -- T lymphoblastic leukaemia/lymphoma with t(10 -- 14)(q24 -- q11.2) -- TLX1 dysregulation -- T lymphoblastic leukaemia/lymphoma with t(5 -- 14)(q35.1 -- q32.2) (cryptic) -- TLX3 dysregulation -- T lymphoblastic leukaemia/lymphoma with cryptic TALd deletion -- STIL::TAL1 -- T lymphoblastic leukaemia/lymphoma with NUP214::ABL1 fusion -- Early T-cell precursor lymphoblastic leukaemia/lymphoma -- The International Consensus Classification of acute lymphoblastic leukaemia/lymphoblastic lymphoma of T lineage -- Natural killer cell lymphoblastic leukaemia/lymphoma -- Therapy-related lymphoblastic leukaemia/lymphoma -- Acute leukaemias of mixed or ambiguous lineage -- Mixed phenotype acute leukaemias -- Mixed phenotype acute leukaemia with defined genetic abnormalities -- Mixed phenotype/ambiguous lineage acute leukaemia, defined by differentiation -- Mixed phenotype acute leukaemia, B/myeloid, not otherwise specified -- Mixed phenotype acute leukaemia, T/myeloid, not otherwise specified -- Mixed phenotype acute leukaemia, rare types -- Acute leukaemia of ambiguous lineage, not otherwise specified -- Acute undifferentiated leukaemia -- Conclusions -- References -- Chapter 5 The Myelodysplastic Syndromes, the Myelodysplastic/Myeloproliferative Neoplasms and Juvenile Myelomonocytic Leukaemia -- MYELODYSPLASTIC SYNDROMES/NEOPLASMS -- Recognition, nature and epidemiology -- Classification -- Cytochemistry -- Immunophenotyping -- Bone marrow trephine biopsy -- Cytogenetic features. Molecular genetic features. |
| Record Nr. | UNINA-9910830203403321 |
|
Bain Barbara J
|
||
| Newark : , : John Wiley & Sons, Incorporated, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||