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Between Theory and Clinic: The Contribution of Neuroimaging in the Field of Consciousness Disorders
| Between Theory and Clinic: The Contribution of Neuroimaging in the Field of Consciousness Disorders |
| Autore | Gosseries Olivia |
| Pubbl/distr/stampa | Frontiers Media SA, 2019 |
| Descrizione fisica | 1 electronic resource (194 p.) |
| Soggetto topico |
Medicine
Neurology & clinical neurophysiology |
| Soggetto non controllato |
disorders of consciousness
neuroimaging neurophysiology diagnosis prognosis treatment unresponsive wakefulness syndrome/vegetative state minimally conscious state coma severe brain injury |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Between Theory and Clinic |
| Record Nr. | UNINA-9910557234703321 |
Gosseries Olivia
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| Frontiers Media SA, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Clinical Neurophysiology in Disorders of Consciousness : Brain Function Monitoring in the ICU and Beyond / / edited by Andrea O. Rossetti, Steven Laureys
| Clinical Neurophysiology in Disorders of Consciousness : Brain Function Monitoring in the ICU and Beyond / / edited by Andrea O. Rossetti, Steven Laureys |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Vienna : , : Springer Vienna : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (161 p.) |
| Disciplina |
610
612.8 616.8 616.804231 616028 |
| Soggetto topico |
Critical care medicine
Neurology Neurosciences Intensive / Critical Care Medicine Neurology |
| ISBN | 3-7091-1634-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. The acute clinical setting -- 2. Electroencephalography (EEG) and evoked potentials (EP): technical background -- 3. Which EEG patterns deserve treatment in the ICU? -- 4. EEG in refractory status epilepticus -- 5. Prognostic use of EEG in acute consciousness impairment -- 6. Prognostic use of somatosensory EP in acute consciousness impairment (including drug effects) -- 7. Prognostic use of cognitive EP in acute consciousness impairment -- 8. The chronic clinical setting -- 9. Correlations of JHD EEG with consciousness recovery -- 10. Correlations of HD EP with consciousness recovery -- 11. Disorders of consciousness and sleep -- EEG-TMS -- 13. Outlook: imaging correlations. |
| Record Nr. | UNINA-9910300225003321 |
| Vienna : , : Springer Vienna : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Coma and Disorders of Consciousness
| Coma and Disorders of Consciousness |
| Autore | Schnakers Caroline |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing AG, , 2024 |
| Descrizione fisica | 1 online resource (325 pages) |
| Disciplina | 616.8/49 |
| Altri autori (Persone) | LaureysSteven |
| ISBN | 3-031-50563-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Foreword -- Preface -- Contents -- Chapter 1: Neural Correlates of Consciousness -- Introduction -- The Neural Correlates of Consciousness -- Neurophysiological Techniques Used in the Study of the NCC -- Physiological States of Consciousness: NCC in Sleep -- Pharmacological States of Consciousness: NCC in Anesthesia -- Pathological States of Consciousness: NCC in Disorders of Consciousness -- Conclusions -- References -- Chapter 2: Behavioral Assessment and Diagnosis of Disorders of Consciousness -- Introduction -- Disorders of Consciousness -- Coma -- Vegetative State/Unresponsive Wakefulness Syndrome -- Minimally Conscious State -- Covert Awareness -- Bedside Assessment -- The Coma Recovery Scale-Revised -- Individualized Quantitative Behavioral Assessment (IQBA) -- Pain Assessment -- Language Assessment -- Diagnostic Accuracy -- Conclusion -- References -- Chapter 3: Brain-Computer Interfaces and Their Place in the Management of Disorders of Consciousness -- What Are BCIs and How Can Patients with a Disorder of Consciousness Benefit From Them? -- BCIs Help to Refine the Taxonomy of Disorders of Consciousness -- The Applications of BCIs in Research for Patients with a Disorder of Consciousness -- P3 -- Motor Imagery -- SSVEP -- Hybrid BCIs -- Body-Computer Interfaces (Biofeedback Machines) -- Recommendations for BCI Use According to Current Guidelines for Clinical Management of Patients with a Disorder of Consciousness -- Future Research and Clinical Directions to Encourage Development and Implementation of BCIs for Patients with a Disorder of Consciousness -- Conclusion -- References -- Chapter 4: Prognosis in Disorders of Consciousness -- Introduction -- Evolution -- Prognostic Issues -- Conclusion -- References -- Chapter 5: Neuromedical Comorbidities and Their Management in Patients with DoC -- Introduction.
Comorbidities Assessment -- Respiratory Complications and Dysphagia -- Neurosurgical Complications -- Spasticity and Other Motor Disorders -- Heterotopic Ossification and Bed Best Syndrome -- ICU-Acquired Weakness (ICU-AW)/Critical Illness Polyneuropathy (CIP) -- Pain Assessment and Treatment -- Language Disorders -- Epilepsy -- Hypopituitarism -- Paroxysmal Sympathetic Hyperactivity (PSH) -- Metabolic and Gastrointestinal Complications -- Discussion and Conclusions -- Appendix -- References -- Chapter 6: Music as Sensory Stimulation and Therapeutic Intervention -- Introduction: Sensory Stimulation in Comatose and DoC Patients -- The Beneficial Effects of Music -- Music in DoC Patients -- Behavioral and Physiological Modulations -- Brain Modulations -- Music Therapy/Intervention -- Music Interventions Using Patient-Preferred Music -- Music Interventions Using Improvised Music -- Combined Approaches -- Music Therapy Within Interdisciplinary Rehabilitation -- Protocols for Music Interventions -- Working with Families -- New Perspectives for Music and Coma -- References -- Chapter 7: Pharmacological Treatments -- Introduction -- Potential Pharmacological Agents -- Amantadine -- Apomorphine -- Levodopa -- Methylphenidate -- Bromocriptine -- Modafinil -- Selegiline -- Zolpidem -- Baclofen -- Underlying Pharmacological Mechanisms -- Clinical Considerations -- Off-Label Use of Specific Medication -- Limitations of Current Research -- Future Directions -- Psychedelics -- The Potential of Whole-Brain Computational Modeling -- Conclusion -- References -- Chapter 8: Emerging Treatment for Patients with Disorders of Consciousness: The Field of Neuromodulation -- Introduction -- Defining the Neurostimulation Target -- Major Neurostimulatory Techniques Being Tested for DOC Treatment -- Central Techniques -- Deep Brain Stimulation (DBS). Transcranial Focused Ultrasound Stimulation (tFUS) -- Bottom-Up Techniques -- Spinal Cord Stimulation (SCS) -- Median Nerve Stimulation (MNS) -- Vagus Nerve Stimulation (VNS) -- Top-Down Techniques -- Transcranial Magnetic Stimulation (TMS) -- Transcranial Electrical Stimulation (tES) -- Conclusion -- Limitations, Future Directions, and Opportunities -- References -- Chapter 9: The Ethics in the Management of Patients with Disorders of Consciousness -- Introduction -- A Heuristic Approach for Identifying Emerging Ethical Issues: Fundamental vs. Practical -- Fundamental Ethical Issues Arising from DOCs -- The Inferential Diagnosis of DOCs -- The Ethical Relevance of the Unconscious -- Practical Ethical Issues -- Misdiagnosis -- Nosology -- The Distributed Responsibility Model -- Institutional Issues -- Clinical Issues -- Interpersonal Issues -- Conclusion -- References -- Chapter 10: Taking Care of Patients with Disorders of Consciousness: Caregivers' Burden and Quality of Life -- Introduction -- Who Is the Informal Caregiver of a Patient with DOC? -- Sociodemographic Characteristics of DOC Patients' Caregivers -- Hours of Care and Support for Caring -- Motivations for Caregiving -- Burden: Definition and Concepts -- Burden and Emotional Distress: The Impact on the Emotional Domain -- Burden as the Impact on Employment, Economic Status, and Leisure Activities of Caregivers -- Burden and Coping Strategies -- Burden as the Impact on Caregivers' Quality of Life -- Caregivers' Involvement During Patients' Assessments -- Caregivers Within the International Guidelines -- Concluding Remarks -- References -- Chapter 11: Models and Systems of Care for Patients with Disorders of Consciousness -- Introduction -- Characteristics of Successful Care Systems in Non-neurological Diseases -- Health Service Delivery Gaps and Opportunities. Existing Models of Systems-Level DoC Care and Research -- The Dutch Model -- History -- Chain of Care Model -- Research Activities Associated with the Chain of Care Model -- Traumatic Brain Injury Model Systems -- TBIMS Infrastructure and Mission -- TBIMS DoC Special Interest Group -- TBIMS DoC-Related Accomplishments -- The Curing Coma Campaign -- Gaps in the Understanding of the Natural History of Coma Recovery -- Impact of the Lack of Data in Hyperacute Management -- COMPOSE Study Addresses the Gap in the Natural History of Coma Recovery -- Moving Toward an Integrated DoC Model System for Clinical Care and Research -- Barrier 1: No Systematic Surveillance Systems to Track and Characterize DoC Admissions -- Barrier 2: Variability in Approaches to Diagnosis, Intervention, and Outcome Assessment in Acute and Chronic Care -- Barrier 3: Limited and Non-Standardized Assessment of Long-Term Recovery -- Barrier 4: Lack of an Infrastructure to Integrate Clinical Data into a Research Database -- A Lesson from the TBI Model Systems -- Conclusion -- References -- Chapter 12: Pediatric DOC: Diagnosis, Prognosis, and Treatment -- Introduction -- Diagnosis -- Neurobehavioral Assessment -- Multi-Modal Assessment -- Neural Abnormalities in Pediatric DoC -- Abnormalities at Rest -- Circadian Abnormalities -- Evoked Abnormalities -- Neuroimaging -- Neurophysiology -- Gaps and Future Directions -- Outcome and Prognosis -- Patient Characteristics -- Neuroimaging -- Neurophysiology -- Gaps and Future Directions -- Treatment -- Gaps and Future Directions -- Summary and Conclusions -- References -- Chapter 13: Near-Death Experiences: What Do We Know? -- Description of the Phenomenon -- Identifying NDEs -- NDE Characteristics -- NDEs Not "Near Death" -- Negative NDEs -- NDE Experiencers' Characteristics -- NDEs and Its Consequences -- Limits and Debates in NDE Research. Explicative Models for NDEs -- Psychological Theories -- Neurobiological Theories -- Conclusion -- References -- Chapter 14: Future Perspectives of Clinical Coma Science -- In the Past … -- Recent Findings on Assessment and Treatment -- In the Future … -- References -- Index. |
| Record Nr. | UNINA-9910841863103321 |
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Schnakers Caroline
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| Cham : , : Springer International Publishing AG, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Coma and Disorders of Consciousness / / edited by Caroline Schnakers, Steven Laureys
| Coma and Disorders of Consciousness / / edited by Caroline Schnakers, Steven Laureys |
| Edizione | [2nd ed. 2018.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (XVII, 276 p. 29 illus., 20 illus. in color.) |
| Disciplina | 616.8 |
| Soggetto topico |
Neurology
Rehabilitation Neurosurgery Psychiatry Neuroradiology Neurology |
| ISBN | 3-319-55964-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Consciousness theories -- Behavioral assessment and diagnosis of disorders of consciousness -- Prognosis in disorders of consciousness -- Neuroimaging in disorders of consciousness -- Electrophysiology in disorders of consciousness -- Caregivers burnout in disorders of consciousness -- Spasticity in disorders of consciousness -- Feasibility of oral feeding in patients with disorders of consciousness -- Sleep in disorders of consciousness -- Sensory stimulation program -- Pharmacological treatments -- Neuromodulation treatments -- Long term care in disorders of consciousness -- Ethics in disorders of consciousness -- Near Death Experience -- Future perspectives of clinical coma science. |
| Record Nr. | UNINA-9910300312203321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The neurology of consciousness [[electronic resource] ] : cognitive neuroscience and neuropathology / / edited by Steven Laureys and Giulio Tononi
| The neurology of consciousness [[electronic resource] ] : cognitive neuroscience and neuropathology / / edited by Steven Laureys and Giulio Tononi |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Boston ; ; London, : Academic, 2009 |
| Descrizione fisica | 1 online resource (438 p.) |
| Disciplina |
153
612.8233 |
| Altri autori (Persone) |
LaureysSteven
TononiGiulio |
| Soggetto topico |
Brain damage
Cognitive neuroscience Consciousness Loss of consciousness Neurology |
| ISBN |
1-282-71135-0
9786612711350 0-08-092102-7 |
| Classificazione |
77.50
CZ 1300 ER 810 WW 2200 YH 3600 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Neurology of Consciousness: Cognitive Neuroscience and Neuropathology; Copyright Page; Contents; Preface; Prologue; List of Contributors; Section I: Basics; Chapter 1. Consciousness: An Overview of the Phenomenon and of Its Possible Neural Basis; DEFINING CONSCIOUSNESS; VARIETIES OF CONSCIOUSNESS; THE NEURAL BASIS OF CONSCIOUSNESS; AN EVOLUTIONARY PERSPECTIVE; REFERENCES; Chapter 2. The Neurological Examination of Consciousness; INTRODUCTION; THE NEUROLOGICAL EXAMINATION; CONSCIOUSNESS; STATES OF IMPAIRED CONSCIOUSNESS
NEUROLOGICAL EXAMINATION IN CLASSIC STATES OF IMPAIRED CONSCIOUSNESSNEUROLOGICAL EXAMINATION IN OTHER STATES OF IMPAIRED CONSCIOUSNESS; STATES RESEMBLING IMPAIRED CONSCIOUSNESS; SUMMARY AND CONCLUSIONS; ACKNOWLEDGEMENTS; REFERENCES; Chapter 3. Functional Neuroimaging; POSITRON EMISSION TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS; MAGNETOENCEPHALOGRAPHY; TRANSCRANIAL MAGNETIC STIMULATION; MAGNETIC RESONANCE SPECTROSCOPY; FUNCTIONAL NEUROIMAGING STUDY DESIGN; ANALYSING BRAIN IMAGING DATA MULTI-MODALITY AND REAL-TIME INTEGRATIONACKNOWLEDGEMENTS; REFERENCES; Chapter 4. Consciousness and Neuronal Synchronization; TWO REPRESENTATIONAL STRATEGIES; THE SIGNATURE OF DISTRIBUTED CODES; EXPERIMENTAL EVIDENCE FOR GROUPING BY SYNCHRONY; RESPONSE SYNCHRONIZATION AND BEHAVIOURAL STATES; PERCEPTION AND RESPONSE SYNCHRONIZATION; THE GENERALITY OF SYNCHRONICITY; SYNCHRONIZED GAMMA OSCILLATIONS AND CONSCIOUS PERCEPTION; AN ATTEMPT OF SYNTHESIS; REFERENCES; Chapter 5. Neural Correlates of Visual Consciousness; BRAIN ACTIVITY ASSOCIATED WITH VISUAL STIMULI THAT DO NOT REACH AWARENESS UNPROMPTED (INVOLUNTARY) CHANGES IN THE CONTENTS OF VISUAL AWARENESSDELIBERATE CHANGES TO THE CONTENTS OF VISUAL AWARENESS; NECESSARY AND SUFFICIENT CORRELATES OF CONSCIOUSNESS; OVERALL SUMMARY AND FUTURE DIRECTIONS; ACKNOWLEDGEMENT; REFERENCES; Chapter 6. The Relationship Between Consciousness and Attention; INTRODUCTION; FUNCTIONAL CONSIDERATIONS; THE FOUR-FOLD WAY OF PROCESSING VISUAL EVENTS AND BEHAVIOURS; ATTENTION WITHOUT CONSCIOUSNESS; CONSCIOUSNESS IN THE ABSENCE OF ATTENTION; PROCESSING WITHOUT TOP-DOWN ATTENTION AND CONSCIOUSNESS; ATTENTION AND CONSCIOUSNESS CAN OPPOSE EACH OTHER PHYSIOLOGICAL TECHNIQUES THAT DEMONSTRATE DISSOCIATIONS BETWEEN ATTENTION AND CONSCIOUSNESSRELATIONSHIP TO OTHER CONCEPTUAL DISTINCTIONS; NEURONAL SUBSTRATE TO CONSCIOUSNESS WITHOUT ATTENTION; DO THESE CONCLUSIONS HOLD FOR REAL LIFE?; QUESTIONS FOR FURTHER RESEARCH; ACKNOWLEDGEMENTS; REFERENCES; Section II: Waking, Sleep and Anaesthesia; Chapter 7. Intrinsic Brain Activity and Consciousness; BACKGROUND; BRAIN IMAGING; ACTIVITY DECREASES; 'NOISE' IN THE FMRI BOLD SIGNAL; A CONCEPTUAL FRAMEWORK; FUTURE QUESTIONS; REFERENCES; Chapter 8. Sleep and Dreaming; SLEEP STAGES AND CYCLES BRAIN CENTRES REGULATING WAKEFULNESS AND SLEEP |
| Record Nr. | UNINA-9910782209703321 |
| Amsterdam ; ; Boston ; ; London, : Academic, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The neurology of consciousness : cognitive neuroscience and neuropathology / / edited by Steven Laureys and Giulio Tononi
| The neurology of consciousness : cognitive neuroscience and neuropathology / / edited by Steven Laureys and Giulio Tononi |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Boston ; ; London, : Academic, 2009 |
| Descrizione fisica | 1 online resource (438 p.) |
| Disciplina |
153
612.8233 |
| Altri autori (Persone) |
LaureysSteven
TononiGiulio |
| Soggetto topico |
Brain damage
Cognitive neuroscience Consciousness Loss of consciousness Neurology |
| ISBN |
1-282-71135-0
9786612711350 0-08-092102-7 |
| Classificazione |
77.50
CZ 1300 ER 810 WW 2200 YH 3600 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Neurology of Consciousness: Cognitive Neuroscience and Neuropathology; Copyright Page; Contents; Preface; Prologue; List of Contributors; Section I: Basics; Chapter 1. Consciousness: An Overview of the Phenomenon and of Its Possible Neural Basis; DEFINING CONSCIOUSNESS; VARIETIES OF CONSCIOUSNESS; THE NEURAL BASIS OF CONSCIOUSNESS; AN EVOLUTIONARY PERSPECTIVE; REFERENCES; Chapter 2. The Neurological Examination of Consciousness; INTRODUCTION; THE NEUROLOGICAL EXAMINATION; CONSCIOUSNESS; STATES OF IMPAIRED CONSCIOUSNESS
NEUROLOGICAL EXAMINATION IN CLASSIC STATES OF IMPAIRED CONSCIOUSNESSNEUROLOGICAL EXAMINATION IN OTHER STATES OF IMPAIRED CONSCIOUSNESS; STATES RESEMBLING IMPAIRED CONSCIOUSNESS; SUMMARY AND CONCLUSIONS; ACKNOWLEDGEMENTS; REFERENCES; Chapter 3. Functional Neuroimaging; POSITRON EMISSION TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS; MAGNETOENCEPHALOGRAPHY; TRANSCRANIAL MAGNETIC STIMULATION; MAGNETIC RESONANCE SPECTROSCOPY; FUNCTIONAL NEUROIMAGING STUDY DESIGN; ANALYSING BRAIN IMAGING DATA MULTI-MODALITY AND REAL-TIME INTEGRATIONACKNOWLEDGEMENTS; REFERENCES; Chapter 4. Consciousness and Neuronal Synchronization; TWO REPRESENTATIONAL STRATEGIES; THE SIGNATURE OF DISTRIBUTED CODES; EXPERIMENTAL EVIDENCE FOR GROUPING BY SYNCHRONY; RESPONSE SYNCHRONIZATION AND BEHAVIOURAL STATES; PERCEPTION AND RESPONSE SYNCHRONIZATION; THE GENERALITY OF SYNCHRONICITY; SYNCHRONIZED GAMMA OSCILLATIONS AND CONSCIOUS PERCEPTION; AN ATTEMPT OF SYNTHESIS; REFERENCES; Chapter 5. Neural Correlates of Visual Consciousness; BRAIN ACTIVITY ASSOCIATED WITH VISUAL STIMULI THAT DO NOT REACH AWARENESS UNPROMPTED (INVOLUNTARY) CHANGES IN THE CONTENTS OF VISUAL AWARENESSDELIBERATE CHANGES TO THE CONTENTS OF VISUAL AWARENESS; NECESSARY AND SUFFICIENT CORRELATES OF CONSCIOUSNESS; OVERALL SUMMARY AND FUTURE DIRECTIONS; ACKNOWLEDGEMENT; REFERENCES; Chapter 6. The Relationship Between Consciousness and Attention; INTRODUCTION; FUNCTIONAL CONSIDERATIONS; THE FOUR-FOLD WAY OF PROCESSING VISUAL EVENTS AND BEHAVIOURS; ATTENTION WITHOUT CONSCIOUSNESS; CONSCIOUSNESS IN THE ABSENCE OF ATTENTION; PROCESSING WITHOUT TOP-DOWN ATTENTION AND CONSCIOUSNESS; ATTENTION AND CONSCIOUSNESS CAN OPPOSE EACH OTHER PHYSIOLOGICAL TECHNIQUES THAT DEMONSTRATE DISSOCIATIONS BETWEEN ATTENTION AND CONSCIOUSNESSRELATIONSHIP TO OTHER CONCEPTUAL DISTINCTIONS; NEURONAL SUBSTRATE TO CONSCIOUSNESS WITHOUT ATTENTION; DO THESE CONCLUSIONS HOLD FOR REAL LIFE?; QUESTIONS FOR FURTHER RESEARCH; ACKNOWLEDGEMENTS; REFERENCES; Section II: Waking, Sleep and Anaesthesia; Chapter 7. Intrinsic Brain Activity and Consciousness; BACKGROUND; BRAIN IMAGING; ACTIVITY DECREASES; 'NOISE' IN THE FMRI BOLD SIGNAL; A CONCEPTUAL FRAMEWORK; FUTURE QUESTIONS; REFERENCES; Chapter 8. Sleep and Dreaming; SLEEP STAGES AND CYCLES BRAIN CENTRES REGULATING WAKEFULNESS AND SLEEP |
| Record Nr. | UNINA-9910828870403321 |
| Amsterdam ; ; Boston ; ; London, : Academic, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||