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3D Printing of Pharmaceutical and Drug Delivery Devices : Progress from Bench to Bedside
3D Printing of Pharmaceutical and Drug Delivery Devices : Progress from Bench to Bedside
Autore Lamprou Dimitrios A
Edizione [1st ed.]
Pubbl/distr/stampa Newark : , : John Wiley & Sons, Incorporated, , 2024
Descrizione fisica 1 online resource (265 pages)
Disciplina 615.19
Altri autori (Persone) DouroumisDennis
QiSheng
Collana Advances in Pharmaceutical Technology Series
ISBN 1-119-83600-X
1-119-83598-4
1-119-83599-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- 3D Printing of Pharmaceutical and Drug Delivery Devices -- Contents -- About the Editors -- List of Contributors -- Series Preface -- Preface -- 1 Materials for 3D Printing -- 1.1 Introduction -- 1.2 Material Processability Considerations for Pharmaceutical 3DP -- 1.2.1 Thermal Extrusion-Based 3D Printing -- 1.2.1.1 Thermal Considerations -- 1.2.1.2 Solubility Enhancement -- 1.2.1.3 Mechanical Considerations -- 1.2.2 Semi-Solid Extrusion 3DP -- 1.2.2.1 Rheological Considerations -- 1.2.2.2 Example Applications -- 1.2.3 Powder Bed Fusion 3D Printing -- 1.2.3.1 Powder Flowability Considerations -- 1.2.3.2 Powder Packing Density Considerations -- 1.2.3.3 Powder Energy Absorbance Considerations -- 1.2.4 Stereolithography 3D Printing -- 1.3 Classification of Common Materials Used in Pharmaceutical 3DP -- 1.3.1 Alcohol Derived Polymers -- 1.3.2 Eudragits -- 1.3.3 Other Polymers -- 1.3.4 Graft Polymers -- 1.3.5 Photocrosslinkable -- 1.3.6 Natural Materials -- 1.3.7 Lipid Materials -- 1.4 Conclusions and Future Perspectives -- References -- 2 The Use of Microstructure Design and 3D Printing for Tailored Drug Release -- 2.1 Introduction -- 2.2 3D-Printing Technologies -- 2.3 3D Design for Drug-Loaded Device -- 2.3.1 CAD Design-Based Design -- 2.3.2 Computational Software-Based Design -- 2.3.3 3D-Printing Parameter-Based Design -- 2.3.4 Polypills and Complex Designs -- 2.4 3D Designs Influence Drug Release -- 2.4.1 Controlling Drug Release -- 2.4.2 Modifying Drug Release -- 2.5 Challenges and Perspective -- References -- 3 3D Printing of Oral Solid Dosage Forms Using Selective Laser Sintering -- 3.1 Introduction -- 3.2 Operational Principles of Selective Laser Sintering -- 3.2.1 Manufacturing Challenges for SLS -- 3.2.2 Laser Selection and Scanning Speed -- 3.2.3 Powder Material Parameters -- 3.2.4 Powder Bed and Recoater Parameters.
3.3 3D-Printed Oral Dosages -- 3.4 Advantages of SLS -- 3.4.1 Printing Features -- 3.4.2 Control of Surface Properties -- 3.4.3 Printing of Complex Geometries -- 3.4.4 Using a Wide Range of Materials -- 3.4.5 Drug Loading and Dose Combinations -- 3.4.6 Personalised Dosage Forms -- 3.4.7 SLS Disadvantages -- 3.5 Conclusions -- References -- 4 3D Printing for Medical Device Applications -- 4.1 Introduction -- 4.2 3D Printers -- 4.2.1 SLA -- 4.2.2 FFF -- 4.2.3 Selective Laser Sintering (SLS) -- 4.3 Biomaterials for 3D-Printed Medical Devices -- 4.3.1 Bioresorbable Polymers -- 4.3.1.1 Synthetic Bioresorbable Polymers -- 4.3.1.2 Natural Bioresorbable Polymers -- 4.3.2 Non-Bioresorbable Polymers -- 4.3.3 Smart Polymers -- 4.3.4 Metal and Ceramic -- 4.4 3D-Printed Personalised Medical Devices -- 4.4.1 Vascular Repair Devices -- 4.4.2 Splints -- 4.4.3 Nerve Guidance Conduits -- 4.4.4 Tissue Engineering -- 4.4.5 3D Printing in Dentistry -- 4.4.6 3D-Printed Orthopaedic Devices -- 4.5 Regulatory -- 4.6 Future Perspectives -- References -- 5 3D Printed Implants for Long-Acting Drug Delivery -- 5.1 Introduction -- 5.2 Types of 3D-Printed Scaffolds -- 5.2.1 Implantable Scaffolds -- 5.2.1.1 Passive Implants -- 5.2.1.2 Active Implants -- 5.2.2 Injectable Scaffolds -- 5.2.3 Innovative 3D-Printed Scaffolds -- 5.3 Critical Parameters in Designing 3D-Printed Implantable Scaffolds -- 5.3.1 Structural Characteristics -- 5.3.1.1 Geometry of Implants -- 5.3.1.2 Porosity Properties and Pore Features -- 5.3.1.3 Surface Properties -- 5.3.2 Mechanical Properties -- 5.3.3 Biological and Physiological Parameters -- 5.3.3.1 Cellular Adhesion -- 5.3.3.2 Absorption and Degradation Rates -- 5.3.3.3 Biocompatibility Aspects -- 5.4 Critical Parameters in Selecting Materials for 3D-Printed Scaffolds -- 5.4.1 Materials Used in 3D-Printed Long-Acting Scaffolds -- 5.4.1.1 Natural Polymers.
5.4.1.2 Synthetic Polymers -- 5.4.1.3 Ceramics and Metals -- 5.4.1.4 Composites -- References -- 5.5 Manufacturing Techniques for Implantable Scaffolds -- 5.5.1 Hot-Melt Extrusion -- 5.5.2 Compression -- 5.5.3 Injection Moulding -- 5.5.4 Solvent Casting -- 5.5.5 3D Printing -- 5.5.6 Scale-Up in 3D-Printing Process for the Manufacturing of Scaffolds -- 5.6 Drug Release Mechanism of Long-Acting 3D-Printing Polymeric Implantable Systems -- 5.7 Outlining Regulatory Framework for 3D-Printed Implantable Scaffolds -- 5.7.1 Commercial Implantable Scaffolds -- 5.8 Conclusions -- References -- 6 Wound Dressings by 3D Printing -- 6.1 Wound Healing Process -- 6.1.1 Haemostasis/Coagulation -- 6.1.2 Inflammation -- 6.1.3 Proliferation -- 6.1.4 Re-epithelisation/Remodelling -- 6.1.5 Wound Classification -- 6.1.6 Wound Dressings -- 6.1.7 3D Printing -- 6.1.8 3D-Printed Dressings -- 6.2 Case Studies -- 6.3 Summary/Conclusions -- References -- 7 3D Printing of Hydrogels -- 7.1 Introduction -- 7.2 Applications of 3D-Printed Hydrogels -- 7.2.1 Tissue Engineering -- 7.2.2 Wound Healing -- 7.2.3 Drug Delivery -- 7.3 Types of Hydrogel Materials for 3D Printing -- 7.3.1 Natural Polymers -- 7.3.2 Synthetic Polymers -- 7.3.3 Natural-Synthetic Hybrid Polymers -- 7.3.4 Ionically Charged Polymers -- 7.3.5 Crosslinked Polymers -- 7.3.6 Method of Hydrogel Preparation -- 7.4 3D Printing Techniques for Hydrogels -- 7.4.1 Laser-Based 3D Printing -- 7.4.1.1 Stereolithography -- 7.4.1.2 Two-Photon Polymerisation -- 7.4.1.3 Laser-Induced Forward Transfer -- 7.4.2 Extrusion-Based Printing -- 7.4.3 Inkjet-Based Printing -- 7.5 Printability and Printing Parameters -- 7.5.1 Bioink Design -- 7.5.1.1 Materials Selection, Concentration and Viscosity -- 7.5.1.2 Rheological Properties -- 7.5.1.3 Shear-Thinning -- 7.5.1.4 Viscoelasticity and Yield Stress -- 7.5.1.5 Cell Encapsulation.
7.5.2 Crosslinking Techniques -- 7.5.2.1 Thermal Crosslinking -- 7.5.2.2 Physical Ionic Crosslinking -- 7.5.2.3 Chemical Crosslinking -- 7.5.2.4 Photocrosslinking -- 7.5.3 3D Printing Parameters -- 7.5.3.1 Temperature -- 7.5.3.2 Pressure -- 7.5.3.3 Speed -- 7.6 Clinical Translation -- 7.6.1 Regulatory Considerations -- 7.6.2 Manufacturing Considerations -- 7.6.3 Limitations and Future Direction -- 7.7 Conclusions -- References -- 8 Analytical Characterisation of 3D-Printed Medicines -- 8.1 Introduction -- 8.2 Preformulation -- 8.2.1 Thermal Analysis -- 8.2.2 X-Ray Powder Diffraction (XRPD) -- 8.2.3 Infrared Spectroscopy -- 8.2.4 Hot-Stage Microscopy (HSM) -- 8.2.5 Customizsd Sample Preparation for the Preformulation Protocol -- 8.3 In-Process Characterisations -- 8.3.1 Mechanical Analysis -- 8.3.2 Rheological Analysis -- 8.3.3 Drug Characterisation -- 8.4 Final Product -- 8.4.1 Morphological Analysis -- 8.4.2 X-Ray Computed Microtomography (XμCT) -- 8.4.3 Terahertz Pulsed Imaging (TPI) -- 8.4.4 Mercury Porosimetry -- 8.4.5 Helium Pycnometry -- 8.5 Conclusions -- References -- 9 Adoption of 3D Printing in Pharmaceutical Industry -- 9.1 Partnering and Growing -- 9.2 Regulatory Strategy -- 9.2.1 Product Development -- 9.2.2 Manufacturing -- 9.3 Business Model -- 9.3.1 In-House Pipeline Products -- 9.3.2 Co-Development -- 9.4 Regulatory Strategy -- 9.5 Partnering and Growing -- 9.6 Business Model and Strategy -- 9.6.1 Closing Remarks -- References -- 10 Clinical Benefits of 3D Printing in Healthcare -- 10.1 Introduction -- 10.2 3D Printing Technologies -- 10.2.1 Binder Jetting -- 10.2.2 Vat Photopolymerization -- 10.2.3 Powder Bed Fusion -- 10.2.4 Material Jetting -- 10.2.5 Material Extrusion -- 10.2.5.1 Fused Deposition Modelling -- 10.2.5.2 Semi-Solid Extrusion -- 10.2.5.3 Direct Powder Extrusion -- 10.3 Preclinical Applications of 3D Printing.
10.3.1 Immediate and Modified Release Oral Printlets -- 10.3.2 3D-Printed Drug Delivery Devices for Other Routes of Administration -- 10.4 Clinical Applications of 3D Printing -- 10.4.1 Personalised Medications -- 10.4.2 Improved Acceptability and Medication Compliance -- 10.4.2.1 Paediatric Patients -- 10.4.2.2 Adult and Geriatric Patients -- 10.4.3 Mass Manufacturing -- 10.4.4 Decentralised On-Demand Fabrication -- 10.4.5 Veterinary Applications -- 10.5 Challenges, Regulatory View and Future Applications -- 10.6 Conclusion -- References -- 11 Regulatory Aspects of 3D-Printed Medicinal Products -- 11.1 Introduction -- 11.2 Current Regulatory Framework -- 11.3 Quality Aspects of 3D-Printed Medicinal Products -- 11.4 3D-Printed Paediatric Medicinal Products -- 11.5 3D-Printed Systems With Tailored Release Profiles -- 11.6 Conclusions -- Disclaimer -- References -- Index -- EULA.
Record Nr. UNINA-9910857797503321
Lamprou Dimitrios A  
Newark : , : John Wiley & Sons, Incorporated, , 2024
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
3D Printing of Pharmaceuticals and Drug Delivery Devices
3D Printing of Pharmaceuticals and Drug Delivery Devices
Autore Lamprou Dimitrios A
Pubbl/distr/stampa Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020
Descrizione fisica 1 electronic resource (436 p.)
Soggetto topico Medicine
Soggetto non controllato digital pharmacy
fused deposition modeling 3D printing
modified drug release
personalized medicines
telemedicine
three dimensional printing
additive manufacturing
3D printed drug products
printlets
personalised medicines
personalized pharmaceuticals
multiple units
spheroids
beads
acetaminophen
3D printing
fused filament fabrication
lignin
antioxidant materials
wound dressing
modified release
filament extrusion
fused layer modeling
theophylline
high API load
three-dimensional printing
fixed-dose combinations
tablets
multiple-layer dosage forms
stereolithography
vat polymerisation
fused deposition modeling
polylactic acid
chemical modification
MTT assay
biofilm formation
warfarin
semisolid extrusion 3D printing
inkjet printing
orodispersible film
oral powder
pediatric
hospital pharmacy
personalized medicine
on-demand manufacturing
drug delivery
micromedicine
drug development
micro-swimmer
micro-implant
oral dosages
microneedle
high-precision targeting
controlled release
geometry
resolution
feature size
release profile
vascularization
digital light processing technology
neural networks
optimization
prediction
FMD
pregabalin
gastric floating
complex structures
patient-specific
structural design
gums
Fused Deposition Modeling 3D Printing
processing parameters
pharmaceutical quality control
hot-melt extrusion
solid dosage forms
3D printed oral dosage forms
sustained drug release tablets
photopolymerization
paracetamol (acetaminophen)
aspirin (acetylsalicylic acid)
amorphous solid dispersion
poor solubility
fixed dose combination
stencil printing
pharmacoprinting
orodispersible discs
orodisperible films
floating systems
pulsatile release
chronotherapeutic delivery
wound-healing
3D bio-printing
pectin
propolis
cyclodextrin
3D bio-inks
fused deposition modelling
extrusion
vaginal meshes
mechanical properties
drug release
anti-infective devices
pelvic organ prolapse
stress urinary incontinence
gastro-retentive floating system
dissolution kinetics
implantable devices
subcutaneous
biodegradable
prolonged drug delivery
polymers
pharmaceuticals
extrusion-based 3D printing
fused deposition modeling (FDM)
pressure-assisted microsyringe (PAM)
materials
process
3D bioprinting
polymeric ink
pseudo-bone
implantable scaffold
computer-aided design (CAD) design
bioprinting
computer-aided design (CAD)
pharmaceutics
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910557780703321
Lamprou Dimitrios A  
Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui