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Oxygen Transport to Tissue XL [[electronic resource] /] / edited by Oliver Thews, Joseph C. LaManna, David K. Harrison
Oxygen Transport to Tissue XL [[electronic resource] /] / edited by Oliver Thews, Joseph C. LaManna, David K. Harrison
Edizione [1st ed. 2018.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018
Descrizione fisica 1 online resource (435 pages)
Disciplina 616.2
Collana Advances in Experimental Medicine and Biology
Soggetto topico Medicine
Biomedicine, general
ISBN 3-319-91287-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cerebral Angioplasticity: The Anatomical Contribution to Ensuring Appropriate Oxygen Transport to Brain -- Changes in Cytochrome-C-Oxidase Account for Changes in Attenuation of Near-Infrared Light in the Healthy Infant Brain -- Hyperspectral Imaging of the Hemodynamic and Metabolic States of the Exposed Cortex: Investigating a Commercial Snapshot Solution -- Impact of Aging on Metabolic Changes in the Ketotic Rat Brain: Glucose, Oxidative and 4-HNE Metabolism -- Increases in Microvascular Perfusion and Tissue Oxygenation via Vasodilatation after Anodal Transcranial Direct Current Stimulation in the Healthy and Traumatized Mouse Brain -- Fluctuations of Nutrition-associated Markers After Decompressive Hemicraniectomy in Middle Cerebral Artery Occlusion Patients -- Resuscitation Fluid with Drag Reducing Polymer Enhances Cerebral Microcirculation and Tissue Oxygenation after Traumatic Brain Injury Complicated by Hemorrhagic Shock -- Comparison of Quantitative and Qualitative Oxygen Extraction Fraction (OEF) in Acute Stroke Patients with Large Vessel Occlusion -- Relation Between Asymmetry of Prefrontal Activity and Autonomic Nervous System in Post-stroke Patients with a Disorder of Consciousness -- Cerebral Hemodynamics after Transcranial Direct Current Stimulation (tDCS) in Patients with Consequences of Traumatic Brain Injury -- Differences in Tissue Oxygenation, Perfusion and Optical Properties in Brain Areas Affected by Stroke: A Time-resolved NIRS Study -- Changes of Doublecortin-immunoreactive Cells from the Acute Phase to Chronic Phase after Transient Global Brain Ischemia in Rat Cingulate Cortex -- Post-resuscitation Arterial Blood Pressure on Survival and Change of Capillary Density following Cardiac Arrest and Resuscitation in Rats -- Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine Study -- Effects of Aerobic Cycling Training on O2 Dynamics in Several Leg Muscles in Early Post-Myocardial Infarction -- Evaluation of Functional Hyperemia using NIRTRS without the Influence of Fat Layer Thickness -- Changes in Spinal Muscle Oxygenation and Perfusion during the Biering-Sørensen Test: Preliminary Results of a Study Employing NIRS-based Muscle Oximetry -- Near Infrared Spectroscopy (NIRS) Observation of Vastus Lateralis (muscle) and Prefrontal Cortex (brain) Tissue Oxygenation during Synchronised Swimming Routines in Elite Athletes -- Impact of Changes in Systemic Physiology on fNIRS/NIRS Signals: Analysis Based on Oblique Subspace Projections Decomposition -- Changes in Cerebral Oxyhaemoglobin Levels During and After a Single 20-minute Bout of Moderate-intensity Cycling -- Changes in the Prefrontal Cortex Oxygenation Levels during Cycling in the Supine and Upright Positions -- Trail Making Test Induces Prefrontal Cortex Activation as Revealed by a cw Wearable-Wireless fNIRS/DOT Imager -- Prediction of MMSE Score Using Time-resolved Near-infrared Spectroscopy -- Broadband NIRS Cerebral Cytochrome-C-Oxidase Response to Anoxia Before and After Hypoxic-Ischaemic Injury in Piglets -- Synchronized Oscillations of Arterial Oxygen Saturation, Cerebral Tissue Oxygenation and Heart Rate in Preterm Neonates: Investigation of Long-Term Measurements with Multiple Einstein’s Cross Wavelet Analysis -- Multispectral Near-Infrared Optical Tomography for Cancer Hypoxia Study in Mice -- Hypoxia-/HIF-1α-Driven Factors of the Tumor Microenvironment Impeding Antitumor Immune Responses and Promoting Malignant Progression -- Differential Expression of PGC1α in Intratumor Redox Subpopulations of Breast Cancer -- Accounting for Two Forms of Hypoxia for Predicting Tumour Control Probability in Radiotherapy: An In Silico Study -- Impact of Temporal Heterogeneity of Acute Hypoxia on the Radiation Response of Experimental Tumors -- Mathematical Description of Changes in Tumour Oxygenation from Repeated Functional Imaging -- An In Vitro Model for Determining Tumor Cell Migration Under Metabolic Gradients -- Expression of MicroRNAs in Fibroblasts and Macrophages Is Regulated by Hypoxia-Induced Extracellular Acidosis -- Influence of Extracellular Acidosis on Matrix Protein Homeostasis in Tumour Cells and Fibroblasts -- Novel Redox Active Tyrosine Mutations Enhance the Regeneration of Functional Oxyhemoglobin from Methemoglobin: Implications for Design of Blood Substitutes -- Septic-induced microRNA Expression Modulations are linked to Angiogenesis, Vasomotion, and Hypoxia-induced Processes -- Guidance to Transfer ‘Bench-ready’ Medical Technology into Usual Clinical Practice - Case Study: Sensors and Spectrometer used in EPR Oximetry -- Regulation of Oxygen Tension in the Mammalian Retina During Systemic Hyperoxia is Species Dependent -- Intravital Observation of Microvascular Remodeling during Chronic Exposure to Hypoxia in Mice -- Analysis of Aortic Remodeling and Stiffness in Patients with Obstructive Sleep Apnea Syndrome: Preliminary Results -- Does Vascular Endothelial Cell or Smooth Muscle affect the Decrease in Oxygen Consumption of Arteriolar Wall during Vasodilation -- Hyperbaric Oxygen Therapy in Necrotizing Soft Tissue Infections: A Retrospective Study -- Dynamic Exercise Elicits Dissociated Changes between Tissue Oxygenation and Cerebral Blood Flow in the Prefrontal Cortex: A Study using NIRS and PET -- Mucine-1 is Related to Cell-Mediated Immunoexpression and Blood Pressure in Pulmonary Artery in Pulmonary Arterial Hypertension (PAH): Preliminary Results -- The Mitochondrial Na+/Ca2+ Exchanger is Necessary but not Sufficient for Ca2+ Homeostasis and Viability -- Hemoglobin Dynamics in the Skeletal Muscle of Patients with Malignant Hematopoietic Disease -- Fatigue, Muscle Oxygen Consumption and Blood Flow to the Skeletal Muscle after Allogeneic Hematopoietic Stem Cell Transplantation -- Reliability of Wearable Two Channel CW-NIRS in Measurements of Brain Function -- Investigation of Confounding Factors in Measuring Tissue Saturation with NIRS Spatially Resolved Spectroscopy -- Discrimination of Complex Activation Patterns in Near Infrared Optical Tomography with Artificial Neural Networks -- ABroAD: A Machine Learning Based Approach to Detect Broadband NIRS Artefacts -- Absolute Values of Optical Properties (µa, µs', µeff and DPF) of Human Head Yissue: Dependence on Head Region and Individual -- Long-term Changes in Optical Properties (µa, µs', µeff and DPF) of Human Head Tissue during Functional Neuroimaging Experiments -- A Fibreless Multiwavelength NIRS System for Imaging Localised Changes in Cerebral Oxidised Cytochrome C Oxidase -- Use of a Turn Coil and Channel above a GMR-SV Device to Observe and Measure the Properties of Deoxidized Red Blood Cells Coupled to Magnetic Beads -- Long-term in vivo Oxygen Sensors for Peripheral Artery Disease Monitoring -- A New Method Based on Virtual Fluence Detectors and Software Toolbox for Handheld Spectral Optoacoustic Tomography -- Computerized Video-capillaroscopy Alteration Related to Diabetes Mellitus and its Complications -- Contrast Ratio Quantification during Visualization of Microvasculature -- In vitro Comparisons of Near-Infrared Spectroscopy Oximeters: Impact of Slow Changes in Scattering of Liquid Phantoms -- Liquid Blood Phantoms to Validate NIRS Oximeters: Yeast versus Nitrogen for Deoxygenation -- Visualization of Methemoglobin Distribution in Tissues: Phantom Validation -- Polyunsaturated Fatty Acids induce ROS Synthesis in Microvascular Endothelial Cells -- Effect of Chain Unsaturation and Temperature on Oxygen Diffusion through Lipid Membranes from Simulations -- Reduced Oxygen Permeability upon Protein Incorporation within Phospholipid Bilayers -- Sanal-Cell Cycle and Primo Vascular System: Regeneration via Sanals -- Role of CXCR4 antagonist in Megakaryocyte Reinstatement with Increased Sinusoidal Vessel Density -- Solid-phase Extraction with Packed-Fiber is a Biological Sample Preparation Tool for Neuro-active Molecule Detection -- Salivary Alpha-amylase and Behavior Reaction in Acute Stress and the Impact of Tridimensional Personality.
Record Nr. UNINA-9910298394603321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Oxygen Transport to Tissue XLI [[electronic resource] /] / edited by Pan-Dong Ryu, Joseph C. LaManna, David K. Harrison, Sang-Suk Lee
Oxygen Transport to Tissue XLI [[electronic resource] /] / edited by Pan-Dong Ryu, Joseph C. LaManna, David K. Harrison, Sang-Suk Lee
Autore Russell-Buckland Joshua
Edizione [1st ed. 2020.]
Pubbl/distr/stampa Springer Nature, 2020
Descrizione fisica 1 online resource (425 pages)
Disciplina 572.47
Collana Advances in Experimental Medicine and Biology
Soggetto topico Medicine
Biomedicine, general
Soggetto non controllato Broadband NIRS, Hypothermia, Systems biology
ISBN 3-030-34461-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part I Brain Oxygenation and Function -- Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury -- Nonlinear Transfer Entropy to Assess the Neurovascular Coupling in Premature Neonates -- Reference Value of Brain Tissue Oxygen Saturation in Newborns Immediately after Birth -- Relationship between Brain Tissue Oxygenation and Metabolism during Rewarming after Neonatal Hypoxia-Ischaemia Relates to Initial Electrical Abnormality -- Impact of Skull Thickness on Cerebral NIRS Oximetry in Neonates: An in silico Study -- Resuscitation with Drag Reducing Polymer after Traumatic Brain Injury with Hemorrhagic Shock Reduces Microthrombosis and Oxidative -- Anodal Transcranial Direct Current Stimulation Improves Impaired Cerebrovascular Reactivity in Traumatized Mouse Brain -- Comparative Analysis of Simultaneous Transcranial Doppler and Perfusion Computed Tomography for Cerebral Perfusion Evaluation in Patients with Traumatic Brain Injury -- Meningeal Lymphatic Pathway of Brain Clearing from the Blood after Hhaemorrhagic Injuries -- Relationship between Cerebral Oxygenation and Skin Blood Flow at the Frontal Lobe during Progressive Hypoxia: Impact of Acute Hypotension -- Cerebral Autoregulation during Active Standing Test in Juvenile Patients with Instantaneous Orthostatic Hypotension -- Cerebral Blood Oxygenation Changes in Juvenile Patients with Delayed Orthostatic Hypotension during an Active Standing Test -- Relationship Between Cognitive Dysfunction and Systemic Metabolic Disorders in Elderly: Dementia Might be a Systematic Disease -- Relationship Between Cerebral Blood Oxygenation and Electrical Activity During Mental Stress Tasks: Simultaneous Measurements of NIRS and EEG -- Right-Left Asymmetry of Prefrontal Cerebral Oxygenation: Does it Depend on Systemic Physiological Activity, Absolute Tissue Oxygenation or Hemoglobin Concentration?- Effect of Gum Chewing on PFC Activity during Discomfort Sound Stimulation -- Effect of Mastication Muscle Activity on Prefrontal Cortex NIRS Measurement: a Pilot Study -- Part II Tumor Oxygenation and Metabolism -- Hypoxia Compromises Anti-Cancer Immune Responses - Peter Vaupel Lecture -- ‘Oxygen Level in a Tissue’ - What do Available Measurements Really Report?- Clinical and Statistical Considerations when Assessing Oxygen Levels in Tumors: Illustrative Results from Clinical EPR Oximetry Studies -- Fatal Alliance of Hypoxia-/HIF-1α-driven Microenvironmental Traits Promoting Cancer Progression -- Quantification of Tumor Oxygenation based on FMISO PET: Influence of Location and Oxygen Level of the Well-Oxygenated Reference Region -- Pathways of Oxygen Diffusion in Cells and Tissues: Hydrophobic channeling via networked lipids -- Part III Muscle Oxygenation and Sports Medicine -- Effect of Exercise Duration on Post-exercise Persistence of Oxyhemoglobin Changes in the Premotor Cortex: A Near-infrared Spectroscopy Study in Moderate-intensity Cycling Exercise -- Relationship Between Muscle Oxygen Saturation and Exercise Load in Patients with Malignant Hematopoietic Disease -- Comparison of the Effects of Continuous and Intermittent Exercise on Cerebral Oxygenation and Cognitive Function -- Relationship between Exercise Capacity and Muscle O2Hb saturation in Patients before Hematopoietic Stem-Cell Transplantation -- Differences in Muscle O2 Dynamics During Treadmill Exercise Between Aerobic Capacity-matched Overweight and Normal-weight Adults -- Cerebral Oxygenation Dynamics of the Prefrontal Cortex and Motor-Related Area During Cardiopulmonary Exercise Test: A Near-infrared Spectroscopy Study -- Reduced Optical Path Length in the Vastus Lateralis during Ramp Cycling Exercise -- Improvements in Skeletal Muscle can be Detected using Broadband NIRS in First-Time Marathon Runners -- Comparison of Two NIRS Tissue Oximeters (Moxy and Nimo) for Non-invasive Assessment of Muscle Oxygenation and Perfusion -- Part IV Cell Metabolism and Tissue Oxygenation -- Effects of Pulsed Magnetic Field on the Hemolysis of Erythrocytes Exposed to Oxidative Stress -- Role of Microtubule-associated Factors in HIF1α Nuclear Translocation -- Extracellular Acidosis Regulates the Expression of Inflammatory Mediators in Rat Epithelial Cells -- Part V Methodology of O2 Measurements -- Reducing False Alarm Rates in Neonatal Intensive Care: A New Machine Learning Approach -- Development of an IoT-based Monitoring System for Healthcare: A Preliminary Study -- Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism -- Validation and Comparison of Monte Carlo and Finite Element Method in Forward Modeling for Near Infrared Optical Tomography -- Development of a Cuff-less Blood Pressure Monitoring System and its Application -- Usefulness of a New Device to Monitor Cerebral Blood Oxygenation using NIRS during Cardiopulmonary Resuscitation in Patients with Cardiac Arrest: A Pilot Study -- Application of Peripheral Near Infrared Spectroscopy to Assess Risk Factors in Patient with Coronary Artery Disease: Part 1 -- Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-oxidase Responses to +Gz Acceleration in Healthy Volunteers -- Time-resolved NIROT ‘Pioneer’ System for Imaging Oxygenation of the Preterm Brain: Preliminary Results -- Application of Peripheral Near Infrared Spectroscopy to Assess Risk Factors in Patient with Coronary Artery Disease: Part 2 -- Optimization of Band Selection in Multispectral and Narrow-Band Imaging: An Analytical Approach -- Fabrication and Optical Characterization of Gelatin-Based Phantoms for Tissue Oximetry -- Two-Photon Autofluorescence Imaging of Fixed Tissues: Feasibility and Potential Values for Biomedical Applications -- Part VI Special Topics -- Acute Anemia Induces Erythropoiesis in Rat Organ Surface Primo-Vascular Tissue -- Analysis and Differential Expression of Primo Genes using RNA-Seq and qRT-PCR Experiments -- Acupuncture Inhibits the Increase in Alpha-synuclein in Substantia nigra in an MPTP- induced Parkinsonism Mouse Model -- On the Biomarkers of Alzheimer’s Disease -- Effective Murine Model Induction for Niche Study in Immune Cells against Leukemia -- Index.
Record Nr. UNINA-9910367257603321
Russell-Buckland Joshua  
Springer Nature, 2020
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Oxygen Transport to Tissue XXXIX [[electronic resource] /] / edited by Howard J. Halpern, Joseph C. LaManna, David K. Harrison, Boris Epel
Oxygen Transport to Tissue XXXIX [[electronic resource] /] / edited by Howard J. Halpern, Joseph C. LaManna, David K. Harrison, Boris Epel
Edizione [1st ed. 2017.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017
Descrizione fisica 1 online resource (435 pages)
Disciplina 616.2
Collana Advances in Experimental Medicine and Biology
Soggetto topico Medicine
Biomedicine, general
ISBN 3-319-55231-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part I Cell Metabolism, Tissue Oxygenation and Treatment -- 1. Oxygen Sensing by the Carotid Body: Past and Present -- 2. Predicted Decrease in Membrane Oxygen Permeability with Addition of Cholesterol -- 3. Chronic Diseases as Barriers to Oxygen Delivery-A Unifying Hypothesis of Tissue Reoxygenation Therapy -- 4. Dorsiflexor Muscle Oxygenation during Low, Moderate and Submaximal Sustained Isometric Contraction -- 5. Factors Determining the Oxygen Permeability of Biological Membranes: Oxygen Transport across Eye Lens Fiber-cell Plasma Membranes -- 6. Multi-site Measurements of Muscle O2 Dynamics during Cycling Exercise in Early Post-Myocardial Infarction -- 7. Effects of 8 Weeks’ Training on Systemic and Muscle Oxygen Dynamics in University Rugby Players -- 8. Imaging Redox State in Mouse Muscles of Different Ages -- 9. Amino Acid Hydration Decreases Radiation-Induced Nausea in Mice: A Pica Model -- 10. Evaluation of Haemoglobin and Cytochrome Responses during Forearm Ischaemia using Multi-Wavelength Time Domain NIRS -- 11. Influence of Free Radicals on the Intrinsic MRI Relaxation Properties -- 12. Inter-individual Differences in Exercise-induced Spatial Working Memory Improvement: A Near-Infrared Spectroscopy Study -- Part II Cancer Oxygenation and Metabolism -- 13. Tumor Oxygenation Status: Facts and Fallacies -- 14. Multiparametric Analysis of the Tumor Microenvironment: Hypoxia Markers and Beyond -- 15. Computational Simulation of Tumor Hypoxia based on in vivo Microvasculature Assessed in a Dorsal Skin Window Chamber -- 16. Hypoxia-related Tumor Acidosis Affects MicroRNA Expression Pattern in Prostate and Breast Tumor Cells -- Part III Brain Oxygenation and Function -- 17. Cortical and Autonomic Stress Responses in Adults with High versus Low Levels of Trait Anxiety: A Pilot Study -- 18. Relation Between EEG Activity and Brain Oxygenation in Preterm Neonates -- 19. Functional NIRS Measurement of Cytochrome-c-oxidase Demonstrates a more Brain-specific Marker of Frontal Lobe Activation Compared to the Haemoglobins -- 20. Brain Tissue PO2 Measurement during Normoxia and Hypoxia using Two-Photon Phosphorescence Lifetime Microscopy of PO2 -- 21. Age-related Changes in Physiological Reactivity to a Stress Task: A Near-Infrared Spectroscopy Study -- 22. Development and Validation of a Sensor Prototype for Near-Infrared Imaging of the Newborn Brain -- 23. Directional Migration of MDA-MB-231 Cells under O2/pH Gradient -- 24. Environmental Enrichment Induces Increased Cerebral Capillary Density and Improved Cognitive Function in Mice -- 25.Improving Retinal Image Quality using Registration with an SIFT Algorithm in Quasi-confocal Line Scanning Ophthalmoscope -- 26. A New Method Based on Graphics Processing Units for Fast Near-Infrared Optical Tomography -- 27. PFC Blood Oxygenation Changes in Four Different Cognitive Tasks -- 28. Diet-induced Ketosis Protects against Focal Cerebral Ischemia in Mouse -- 29. Evaluation of Pleasure-Unpleasure Induced by Use of Lipsticks with Near-Infrared Spectroscopy (NIRS): Usefulness of 2-Channel NIRS in Neuromarketing -- 30. Relationships Between Gum Chewing and Stroop Test: A Pilot Study -- 31. Effects of Motor Imagery on Cognitive Function and Prefrontal Cortex Activity in Normal Adults Evaluated by NIRS -- 32. Site Specificity of Changes in Cortical Oxyhaemoglobin Concentration Induced by Water Immersion -- 33.Changes in Oxyhemoglobin Concentration in the Prefrontal Cortex and Primary Motor Cortex during Low- and Moderate-intensity Exercise on a Cycle Ergometer -- 34. Tissue Blood Volume Parameters Measured by Continuous-wave and Spatially Resolved NIRS Show Different Changes during Prolonged Cycling Exercise -- 35. Delayed Onset of Reoxygenation in Inactive Muscles after High-intensity Exercise -- 36. Cortical Oxyhemoglobin Elevation Persists After Moderate-Intensity Cycling Exercise: A Near-Infrared Spectroscopy Study -- 37. Relation Between Cognitive Function and Baseline Concentrations of Hemoglobin in Prefrontal Cortex of Elderly People Measured by Time-Resolved Near-Infrared Spectroscopy -- 38. Physiological Effects of Continuous Colored Light Exposure on Mayer Wave Activity in Cerebral Hemodynamics: A Functional Near-Infrared Spectroscopy (fNIRS) Study -- Part III EPR oximetry and imaging -- 39. Electron Paramagnetic Resonance pO2 Image Tumor Oxygen-guided Radiation Therapy Optimization -- 40. Using India ink as a Sensor for Oximetry: Evidence of its safety as a medical device -- 41. Measurement of pO2 in a Pre-clinical Model of Rabbit Tumor using OxyChip, a Paramagnetic Oxygen Sensor -- 42. Correlation between Hypoxia Proteins and EPR-detected Hypoxia in Tumors -- 43. Triarylmethyl Radical OX063d24 Oximetry: Electron Spin Relaxation at 250 MHz and RF Frequency Dependence of Relaxation and Signal-to-Noise -- 44. In vivo EPR Resolution Enhancement using Techniques known from Quantum Computing Spin Technology -- Part IV Blood Products & Substitutes -- 45. Hemoglobin-based Oxygen Carrier (HBOC) Development in Trauma: Previous Regulatory Challenges, Lessons Learned, and a Path Forward -- 46. The Penultimate Tyrosine Residues are Critical for the Genotoxic Effect of Human Hemoglobin -- 45. Methemoglobin: A New Way to Distinguish Burn Depth -- 47. Characterization of Protein-Protein Interactions in Recombinant Hemoglobin Producing Escherichia coli cells using Molecularly Imprinted Polymers -- Part V Other -- 48. Tissue-Integrating Oxygen Sensors: Continuous tracking of tissue hypoxia -- 49. optical Design of Adaptive Optics Confocal Scanning Laser Ophthalmoscope with Two Deformable Mirrors -- 50. Construction of 0.15 Tesla Overhauser Enhanced MRI -- 51. Gold Nanoparticle-Based Fluorescent Contrast Agent with Enhanced Sensitivity -- 52. Potential Erythropoiesis in the Primo-Vascular System in Heart Failure -- ADDENDUM. 53. Quantitative Biology of Exercise-Induced Signal Transduction Pathways.
Record Nr. UNINA-9910253925003321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017
Materiale a stampa
Lo trovi qui: Univ. Federico II
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