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Kinomics : approaches and applications / / edited by Heinz-Bernhard Kraatz and Sanela Martic
| Kinomics : approaches and applications / / edited by Heinz-Bernhard Kraatz and Sanela Martic |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2015] |
| Descrizione fisica | 1 online resource (365 p.) |
| Disciplina | 616.109283746 |
| Soggetto topico | Protein kinases |
| ISBN |
3-527-68305-4
3-527-68303-8 3-527-68304-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Part I Protein Kinases Cell Signaling; Chapter 1 Global Approaches to Understanding Protein Kinase Functions; 1.1 A Brief History of the Structure of the Human Kinome; 1.1.1 AGC Kinases; 1.1.2 The CaMK Family; 1.1.3 CMGC Family Kinases; References; 1.1.4 STE Family Kinases; 1.1.5 Tyrosine Kinases; 1.1.6 Casein Kinases; 1.1.7 Tyrosine Kinase-Like Family; 1.1.8 RGC Kinases; 1.1.9 Atypical/Other Protein Kinases; 1.2 Why Study Protein Kinases - Their Roles in Disease; 1.2.1 Neurodegenerative Disease; 1.2.2 Hallmarks of Cancer
1.3 Methodology for Assessment of Protein Kinase Functions1.3.1 Mass Spectrometry; 1.3.2 Fluorescence Resonance Energy Transfer; 1.3.3 Assessment of Kinase Functions in vitro: Genetic and Chemical; 1.3.4 Functional Assessment of Kinase Function in vivo: Animal Models; 1.3.5 CRISPR/Cas9 Genomic Recombineering; 1.4 Final Thoughts; Acknowledgments; Chapter 2 ""Genuine"" Casein Kinase (Fam20C): The Mother of the Phosphosecretome; 2.1 Introduction; 2.2 Early Detection of the pS-x-E Motif in Secreted Phosphoproteins; 2.3 CK1 and CK2 are Not Genuine Casein Kinases 2.4 Polo-Like Kinases: Newcomers in the Club of False ""Casein Kinases""2.5 Characterization of an Orphan Enzyme: The Spectacular Performance of a Peptide Substrate; 2.6 Catalytic Activity of Fam20C: Mechanistic Aspects; 2.7 A Kinase in Need of Control; 2.7.1 Constitutively Active or Inactive?; 2.7.2 A Potential Mediator of Sphingosine Signaling; 2.7.3 Fam20c as a Novel Regulator of Blood Phosphate Homeostasis; 2.7.4 Does it Make Sense to Develop Fam20C Inhibitors?; 2.8 Outlook; Funding; References; Chapter 3 Chemical Biology of Protein Kinases; 3.1 The Basis of Chemical Genetics 4.2.2 Caspase-Dependent Intrinsic Apoptosis3.2 Protein Kinase Chemical Genetics; 3.3 Applications for AS Kinases; 3.3.1 Substrate Identification: General Phosphoproteomics; 3.3.2 Substrate Identification: Refinements through the Use of AS Kinases; 3.3.3 Substrate Identification in Action: What Have We Learned?; 3.3.4 Use of Specific Inhibitors for AS Kinases; 3.4 Current Challenges; 3.5 Conclusions; Acknowledgments; References; Chapter 4 Protein Kinases and Caspases: Bidirectional Interactions in Apoptosis; 4.1 Introduction; 4.2 Apoptosis: Caspase-Dependent Pathways; 4.2.1 Extrinsic Apoptosis 4.3 Functional Crosstalk between Protein Kinases and Caspases4.3.1 Direct Phosphorylation of Caspases by Protein Kinases; 4.3.1.1 Initiator Caspases; 4.3.1.2 Executioner Caspases; 4.3.2 Cleavage of Caspase Substrates is Positively and Negatively Regulated by Protein Kinase Phosphorylation; 4.3.3 Caspase-Mediated Degradation of Kinases and Apoptotic Progression; 4.3.3.1 Rho-Associated Coiled-Coil-Containing Protein 1 (ROCK1); 4.3.3.2 p21-Activated Protein Kinase 2 (PAK2); 4.3.3.3 Focal Adhesion Kinase (FAK); 4.3.3.4 Protein Kinase Akt; 4.3.3.5 Protein Kinase Cδ (PKCδ) 4.4 Strategies to Investigate Global Crosstalk between Protein Kinases and Caspases |
| Record Nr. | UNINA-9910131606403321 |
| Weinheim, Germany : , : Wiley-VCH, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Kinomics : approaches and applications / / edited by Heinz-Bernhard Kraatz and Sanela Martic
| Kinomics : approaches and applications / / edited by Heinz-Bernhard Kraatz and Sanela Martic |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2015] |
| Descrizione fisica | 1 online resource (365 p.) |
| Disciplina | 616.109283746 |
| Soggetto topico | Protein kinases |
| ISBN |
3-527-68305-4
3-527-68303-8 3-527-68304-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Part I Protein Kinases Cell Signaling; Chapter 1 Global Approaches to Understanding Protein Kinase Functions; 1.1 A Brief History of the Structure of the Human Kinome; 1.1.1 AGC Kinases; 1.1.2 The CaMK Family; 1.1.3 CMGC Family Kinases; References; 1.1.4 STE Family Kinases; 1.1.5 Tyrosine Kinases; 1.1.6 Casein Kinases; 1.1.7 Tyrosine Kinase-Like Family; 1.1.8 RGC Kinases; 1.1.9 Atypical/Other Protein Kinases; 1.2 Why Study Protein Kinases - Their Roles in Disease; 1.2.1 Neurodegenerative Disease; 1.2.2 Hallmarks of Cancer
1.3 Methodology for Assessment of Protein Kinase Functions1.3.1 Mass Spectrometry; 1.3.2 Fluorescence Resonance Energy Transfer; 1.3.3 Assessment of Kinase Functions in vitro: Genetic and Chemical; 1.3.4 Functional Assessment of Kinase Function in vivo: Animal Models; 1.3.5 CRISPR/Cas9 Genomic Recombineering; 1.4 Final Thoughts; Acknowledgments; Chapter 2 ""Genuine"" Casein Kinase (Fam20C): The Mother of the Phosphosecretome; 2.1 Introduction; 2.2 Early Detection of the pS-x-E Motif in Secreted Phosphoproteins; 2.3 CK1 and CK2 are Not Genuine Casein Kinases 2.4 Polo-Like Kinases: Newcomers in the Club of False ""Casein Kinases""2.5 Characterization of an Orphan Enzyme: The Spectacular Performance of a Peptide Substrate; 2.6 Catalytic Activity of Fam20C: Mechanistic Aspects; 2.7 A Kinase in Need of Control; 2.7.1 Constitutively Active or Inactive?; 2.7.2 A Potential Mediator of Sphingosine Signaling; 2.7.3 Fam20c as a Novel Regulator of Blood Phosphate Homeostasis; 2.7.4 Does it Make Sense to Develop Fam20C Inhibitors?; 2.8 Outlook; Funding; References; Chapter 3 Chemical Biology of Protein Kinases; 3.1 The Basis of Chemical Genetics 4.2.2 Caspase-Dependent Intrinsic Apoptosis3.2 Protein Kinase Chemical Genetics; 3.3 Applications for AS Kinases; 3.3.1 Substrate Identification: General Phosphoproteomics; 3.3.2 Substrate Identification: Refinements through the Use of AS Kinases; 3.3.3 Substrate Identification in Action: What Have We Learned?; 3.3.4 Use of Specific Inhibitors for AS Kinases; 3.4 Current Challenges; 3.5 Conclusions; Acknowledgments; References; Chapter 4 Protein Kinases and Caspases: Bidirectional Interactions in Apoptosis; 4.1 Introduction; 4.2 Apoptosis: Caspase-Dependent Pathways; 4.2.1 Extrinsic Apoptosis 4.3 Functional Crosstalk between Protein Kinases and Caspases4.3.1 Direct Phosphorylation of Caspases by Protein Kinases; 4.3.1.1 Initiator Caspases; 4.3.1.2 Executioner Caspases; 4.3.2 Cleavage of Caspase Substrates is Positively and Negatively Regulated by Protein Kinase Phosphorylation; 4.3.3 Caspase-Mediated Degradation of Kinases and Apoptotic Progression; 4.3.3.1 Rho-Associated Coiled-Coil-Containing Protein 1 (ROCK1); 4.3.3.2 p21-Activated Protein Kinase 2 (PAK2); 4.3.3.3 Focal Adhesion Kinase (FAK); 4.3.3.4 Protein Kinase Akt; 4.3.3.5 Protein Kinase Cδ (PKCδ) 4.4 Strategies to Investigate Global Crosstalk between Protein Kinases and Caspases |
| Record Nr. | UNINA-9910830933303321 |
| Weinheim, Germany : , : Wiley-VCH, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||