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Brain-iron cross talk / / edited by Wael Mohamed, Nicola Luigi Brogazzi, and Richard M. Kostrzewa
| Brain-iron cross talk / / edited by Wael Mohamed, Nicola Luigi Brogazzi, and Richard M. Kostrzewa |
| Pubbl/distr/stampa | Gateway East, Singapore : , : Springer, , [2023] |
| Descrizione fisica | 1 online resource (289 pages) |
| Disciplina | 599.0188 |
| Collana | Nutritional Neurosciences |
| Soggetto topico |
Iron - Physiological effect
Brain chemistry |
| ISBN | 981-19-7327-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Foreword -- Preface -- Acknowledgments -- Contents -- Editors and Contributors -- Part I: Iron, Brain Function and Behavior -- Chapter 1: Iron and Neuro-Cognition -- 1 Introduction -- 2 Delicate Regulation of Iron in the Brain -- 3 Iron Buildup and Neurodegenerative Diseases -- 3.1 Friedreich´s Ataxia -- 3.2 Wilson´s Disease -- 3.3 Alzheimer´s Disease (AD) -- 3.4 Case Study -- 4 Brain Running Short on Iron -- 4.1 Iron Deficiency and Neurotransmitters Synthesis, Signaling, and Energy Demand -- 4.2 Neurons Insulation (Myelination) -- 4.3 Developmental Delays -- 4.4 ADHD -- 4.5 RLS -- 4.6 Effect of Iron on the Dopaminergic and Serotonergic System -- 5 Brain Iron Research Has a Way to Go -- 6 Conclusion -- References -- Chapter 2: The Interplay between Iron and Oxidative Stress in Brain Neurodegenerative Diseases -- 1 Iron as an Essential Micronutrient -- 1.1 Introduction -- 1.2 Dietary Sources, Forms and Requirements of Iron -- 1.2.1 Iron Dietary Sources -- 1.2.2 Iron Forms -- 1.2.3 Human Requirements of Iron -- 1.3 Iron Bioavailability -- 1.4 Iron Metabolism -- 1.4.1 Iron Uptake, Absorption, and Transportation -- 1.4.2 Iron Utilization, Circulation, Reutilization, and Storage -- 1.4.3 Iron Excretion and Regulation -- 1.5 Brain Iron -- 2 Oxidative Stress, Iron Overload, and Brain Degenerative Diseases -- 2.1 The Concept of Oxidative Stress and Redox Signaling -- 2.2 The Crosstalk Between Iron and Redox Signaling and the Consequences of Iron Homeostasis Impairment -- 2.3 Iron Overload, Oxidative Stress, and Brain Degenerative Diseases (Selective Cases) -- 3 Conclusion -- References -- Chapter 3: Specific Nutritional Therapeutic Approaches Targeting Iron Overload and Other Hallmarks of Brain Degenerative Disea... -- 1 Therapeutic Opportunities from Nutritional Point of View -- 1.1 Introduction -- 1.2 Nutritional Therapeutic Opportunities.
1.2.1 Nutritional Treatment of Iron Overload -- Iron Chelators -- Natural Antioxidants -- 1.2.2 Diet Modification -- Diets Rich in Iron Chelators, Antioxidants, and Neurogenerative Molecules -- Caloric Restriction Diets -- Mediterranean Diet -- Gut Microbiota -- 2 Iron Between Deficiency and Overload -- 3 Conclusion -- References -- Chapter 4: Mediterranean Diet and Neuro-Cognition: Focus on Alzheimer Disease -- 1 Introduction -- 2 Mediterranean Diet and Cognitive Health -- 3 Mediterranean Diet and Alzheimer Disease -- 3.1 Fish, Dietary Fatty Acids and Risk of Cognitive Decline and Alzheimer´s Disease -- 3.2 Olive Oil and Risk of Cognitive Decline and Alzheimer´s Disease -- 3.3 Dairy Products and Risk of Cognitive Decline and Alzheimer´s Disease -- 3.4 Tea, Coffee and Risk of Cognitive Decline and Alzheimer´s Disease -- 3.5 Fruits, Vegetables and Risk of Cognitive Decline and Alzheimer´s Disease -- 4 Possible Mechanisms of Mediterranean Diet -- 5 Conclusion -- References -- Part II: Brain Disorders Related to Iron -- Chapter 5: The Critical Roleplay of Iron Neurochemistry in Progression of Parkinson´s Disease -- 1 Introduction -- 2 Brain Iron Transport -- 2.1 Overview of Iron Movement across Brain -- 2.2 Astrocyte Iron Movement -- 2.3 Oligodendrocytes (Transferrin Secretion) -- 2.4 Microglia -- 3 Iron Metabolism in Brain -- 3.1 Absorption -- 3.2 Storage -- 3.3 Brain Iron Toxicity and Accumulation -- 4 Gut Microbiota: A Bridging Stone Between Iron Metabolism and Neurodegeneration -- 5 Biochemical Pathways Accelerating Iron Aggregation -- 5.1 Disabled Iron Discharge -- 5.2 Modified Iron Deposition -- 5.3 Enhanced Iron Influx -- 6 Altered Neurobiology of Iron in PD -- 6.1 Abnormal Iron Homeostasis under Pathophysiological Condition of PD -- 6.2 Interconnection Between Iron and Alpha Synuclein -- 6.3 Ubiquitin-Proteasome System Induced Cell Death. 6.4 How Oxidative Stress Is Linked to Iron Imbalance -- 7 Ferroptosis -Cell Death Pathway in PD Utilizing Iron -- 8 Treatment Strategies for Parkinson´s Disease Targeting Iron Homeostasis -- 8.1 Iron Chelators: A Promising Treatment for PD -- 9 Conclusions and Future Prospects -- References -- Chapter 6: Iron-Calcium Crosstalk in Neurodegenerative Diseases -- 1 Introduction -- 2 Iron -- 2.1 Homeostasis and Repercussion of Altered Concentration of Brain Iron -- 2.2 Brain Anomalies and Iron -- 3 Calcium -- 3.1 Homeostasis and Repercussion of Altered Concentration of Brain Calcium -- 3.2 Brain Anomalies and Calcium -- 4 Calcium-Iron Crosstalk: A Strange Phenomenon -- 5 Ferroptosis: A Cell Death -- 5.1 Iron Balancing in Ferroptosis -- 5.2 Calcium and Iron Induced Cell Death: Play Collective Role in Oxytosis or Ferroptosis -- 6 Connecting Link to Neurodegeneration: Iron, Calcium, and Ferroptosis -- 6.1 Pantothenate Kinase-Associated Neurodegeneration (PKAN) -- 6.2 Calcineurin -- 6.3 Ryanodine Receptor -- 6.4 Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) -- 7 Conclusion -- References -- Chapter 7: Iron and Alzheimer´s Disease -- 1 Introduction -- 2 Alzheimer´s Disease -- 2.1 Pathogenesis -- 2.2 Symptoms and Treatments -- 3 Brain Iron Metabolism -- 3.1 What Is Iron? -- 3.2 Iron Absorption and Transport into the Brain -- 3.3 Iron Regulation in the Brain -- 4 Iron and Alzheimer´s Disease: What Is the Interplay? -- 5 Conclusion -- References -- Chapter 8: Iron and Multiple Sclerosis -- 1 Introduction -- 2 Brain-Iron Homeostasis -- 2.1 Iron Uptake in the Brain -- 3 Imaging and Brain Iron in Multiple Sclerosis -- 4 Disruption of Iron Homeostasis in Multiple Sclerosis -- 4.1 Iron Accumulation in Brain -- 4.2 Ferroptosis: Tissue Damage Via Iron Accumulation -- 5 Astrocytes -- 6 Oligodendrocytes -- 7 Grey Matter Iron Accumulation. 8 White Matter Iron Deposition -- 9 Iron Genetic Relation in Multiple Sclerosis -- 10 Iron Chelation Therapy in Multiple Sclerosis -- 11 Chelation Therapy in EAE Model of Multiple Sclerosis -- 11.1 Impact of Brain Iron Accumulation on Cognition and Memory -- 11.2 Brain Iron in Fetus Development -- 11.3 Association of Aging to Iron Induced Neurodegeneration -- 12 Conclusion -- References -- Chapter 9: Iron and Epilepsy -- 1 Introduction -- 1.1 Epilepsy- a Neurological Disorder -- 1.2 Epilepsy Prevalence around the World -- 1.3 Epilepsy in Adults -- 1.4 Risk Factors of Epilepsy -- 1.5 Epilepsy Classification -- 1.6 Seizure -- 1.6.1 The Structure of Classification -- 1.6.2 Classification of Seizure -- 1.6.3 Seizures Are further Classified into Three Based on the Onset (Auvin, 2018) -- 2 Mortality in Epilepsy -- 3 Neuropathology of Epileptic Seizures -- 4 Iron in Brain -- 5 Modulation of Erythropoiesis in the Blood-Brain Barrier (BBB) -- 6 Brain Iron Deposition and Neuronal Death -- 7 Iron in Epilepsy -- 8 Epilepsy Induced by Iron -- 9 Iron Metabolic Process in Epilepsy -- 10 Histopathological Changes in the Epileptic Brain Tissue -- 11 Histopathological Changes in the Iron Induced Epileptic Brain Tissue -- 12 Management of Epilepsy -- 12.1 Initial Management of Epilepsy -- 12.2 Diagnosis of Epilepsy -- 12.3 Pharmaceutical Intervention -- 12.4 Few Common Antiepileptic Drugs (AEDs) -- 12.5 Common Basic Issues Using Anti-Epileptic Drugs -- 12.6 Epilepsy that Is Resistant to Medication -- 12.7 Surgical Therapy -- 12.8 Alternative Treatment Options -- 12.9 Precision Medicine -- 13 Treatment of Epilepsy Induced by Iron -- 14 Conclusion -- References -- Chapter 10: Iron and Subarachnoid Hemorrhage -- 1 Introduction to Subarachnoid Hemorrhage (SAH) -- 2 Epidemiology -- 3 Signs and Symptoms -- 4 Introduction to Iron -- 5 Overview of the Anatomy of Brain. 6 Homeostasis of Iron in the Brain -- 7 Early Brain Injury Post-SAH -- 8 Cerebral Vasospasm Post-SAH -- 9 Role of Iron after SAH -- 10 Body´s Defense against Unbound Heme -- 11 SAH Markers -- 11.1 Hepcidin -- 11.2 Haptoglobin -- 11.3 Haptoglobin Genotype -- 11.4 Total Iron Binding Capacity -- 12 Other Markers -- 13 Heme-Oxygenase 1 -- 14 Ferroptosis -- 15 Biomarker for Ferroptosis -- 16 Ferroptosis and GPX4 -- 17 Ferroptosis and Liproxstatin-1 -- 18 Intracerebral Iron Accumulation -- 19 SAH and Acute Seizures -- 20 SAH and Acute Hydrocephalus -- 21 MRI-QSM (Magnetic Resonance Imaging-Quantitative Susceptibility Mapping) -- 22 Nimodipine and Deferoxamine -- 23 Treatment of Neurotoxicity Caused by HB with Vitreous -- 24 Heat Shock Protein (HSP) and SAH -- 25 Conclusion -- References -- Chapter 11: Iron Deficiency and Psychiatric Disorders -- 1 Introduction -- 2 The Association Between ID and Psychiatric Disorders -- 2.1 Anxiety Disorders -- 2.2 Depressive Disorders -- 2.3 Bipolar Disorders -- 2.4 Schizophrenia and Related Psychoses -- 2.5 ID and Women´s Mental Health -- 2.5.1 Premenstrual Syndrome (PMS) -- 2.5.2 Iron and Pregnancy -- 3 Explaining Mechanisms of the Relationship Between ID and Psychiatric Disorders -- 4 Iron Supplementation and Risk of Psychiatric Disorders -- 5 Conclusion -- References -- Chapter 12: Iron and Neurodevelopmental Disorders -- 1 Introduction -- 2 Role of Iron in Nervous System Development -- 3 Iron and Neurodevelopmental Disorders -- 3.1 Iron and Neural Tube Defects -- 3.2 Iron and Autism Spectrum Disorder -- 3.3 Iron and Attention-Deficit/Hyperactivity Disorder (ADHD) -- 4 Conclusion -- References -- Chapter 13: Iron and Neuropathies -- 1 Introduction -- 2 Iron and Nerve Conduction -- 3 Iron and Neuropathies -- 3.1 Optic Neuropathy -- 3.2 Neurodegeneration with Brain Iron Accumulation (NBIA) -- 3.2.1 Neuroferritinopathy. 3.2.2 Infantile Neuroaxonal Dystrophy. |
| Record Nr. | UNINA-9910635385103321 |
| Gateway East, Singapore : , : Springer, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of Neurotoxicity / / edited by Richard M. Kostrzewa
| Handbook of Neurotoxicity / / edited by Richard M. Kostrzewa |
| Edizione | [2nd ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (2551 pages) |
| Disciplina | 612.82 |
| Soggetto topico |
Neurophysiology
Neurons Nervous system - Diseases Toxicology Neurochemistry Cellular Neuroscience Neurological Disorders Neurotoxicologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN |
9783031150807
9783031150791 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cell Death Processes: Neurons and Glia -- Neuronal Necrosis -- Neuronal Apoptosis -- Autophagy Pathways -- Necrostatin Neuroprotection -- Neuronal Necroptosis, Relation to Neurological Disorders -- Multiple Cell Death Processes in Neurological Disorders -- Micorglia: Neuroprotective and Neurodestructive Propertie.s, - Selective Neurotoxins -- Survey of Selective Neurotoxinx -- RCSN Cell System for Identifying Dopaminergic Neurotoxicity -- Neurotoxicity: A complex multistage process -- Dopaminergic and Noradrenergic Neurotoxins -- Dopamine and L-dopa as Selective Endogenous Neurotoxins., Dopamine D2 Receptor Supersensitivity as a non-Degenerative Neurotoxin -- Trace Amine-Associated Receptor 1 (TAAR1) and Doapmine Receptor Sensitivity -- Dopamine Receptor Supersensitivity to Model Schizophrenia -- Pathophysiology of Obsessive-Compulsive Disorder: Insights from Normal Function and Neurotoxic Effects of Drugs, Infection, and Brain Injury -- Dopamine D3 receptors and schizophrenia / drug addiction -- Tardive Dyskinesia: Outcome of Antipsychotic Treatment and Brain Damage? -- 6-Hydroxydopamine Neurotoxicity in Adult Animal -- 6-Hydroxydopamine Neurotoxicity in Perinatal Animals -- 6-Hydroxydopa in Perinatal and Adult Animals -- MPTP Neurotoxicity Mechanisms -- Dopaminergic and Noradrenergic Neurotoxins and Neurodegenerative Disorders -- anti-NGF -- Advances in Stem Cell Research for Parkinson's Disease -- Autophagy Pathways and Parkinson's Disease -- Regulation of DA Homeostasis and Role of VMAT2 in Parkinson's Disease -- Alpha-Synuclein in Parkinson's Disease -- Dopaminergic Neurons in Parkinson's Disease -- Dopamine Oxidation and Parkinson's Disease -- Neuromelanin and Parkinson's Disease., -Iron-Induced Dopaminergic Cell Death in vivo as a Model of Parkinson's Disease -- Iron Neurotoxicity in Parkinson's Disease -- 6-Hydroxydopamine as Preclinical Model of Parkinson's Disease. - MPTP modeling of Parkinson's Disease -- MPTP: Advances from and Evergreen Neurotoxin. - MPTP and Motor Neurons -- MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson's Disease -- Paraquat and Parkinson's Disease -- Rotenone Preclinical Modeling of Parkinson's Disease -- N-Methyl-(R)-Salsolinol and Parkinson's Disease -- Fusion Models and "Fusioning" in Parkinsonism: 1-Benzyl-1,2,3,4-tetrahydroisoquinoline -- Amphetamines as Neurotoxins -- METH Neurotoxicity -- Neurotoxicity of MDMA -- Cocaine influence of A2/D2 receptor heteromers -- Cocaine as a Neurotoxin -- NBOMe Neurotoxicity -- Cathinone Neurotoxicity - several chapters -- Neurotoxic Vulnerability Underlying Schizophrenia Spectrum Disorders -- Molecular Mechanism and Effects of Clostridial Neurotoxins -- Botulinum Neurotoxicity -- ~3 addl subchapters on Botulinum Neurotoxicity -- Neurotoxic Effects, Mechanisms, and Outcome of 192-IgG Saporin -- TRPV1 Activators ("Vanilloids") as Neurotoxins -- Protective Agents in Parkinson's Disease:Caffeine and Adenosine A2A Receptor Antagonists -- Physical Exercise as Intervention in Parkinsonism -- Manganese Neurotoxicity and Parkinson's Disease -- Neuroinflammation and Parkinson's Disease -- Neurotoxicity in Psychostimulant and Opiate Addiction -- Homocysteine and Cerebellar Damage -- Propionic Acid, Modeling of Autism Spectrum Disorders -- 1-Me-TIQ, and endogenous Neuroprotectant -- 5-MeO-DIPT -- 3-MD-Glutaric acid -- 3-NP and Huntington's Disease -- 25C-NBOMe -- M-30 -- Trace amine-associated receptor 1 and neuropsychiatric disorders -- PACAP as a Neuroprotectant -- Doxycycline as a Neuroprotectant -- PCP Modeling Amnesia -- Drug Abuse Neurotoxicity: Alcohol and Nicotine as Developmental Stressors -- Neurotrophic Factors and Ethanol Neurotoxicity -- Salsolinol and Addiction -- Snake Venom Toxins -- Salicylate Ototoxicity -- Serotoninergic Neurotoxins -- Nature of DSP-4-Induced Neurotoxicity -- 5,6- and 5,7-Dihydroxytryptamines as Serotoninergic Neurotoxins -- 2'NH(2)-MPTP: A Serotonin and Norepinephrine Neurotoxin -- Excitotoxins and Excitotoxicity -- Glutamate as a Neurotoxin -- Aspartate as a Neurotoxin -- Concept of Excitotoxicity via Glutamate Receptors -- Glutamate Neurotoxicity, Transport and Alternative Splicing of Transporters -- Excitotoxicity: A Complex Multistage Process Involving Different Mechanisms -- Glutamate Excitotoxicity Relation to Energy Failure -- Ionotropic Receptors in the Central Nervous System and Neurodegenerative Disorders -- Excitotoxicity and Axon Degeneration -- Glutamate Scavengers -- Quinolinate and Related Excitotoxins: Mechanisms of Neurotoxicity and Disease Relevanc -- Domoic Acid as a Neurotoxin -- BOAA and Neurotoxicit -- Endogenous Kynurenic Acid and Neurotoxicity -- Neuroprotection by Kynurenine Metabolites -- BMAA (beta-N-Methylamin -- Ionotropic Glutamate Receptors in Neurodegenerative and Other Disorders -- Okadaic acid modeling of Alzheimer's Disease -- Excitotoxicity in Parkinson's Disease -- Excitotoxicity and the Pathogenesis of Gliomas Excitotoxicity and Epielpsy; Epilepsy re Neurotoxicity Mechs -- Excitotoxicity in Multiple Sclerosis -- Excitotoxicity: Insights into Pathogenesis of AD -- Excitotoxicity and ALS: Insights into Pathogenesis -- Excitotoxicity and Amyotrophic Lateral Sclerosis -- Fungal Neurotoxins and ALS -- Excitotoxicity and Huntington Disease -- Excitotoxicity and Stroke -- Excitotoxicity in HIV Associated Neurocognitive Disordders -- Excitotoxicity and AIDS -- Excitotoxicity and Neuroprotection in Spinal Cord Injury -- Excitotoxicity in the Pathogenesis of Autism -- Cancer-Mediated Excitotoxicity., Excitotoxicity and Depression -- Lead and Excitotoxicity -- Glutamate and Neurodegeneration in the Retina -- Excitotoxicity and Epielpsy -- Seizures, Neurotrophin, Neuronal Death -- Neurodegenerative Aspets of Multiple System Atrophy -- Excitotoxicity in Ischemia and Reperfusion Injury -- Molecular, Cellular, and Behavioural Effects Produced by Perinatal Asphyxia: Neuroprotectants Targeting NMDA Receptor Signaling -- Neuroprotective Strategies in Amyotrophic Lateral Sclerosis Modulation of Neurotransmitory and Neurotrophic Input to Motor Neurons -- Neuroprotection in Demyelinating Diseases: The Therapeutic Potential of the Neurotrophins -- p75NTR: A Molecule with Multiple Functions in Amyloid-beta -- Metabolism and Neurotoxicity -- Neurotrophins and ALS -- Neurotrophic Factors & NeuroAIDS -- Neuroprotection by Poly (ADP-Ribose) Polymerase 1 (PARP-1) Inhibition -- Alzheimer's Disease and Neurotoxic Aspects -- Stem Cell Therapies for Age Associated Neurodegeneration -- Pathogenesis of Alzheimer's Disease -- Experimental Approach to Alzheimer Disease -- Potential Therapeutic Effects of Statins in Alzheimer's Disease -- Excitotoxicity and Alzheimer's Disease: Treatment Challenges -- Amyloid-beta, BDNF, and Mechanism of Neurodegeneration in Alzheimer's Diseases -- Drug Treatments: hopes, challenges -- Cannabinoids and Alzheimer's -- Heavy Metal Neurotoxicity -- Trimethyltin Neurotoxicity -- Mn Neurotoxicity -- MeHG -- Cd Neurotoxicity -- Fe Neurotoxicity -- Organoselenium -- Al Neurotoxicity -- Se Neurotoxicity -- Pb Neurotoxicity -- Cuprizone modelin of Multiple sclerosis. |
| Record Nr. | UNINA-9910637715403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||