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Biophysics of computation [[electronic resource] ] : information processing in single neurons / / Christof Koch
| Biophysics of computation [[electronic resource] ] : information processing in single neurons / / Christof Koch |
| Autore | Koch Christof <1956-> |
| Pubbl/distr/stampa | New York, : Oxford University Press, 1999 |
| Descrizione fisica | 1 online resource (587 p.) |
| Disciplina | 573.8/536 |
| Collana | Computational neuroscience |
| Soggetto topico |
Computational neuroscience
Neurons Neural networks (Neurobiology) Action potentials (Electrophysiology) Neural conduction |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-756233-7
1-280-59509-4 9786613624925 0-19-976055-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Contents; Preface; List of Symbols; Introduction; 1 The Membrane Equation; 1.1 Structure of the Passive Neuronal Membrane; 1.1.1 Resting Potential; 1.1.2 Membrane Capacity; 1.1.3 Membrane Resistance; 1.2 A Simple RC Circuit; 1.3 RC Circuits as Linear Systems; 1.3.1 Filtering by RC Circuits; 1.4 Synaptic Input; 1.5 Synaptic Input Is Nonlinear; 1.5.1 Synaptic Input, Saturation, and the Membrane Time Constant; 1.5.2 Synaptic Interactions among Excitation and Shunting Inhibition; 1.5.3 Gain Normalization in Visual Cortex and Synaptic Input; 1.6 Recapitulation; 2 Linear Cable Theory
2.1 Basic Assumptions Underlying One-Dimensional Cable Theory2.1.1 Linear Cable Equation; 2.2 Steady-State Solutions; 2.2.1 Infinite Cable; 2.2.2 Finite Cable; 2.3 Time-Dependent Solutions; 2.3.1 Infinite Cable; 2.3.2 Finite Cable; 2.4 Neuronal Delays and Propagation Velocity; 2.5 Recapitulation; 3 Passive Dendritic Trees; 3.1 Branched Cables; 3.1.1 What Happens at Branch Points?; 3.2 Equivalent Cylinder; 3.3 Solving the Linear Cable Equation for Branched Structures; 3.3.1 Exact Methods; 3.3.2 Compartmental Modeling; 3.4 Transfer Resistances; 3.4.1 General Definition; 3.4.2 An Example 3.4.3 Properties of K[sub(ij)]3.4.4 Transfer Resistances in a Pyramidal Cell; 3.5 Measures of Synaptic Efficiency; 3.5.1 Electrotonic Distance; 3.5.2 Voltage Attenuation; 3.5.3 Charge Attenuation; 3.5.4 Graphical Morphoelectrotonic Transforms; 3.6 Signal Delays in Dendritic Trees; 3.6.1 Experimental Determination of T[sub(m)]; 3.6.2 Local and Propagation Delays in Dendritic Trees; 3.6.3 Dependence of Fast Synaptic Inputs on Cable Parameters; 3.7 Recapitulation; 4 Synaptic Input; 4.1 Neuronal and Synaptic Packing Densities; 4.2 Synaptic Transmission Is Stochastic 4.2.1 Probability of Synaptic Release p4.2.2 What Is the Synaptic Weight?; 4.3 Neurotransmitters; 4.4 Synaptic Receptors; 4.5 Synaptic Input as Conductance Change; 4.5.1 Synaptic Reversal Potential in Series with an Increase in Conductance; 4.5.2 Conductance Decreasing Synapses; 4.6 Excitatory NMDA and Non-NMDA Synaptic Input; 4.7 Inhibitory GABAergic Synaptic Input; 4.8 Postsynaptic Potential; 4.8.1 Stationary Synaptic Input; 4.8.2 Transient Synaptic Input; 4.8.3 Infinitely Fast Synaptic Input; 4.9 Visibility of Synaptic Inputs; 4.9.1 Input Impedance in the Presence of Synaptic Input 4.10 Electrical Gap Junctions4.11 Recapitulation; 5 Synaptic Interactions in a Passive Dendritic Tree; 5.1 Nonlinear Interaction among Excitation and Inhibition; 5.1.1 Absolute versus Relative Suppression; 5.1.2 General Analysis of Synaptic Interaction in a Passive Tree; 5.1.3 Location of the Inhibitory Synapse; 5.1.4 Shunting Inhibition Implements a ""Dirty"" Multiplication; 5.1.5 Hyperpolarizing Inhibition Acts Like a Linear Subtraction; 5.1.6 Functional Interpretation of the Synaptic Architecture and Dendritic Morphology: AND-NOT Gates 5.1.7 Retinal Directional Selectivity and Synaptic Logic |
| Record Nr. | UNINA-9910457836903321 |
Koch Christof <1956->
|
||
| New York, : Oxford University Press, 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biophysics of computation [[electronic resource] ] : information processing in single neurons / / Christof Koch
| Biophysics of computation [[electronic resource] ] : information processing in single neurons / / Christof Koch |
| Autore | Koch Christof <1956-> |
| Pubbl/distr/stampa | New York, : Oxford University Press, 1999 |
| Descrizione fisica | 1 online resource (587 p.) |
| Disciplina | 573.8/536 |
| Collana | Computational neuroscience |
| Soggetto topico |
Computational neuroscience
Neurons Neural networks (Neurobiology) Action potentials (Electrophysiology) Neural conduction |
| ISBN |
0-19-029285-7
0-19-756233-7 1-280-59509-4 9786613624925 0-19-976055-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Contents; Preface; List of Symbols; Introduction; 1 The Membrane Equation; 1.1 Structure of the Passive Neuronal Membrane; 1.1.1 Resting Potential; 1.1.2 Membrane Capacity; 1.1.3 Membrane Resistance; 1.2 A Simple RC Circuit; 1.3 RC Circuits as Linear Systems; 1.3.1 Filtering by RC Circuits; 1.4 Synaptic Input; 1.5 Synaptic Input Is Nonlinear; 1.5.1 Synaptic Input, Saturation, and the Membrane Time Constant; 1.5.2 Synaptic Interactions among Excitation and Shunting Inhibition; 1.5.3 Gain Normalization in Visual Cortex and Synaptic Input; 1.6 Recapitulation; 2 Linear Cable Theory
2.1 Basic Assumptions Underlying One-Dimensional Cable Theory2.1.1 Linear Cable Equation; 2.2 Steady-State Solutions; 2.2.1 Infinite Cable; 2.2.2 Finite Cable; 2.3 Time-Dependent Solutions; 2.3.1 Infinite Cable; 2.3.2 Finite Cable; 2.4 Neuronal Delays and Propagation Velocity; 2.5 Recapitulation; 3 Passive Dendritic Trees; 3.1 Branched Cables; 3.1.1 What Happens at Branch Points?; 3.2 Equivalent Cylinder; 3.3 Solving the Linear Cable Equation for Branched Structures; 3.3.1 Exact Methods; 3.3.2 Compartmental Modeling; 3.4 Transfer Resistances; 3.4.1 General Definition; 3.4.2 An Example 3.4.3 Properties of K[sub(ij)]3.4.4 Transfer Resistances in a Pyramidal Cell; 3.5 Measures of Synaptic Efficiency; 3.5.1 Electrotonic Distance; 3.5.2 Voltage Attenuation; 3.5.3 Charge Attenuation; 3.5.4 Graphical Morphoelectrotonic Transforms; 3.6 Signal Delays in Dendritic Trees; 3.6.1 Experimental Determination of T[sub(m)]; 3.6.2 Local and Propagation Delays in Dendritic Trees; 3.6.3 Dependence of Fast Synaptic Inputs on Cable Parameters; 3.7 Recapitulation; 4 Synaptic Input; 4.1 Neuronal and Synaptic Packing Densities; 4.2 Synaptic Transmission Is Stochastic 4.2.1 Probability of Synaptic Release p4.2.2 What Is the Synaptic Weight?; 4.3 Neurotransmitters; 4.4 Synaptic Receptors; 4.5 Synaptic Input as Conductance Change; 4.5.1 Synaptic Reversal Potential in Series with an Increase in Conductance; 4.5.2 Conductance Decreasing Synapses; 4.6 Excitatory NMDA and Non-NMDA Synaptic Input; 4.7 Inhibitory GABAergic Synaptic Input; 4.8 Postsynaptic Potential; 4.8.1 Stationary Synaptic Input; 4.8.2 Transient Synaptic Input; 4.8.3 Infinitely Fast Synaptic Input; 4.9 Visibility of Synaptic Inputs; 4.9.1 Input Impedance in the Presence of Synaptic Input 4.10 Electrical Gap Junctions4.11 Recapitulation; 5 Synaptic Interactions in a Passive Dendritic Tree; 5.1 Nonlinear Interaction among Excitation and Inhibition; 5.1.1 Absolute versus Relative Suppression; 5.1.2 General Analysis of Synaptic Interaction in a Passive Tree; 5.1.3 Location of the Inhibitory Synapse; 5.1.4 Shunting Inhibition Implements a ""Dirty"" Multiplication; 5.1.5 Hyperpolarizing Inhibition Acts Like a Linear Subtraction; 5.1.6 Functional Interpretation of the Synaptic Architecture and Dendritic Morphology: AND-NOT Gates 5.1.7 Retinal Directional Selectivity and Synaptic Logic |
| Record Nr. | UNINA-9910779059703321 |
|
Koch Christof <1956->
|
||
| New York, : Oxford University Press, 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biophysics of computation : information processing in single neurons / / Christof Koch
| Biophysics of computation : information processing in single neurons / / Christof Koch |
| Autore | Koch Christof <1956-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Oxford University Press, 1999 |
| Descrizione fisica | 1 online resource (587 p.) |
| Disciplina |
573.8/536
573.8536 |
| Collana | Computational neuroscience |
| Soggetto topico |
Computational neuroscience
Neurons Neural networks (Neurobiology) Action potentials (Electrophysiology) Neural conduction |
| ISBN |
0-19-029285-7
0-19-756233-7 1-280-59509-4 9786613624925 0-19-976055-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Contents; Preface; List of Symbols; Introduction; 1 The Membrane Equation; 1.1 Structure of the Passive Neuronal Membrane; 1.1.1 Resting Potential; 1.1.2 Membrane Capacity; 1.1.3 Membrane Resistance; 1.2 A Simple RC Circuit; 1.3 RC Circuits as Linear Systems; 1.3.1 Filtering by RC Circuits; 1.4 Synaptic Input; 1.5 Synaptic Input Is Nonlinear; 1.5.1 Synaptic Input, Saturation, and the Membrane Time Constant; 1.5.2 Synaptic Interactions among Excitation and Shunting Inhibition; 1.5.3 Gain Normalization in Visual Cortex and Synaptic Input; 1.6 Recapitulation; 2 Linear Cable Theory
2.1 Basic Assumptions Underlying One-Dimensional Cable Theory2.1.1 Linear Cable Equation; 2.2 Steady-State Solutions; 2.2.1 Infinite Cable; 2.2.2 Finite Cable; 2.3 Time-Dependent Solutions; 2.3.1 Infinite Cable; 2.3.2 Finite Cable; 2.4 Neuronal Delays and Propagation Velocity; 2.5 Recapitulation; 3 Passive Dendritic Trees; 3.1 Branched Cables; 3.1.1 What Happens at Branch Points?; 3.2 Equivalent Cylinder; 3.3 Solving the Linear Cable Equation for Branched Structures; 3.3.1 Exact Methods; 3.3.2 Compartmental Modeling; 3.4 Transfer Resistances; 3.4.1 General Definition; 3.4.2 An Example 3.4.3 Properties of K[sub(ij)]3.4.4 Transfer Resistances in a Pyramidal Cell; 3.5 Measures of Synaptic Efficiency; 3.5.1 Electrotonic Distance; 3.5.2 Voltage Attenuation; 3.5.3 Charge Attenuation; 3.5.4 Graphical Morphoelectrotonic Transforms; 3.6 Signal Delays in Dendritic Trees; 3.6.1 Experimental Determination of T[sub(m)]; 3.6.2 Local and Propagation Delays in Dendritic Trees; 3.6.3 Dependence of Fast Synaptic Inputs on Cable Parameters; 3.7 Recapitulation; 4 Synaptic Input; 4.1 Neuronal and Synaptic Packing Densities; 4.2 Synaptic Transmission Is Stochastic 4.2.1 Probability of Synaptic Release p4.2.2 What Is the Synaptic Weight?; 4.3 Neurotransmitters; 4.4 Synaptic Receptors; 4.5 Synaptic Input as Conductance Change; 4.5.1 Synaptic Reversal Potential in Series with an Increase in Conductance; 4.5.2 Conductance Decreasing Synapses; 4.6 Excitatory NMDA and Non-NMDA Synaptic Input; 4.7 Inhibitory GABAergic Synaptic Input; 4.8 Postsynaptic Potential; 4.8.1 Stationary Synaptic Input; 4.8.2 Transient Synaptic Input; 4.8.3 Infinitely Fast Synaptic Input; 4.9 Visibility of Synaptic Inputs; 4.9.1 Input Impedance in the Presence of Synaptic Input 4.10 Electrical Gap Junctions4.11 Recapitulation; 5 Synaptic Interactions in a Passive Dendritic Tree; 5.1 Nonlinear Interaction among Excitation and Inhibition; 5.1.1 Absolute versus Relative Suppression; 5.1.2 General Analysis of Synaptic Interaction in a Passive Tree; 5.1.3 Location of the Inhibitory Synapse; 5.1.4 Shunting Inhibition Implements a ""Dirty"" Multiplication; 5.1.5 Hyperpolarizing Inhibition Acts Like a Linear Subtraction; 5.1.6 Functional Interpretation of the Synaptic Architecture and Dendritic Morphology: AND-NOT Gates 5.1.7 Retinal Directional Selectivity and Synaptic Logic |
| Record Nr. | UNINA-9910972234703321 |
|
Koch Christof <1956->
|
||
| New York, : Oxford University Press, 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Consciousness [[electronic resource] ] : confessions of a romantic reductionist / / Christof Koch
| Consciousness [[electronic resource] ] : confessions of a romantic reductionist / / Christof Koch |
| Autore | Koch Christof <1956-> |
| Pubbl/distr/stampa | Cambridge, Mass., : MIT Press, 2012 |
| Descrizione fisica | 1 online resource (194 p.) |
| Disciplina | 153 |
| Soggetto topico |
Consciousness
Mind and body Free will and determinism Life |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-49917-6
9786613594402 0-262-30178-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910461300803321 |
|
Koch Christof <1956->
|
||
| Cambridge, Mass., : MIT Press, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Consciousness : confessions of a romantic reductionist / / Christof Koch
| Consciousness : confessions of a romantic reductionist / / Christof Koch |
| Autore | Koch Christof <1956-> |
| Pubbl/distr/stampa | Cambridge, Massachusetts, : MIT Press, ©2012 |
| Descrizione fisica | 1 online resource (194 p.) |
| Disciplina | 153 |
| Soggetto topico |
Neurosciences - History - 20th century
Neurosciences - History - 21st century Neuroscientists Consciousness Mind and body Free will and determinism Life |
| Soggetto non controllato |
NEUROSCIENCE/General
COGNITIVE SCIENCES/General |
| ISBN |
0-262-30103-2
1-280-49917-6 9786613594402 0-262-30178-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | In which I introduce the ancient mind-body problem, explain why I am on a quest to use reason and empirical inquiry to solve it, acquaint you with Francis Crick, explain how he relates to this quest, make a confession, and end on a sad note -- In which I write about the wellsprings of my inner conflict between religion and reason, why I grew up wanting to be a scientist, why I wear a lapel pin of Professor Calculus, and how I acquired a second mentor late in life -- In which I explain why consciousness challenges the scientific view of the world, how consciousness can be investigated empirically with both feet firmly planted on the ground, why animals share consciousness with humans, and why self-consciousness is not as important as many people think it is -- In which you hear tales of scientist-magicians that make you look but not see, how they track the footprints of consciousness by peering into your skull, why you don't see with your eyes, and why attention and consciousness are not the same -- In which you learn from neurologists and neurosurgeons that some neurons care a great deal about celebrities, that cutting the cerebral cortex in two does not reduce consciousness by half, that color is leached from the world by the loss of a small cortical region, and that the destruction of a sugar cube-sized chunk of brain stem or thalamic tissue leaves you undead -- In which I defend two propositions that my younger self found nonsense--you are unaware of most of the things that go on in your head, and zombie agents control much of your life, even though you confidently believe that you are in charge -- In which I throw caution to the wind, bring up free will, Der ring des Nibelungen, and what physics says about determinism, explain the impoverished ability of your mind to choose, show that your will lags behind your brain's decision, and that freedom is just another word for feeling -- In which I argue that consciousness is a fundamental property of complex things, rhapsodize about integrated information theory, how it explains many puzzling facts about consciousness and provides a blueprint for building sentient machines -- In which I outline an electromagnetic gadget to measure consciousness, describe efforts to harness the power of genetic engineering to track consciousness in mice, and find myself building cortical observatories -- In which I muse about final matters considered off-limits to polite scientific discourse: to wit, the relationship between science and religion, the existence of God, whether this God can intervene in the universe, the death of my mentor, and my recent tribulations. |
| Record Nr. | UNINA-9910790196503321 |
|
Koch Christof <1956->
|
||
| Cambridge, Massachusetts, : MIT Press, ©2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Consciousness : confessions of a romantic reductionist / / Christof Koch
| Consciousness : confessions of a romantic reductionist / / Christof Koch |
| Autore | Koch Christof <1956-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cambridge, Massachusetts, : MIT Press, ©2012 |
| Descrizione fisica | 1 online resource (194 p.) |
| Disciplina | 153 |
| Soggetto topico |
Neurosciences - History - 20th century
Neurosciences - History - 21st century Neuroscientists Consciousness Mind and body Free will and determinism Life |
| ISBN |
9786613594402
9780262301039 0262301032 9781280499173 1280499176 9780262301787 0262301784 |
| Classificazione | SCI089000SCI090000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | In which I introduce the ancient mind-body problem, explain why I am on a quest to use reason and empirical inquiry to solve it, acquaint you with Francis Crick, explain how he relates to this quest, make a confession, and end on a sad note -- In which I write about the wellsprings of my inner conflict between religion and reason, why I grew up wanting to be a scientist, why I wear a lapel pin of Professor Calculus, and how I acquired a second mentor late in life -- In which I explain why consciousness challenges the scientific view of the world, how consciousness can be investigated empirically with both feet firmly planted on the ground, why animals share consciousness with humans, and why self-consciousness is not as important as many people think it is -- In which you hear tales of scientist-magicians that make you look but not see, how they track the footprints of consciousness by peering into your skull, why you don't see with your eyes, and why attention and consciousness are not the same -- In which you learn from neurologists and neurosurgeons that some neurons care a great deal about celebrities, that cutting the cerebral cortex in two does not reduce consciousness by half, that color is leached from the world by the loss of a small cortical region, and that the destruction of a sugar cube-sized chunk of brain stem or thalamic tissue leaves you undead -- In which I defend two propositions that my younger self found nonsense--you are unaware of most of the things that go on in your head, and zombie agents control much of your life, even though you confidently believe that you are in charge -- In which I throw caution to the wind, bring up free will, Der ring des Nibelungen, and what physics says about determinism, explain the impoverished ability of your mind to choose, show that your will lags behind your brain's decision, and that freedom is just another word for feeling -- In which I argue that consciousness is a fundamental property of complex things, rhapsodize about integrated information theory, how it explains many puzzling facts about consciousness and provides a blueprint for building sentient machines -- In which I outline an electromagnetic gadget to measure consciousness, describe efforts to harness the power of genetic engineering to track consciousness in mice, and find myself building cortical observatories -- In which I muse about final matters considered off-limits to polite scientific discourse: to wit, the relationship between science and religion, the existence of God, whether this God can intervene in the universe, the death of my mentor, and my recent tribulations. |
| Record Nr. | UNINA-9910964087703321 |
|
Koch Christof <1956->
|
||
| Cambridge, Massachusetts, : MIT Press, ©2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||