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Endocrine disruptors in the environment / / Sushil K. Khetan
Endocrine disruptors in the environment / / Sushil K. Khetan
Autore Khetan Sushil K.
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2014
Descrizione fisica 1 online resource (410 p.)
Disciplina 614.5/94
Soggetto topico Endocrine disrupting chemicals - Environmental aspects
Endocrine disrupting chemicals - Toxicity testing
Endocrine toxicology
ISBN 1-5231-1066-X
1-118-89115-5
1-118-89109-0
1-118-89103-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cover; Title Page; Contents; Foreword; Preface; Acronyms; Glossary; Chapter 1 Environmental Endocrine Disruptors; 1.1 Introduction; 1.1.1 The Endocrine System; 1.1.2 Endocrine Disrupting Chemicals (EDCs); 1.1.3 Sources of EDCs in the Environment; 1.1.4 Deleterious Effects of EDCs on Wildlife and on Humans; 1.1.5 Endocrine Disruption Endpoints; 1.2 Salient Aspects about Endocrine Disruption; 1.2.1 Low-Dose Effects and Nonmonotonic Dose Responses; 1.2.2 Exposures during Periods of Heightened Susceptibility in Critical Life Stages; 1.2.3 Delayed Dysfunction; 1.2.4 Importance of Mixtures
1.2.5 Transgenerational, Epigenetic Effects1.3 Historical Perspective of Endocrine Disruption; 1.4 Scope and Layout of this Book; 1.5 Conclusion; References; Part I Mechanisms of Hormonal Action and Putative Endocrine Disruptors; Chapter 2 Mechanisms of Endocrine System Function; 2.1 Introduction; 2.2 Hormonal Axes; 2.2.1 Hypothalamus-Pituitary-Gonad (HPG) Axis; 2.2.2 The Hypothalamic-Pituitary-Thyroid (HPT) Axis; 2.2.3 The Hypothalamic-Pituitary-Adrenal (HPA) Axis; 2.3 Hormonal Cell Signaling; 2.3.1 Receptors and Hormone Action; 2.3.2 Genomic Signaling Pathway
2.3.3 Rapid-Response Pathway (Nongenomic Signaling)2.3.4 Receptor Agonists, Partial Agonists, and Antagonists; 2.4 Sex Steroids; 2.4.1 Physiologic Estrogens; 2.4.2 Androgens; 2.5 Thyroid Hormones; 2.6 Conclusions and Future Prospects; References; Chapter 3 Environmental Chemicals Targeting Estrogen Signaling Pathways; 3.1 Introduction; 3.1.1 Gonadal Estrogen Function Disruptors; 3.2 Steroidal Estrogens; 3.2.1 Physiologic Estrogens; 3.2.2 17alpha-Ethinylestradiol (EE2); 3.2.3 Phytoestrogens; 3.2.4 Mycoestrogen-Zearalenone (ZEN); 3.3 Nonsteroidal Estrogenic Chemicals
3.3.1 Diethylstilbestrol (DES)3.3.2 Organochlorine Insecticides; 3.3.3 Polychlorinated Biphenyls (PCBs); 3.3.4 Alkyphenols; 3.3.5 Parabens (Hydroxy Benzoates); 3.3.6 Sun Screens (Chemical UV Filters); 3.4 Metalloestrogens; 3.4.1 Cadmium (Cd); 3.4.2 Lead (Pb); 3.4.3 Mercury (Hg); 3.4.4 Arsenic (As); 3.5 Conclusion and Future Prospects; References; Chapter 4 Anti-Androgenic Chemicals; 4.1 Introduction; 4.2 Testosterone Synthesis Inhibitors; 4.2.1 Phthalates; 4.3 Androgen Receptor (AR) Antagonists; 4.3.1 Organochlorine (OC) Pesticides; 4.3.2 Organophosphorus (OP) Insecticides
4.3.3 Bisphenol A (BPA)4.3.4 Polybrominated Diphenyl Ethers (PBDEs); 4.3.5 Vinclozolin (VZ); 4.3.6 Procymidone; 4.4 AR Antagonists and Fetal Testosterone Synthesis Inhibitors; 4.4.1 Prochloraz; 4.4.2 Linuron; 4.5 Comparative Anti-Androgenic Effects of Pesticides to Androgen Agonist DHT; 4.6 Conclusions and Future Prospects; References; Chapter 5 Thyroid-Disrupting Chemicals; 5.1 Introduction; 5.2 Thyroid Synthesis Inhibition by Interference in Iodide Uptake; 5.2.1 Perchlorate; 5.3 TH Transport Disruptors and Estrogen Sulfotransferases Inhibitors; 5.3.1 Polychlorinated Biphenyls (PCBs)
5.3.2 Triclosan
Record Nr. UNINA-9910132211703321
Khetan Sushil K.  
Hoboken, New Jersey : , : Wiley, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Endocrine disruptors in the environment / / Sushil K. Khetan
Endocrine disruptors in the environment / / Sushil K. Khetan
Autore Khetan Sushil K.
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2014
Descrizione fisica 1 online resource (410 p.)
Disciplina 614.5/94
Soggetto topico Endocrine disrupting chemicals - Environmental aspects
Endocrine disrupting chemicals - Toxicity testing
Endocrine toxicology
ISBN 1-5231-1066-X
1-118-89115-5
1-118-89109-0
1-118-89103-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cover; Title Page; Contents; Foreword; Preface; Acronyms; Glossary; Chapter 1 Environmental Endocrine Disruptors; 1.1 Introduction; 1.1.1 The Endocrine System; 1.1.2 Endocrine Disrupting Chemicals (EDCs); 1.1.3 Sources of EDCs in the Environment; 1.1.4 Deleterious Effects of EDCs on Wildlife and on Humans; 1.1.5 Endocrine Disruption Endpoints; 1.2 Salient Aspects about Endocrine Disruption; 1.2.1 Low-Dose Effects and Nonmonotonic Dose Responses; 1.2.2 Exposures during Periods of Heightened Susceptibility in Critical Life Stages; 1.2.3 Delayed Dysfunction; 1.2.4 Importance of Mixtures
1.2.5 Transgenerational, Epigenetic Effects1.3 Historical Perspective of Endocrine Disruption; 1.4 Scope and Layout of this Book; 1.5 Conclusion; References; Part I Mechanisms of Hormonal Action and Putative Endocrine Disruptors; Chapter 2 Mechanisms of Endocrine System Function; 2.1 Introduction; 2.2 Hormonal Axes; 2.2.1 Hypothalamus-Pituitary-Gonad (HPG) Axis; 2.2.2 The Hypothalamic-Pituitary-Thyroid (HPT) Axis; 2.2.3 The Hypothalamic-Pituitary-Adrenal (HPA) Axis; 2.3 Hormonal Cell Signaling; 2.3.1 Receptors and Hormone Action; 2.3.2 Genomic Signaling Pathway
2.3.3 Rapid-Response Pathway (Nongenomic Signaling)2.3.4 Receptor Agonists, Partial Agonists, and Antagonists; 2.4 Sex Steroids; 2.4.1 Physiologic Estrogens; 2.4.2 Androgens; 2.5 Thyroid Hormones; 2.6 Conclusions and Future Prospects; References; Chapter 3 Environmental Chemicals Targeting Estrogen Signaling Pathways; 3.1 Introduction; 3.1.1 Gonadal Estrogen Function Disruptors; 3.2 Steroidal Estrogens; 3.2.1 Physiologic Estrogens; 3.2.2 17alpha-Ethinylestradiol (EE2); 3.2.3 Phytoestrogens; 3.2.4 Mycoestrogen-Zearalenone (ZEN); 3.3 Nonsteroidal Estrogenic Chemicals
3.3.1 Diethylstilbestrol (DES)3.3.2 Organochlorine Insecticides; 3.3.3 Polychlorinated Biphenyls (PCBs); 3.3.4 Alkyphenols; 3.3.5 Parabens (Hydroxy Benzoates); 3.3.6 Sun Screens (Chemical UV Filters); 3.4 Metalloestrogens; 3.4.1 Cadmium (Cd); 3.4.2 Lead (Pb); 3.4.3 Mercury (Hg); 3.4.4 Arsenic (As); 3.5 Conclusion and Future Prospects; References; Chapter 4 Anti-Androgenic Chemicals; 4.1 Introduction; 4.2 Testosterone Synthesis Inhibitors; 4.2.1 Phthalates; 4.3 Androgen Receptor (AR) Antagonists; 4.3.1 Organochlorine (OC) Pesticides; 4.3.2 Organophosphorus (OP) Insecticides
4.3.3 Bisphenol A (BPA)4.3.4 Polybrominated Diphenyl Ethers (PBDEs); 4.3.5 Vinclozolin (VZ); 4.3.6 Procymidone; 4.4 AR Antagonists and Fetal Testosterone Synthesis Inhibitors; 4.4.1 Prochloraz; 4.4.2 Linuron; 4.5 Comparative Anti-Androgenic Effects of Pesticides to Androgen Agonist DHT; 4.6 Conclusions and Future Prospects; References; Chapter 5 Thyroid-Disrupting Chemicals; 5.1 Introduction; 5.2 Thyroid Synthesis Inhibition by Interference in Iodide Uptake; 5.2.1 Perchlorate; 5.3 TH Transport Disruptors and Estrogen Sulfotransferases Inhibitors; 5.3.1 Polychlorinated Biphenyls (PCBs)
5.3.2 Triclosan
Record Nr. UNINA-9910826916503321
Khetan Sushil K.  
Hoboken, New Jersey : , : Wiley, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui