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Catalytic antibodies [[electronic resource] /] / edited by Ehud Keinan
| Catalytic antibodies [[electronic resource] /] / edited by Ehud Keinan |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (618 p.) |
| Disciplina |
571.967
616.0798 |
| Altri autori (Persone) | KeinanEhud |
| Soggetto topico |
Monoclonal antibodies
Antibody-enzyme conjugates |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-52020-5
9786610520206 3-527-60366-2 3-527-60505-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Catalytic Antibodies; Foreword; Table of Contents; Preface; List of Contributors; 1 Immunological Evolution of Catalysis; 1.1 Introduction; 1.2 Parallels between Antibody and Enzyme Evolution; 1.3 Evolution of Catalytic Antibodies; 1.4 Ferrochelatase Antibody 7G12 - Evolution of the Strain Mechanism; 1.5 Esterase Antibody 48G7 - Effect of Distant Mutations on Catalysis; 1.6 Sulfur Oxidase Antibody 28B4 - Incremental Changes in Evolution; 1.7 Oxy-Cope Antibody AZ28 - Evolution of Conformational Diversity in Catalysis
1.8 Diels-Alderase Antibody 39A11 - Evolution of a Polyspecific Antibody combining Site1.9 Conclusions; References; 2 Critical Analysis of Antibody Catalysis; 2.1 Introduction; 2.2 Exploiting Antibodies as Catalysts; 2.3 Catalytic Efficiency; 2.4 Hapten Design; 2.5 Representative Catalytic Antibodies; 2.5.1 Proximity Effects; 2.5.1.1 Sigmatropic Rearrangements; 2.5.1.2 Cycloadditions; 2.5.2 Strain; 2.5.2.1 Ferrochelatase Mimics; 2.5.2.2 Other Systems; 2.5.3 Electrostatic Catalysis; 2.5.3.1 Acyl Transfer Reactions; 2.5.4 Functional Groups; 2.5.4.1 Aldolases; 2.6 Perspectives 2.6.1 General Lessons from Comparisons of Enzymes and Antibodies2.6.2 How efficient does catalysis need to be?; 2.6.3 Strategies for Optimizing Efficiency; 2.6.3.1 Better Haptens; 2.6.3.2 Screening; 2.6.3.3 Engineering; 2.6.3.4 Selection; 2.6.3.5 Other Scaffolds; 2.7 Conclusions; References; 3 Theoretical Studies of Antibody Catalysis; 3.1 Introduction; 3.2 Questions Subject to Theoretical Elucidation; 3.2.1 Predicting Antibody Structure from Sequence; 3.2.2 Predicting Binding Modes and Binding Energies; 3.2.3 Understanding Antibody Catalysis [14]; 3.2.4 General Considerations 3.3 Hydrolytic Antibodies3.3.1 Gas and Solution Phase Hydrolysis of Aryl Esters; 3.3.2 Hapten Fidelity; 3.3.3 Theoretical Exploration of Antibody Catalysis; 3.3.3.1 16G3; 3.3.3.2 6D9; 3.3.3.3 43C9; 3.3.3.4 CNJ206; 3.3.3.5 48G7; 3.3.3.6 17E8 and 29G11; 3.4 Cationic Cyclizations; 3.4.1 Antibody Catalysis of Solvolysis; 3.4.2 Antibody-Catalyzed Hydroxyepoxide Cyclization; 3.5 Antibody-Catalyzed Diels-Alder and retro-Diels-Alder Reactions; 3.5.1 The Most Efficient endo-Diels-Alderase 1E9; 3.5.2 endo-Diels-Alderase 39A11 and its Germline Precursor; 3.5.3 exo-Diels-Alderase 13G5 3.5.4 retro-Diels-Alderase 10F113.6 Other Antibody-Catalyzed Pericyclic Reactions; 3.6.1 Oxy-Cope Rearrangement Catalyzed by Antibody AZ-28; 3.6.2 1,3-Dipolar Cycloaddition Catalyzed by Antibody 29G12; 3.6.3 Chorismate-Prephenate Claisen Rearrangement Catalyzed by Antibody 1F7; 3.7 Antibody-Catalyzed Carboxybenzisoxazole Decarboxylation; 3.8 Summary; References; 4 The Enterprise of Catalytic Antibodies: A Historical Perspective; 4.1 Introduction; 4.2 Methods; 4.3 Results; 4.3.1 The Conceptual Origins of Catalytic Antibodies; 4.3.2 Tapping the Immune System for Catalysts; 4.4 Conclusions References |
| Record Nr. | UNINA-9910143966603321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Catalytic antibodies [[electronic resource] /] / edited by Ehud Keinan
| Catalytic antibodies [[electronic resource] /] / edited by Ehud Keinan |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (618 p.) |
| Disciplina |
571.967
616.0798 |
| Altri autori (Persone) | KeinanEhud |
| Soggetto topico |
Monoclonal antibodies
Antibody-enzyme conjugates |
| ISBN |
1-280-52020-5
9786610520206 3-527-60366-2 3-527-60505-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Catalytic Antibodies; Foreword; Table of Contents; Preface; List of Contributors; 1 Immunological Evolution of Catalysis; 1.1 Introduction; 1.2 Parallels between Antibody and Enzyme Evolution; 1.3 Evolution of Catalytic Antibodies; 1.4 Ferrochelatase Antibody 7G12 - Evolution of the Strain Mechanism; 1.5 Esterase Antibody 48G7 - Effect of Distant Mutations on Catalysis; 1.6 Sulfur Oxidase Antibody 28B4 - Incremental Changes in Evolution; 1.7 Oxy-Cope Antibody AZ28 - Evolution of Conformational Diversity in Catalysis
1.8 Diels-Alderase Antibody 39A11 - Evolution of a Polyspecific Antibody combining Site1.9 Conclusions; References; 2 Critical Analysis of Antibody Catalysis; 2.1 Introduction; 2.2 Exploiting Antibodies as Catalysts; 2.3 Catalytic Efficiency; 2.4 Hapten Design; 2.5 Representative Catalytic Antibodies; 2.5.1 Proximity Effects; 2.5.1.1 Sigmatropic Rearrangements; 2.5.1.2 Cycloadditions; 2.5.2 Strain; 2.5.2.1 Ferrochelatase Mimics; 2.5.2.2 Other Systems; 2.5.3 Electrostatic Catalysis; 2.5.3.1 Acyl Transfer Reactions; 2.5.4 Functional Groups; 2.5.4.1 Aldolases; 2.6 Perspectives 2.6.1 General Lessons from Comparisons of Enzymes and Antibodies2.6.2 How efficient does catalysis need to be?; 2.6.3 Strategies for Optimizing Efficiency; 2.6.3.1 Better Haptens; 2.6.3.2 Screening; 2.6.3.3 Engineering; 2.6.3.4 Selection; 2.6.3.5 Other Scaffolds; 2.7 Conclusions; References; 3 Theoretical Studies of Antibody Catalysis; 3.1 Introduction; 3.2 Questions Subject to Theoretical Elucidation; 3.2.1 Predicting Antibody Structure from Sequence; 3.2.2 Predicting Binding Modes and Binding Energies; 3.2.3 Understanding Antibody Catalysis [14]; 3.2.4 General Considerations 3.3 Hydrolytic Antibodies3.3.1 Gas and Solution Phase Hydrolysis of Aryl Esters; 3.3.2 Hapten Fidelity; 3.3.3 Theoretical Exploration of Antibody Catalysis; 3.3.3.1 16G3; 3.3.3.2 6D9; 3.3.3.3 43C9; 3.3.3.4 CNJ206; 3.3.3.5 48G7; 3.3.3.6 17E8 and 29G11; 3.4 Cationic Cyclizations; 3.4.1 Antibody Catalysis of Solvolysis; 3.4.2 Antibody-Catalyzed Hydroxyepoxide Cyclization; 3.5 Antibody-Catalyzed Diels-Alder and retro-Diels-Alder Reactions; 3.5.1 The Most Efficient endo-Diels-Alderase 1E9; 3.5.2 endo-Diels-Alderase 39A11 and its Germline Precursor; 3.5.3 exo-Diels-Alderase 13G5 3.5.4 retro-Diels-Alderase 10F113.6 Other Antibody-Catalyzed Pericyclic Reactions; 3.6.1 Oxy-Cope Rearrangement Catalyzed by Antibody AZ-28; 3.6.2 1,3-Dipolar Cycloaddition Catalyzed by Antibody 29G12; 3.6.3 Chorismate-Prephenate Claisen Rearrangement Catalyzed by Antibody 1F7; 3.7 Antibody-Catalyzed Carboxybenzisoxazole Decarboxylation; 3.8 Summary; References; 4 The Enterprise of Catalytic Antibodies: A Historical Perspective; 4.1 Introduction; 4.2 Methods; 4.3 Results; 4.3.1 The Conceptual Origins of Catalytic Antibodies; 4.3.2 Tapping the Immune System for Catalysts; 4.4 Conclusions References |
| Record Nr. | UNINA-9910829843303321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Catalytic antibodies / / edited by Ehud Keinan
| Catalytic antibodies / / edited by Ehud Keinan |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (618 p.) |
| Disciplina |
571.967
616.0798 |
| Altri autori (Persone) | KeinanEhud |
| Soggetto topico |
Monoclonal antibodies
Antibody-enzyme conjugates |
| ISBN |
1-280-52020-5
9786610520206 3-527-60366-2 3-527-60505-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Catalytic Antibodies; Foreword; Table of Contents; Preface; List of Contributors; 1 Immunological Evolution of Catalysis; 1.1 Introduction; 1.2 Parallels between Antibody and Enzyme Evolution; 1.3 Evolution of Catalytic Antibodies; 1.4 Ferrochelatase Antibody 7G12 - Evolution of the Strain Mechanism; 1.5 Esterase Antibody 48G7 - Effect of Distant Mutations on Catalysis; 1.6 Sulfur Oxidase Antibody 28B4 - Incremental Changes in Evolution; 1.7 Oxy-Cope Antibody AZ28 - Evolution of Conformational Diversity in Catalysis
1.8 Diels-Alderase Antibody 39A11 - Evolution of a Polyspecific Antibody combining Site1.9 Conclusions; References; 2 Critical Analysis of Antibody Catalysis; 2.1 Introduction; 2.2 Exploiting Antibodies as Catalysts; 2.3 Catalytic Efficiency; 2.4 Hapten Design; 2.5 Representative Catalytic Antibodies; 2.5.1 Proximity Effects; 2.5.1.1 Sigmatropic Rearrangements; 2.5.1.2 Cycloadditions; 2.5.2 Strain; 2.5.2.1 Ferrochelatase Mimics; 2.5.2.2 Other Systems; 2.5.3 Electrostatic Catalysis; 2.5.3.1 Acyl Transfer Reactions; 2.5.4 Functional Groups; 2.5.4.1 Aldolases; 2.6 Perspectives 2.6.1 General Lessons from Comparisons of Enzymes and Antibodies2.6.2 How efficient does catalysis need to be?; 2.6.3 Strategies for Optimizing Efficiency; 2.6.3.1 Better Haptens; 2.6.3.2 Screening; 2.6.3.3 Engineering; 2.6.3.4 Selection; 2.6.3.5 Other Scaffolds; 2.7 Conclusions; References; 3 Theoretical Studies of Antibody Catalysis; 3.1 Introduction; 3.2 Questions Subject to Theoretical Elucidation; 3.2.1 Predicting Antibody Structure from Sequence; 3.2.2 Predicting Binding Modes and Binding Energies; 3.2.3 Understanding Antibody Catalysis [14]; 3.2.4 General Considerations 3.3 Hydrolytic Antibodies3.3.1 Gas and Solution Phase Hydrolysis of Aryl Esters; 3.3.2 Hapten Fidelity; 3.3.3 Theoretical Exploration of Antibody Catalysis; 3.3.3.1 16G3; 3.3.3.2 6D9; 3.3.3.3 43C9; 3.3.3.4 CNJ206; 3.3.3.5 48G7; 3.3.3.6 17E8 and 29G11; 3.4 Cationic Cyclizations; 3.4.1 Antibody Catalysis of Solvolysis; 3.4.2 Antibody-Catalyzed Hydroxyepoxide Cyclization; 3.5 Antibody-Catalyzed Diels-Alder and retro-Diels-Alder Reactions; 3.5.1 The Most Efficient endo-Diels-Alderase 1E9; 3.5.2 endo-Diels-Alderase 39A11 and its Germline Precursor; 3.5.3 exo-Diels-Alderase 13G5 3.5.4 retro-Diels-Alderase 10F113.6 Other Antibody-Catalyzed Pericyclic Reactions; 3.6.1 Oxy-Cope Rearrangement Catalyzed by Antibody AZ-28; 3.6.2 1,3-Dipolar Cycloaddition Catalyzed by Antibody 29G12; 3.6.3 Chorismate-Prephenate Claisen Rearrangement Catalyzed by Antibody 1F7; 3.7 Antibody-Catalyzed Carboxybenzisoxazole Decarboxylation; 3.8 Summary; References; 4 The Enterprise of Catalytic Antibodies: A Historical Perspective; 4.1 Introduction; 4.2 Methods; 4.3 Results; 4.3.1 The Conceptual Origins of Catalytic Antibodies; 4.3.2 Tapping the Immune System for Catalysts; 4.4 Conclusions References |
| Record Nr. | UNINA-9910876996603321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter
| Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 2001 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
540
660.28 |
| Soggetto topico | Chemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-76400-0
9786611764005 3-527-61294-7 3-527-61295-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry for the 21st Century; Contents; 1 Some Reflections on Chemistry - Molecular, Supramolecular and Beyond; 1.1 From Structure to Information. The Challenge of Instructed Chemistry; 1.2 Steps Towards Complexity; 1.3 Chemistry and Biology, Creativity and Art; 2 Chemical Synthesis and Biological Studies of the Epothilones - Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug Resistant Cell Lines and Tumors; 2.1 Introduction; 2.2 Total Synthesis of Epothilones; 2.3 First Generation Syntheses of Epothilones A and B; 2.4 First Generation Synthesis of the Acyl Domain
2.5 Investigation of C9-C10 Bond Construction Through Ring Closing Metathesis2.6 B-Alkyl Suzuki Strategy; 2.7 Macrolactonization and Macroaldolization Approaches; 2.8 A New and More Efficient Synthesis of Epothilone B; 2.9 Dianion Equivalents Corresponding to the Polypropionate Domain of Epothilone B; 2.10 B-Alkyl Suzuki Merger; 2.11 Stereoselective Noyori Reduction; 2.12 Discovery of a Remarkable Long-Range Effect on the Double Diastereoface Selectivity in an Aldol Condensation; 2.13 Preparation of Other Epothilone Analogs; 2.14 Biological Evaluation of Epothilones 2.15 SAR Analysis of Epothilones: The Zone Approach2.16 In Vitro Analysis Comparison to Paclitaxel and Related Agents; 2.17 In Vivo Analysis: Comparisons to Paclitaxel; 2.18 Conclusions; 2.19 Acknowledgements; 3 The Spirotetrahydrofuran Motif: its Role in Enhancing Ligation in Belted lonophores, Biasing Cyclohexane Conformation, and Restricting Nucleoside/Nucleotide Conformation; 3.1 Introduction; 3.2 syn-1,3,5-Orientation on a Cyclohexane Core; 3.3 Maximally Substituted Hexa(spirotetrahydrofuranyl)-cyclohexanes; 3.4 Spirocyclic Restriction of Nucleosides/Nucleotides; 3.5 Acknowledgement 4 Heterogeneous Catalysis: from ""Black Art"" to Atomic Understanding4.1 Introduction; 4.2 A Case Study Ammonia Synthesis; 4.3 The Surface Science Approach; 4.4 The Atomic Mechanism of a Catalytic Reaction: Oxidation of Carbon Monoxide; 4.5 Further Aspects; 5 Drugs for a New Millennium; 5.1 Introduction; 5.2 Cell Death; 5.3 Stroke and Myocardial Infarct; 5.4 Schizophrenia; 5.4.1 Neuroleptic Drug Development; 5.4.2 Drug Psychoses; 5.5 Drugs of Abuse; 5.5.1 Definitions and Varieties; 5.5.2 Approaches to Treatment: Focus on Cocaine; 5.6 Conclusions and New Directions; 5.7 Acknowledgements 6 Protein Folding and Beyond6.1 Introduction; 6.1.1 Computational Protein Folding; 6.1.2 All-atom Simulations of Protein Unfolding and Short Peptide Folding; 6.2 All-Atom Simulations of Folding of Small Proteins; 6.2.1 Concomitant Hydrophobic Collapse and Partial Helix Formation; 6.2.2 A Marginally Stable Intermediate State; 6.3 A Perspective View; 7 The Enzymology of Biological Nitrogen Fixation; 7.1 Early History; 7.2 Practical Applications; 7.3 Biochemistry of N2 Fixation; 7.4 First Product of N2 Fixation; 7.5 Studies with 15N as a Tracer; 7.6 N2 Fixation with Cell-Free Preparations 7.7 Nitrogenase Consists of Two Proteins |
| Record Nr. | UNINA-9910143990503321 |
| Weinheim, [Germany] : , : Wiley-VCH, , 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter
| Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 2001 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
540
660.28 |
| Soggetto topico | Chemistry |
| ISBN |
1-281-76400-0
9786611764005 3-527-61294-7 3-527-61295-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry for the 21st Century; Contents; 1 Some Reflections on Chemistry - Molecular, Supramolecular and Beyond; 1.1 From Structure to Information. The Challenge of Instructed Chemistry; 1.2 Steps Towards Complexity; 1.3 Chemistry and Biology, Creativity and Art; 2 Chemical Synthesis and Biological Studies of the Epothilones - Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug Resistant Cell Lines and Tumors; 2.1 Introduction; 2.2 Total Synthesis of Epothilones; 2.3 First Generation Syntheses of Epothilones A and B; 2.4 First Generation Synthesis of the Acyl Domain
2.5 Investigation of C9-C10 Bond Construction Through Ring Closing Metathesis2.6 B-Alkyl Suzuki Strategy; 2.7 Macrolactonization and Macroaldolization Approaches; 2.8 A New and More Efficient Synthesis of Epothilone B; 2.9 Dianion Equivalents Corresponding to the Polypropionate Domain of Epothilone B; 2.10 B-Alkyl Suzuki Merger; 2.11 Stereoselective Noyori Reduction; 2.12 Discovery of a Remarkable Long-Range Effect on the Double Diastereoface Selectivity in an Aldol Condensation; 2.13 Preparation of Other Epothilone Analogs; 2.14 Biological Evaluation of Epothilones 2.15 SAR Analysis of Epothilones: The Zone Approach2.16 In Vitro Analysis Comparison to Paclitaxel and Related Agents; 2.17 In Vivo Analysis: Comparisons to Paclitaxel; 2.18 Conclusions; 2.19 Acknowledgements; 3 The Spirotetrahydrofuran Motif: its Role in Enhancing Ligation in Belted lonophores, Biasing Cyclohexane Conformation, and Restricting Nucleoside/Nucleotide Conformation; 3.1 Introduction; 3.2 syn-1,3,5-Orientation on a Cyclohexane Core; 3.3 Maximally Substituted Hexa(spirotetrahydrofuranyl)-cyclohexanes; 3.4 Spirocyclic Restriction of Nucleosides/Nucleotides; 3.5 Acknowledgement 4 Heterogeneous Catalysis: from ""Black Art"" to Atomic Understanding4.1 Introduction; 4.2 A Case Study Ammonia Synthesis; 4.3 The Surface Science Approach; 4.4 The Atomic Mechanism of a Catalytic Reaction: Oxidation of Carbon Monoxide; 4.5 Further Aspects; 5 Drugs for a New Millennium; 5.1 Introduction; 5.2 Cell Death; 5.3 Stroke and Myocardial Infarct; 5.4 Schizophrenia; 5.4.1 Neuroleptic Drug Development; 5.4.2 Drug Psychoses; 5.5 Drugs of Abuse; 5.5.1 Definitions and Varieties; 5.5.2 Approaches to Treatment: Focus on Cocaine; 5.6 Conclusions and New Directions; 5.7 Acknowledgements 6 Protein Folding and Beyond6.1 Introduction; 6.1.1 Computational Protein Folding; 6.1.2 All-atom Simulations of Protein Unfolding and Short Peptide Folding; 6.2 All-Atom Simulations of Folding of Small Proteins; 6.2.1 Concomitant Hydrophobic Collapse and Partial Helix Formation; 6.2.2 A Marginally Stable Intermediate State; 6.3 A Perspective View; 7 The Enzymology of Biological Nitrogen Fixation; 7.1 Early History; 7.2 Practical Applications; 7.3 Biochemistry of N2 Fixation; 7.4 First Product of N2 Fixation; 7.5 Studies with 15N as a Tracer; 7.6 N2 Fixation with Cell-Free Preparations 7.7 Nitrogenase Consists of Two Proteins |
| Record Nr. | UNISA-996205069003316 |
| Weinheim, [Germany] : , : Wiley-VCH, , 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter
| Chemistry for the 21st century / / edited by Ehud Keinan, Israel Schechter |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 2001 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
540
660.28 |
| Soggetto topico | Chemistry |
| ISBN |
1-281-76400-0
9786611764005 3-527-61294-7 3-527-61295-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry for the 21st Century; Contents; 1 Some Reflections on Chemistry - Molecular, Supramolecular and Beyond; 1.1 From Structure to Information. The Challenge of Instructed Chemistry; 1.2 Steps Towards Complexity; 1.3 Chemistry and Biology, Creativity and Art; 2 Chemical Synthesis and Biological Studies of the Epothilones - Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug Resistant Cell Lines and Tumors; 2.1 Introduction; 2.2 Total Synthesis of Epothilones; 2.3 First Generation Syntheses of Epothilones A and B; 2.4 First Generation Synthesis of the Acyl Domain
2.5 Investigation of C9-C10 Bond Construction Through Ring Closing Metathesis2.6 B-Alkyl Suzuki Strategy; 2.7 Macrolactonization and Macroaldolization Approaches; 2.8 A New and More Efficient Synthesis of Epothilone B; 2.9 Dianion Equivalents Corresponding to the Polypropionate Domain of Epothilone B; 2.10 B-Alkyl Suzuki Merger; 2.11 Stereoselective Noyori Reduction; 2.12 Discovery of a Remarkable Long-Range Effect on the Double Diastereoface Selectivity in an Aldol Condensation; 2.13 Preparation of Other Epothilone Analogs; 2.14 Biological Evaluation of Epothilones 2.15 SAR Analysis of Epothilones: The Zone Approach2.16 In Vitro Analysis Comparison to Paclitaxel and Related Agents; 2.17 In Vivo Analysis: Comparisons to Paclitaxel; 2.18 Conclusions; 2.19 Acknowledgements; 3 The Spirotetrahydrofuran Motif: its Role in Enhancing Ligation in Belted lonophores, Biasing Cyclohexane Conformation, and Restricting Nucleoside/Nucleotide Conformation; 3.1 Introduction; 3.2 syn-1,3,5-Orientation on a Cyclohexane Core; 3.3 Maximally Substituted Hexa(spirotetrahydrofuranyl)-cyclohexanes; 3.4 Spirocyclic Restriction of Nucleosides/Nucleotides; 3.5 Acknowledgement 4 Heterogeneous Catalysis: from ""Black Art"" to Atomic Understanding4.1 Introduction; 4.2 A Case Study Ammonia Synthesis; 4.3 The Surface Science Approach; 4.4 The Atomic Mechanism of a Catalytic Reaction: Oxidation of Carbon Monoxide; 4.5 Further Aspects; 5 Drugs for a New Millennium; 5.1 Introduction; 5.2 Cell Death; 5.3 Stroke and Myocardial Infarct; 5.4 Schizophrenia; 5.4.1 Neuroleptic Drug Development; 5.4.2 Drug Psychoses; 5.5 Drugs of Abuse; 5.5.1 Definitions and Varieties; 5.5.2 Approaches to Treatment: Focus on Cocaine; 5.6 Conclusions and New Directions; 5.7 Acknowledgements 6 Protein Folding and Beyond6.1 Introduction; 6.1.1 Computational Protein Folding; 6.1.2 All-atom Simulations of Protein Unfolding and Short Peptide Folding; 6.2 All-Atom Simulations of Folding of Small Proteins; 6.2.1 Concomitant Hydrophobic Collapse and Partial Helix Formation; 6.2.2 A Marginally Stable Intermediate State; 6.3 A Perspective View; 7 The Enzymology of Biological Nitrogen Fixation; 7.1 Early History; 7.2 Practical Applications; 7.3 Biochemistry of N2 Fixation; 7.4 First Product of N2 Fixation; 7.5 Studies with 15N as a Tracer; 7.6 N2 Fixation with Cell-Free Preparations 7.7 Nitrogenase Consists of Two Proteins |
| Record Nr. | UNINA-9910830064003321 |
| Weinheim, [Germany] : , : Wiley-VCH, , 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||