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Chaperokine Activity of Heat Shock Proteins / / edited by Alexzander A. A. Asea, Punit Kaur
| Chaperokine Activity of Heat Shock Proteins / / edited by Alexzander A. A. Asea, Punit Kaur |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (IX, 320 p. 49 illus., 28 illus. in color.) |
| Disciplina | 572.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Proteins
Protein Science |
| ISBN | 3-030-02254-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Chaperokine Activity of Heat Shock Protein -- Chapter 2. Extracellular HSP70, Neuroinflammation and Protection against Viral Virulence -- Chapter 3. The Biology of Extracellular HSP60 -- Chapter 4. Heat Shock Protein 60: A Mediator of Atherosclerosis and its Potential Therapeutic Role -- Chapter 5. Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases -- Chapter 6. Upregulation of Cytoprotective Chaperones Mediate Better Tolerance to High Altitude -- Chapter 7. Role of Chaperone Mediated Autophagy in Viral Infections -- Chapter 8. Chaperones in Sterile Inflammation and Injury -- Chapter 9. Chaperone in Inflammation and Immunomodulation: Resistin and PPlases -- Chapter 10. Exercise-induced Chaperokine Activity of Hsp70: Possible Role in Chronic Diseases -- Chapter 11. Physical Exercise and Heat Shock Proteins -- Chapter 12. Extracellular Hsp90 Governs Spatio-temporal Regulation of Biological Responses -- Chapter 13. HSP47 and its Involvement in Fibrotic Disorders -- Chapter 14. Therapeutic Implications of Heat Shock Proteins in Cancer -- Chapter 15. Targeting Heat Shock Proteins for Immunotherapy -- Chapter 16. Modulation of Heat Shock Proteins by Natural Products. |
| Record Nr. | UNINA-9910337953603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Coronavirus therapeutics . Volume II Clinical management and public health / / Alexzander A. A. Asea, Punit Kaur, editors
| Coronavirus therapeutics . Volume II Clinical management and public health / / Alexzander A. A. Asea, Punit Kaur, editors |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (242 pages) |
| Disciplina | 614.592414 |
| Collana | Advances in experimental medicine and biology |
| Soggetto topico |
COVID-19 (Disease)
COVID-19 Terapèutica |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-85113-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910544848803321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Coronavirus therapeutics . Volume I Basic science and therapy development / / edited by Alexzander A. A. Asea, Punit Kaur
| Coronavirus therapeutics . Volume I Basic science and therapy development / / edited by Alexzander A. A. Asea, Punit Kaur |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (225 pages) |
| Disciplina | 614.592414 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Coronaviruses
COVID-19 Terapèutica |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-85109-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910544874503321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat Shock Protein 60 in Human Diseases and Disorders / / edited by Alexzander A. A. Asea, Punit Kaur
| Heat Shock Protein 60 in Human Diseases and Disorders / / edited by Alexzander A. A. Asea, Punit Kaur |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (xi, 363 pages) : illustrations |
| Disciplina | 572.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Proteins
Protein Science Proteïnes |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-23154-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | SECTION I: BIOMOLECULAR ASPECTS OF HSP60 -- Chapter 1. HSP60: A Story as Long as Life on the Earth -- Chapter 2. Single-Ring Intermediates in the Catalytic Cycle of the Human Mitochondrial HSP60 -- Chapter 3. HSP60 Inhibitors and Modulators -- Chapter 4. HSP60 as Modulators of Apoptosis -- Chapter 5. Utilizing The Unique Architecture And Abilities of Hsp60 In Drug Development -- Chapter 6. Role of The Post-Translational Modifications of HSP60 In Disease -- SECTION II: HSP60 AND CANCER -- Chapter 7. Evaluation of Heat Shock Protein 60 (HSP60) Chaperonin in Oncology -- Chapter 8. Exosomal Hsp60: a Tumor Biomarker? -- Chapter 9. HSP60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities -- Chapter 10. Hsp60 Involvement During Carcinogenesis -- SECTION III: HSP60 AND INFLAMMATORY DISEASES AND DISORDERS -- Chapter 11. Anti-Human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases -- Chapter 12. Hsp60 In Inflammatory Disorders -- SECTION IV: HSP60 AND CARDIOVASCULAR DISEASES AND DISORDERS -- Chapter 13. HSP60 In Atherosclerosis - Past, Present and Future -- Chapter 14. Cardiac Myopathy In Conditional HSP60 Transgenic Mice -- SECTION V: HSP60 AND NEUROLOGICAL AND NEUROSCIENCES -- Chapter 15. Heat Shock Protein 60: An Effective Target Candidate In Neurological Diseases Treatment -- Chapter 16. Hsp60 In Modifications of Nervous System Homeostasis and Neurodegeneration -- SECTION VI: HSP60 AND SKELETAL MUSCLE DISEASES AND DISORDERS -- Chapter 17. Hsp60 in Skeletal Muscle: From Molecular Anatomy To Pathophysiology -- Chapter 18. Heat Shock Protein 60 (HSP60): Its Role in Skeletal Muscle Diseases and Novel Prospects for Therapy -- Chapter 19. Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity -- SECTION VII: HSP60 IN HUMAN HEALTH -- Chapter 20. Role of HSP60 In The Steroidogenesis and Reproduction -- Chapter 21. Heat Shock Protein 60 in Skin Diseases. |
| Record Nr. | UNINA-9910349438903321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat Shock Protein 90 in Human Diseases and Disorders / / edited by Alexzander A. A. Asea, Punit Kaur
| Heat Shock Protein 90 in Human Diseases and Disorders / / edited by Alexzander A. A. Asea, Punit Kaur |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (XI, 607 p. 102 illus., 73 illus. in color.) |
| Disciplina | 572.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Proteins
Protein Science Proteïnes |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-23158-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | SECTION I: ONCOGENIC ASPECTS OF HSP90 -- Chapter 1. Regulatory Roles of HSP90-rich Extracellular Vesicles -- Chapter 2. HSP90-Based Heterocomplex as Essential Regulator for Cancer Disease -- Chapter 3. Therapeutic Potential of Heat Shock Protein 90 Inhibitors in Colorectal Cancer -- Chapter 4. Hsp90 in the Migration of Primordial Germ Cells: A Model to Study Long-Distance Cell Migration and Perhaps Cancer? -- Chapter 5. Role of Heat Shock Protein 90 in Mammary Tumorigenesis -- Chapter 6. Role of HSP90 Inhibitors in the Treatment of Cancer -- Chapter 7. p53-HSP90 Axis in Human Cancer -- Chapter 8. HSP90 and its Inhibitors for Cancer Therapy: Use of Nano-delivery System to Improve its Clinical Application -- Chapter 9. Hsp90 is a Pivotal Player in Retinal Disease and Cancer -- Chapter 10. Targeting Hsp-90 Related Disease Entities for Therapeutic Development -- Chapter 11. HSP90: A Key Player in Metal-Induced Carcinogenesis? -- Section II: Biomolecular Aspects of HSP90 -- Chapter 12. Hsp90 and its Role in Heme-Maturation of Client Proteins: Implications for Human Diseases -- Chapter 13. Moonlighting Functions of Heat Shock Protein 90 -- Chapter 14. Hsp90 as a Member of Dicarboxylate Clamp TPR Protein Interaction Network: Implication in Human Diseases and Prospect as a Drug Target -- Chapter 15. ‘Complex World’ of Hsp90 Co-chaperone R2TP -- Chapter 16. Functions of SGT1, a Co-chaperone -- Chapter 17. Sti1/Hop Plays a Pivotal Role in Hsp90 Regulation beyond Bridging Hsp70 -- Section III: HSP90 in Natural Products Development.-Chapter 18. Hsp90: A Target for Susceptibilities and Substitutions in Biotechnological and Medicinal Application -- Chapter 19. Screening Technique for Heat Shock Protein 90 Inhibitors from Natural Products -- Chapter 20. Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family -- Section IV: Clinical Aspects of HSP90 -- Chapter 21. Hsp90 Chaperone in Disease -- Chapter 22. Theranostic Implications of Heat Shock Proteins in Idiopathic Pulmonary Fibrosis -- Chapter 23. Heat Shock Protein 90 and Reproduction in Female Animals: Ovary, Oocyte and Early Embryo -- Chapter 24. Heat Shock Protein 90 in Severe Trauma -- Chapter 25. HSP90 - Is there an Unknown Role in Pain Neurobiology -- Chapter 26. Heat Shock Protein 90 in Kidney Stone Disease -- Chapter 27. HSP90 et al. - Chaperome and Proteostasis Deregulation in Human Disease. |
| Record Nr. | UNINA-9910373921403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat Shock Protein-Based Therapies / / edited by Alexzander A.A. Asea, Naif N. Almasoud, Sunil Krishnan, Punit Kaur
| Heat Shock Protein-Based Therapies / / edited by Alexzander A.A. Asea, Naif N. Almasoud, Sunil Krishnan, Punit Kaur |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (389 p.) |
| Disciplina | 572.645 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Medicine
Life sciences Biomedicine, general Life Sciences, general Science, Humanities and Social Sciences, multidisciplinary Medicine/Public Health, general |
| ISBN | 3-319-17211-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Contributors -- Preface -- 1 HSP27 as a Therapeutic Target of Novel Inhibitors and Dietary Phytochemicals in Cancer -- 2 Heat Shock Protein 27 (HSP27, HSPB1) is Up-Regulated by Targeted Agents and Confers Resistance to Both Targeted Drugs and Chemotherapeutics -- 3 Heat Shock Proteins and Cancer: Plant Based Therapy -- 4 Chaperonotherapy for Alzheimer’s Disease: Focusing on HSP60 -- 5 Secreted and Circulating Cell Stress Proteins in the Periodontal Diseases -- 6 The Role of Heat Shock Protein 70 in Infection and Immunity -- 7 Potential Cytoprotective Effects of Heat Shock Proteins to Skeletal Muscle -- 8 Heat Shock Proteins in Triple-Negative Breast Cancer (TNBC) Treatment -- 9 Heat Shock Proteins in Multiple Sclerosis Pathogenesis: Friend or Foe? -- 10 New Indications for HSP90 and HSP70 Inhibitors as Antiviral Drugs -- 11 Potential Applications of Nanoparticles for Hyperthermia -- 12 Gene Therapy Against HSP90: Glucocorticoid Receptor-Assisted Cancer Treatment -- 13 Potential of HSP90 Inhibitors to Treat Neurofibromatosis-Related Tumors -- 14 Role of Heat Shock Protein 90 in the Cause of Various Diseases: A Potential Therapeutic Target -- 15 HSP90 Inhibitor-Based Strategies for Cancer Therapy: Advancing Toward Clinical Impact -- 16 Molecular Survival Strategies of Organisms: HSP and Small Molecules for Diagnostics and Drug Development.-17 Targeting Heat Shock Proteins in Colorectal Cancer -- Index. |
| Record Nr. | UNINA-9910298441503321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Heat Shock Proteins and Plants / / edited by Alexzander A. A. Asea, Stuart K. Calderwood, Punit Kaur
| Heat Shock Proteins and Plants / / edited by Alexzander A. A. Asea, Stuart K. Calderwood, Punit Kaur |
| Edizione | [1st ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (VIII, 344 p. 64 illus., 48 illus. in color.) |
| Disciplina | 616.079 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Plant science
Botany Cell biology Gene expression Proteins Plant Sciences Cell Biology Gene Expression Protein Science |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface. -Part I: Small Plant Heat Shock Proteins -- 1 Small Heat Shock Proteins: Emerging Roles in Seed Vigor and Longevity, Harmeet Kaur, Bhanu Prakash Petla and Manoj Majee -- 2 Plant Small Heat Shock Proteins and its Interations with Biotic Stress, Valéria Stefania Lopes-Caitar, Suellen Mika Hishinuma Silva and Francismar Corrêa Marcelino-Guimaraes -- 3 Small Heat Shock Proteins, a Key Player in Grass Plant Thermotolerance, Kehua Wang -- 4 Induction of Heat Shock Proteins During the Bud Dormancy Stage in Woody Fruit Plants, Yoshihiro Takemura and Fumio Tamura -- 5 Evolution Canyon, Eviatar Nevo and Yang Zujun -- 6 Insights into the Mechanism of Heat Shock Mitigation Through Protein Repair, Recycling and Degradation, Rashid Mehmood Rana, Muhammad Ammar Khan, Muhammad Kausar Nawaz Shah, Zulfiqar Ali and Hongsheng Zhang -- Part II: Large Plant Heat Shock Proteins -- 7 Plant Stress Response: HSP70 in the Spotlight, Sanghamitra Raha, Doel Ray, Anupama Ghosh and Soumyajit Banerjee Mustafi -- 8 The Role of Plant 90-kDa Heat Shock Protein in Plant Immunity, Marina Clemente -- 9 Chloroplasts HSP70B and HSP90C as Markers for Oxidative Stress, Stephanie Chankova and N.P. Yurina -- 10 The Involvement of HSP70 and HSP90 in Tomato Yellow Leaf Curl Virus Infection in Tomato Plants and Insect Vectors, Rena Gorovits, Yule Liu and Henryk Czosnek -- Part III: Heat Shock Proteins and Plant Therapeutics -- 11 ADAPTOGENS: Evidence-Based Effects and Recent Achievements in Elucidation of Molecular Mechanisms of Stress-Protection, Punit Kaur and Alexzander Asea -- 12 Heat Shock Proteins and Phytochemicals: Role in Human Health and Disease, Xinyu Wang, Srujana Rayalam and Vishakha Bhave -- 13 Plant Extracts and Animal Heat Shock Proteins in Aging, Sam Schriner -- 14 Molecular Chaperones and HSPs in Sugarcane and Eucalyptus, Carlos H. I. Ramos and Conrado de Campos Gonçalves -- 15 Role of Heat Shock Proteins in Improving Heat Stress Tolerance in Crop Plants, Palakolanu Sudhakar Reddy, Thammineni Chakradhar, Ramesha A. Reddy, Srikrishna Mahanty and Malireddy K. Reddy -- 16 NGS-Based Expression Profiling of HSP Genes During Cold and Freeze Stress in Seabuckthorn (Hippophae rhamnoides L.), P. C. Sharma and Saurabh Chaudhary -- 17 Epigenetic Regulation of Plant Heat Shock Protein (HSP) Gene Expression, Yuanyuan Ren and Yan Zhu -- Index. |
| Record Nr. | UNINA-9910155331103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat Shock Proteins and Stress / / edited by Alexzander A. A. Asea, Punit Kaur
| Heat Shock Proteins and Stress / / edited by Alexzander A. A. Asea, Punit Kaur |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (317 pages) |
| Disciplina | 572.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Proteins
Protein Science |
| ISBN | 3-319-90725-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Molecular Chaperones and the Nuclear Response to Stress -- Extracellular Hsp70 and Low-grade Inflammation- and Stress-related Pathologies -- Heat Shock Proteins and Endoplasmic Reticulum Stress -- Features of Stress-induced Changes of HSP70 Expression in Populations of Immunocompetent Cells -- Relationship between Oxidative Stress-induced Effects and Physical Exercise -- Role of Heat Shock Proteins in Oxidative Stress and Stress Tolerance -- Heat Shock Proteins in Oxidative and Nitrosative Stress -- High Content Screening of Small Molecule Modulators Targeting Heat Shock Response Pathway -- Regulation of Autophagy by the Heat Shock Factor 1-mediated Stress Response Pathway -- Involvement of Heat Shock Proteins in Invertebrate Anhydrobiosis -- Molecular Stress Responses against Trace Metal Contamination in Aquatic Invertebrates -- Heat Shock-induced Transcriptional and Translational Arrest in Mammalian Cells -- HSP70 Mediated Stress Modulation in Plants -- Small Heat Shock Proteins in Stress Response of Higher Eukaryotes. |
| Record Nr. | UNINA-9910298400303321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat shock proteins in human diseases / / Alexzander A. A. Asea and Punit Kaur (editors)
| Heat shock proteins in human diseases / / Alexzander A. A. Asea and Punit Kaur (editors) |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (301 pages) : illustrations |
| Disciplina | 572.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Heat shock proteins - Physiological effect
Proteïnes Neuroimmunologia Malalties |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-62289-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- About the Editors -- Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and ... -- 1 Introduction -- 2 Cancer, Inflammation and HSP -- 2.1 Role of Inflammation in Cancer Development -- 2.2 Role of Heat Shock Proteins (HSP) in Cancer Development -- 2.3 Relationship Between HSP and Inflammation in Cancer Development -- 3 Role of the Immune System and HSP in Cancer Diagnosis and Prevention -- 3.1 Ingenious Tumour Immune Surveillance Mechanism to Prevent Cancer -- 3.2 HSP as a Biomarker for Cancer Diagnosis -- 3.3 Targeting the HSP-Inflammation Cooperative System as a Target for Cancer Diagnosis Therapeutics -- 3.4 HSP Based Cancer Immunotherapy -- 3.4.1 Vaccines Based on HSP -- 3.4.2 Immune Responses Stimulation Using HSP as an Antigen -- 3.4.3 The Application of HSP as an Adjuvant for the Immune System Stimulation -- 4 Conclusions -- References -- Chaperonin Hsp60 and Cancer Therapies -- 1 Introduction -- 2 Human Hsp60 and Its Bacterial Orthologues -- 2.1 Hsp60 vs. GroEL -- 2.2 Hsp60 and Autoimmune Diseases -- 3 Hsp60 in Carcinogenesis -- 3.1 Chaperonopathy by Mistake -- 3.2 Hsp60 in Cancer -- 4 Hsp60 in Cancer Management -- 4.1 Exosomes: Definition and Biogenesis -- 4.2 Exosomes in Disease: Cancer -- 4.3 Exosomal Hsp60 in Tumorigenesis -- 5 Hsp60 in Cancer Therapy -- 5.1 Hsp and the Immune System -- 5.2 Hsp60-Associated Vaccines in Tumors -- 5.3 Exosomal Hsp60 for Tumor Therapy -- 6 Conclusions -- References -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- 1 Introduction -- 1.1 Heat Shock Proteins in Cancer Cells -- 1.1.1 Intracellular HSP -- 1.1.2 Extracellular HSP in Cancer -- 1.2 Heat Shock Protein Modulation as a Target for Cancer Therapy -- 1.2.1 Targeting Hsp90 -- 1.2.2 Targeting Hsp70.
1.2.3 Targeting Hsp60 in Cancer -- 1.2.4 Targeting Hsp27 in Cancer -- 1.3 Targeted Cancer Thermotherapy -- 1.3.1 Nanoparticles in Cancer Therapy -- 1.3.2 SPIONs -- 1.3.3 Synthesis Approaches -- 1.3.4 Chemical Synthesis: Co-precipitation -- 1.3.5 SPIONs Enhancement: Surface Functionalization -- 1.3.6 Targeting -- 1.3.7 Magnetic Field-Induced Hyperthermia -- 1.4 Combined HSP Targeting with Hyperthermia -- 2 Conclusions -- References -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Ther... -- 1 Introduction -- 2 HSR Inhibitors Currently in Human Clinical Studies (Table 1 and Fig. 2) -- 2.1 Quercetin -- 2.2 QC12 (Analog Prodrug of Quercetin) -- 2.3 Triptolide -- 2.4 Minnelide (Analog Prodrug of Triptolide) -- 3 HSR Inhibitors Currently in Preclinical Animal Studies (Table 2 and Fig. 3) -- 3.1 PW3405 -- 3.2 Cantharidin -- 3.3 KNK437 -- 3.4 KRIBB11 -- 3.5 Fisetin -- 3.6 Racoglamide A -- 3.7 CCT251236 -- 4 HSR Inhibitors in Early Preclinical Studies (Cancer Cell Lines, Table 3 and Fig. 4) -- 5 Lessons Learned from Preclinical and Clinical Studies -- 5.1 Improvement of Therapeutic Window by Prodrug Design and Nanoparticle Packaging -- 5.2 Combined Application with Chemotherapy Drugs or Drugs against a Different Cancer Target -- 5.3 Target Validation and Use of RNA Aptamer -- 5.4 HSF1 as a Potential Biomarker for Clinical Trial Design and Prognosis Prediction -- 6 Conclusions -- References -- Multifaceted Roles of Heat Shock Factor 1 (HSF 1) in Cancer -- 1 Introduction -- 2 HSF1 Becomes Constitutively Activated Within Cancer Cells -- 2.1 Activation of HSF1 by the Oncogenic RAS Signaling Pathway -- 2.2 Activation of HSF1 by Other Oncogenic Signaling Pathways -- 2.3 Inactivation of HSF1 by Metabolic Stress Signaling -- 2.4 Other Signaling Pathways Suppress HSF1 Through Phosphorylation. 3 HSF1 Enables Oncogenesis Through Multifaceted Mechanisms -- 3.1 Guarding Proteomic Stability in Cancer -- 3.2 Preventing Cell Senescence and Promoting Survival -- 3.3 Contributing to Genomic Instability and Alleviating Genotoxic Stress -- 4 Enhancing Tumor Cell Invasion and Metastasis -- 4.1 Augmenting Critical Oncogenic Signaling Pathways -- 4.2 Reprogramming Cancer Metabolism -- 4.3 Modulating Tumor Immune Evasion -- 4.4 Promoting Oncogenic Growth Non-cell-autonomously -- 5 HSF1 Is a Potential Therapeutic Target and Prognostic Marker -- 6 Conclusions -- References -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- 1 Introduction -- 2 Heat Shock Proteins -- 3 Mode of Action -- 4 HSP27 -- 5 HSP40 -- 6 HSP60 -- 7 HSP70 -- 8 HSP90 -- 9 Differential Expression of Hsp in Gastric Cancer -- 10 HSP70 -- 11 HSP40 -- 12 HSP60 -- 13 Hsp27 -- 14 HSP90 -- 15 Diagnostic and Prognostic Applications of HSP in Gastric Cancer -- 16 HSP70 in H. pylori and EBV Positive Gastric Cancer -- 17 Genetic Polymorphism of HSP70 in Gastric Cancer -- 18 Inhibitors of HSP -- 19 HSP70 Based Vaccines -- 20 Conclusions -- References -- Heat Shock Proteins in Atrial Fibrillation -- 1 Introduction -- 2 HSP and Electrical Remodeling in AF -- 3 HSP and Structural Remodeling in AF -- 4 HSP and Inflammatory Reactions in AF -- 5 HSP and Oxidative Stress in AF -- 6 Clinical Application of HSP -- 7 Conclusions -- References -- Threading Microarrays into Novel Applications -- 1 Introduction -- 1.1 HSP90 as a Stress Marker -- 1.2 HSP90-Oriented Screening of Compound Libraries by the Use of Protein Microarrays (PMA) -- 1.3 Novel Applications by Protein Microarrays (PMA) -- 1.3.1 Quantum Dots as a Sensor for Biomarker -- Studying Mutational Effects by PMA -- 2 Conclusions -- References. Regulation of Kaposi´s Sarcoma-Associated Herpesvirus Biology by Host Molecular Chaperones -- 1 Introduction -- 1.1 KSHV Lifecycle and Biology -- 1.2 KSHV Structure -- 1.3 KSHV Associated Malignancies -- 1.4 KSHV, Protein Folding and Molecular Chaperones -- 1.5 KSHV and Hsp90 -- 1.6 Hsp70 and KSHV -- 1.7 Endoplasmic Reticulum Chaperones and KSHV -- 1.8 KSHV and Nucleophosmin -- 1.9 Putative Candidate KSHV Chaperone Clients Inferred from Proteomics Datasets -- 2 Conclusions -- References -- Role of Heat Shock Factors in Diseases and Immunity -- 1 Introduction -- 1.1 Heat Shock Factors - Functions, Characteristics, Organization and Role in Diseases -- 1.1.1 Heat Shock Response and Importance of HSF -- 1.1.2 Organization and Regulation of HSF -- 1.1.3 PTMs and HSF -- 1.1.4 Importance of Small Molecules in HSF Activation -- 1.1.5 Relationship Between HSF, Diseases and Immunity -- HSF and Cancer -- HSF and Neurodegenerative Diseases -- HSF and Bacterial Infections -- 1.1.6 HSF and Its Turnover Mechanism -- 2 Conclusions -- References -- Heat Shock Proteins and Pain -- 1 Introduction -- 1.1 Inflammation and Pain -- 1.1.1 Pain Signaling -- 1.1.2 Inflammation and Pain -- 1.2 Heat Shock Proteins and Pain -- 1.2.1 Small Heat Shock Proteins(sHsp) -- 1.2.2 Heat Shock Protein 60 (Hsp60) -- 1.2.3 Heat Shock Protein 70 (Hsp70) -- 1.2.4 Heat Shock Protein 90 (Hsp90) -- 1.3 Heat Shock Proteins and Pain Management -- 1.3.1 sHsp -- 1.3.2 Hsp70 -- 1.3.3 Hsp90 -- 2 Conclusions -- References -- HSF1 Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- 1 Introduction -- 1.1 Cellular Senescence -- 1.2 Acute Depletion of HSF1 Induces Cellular Senescence -- 1.3 Role of HDIS in Tumorigenesis -- 1.3.1 The DHRS2-MDM2-p53 Pathway -- 1.4 Role of HDIS in Age-Related Pathologies -- 2 Conclusions -- References. Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with Diverse Cellular... -- 1 Introduction -- 1.1 Regulation of Heat Shock Proteins by HSF1 -- 1.2 Functions of Heat Shock Proteins -- 1.3 Characteristics of Intrinsically Unstructured/Disordered Protein (IUP/IDP) -- 1.4 Huntingtin Yeast Two-Hybrid Protein K (HYPK) Is an Intrinsically Unstructured/Disordered Protein (IUP/IDP) -- 1.5 In Vitro and In Vivo Chaperone Activity of HYPK -- 1.6 HYPK Binds with Newly Synthesized Peptides/Proteins -- 1.7 HYPK Interacting Proteins -- 1.8 Chaperones Are in Hub of Protein-Protein Interaction Network -- 1.9 HYPK Is Associated with Aggregate Prone Proteins -- 1.10 Thermal Stress, Hypoxia and Proteasome Inhibitor MG132 Enhance Expression of HYPK in Cultured Cells -- 1.11 HSF1 Binds to the Promoter Sequence of HYPK and Regulates the Expression -- 1.12 HYPK Negatively Regulates Heat Shock Response -- 1.13 HSF1 Also Regulate HYPK Conjoined SERF2 Gene -- 1.14 Functions of HYPK -- 1.15 Does HYPK Modify Expression of Other Genes? -- 1.16 Does HYPK Play Any Role Human Disease? -- 2 Conclusions -- References -- Roles of HSP on Antigen Presentation -- 1 Introduction -- 1.1 Mechanisms of Antigen Presentation by Dendritic Cells -- 1.2 Roles of HSP in Antigen Presentation by MHC-I -- 1.3 Roles of HSP in Antigen Presentation by MHC-II -- 2 Conclusions -- References -- Heat Shock Proteins Mediate Anastasis and Plasticity of Thermotolerant Cells -- 1 Introduction -- 2 Apoptosis -- 2.1 The Role of Mitochondria in Apoptosis -- 2.2 The Role of Death Receptors in Apoptosis -- 3 Thermotolernce and Anastasis -- 4 Role of HSP in Anastasis -- 5 Conclusions and Perspectives -- References -- Index. |
| Record Nr. | UNINA-9910484696803321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heat shock proteins in inflammatory diseases / / edited by Alexzander A. A. Asea ; Punit Kaur
| Heat shock proteins in inflammatory diseases / / edited by Alexzander A. A. Asea ; Punit Kaur |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (520 pages) |
| Disciplina | 571.6 |
| Collana | Heat Shock Proteins |
| Soggetto topico |
Immunology
Cytology Medicine Inflamació |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-85168-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910502590903321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
