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Microwaves in organic and medicinal chemistry [[electronic resource] /] / C. Oliver Kappe, Alexander Stadler and Doris Dallinger
| Microwaves in organic and medicinal chemistry [[electronic resource] /] / C. Oliver Kappe, Alexander Stadler and Doris Dallinger |
| Autore | Kappe C. Oliver |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2012 |
| Descrizione fisica | 1 online resource (686 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
DallingerDoris
StadlerAlexander <1973-> |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Microwaves
Organic compounds - Synthesis Pharmaceutical chemistry |
| ISBN |
3-527-64784-8
1-280-66359-6 9786613640529 3-527-64782-1 3-527-64785-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Microwaves in Organic and Medicinal Chemistry; Contents; Preface; Personal Foreword to the First Edition; Personal Foreword to the Second Edition; 1 Introduction: Microwave Synthesis in Perspective; 1.1 Microwave Synthesis and Medicinal Chemistry; 1.2 Microwave-Assisted Organic Synthesis (MAOS): A Brief History; 1.3 Scope and Organization of the Book; References; 2 Microwave Theory; 2.1 Microwave Radiation; 2.2 Microwave Dielectric Heating; 2.3 Dielectric Properties; 2.4 Microwave versus Conventional Thermal Heating; 2.5 Microwave Effects; 2.5.1 Temperature Monitoring in Microwave Chemistry
2.5.2 Thermal Effects (Kinetics)2.5.3 Specific Microwave Effects; 2.5.4 Nonthermal (Athermal) Microwave Effects; References; 3 Equipment Review; 3.1 Introduction; 3.2 Domestic Microwave Ovens; 3.3 Dedicated Microwave Reactors for Organic Synthesis; 3.4 Single-Mode Instruments; 3.4.1 Anton Paar GmbH; 3.4.1.1 Monowave 300; 3.4.2 Biotage AB; 3.4.2.1 Initiator Platform; 3.4.2.2 Chemspeed SWAVE; 3.4.2.3 Peptide Synthesizers; 3.4.3 CEM Corporation; 3.4.3.1 Discover Platform; 3.4.3.2 Explorer Systems; 3.4.3.3 Voyager System; 3.4.3.4 Peptide Synthesizers; 3.5 Multimode Instruments 3.5.1 Anton Paar GmbH3.5.1.1 Synthos 3000; 3.5.1.2 Masterwave Benchtop Reactor; 3.5.2 Biotage AB; 3.5.3 CEM Corporation; 3.5.3.1 MARS Scale-Up System Accessories; 3.5.3.2 MARS Parallel System Accessories; 3.5.4 Milestone s.r.l; 3.5.4.1 MultiSYNTH System; 3.5.4.2 MicroSYNTH Labstation; 3.5.4.3 StartSYNTH; 3.5.4.4 Scale-Up Systems; 3.5.4.5 Microwave-Heated Autoclave Systems; References; 4 Microwave Processing Techniques; 4.1 Solvent-Free Reactions; 4.2 Phase-Transfer Catalysis; 4.3 Open- versus Closed-Vessel Conditions; 4.4 Pre-pressurized Reaction Vessels; 4.5 Nonclassical Solvents 4.5.1 Water as Solvent 4.5.2 Ionic Liquids; 4.6 Passive Heating Elements; 4.7 Processing Techniques in Drug Discovery and High-Throughput Synthesis; 4.7.1 Automated Sequential versus Parallel Processing; 4.7.2 High-Throughput Synthesis Methods; 4.7.2.1 Solid-Phase Synthesis; 4.7.2.2 Soluble Polymer-Supported Synthesis; 4.7.2.3 Fluorous-Phase Organic Synthesis; 4.7.2.4 Polymer-Supported Reagents, Catalysts, and Scavengers; 4.8 Scale-Up in Batch and Continuous Flow; 4.8.1 Scale-Up in Batch and Parallel; 4.8.2 Scale-Up Using Continuous Flow Techniques; 4.8.3 Scale-Up Using Stop-Flow Techniques 4.8.4 Microwave Reactor Systems for Production Scale References; 5 Literature Survey Part A: Transition Metal-Catalyzed Reactions; 5.1 General Comments; 5.2 Carbon-Carbon Bond Formations; 5.2.1 Heck Reactions; 5.2.2 Suzuki-Miyaura Reactions; 5.2.3 Sonogashira Reactions; 5.2.4 Stille Reactions; 5.2.5 Negishi, Kumada, and Related Reactions; 5.2.6 Carbonylation Reactions; 5.2.7 Asymmetric Allylic Alkylations; 5.2.8 Miscellaneous Carbon-Carbon Bond-Forming Reactions; 5.3 Carbon-Heteroatom Bond Formations; 5.3.1 Buchwald-Hartwig Reactions; 5.3.2 Ullmann Condensation Reactions 5.3.3 Miscellaneous Carbon-Heteroatom Bond-Forming Reactions |
| Record Nr. | UNINA-9910141288103321 |
Kappe C. Oliver
|
||
| Weinheim, : Wiley-VCH, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microwaves in organic and medicinal chemistry / / C. Oliver Kappe, Alexander Stadler and Doris Dallinger
| Microwaves in organic and medicinal chemistry / / C. Oliver Kappe, Alexander Stadler and Doris Dallinger |
| Autore | Kappe C. Oliver |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2012 |
| Descrizione fisica | 1 online resource (686 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
DallingerDoris
StadlerAlexander <1973-> |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Microwaves
Organic compounds - Synthesis Pharmaceutical chemistry |
| ISBN |
3-527-64784-8
1-280-66359-6 9786613640529 3-527-64782-1 3-527-64785-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Microwaves in Organic and Medicinal Chemistry; Contents; Preface; Personal Foreword to the First Edition; Personal Foreword to the Second Edition; 1 Introduction: Microwave Synthesis in Perspective; 1.1 Microwave Synthesis and Medicinal Chemistry; 1.2 Microwave-Assisted Organic Synthesis (MAOS): A Brief History; 1.3 Scope and Organization of the Book; References; 2 Microwave Theory; 2.1 Microwave Radiation; 2.2 Microwave Dielectric Heating; 2.3 Dielectric Properties; 2.4 Microwave versus Conventional Thermal Heating; 2.5 Microwave Effects; 2.5.1 Temperature Monitoring in Microwave Chemistry
2.5.2 Thermal Effects (Kinetics)2.5.3 Specific Microwave Effects; 2.5.4 Nonthermal (Athermal) Microwave Effects; References; 3 Equipment Review; 3.1 Introduction; 3.2 Domestic Microwave Ovens; 3.3 Dedicated Microwave Reactors for Organic Synthesis; 3.4 Single-Mode Instruments; 3.4.1 Anton Paar GmbH; 3.4.1.1 Monowave 300; 3.4.2 Biotage AB; 3.4.2.1 Initiator Platform; 3.4.2.2 Chemspeed SWAVE; 3.4.2.3 Peptide Synthesizers; 3.4.3 CEM Corporation; 3.4.3.1 Discover Platform; 3.4.3.2 Explorer Systems; 3.4.3.3 Voyager System; 3.4.3.4 Peptide Synthesizers; 3.5 Multimode Instruments 3.5.1 Anton Paar GmbH3.5.1.1 Synthos 3000; 3.5.1.2 Masterwave Benchtop Reactor; 3.5.2 Biotage AB; 3.5.3 CEM Corporation; 3.5.3.1 MARS Scale-Up System Accessories; 3.5.3.2 MARS Parallel System Accessories; 3.5.4 Milestone s.r.l; 3.5.4.1 MultiSYNTH System; 3.5.4.2 MicroSYNTH Labstation; 3.5.4.3 StartSYNTH; 3.5.4.4 Scale-Up Systems; 3.5.4.5 Microwave-Heated Autoclave Systems; References; 4 Microwave Processing Techniques; 4.1 Solvent-Free Reactions; 4.2 Phase-Transfer Catalysis; 4.3 Open- versus Closed-Vessel Conditions; 4.4 Pre-pressurized Reaction Vessels; 4.5 Nonclassical Solvents 4.5.1 Water as Solvent 4.5.2 Ionic Liquids; 4.6 Passive Heating Elements; 4.7 Processing Techniques in Drug Discovery and High-Throughput Synthesis; 4.7.1 Automated Sequential versus Parallel Processing; 4.7.2 High-Throughput Synthesis Methods; 4.7.2.1 Solid-Phase Synthesis; 4.7.2.2 Soluble Polymer-Supported Synthesis; 4.7.2.3 Fluorous-Phase Organic Synthesis; 4.7.2.4 Polymer-Supported Reagents, Catalysts, and Scavengers; 4.8 Scale-Up in Batch and Continuous Flow; 4.8.1 Scale-Up in Batch and Parallel; 4.8.2 Scale-Up Using Continuous Flow Techniques; 4.8.3 Scale-Up Using Stop-Flow Techniques 4.8.4 Microwave Reactor Systems for Production Scale References; 5 Literature Survey Part A: Transition Metal-Catalyzed Reactions; 5.1 General Comments; 5.2 Carbon-Carbon Bond Formations; 5.2.1 Heck Reactions; 5.2.2 Suzuki-Miyaura Reactions; 5.2.3 Sonogashira Reactions; 5.2.4 Stille Reactions; 5.2.5 Negishi, Kumada, and Related Reactions; 5.2.6 Carbonylation Reactions; 5.2.7 Asymmetric Allylic Alkylations; 5.2.8 Miscellaneous Carbon-Carbon Bond-Forming Reactions; 5.3 Carbon-Heteroatom Bond Formations; 5.3.1 Buchwald-Hartwig Reactions; 5.3.2 Ullmann Condensation Reactions 5.3.3 Miscellaneous Carbon-Heteroatom Bond-Forming Reactions |
| Record Nr. | UNINA-9910808104203321 |
|
Kappe C. Oliver
|
||
| Weinheim, : Wiley-VCH, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Practical microwave synthesis for organic chemists : strategies, instruments, and protocols / / C. Oliver Kappe, Doris Dallinger, and S. Shaun Murphree
| Practical microwave synthesis for organic chemists : strategies, instruments, and protocols / / C. Oliver Kappe, Doris Dallinger, and S. Shaun Murphree |
| Autore | Kappe C. Oliver |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2009 |
| Descrizione fisica | 1 online resource (311 p.) |
| Disciplina |
541.39
547.2 |
| Soggetto topico |
Organic compounds - Synthesis
Microwave devices |
| ISBN |
1-282-02141-9
9786612021411 3-527-62390-6 3-527-62391-4 |
| Classificazione | VK 5500 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Practical Microwave Synthesis for Organic Chemists; Contents; Preface; 1 Microwave Synthesis - An Introduction; References; 2 Microwave Theory; 2.1 Microwave Radiation; 2.2 Microwave Dielectric Heating; 2.3 Dielectric Properties; 2.4 Microwave versus Conventional Thermal Heating; 2.5 Microwave Effects; 2.5.1 Temperature Monitoring in Microwave Chemistry; 2.5.2 Thermal Effects (Kinetics); 2.5.3 Specic Microwave Effects; 2.5.4 Non-Thermal (Athermal) Microwave Effects; References; 3 Equipment Review; 3.1 Introduction; 3.2 Domestic Microwave Ovens
3.3 Dedicated Microwave Reactors for Organic Synthesis3.4 Single-Mode Instruments; 3.4.1 Biotage AB; 3.4.1.1 Initiator Platform; 3.4.1.2 Emrys Platform (2000-2004); 3.4.1.3 Chemspeed SWAVE; 3.4.2 CEM Corporation; 3.4.2.1 Discover Platform; 3.4.2.2 Explorer PLS Systems; 3.4.2.3 Voyager Systems; 3.4.2.4 Peptide Synthesizers; 3.4.3 Milestone s.r.l.; 3.5 Multimode Instruments; 3.5.1 Anton Paar GmbH; 3.5.1.1 Rotors and Vessels; 3.5.2 Biotage AB; 3.5.3 CEM Corporation; 3.5.3.1 MARS Scale-Up System Accessories; 3.5.3.2 MARS Parallel System Accessories; 3.5.4 Milestone s.r.l. 3.5.4.1 MultiSYNTH System3.5.4.2 MicroSYNTH Labstation; 3.5.4.3 StartSYNTH; 3.5.4.4 Scale-Up Systems; 3.5.4.5 RotoSYNTH; References; 4 Microwave Processing Techniques; 4.1 Solvent-Free Reactions; 4.2 Phase-Transfer Catalysis; 4.3 Open- versus Closed-Vessel Conditions; 4.4 Pre-Pressurized Reaction Vessels; 4.5 Non-Classical Solvents; 4.5.1 Water as Solvent; 4.5.2 Ionic Liquids; 4.6 Passive Heating Elements; 4.7 Processing Techniques in Drug Discovery and High-Throughput Synthesis; 4.7.1 Automated Sequential versus Parallel Processing; 4.7.2 High-Throughput Synthesis Methods 4.7.2.1 Solid-Phase Synthesis4.7.2.2 Soluble Polymer-Supported Synthesis; 4.7.2.3 Fluorous-Phase Organic Synthesis; 4.7.2.4 Polymer-Supported Reagents, Catalysts and Scavengers; 4.8 Scale-Up in Batch and Continuous Flow; 4.8.1 Scale-Up in Batch and Parallel; 4.8.2 Scale-Up Using Continuous Flow Techniques; 4.8.3 Scale-Up Using Stop Flow Techniques; 4.8.4 Flow-Through Techniques using Microreactors; References; 5 Starting With Microwave Chemistry; 5.1 Why Use Microwave Reactors?; 5.2 Getting Started-Method Development; 5.2.1 Open or Closed Vessels?; 5.2.2 Choice of Solvent 5.2.3 Temperature, Time and Microwave Power5.2.4 Microwave Instrument Software; 5.2.5 Reaction Optimization; 5.3 Additional Aspects; 5.3.1 Temperature Measurement; 5.3.2 Simultaneous Cooling; 5.3.3 Filling Volume; 5.3.4 The Importance of Stirring; 5.3.5 Pressure Release; 5.3.6 Inert Atmosphere; 5.3.7 Multiple Heating Steps; 5.3.8 Reaction Monitoring; 5.3.9 Reaction Scale versus Instrument; 5.4 Equipment/Maintenance; 5.5 General Suggestions; 5.6 Safety Aspects; 5.7 Advantages and Limitations; 5.8 Frequently Asked Questions (FAQs); References; 6 Experimental Protocols 6.1 General Small-Scale Sealed-Vessel Microwave Processing |
| Record Nr. | UNINA-9910144391203321 |
|
Kappe C. Oliver
|
||
| Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Practical microwave synthesis for organic chemists : strategies, instruments, and protocols / / C. Oliver Kappe, Doris Dallinger, and S. Shaun Murphree
| Practical microwave synthesis for organic chemists : strategies, instruments, and protocols / / C. Oliver Kappe, Doris Dallinger, and S. Shaun Murphree |
| Autore | Kappe C. Oliver |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2009] |
| Descrizione fisica | 1 online resource (311 p.) |
| Disciplina | 547.2 |
| Soggetto topico |
Microwave devices
Organic compounds - Synthesis |
| ISBN |
1-282-02141-9
9786612021411 3-527-62390-6 3-527-62391-4 |
| Classificazione | VK 5500 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Practical Microwave Synthesis for Organic Chemists; Contents; Preface; 1 Microwave Synthesis - An Introduction; References; 2 Microwave Theory; 2.1 Microwave Radiation; 2.2 Microwave Dielectric Heating; 2.3 Dielectric Properties; 2.4 Microwave versus Conventional Thermal Heating; 2.5 Microwave Effects; 2.5.1 Temperature Monitoring in Microwave Chemistry; 2.5.2 Thermal Effects (Kinetics); 2.5.3 Specic Microwave Effects; 2.5.4 Non-Thermal (Athermal) Microwave Effects; References; 3 Equipment Review; 3.1 Introduction; 3.2 Domestic Microwave Ovens
3.3 Dedicated Microwave Reactors for Organic Synthesis3.4 Single-Mode Instruments; 3.4.1 Biotage AB; 3.4.1.1 Initiator Platform; 3.4.1.2 Emrys Platform (2000-2004); 3.4.1.3 Chemspeed SWAVE; 3.4.2 CEM Corporation; 3.4.2.1 Discover Platform; 3.4.2.2 Explorer PLS Systems; 3.4.2.3 Voyager Systems; 3.4.2.4 Peptide Synthesizers; 3.4.3 Milestone s.r.l.; 3.5 Multimode Instruments; 3.5.1 Anton Paar GmbH; 3.5.1.1 Rotors and Vessels; 3.5.2 Biotage AB; 3.5.3 CEM Corporation; 3.5.3.1 MARS Scale-Up System Accessories; 3.5.3.2 MARS Parallel System Accessories; 3.5.4 Milestone s.r.l. 3.5.4.1 MultiSYNTH System3.5.4.2 MicroSYNTH Labstation; 3.5.4.3 StartSYNTH; 3.5.4.4 Scale-Up Systems; 3.5.4.5 RotoSYNTH; References; 4 Microwave Processing Techniques; 4.1 Solvent-Free Reactions; 4.2 Phase-Transfer Catalysis; 4.3 Open- versus Closed-Vessel Conditions; 4.4 Pre-Pressurized Reaction Vessels; 4.5 Non-Classical Solvents; 4.5.1 Water as Solvent; 4.5.2 Ionic Liquids; 4.6 Passive Heating Elements; 4.7 Processing Techniques in Drug Discovery and High-Throughput Synthesis; 4.7.1 Automated Sequential versus Parallel Processing; 4.7.2 High-Throughput Synthesis Methods 4.7.2.1 Solid-Phase Synthesis4.7.2.2 Soluble Polymer-Supported Synthesis; 4.7.2.3 Fluorous-Phase Organic Synthesis; 4.7.2.4 Polymer-Supported Reagents, Catalysts and Scavengers; 4.8 Scale-Up in Batch and Continuous Flow; 4.8.1 Scale-Up in Batch and Parallel; 4.8.2 Scale-Up Using Continuous Flow Techniques; 4.8.3 Scale-Up Using Stop Flow Techniques; 4.8.4 Flow-Through Techniques using Microreactors; References; 5 Starting With Microwave Chemistry; 5.1 Why Use Microwave Reactors?; 5.2 Getting Started-Method Development; 5.2.1 Open or Closed Vessels?; 5.2.2 Choice of Solvent 5.2.3 Temperature, Time and Microwave Power5.2.4 Microwave Instrument Software; 5.2.5 Reaction Optimization; 5.3 Additional Aspects; 5.3.1 Temperature Measurement; 5.3.2 Simultaneous Cooling; 5.3.3 Filling Volume; 5.3.4 The Importance of Stirring; 5.3.5 Pressure Release; 5.3.6 Inert Atmosphere; 5.3.7 Multiple Heating Steps; 5.3.8 Reaction Monitoring; 5.3.9 Reaction Scale versus Instrument; 5.4 Equipment/Maintenance; 5.5 General Suggestions; 5.6 Safety Aspects; 5.7 Advantages and Limitations; 5.8 Frequently Asked Questions (FAQs); References; 6 Experimental Protocols 6.1 General Small-Scale Sealed-Vessel Microwave Processing |
| Record Nr. | UNINA-9910830581803321 |
|
Kappe C. Oliver
|
||
| Weinheim, Germany : , : Wiley-VCH, , [2009] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||