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Combinatorial chemistry [[electronic resource] ] : synthesis, analysis, screening / / edited by Günther Jung
| Combinatorial chemistry [[electronic resource] ] : synthesis, analysis, screening / / edited by Günther Jung |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, 2001, c1999 |
| Descrizione fisica | 1 online resource (635 p.) |
| Disciplina |
547.2
615.19 |
| Altri autori (Persone) | JungGünther |
| Soggetto topico |
Combinatorial chemistry
Organic compounds - Synthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-76416-7
9786611764166 3-527-61350-1 3-527-61351-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Combinatorial Chemistry; Contents; 1. Combinatorial Chemistry; 1.1 Introduction; 1.2 Principles of Combinatorial Chemistry; 1.3 Methods and Techniques of Combinatorial Synthesis; 1.3.1 Synthetic Strategies Towards Combinatorial Libraries; 1.3.1.1 Split-Pool Synthesis Towards Combinatorial Libraries; 1.3.1.2 Parallel Synthesis Towards Combinatorial Libraries; 1.3.1.3 Reagent Mixture Synthesis Towards Combinatorial Libraries; 1.3.2 Synthetic Methodology for Organic Library Construction; 1.3.2.1 Solid-Phase Organic Synthesis; 1.3.2.2 Synthesis in Solution and Liquid-Phase Synthesis
1.4 Characterization of Combinatorial Libraries1.4.1 Analytical Characterization; 1.4.1.1 Analytical Characterization of Compound Mixtures; 1.4.1.2 Analytical Characterization of Single Substances; 1.4.2 Hit Identification in Combinatorial Libraries by High-Throughput Screening; 1.4.2.1 Strategies for Libraries of Compound Mixtures; 1.4.2.2 Strategies for Libraries of Separate Single Compounds; 1.5 Automation and Data Processing; 1.5.1 Synthesis Automation and Data Processing; 1.5.2 Automated Purification; 1.6 Library Design and Diversity Assessment 1.6.1 Diversity Assessment for Selection of Building Blocks or Compounds1.6.2 Iterative Optimization Methods; 1.7 Economic Aspects; 1.8 Acknowledgements; 1.9 References; 2. Survey of Solid-Phase Organic Reactions; 2.1 Introduction; 2.2 Observed Trends; 2.2.1 The Synthetic Repertoire; 2.2.1.1 Robust, Reliable Solid-Phase Reactions; 2.2.1.2 Emerging Solid-Phase Reactions; 2.2.2 Linkers and Cleavage Step; 2.2.3 Reaction-Monitoring; 2.2.4 Highlights; 2.3 Conclusions; 2.4 Reaction Tables; 2.4.1 Substitution Nucleophilic and Electrophilic Type of Reaction: Amide Bond Formation and Related Reactions 2.4.1.1 Sulphonamide2.4.1.2 (Thio)urea; 2.4.1.3 Carbonate; 2.4.1.4 Urethane; 2.4.1.5 Guanidine; 2.4.1.6 Imide; 2.4.1.7 Amide; 2.4.1.8 Lactam; 2.4.2 Type of Reaction: Aromatic Substitution; Electrophilic Carbon-Carbon Bond Formation; 2.4.2.1 Suzuki; 2.4.2.2. Stille; 2.4.2.3 Heck; 2.4.2.4 Other; 2.4.3 Type of Reaction: Aromatic Substitution; Nucleophilic (N-Arylation); 2.4.4 Type of Reaction: Cleavage; 2.4.4.1 Cyclative Cleavage; 2.4.4.2 Functional Group: None (traceless); 2.4.4.3 Functional Group: Halogens; 2.4.4.4 Functional Group: Alkenes; 2.4.4.5 Functional Group: Alcohols, Phenols 2.4.4.6 Functional Group: Primary Amine2.4.4.7 Functional Group: sec-Amine; 2.4.4.8 Functional Group: tert-Amine; 2.4.4.9 Functional Group: Aldehyde/Ketone; 2.4.4.10 Functional Group: Hydroxamic Acid; 2.4.4.11 Functional Group: Amidine; 2.4.4.12 Functional Group: Guanidine; 2.4.4.13 Functional Group: sec Amideltert Amide/Sulfonamide; 2.4.5 Type of Reaction: Condensation; 2.4.6 Type of Reaction: Cycloaddition; 2.4.6.1 [2+2] Cycloaddition; 2.4.6.2 [3+2] Cycloaddition; 2.4.6.3 [4+2] Cycloaddition; 2.4.7 Type of Reaction: Grignard and Related Reactions 2.4.8 Type of Reaction: Heterocycle Formation |
| Record Nr. | UNINA-9910144283003321 |
| Weinheim ; ; New York, : Wiley-VCH, 2001, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Combinatorial chemistry [[electronic resource] ] : synthesis, analysis, screening / / edited by Günther Jung
| Combinatorial chemistry [[electronic resource] ] : synthesis, analysis, screening / / edited by Günther Jung |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, 2001, c1999 |
| Descrizione fisica | 1 online resource (635 p.) |
| Disciplina |
547.2
615.19 |
| Altri autori (Persone) | JungGünther |
| Soggetto topico |
Combinatorial chemistry
Organic compounds - Synthesis |
| ISBN |
1-281-76416-7
9786611764166 3-527-61350-1 3-527-61351-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Combinatorial Chemistry; Contents; 1. Combinatorial Chemistry; 1.1 Introduction; 1.2 Principles of Combinatorial Chemistry; 1.3 Methods and Techniques of Combinatorial Synthesis; 1.3.1 Synthetic Strategies Towards Combinatorial Libraries; 1.3.1.1 Split-Pool Synthesis Towards Combinatorial Libraries; 1.3.1.2 Parallel Synthesis Towards Combinatorial Libraries; 1.3.1.3 Reagent Mixture Synthesis Towards Combinatorial Libraries; 1.3.2 Synthetic Methodology for Organic Library Construction; 1.3.2.1 Solid-Phase Organic Synthesis; 1.3.2.2 Synthesis in Solution and Liquid-Phase Synthesis
1.4 Characterization of Combinatorial Libraries1.4.1 Analytical Characterization; 1.4.1.1 Analytical Characterization of Compound Mixtures; 1.4.1.2 Analytical Characterization of Single Substances; 1.4.2 Hit Identification in Combinatorial Libraries by High-Throughput Screening; 1.4.2.1 Strategies for Libraries of Compound Mixtures; 1.4.2.2 Strategies for Libraries of Separate Single Compounds; 1.5 Automation and Data Processing; 1.5.1 Synthesis Automation and Data Processing; 1.5.2 Automated Purification; 1.6 Library Design and Diversity Assessment 1.6.1 Diversity Assessment for Selection of Building Blocks or Compounds1.6.2 Iterative Optimization Methods; 1.7 Economic Aspects; 1.8 Acknowledgements; 1.9 References; 2. Survey of Solid-Phase Organic Reactions; 2.1 Introduction; 2.2 Observed Trends; 2.2.1 The Synthetic Repertoire; 2.2.1.1 Robust, Reliable Solid-Phase Reactions; 2.2.1.2 Emerging Solid-Phase Reactions; 2.2.2 Linkers and Cleavage Step; 2.2.3 Reaction-Monitoring; 2.2.4 Highlights; 2.3 Conclusions; 2.4 Reaction Tables; 2.4.1 Substitution Nucleophilic and Electrophilic Type of Reaction: Amide Bond Formation and Related Reactions 2.4.1.1 Sulphonamide2.4.1.2 (Thio)urea; 2.4.1.3 Carbonate; 2.4.1.4 Urethane; 2.4.1.5 Guanidine; 2.4.1.6 Imide; 2.4.1.7 Amide; 2.4.1.8 Lactam; 2.4.2 Type of Reaction: Aromatic Substitution; Electrophilic Carbon-Carbon Bond Formation; 2.4.2.1 Suzuki; 2.4.2.2. Stille; 2.4.2.3 Heck; 2.4.2.4 Other; 2.4.3 Type of Reaction: Aromatic Substitution; Nucleophilic (N-Arylation); 2.4.4 Type of Reaction: Cleavage; 2.4.4.1 Cyclative Cleavage; 2.4.4.2 Functional Group: None (traceless); 2.4.4.3 Functional Group: Halogens; 2.4.4.4 Functional Group: Alkenes; 2.4.4.5 Functional Group: Alcohols, Phenols 2.4.4.6 Functional Group: Primary Amine2.4.4.7 Functional Group: sec-Amine; 2.4.4.8 Functional Group: tert-Amine; 2.4.4.9 Functional Group: Aldehyde/Ketone; 2.4.4.10 Functional Group: Hydroxamic Acid; 2.4.4.11 Functional Group: Amidine; 2.4.4.12 Functional Group: Guanidine; 2.4.4.13 Functional Group: sec Amideltert Amide/Sulfonamide; 2.4.5 Type of Reaction: Condensation; 2.4.6 Type of Reaction: Cycloaddition; 2.4.6.1 [2+2] Cycloaddition; 2.4.6.2 [3+2] Cycloaddition; 2.4.6.3 [4+2] Cycloaddition; 2.4.7 Type of Reaction: Grignard and Related Reactions 2.4.8 Type of Reaction: Heterocycle Formation |
| Record Nr. | UNISA-996201948303316 |
| Weinheim ; ; New York, : Wiley-VCH, 2001, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Combinatorial chemistry [[electronic resource] ] : synthesis, analysis, screening / / edited by Günther Jung
| Combinatorial chemistry [[electronic resource] ] : synthesis, analysis, screening / / edited by Günther Jung |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, 2001, c1999 |
| Descrizione fisica | 1 online resource (635 p.) |
| Disciplina |
547.2
615.19 |
| Altri autori (Persone) | JungGünther |
| Soggetto topico |
Combinatorial chemistry
Organic compounds - Synthesis |
| ISBN |
1-281-76416-7
9786611764166 3-527-61350-1 3-527-61351-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Combinatorial Chemistry; Contents; 1. Combinatorial Chemistry; 1.1 Introduction; 1.2 Principles of Combinatorial Chemistry; 1.3 Methods and Techniques of Combinatorial Synthesis; 1.3.1 Synthetic Strategies Towards Combinatorial Libraries; 1.3.1.1 Split-Pool Synthesis Towards Combinatorial Libraries; 1.3.1.2 Parallel Synthesis Towards Combinatorial Libraries; 1.3.1.3 Reagent Mixture Synthesis Towards Combinatorial Libraries; 1.3.2 Synthetic Methodology for Organic Library Construction; 1.3.2.1 Solid-Phase Organic Synthesis; 1.3.2.2 Synthesis in Solution and Liquid-Phase Synthesis
1.4 Characterization of Combinatorial Libraries1.4.1 Analytical Characterization; 1.4.1.1 Analytical Characterization of Compound Mixtures; 1.4.1.2 Analytical Characterization of Single Substances; 1.4.2 Hit Identification in Combinatorial Libraries by High-Throughput Screening; 1.4.2.1 Strategies for Libraries of Compound Mixtures; 1.4.2.2 Strategies for Libraries of Separate Single Compounds; 1.5 Automation and Data Processing; 1.5.1 Synthesis Automation and Data Processing; 1.5.2 Automated Purification; 1.6 Library Design and Diversity Assessment 1.6.1 Diversity Assessment for Selection of Building Blocks or Compounds1.6.2 Iterative Optimization Methods; 1.7 Economic Aspects; 1.8 Acknowledgements; 1.9 References; 2. Survey of Solid-Phase Organic Reactions; 2.1 Introduction; 2.2 Observed Trends; 2.2.1 The Synthetic Repertoire; 2.2.1.1 Robust, Reliable Solid-Phase Reactions; 2.2.1.2 Emerging Solid-Phase Reactions; 2.2.2 Linkers and Cleavage Step; 2.2.3 Reaction-Monitoring; 2.2.4 Highlights; 2.3 Conclusions; 2.4 Reaction Tables; 2.4.1 Substitution Nucleophilic and Electrophilic Type of Reaction: Amide Bond Formation and Related Reactions 2.4.1.1 Sulphonamide2.4.1.2 (Thio)urea; 2.4.1.3 Carbonate; 2.4.1.4 Urethane; 2.4.1.5 Guanidine; 2.4.1.6 Imide; 2.4.1.7 Amide; 2.4.1.8 Lactam; 2.4.2 Type of Reaction: Aromatic Substitution; Electrophilic Carbon-Carbon Bond Formation; 2.4.2.1 Suzuki; 2.4.2.2. Stille; 2.4.2.3 Heck; 2.4.2.4 Other; 2.4.3 Type of Reaction: Aromatic Substitution; Nucleophilic (N-Arylation); 2.4.4 Type of Reaction: Cleavage; 2.4.4.1 Cyclative Cleavage; 2.4.4.2 Functional Group: None (traceless); 2.4.4.3 Functional Group: Halogens; 2.4.4.4 Functional Group: Alkenes; 2.4.4.5 Functional Group: Alcohols, Phenols 2.4.4.6 Functional Group: Primary Amine2.4.4.7 Functional Group: sec-Amine; 2.4.4.8 Functional Group: tert-Amine; 2.4.4.9 Functional Group: Aldehyde/Ketone; 2.4.4.10 Functional Group: Hydroxamic Acid; 2.4.4.11 Functional Group: Amidine; 2.4.4.12 Functional Group: Guanidine; 2.4.4.13 Functional Group: sec Amideltert Amide/Sulfonamide; 2.4.5 Type of Reaction: Condensation; 2.4.6 Type of Reaction: Cycloaddition; 2.4.6.1 [2+2] Cycloaddition; 2.4.6.2 [3+2] Cycloaddition; 2.4.6.3 [4+2] Cycloaddition; 2.4.7 Type of Reaction: Grignard and Related Reactions 2.4.8 Type of Reaction: Heterocycle Formation |
| Record Nr. | UNINA-9910831168603321 |
| Weinheim ; ; New York, : Wiley-VCH, 2001, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Combinatorial chemistry : synthesis, analysis, screening / / edited by Günther Jung
| Combinatorial chemistry : synthesis, analysis, screening / / edited by Günther Jung |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, 2001, c1999 |
| Descrizione fisica | 1 online resource (635 p.) |
| Disciplina |
547.2
615.19 |
| Altri autori (Persone) | JungGünther |
| Soggetto topico |
Combinatorial chemistry
Organic compounds - Synthesis |
| ISBN |
1-281-76416-7
9786611764166 3-527-61350-1 3-527-61351-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Combinatorial Chemistry; Contents; 1. Combinatorial Chemistry; 1.1 Introduction; 1.2 Principles of Combinatorial Chemistry; 1.3 Methods and Techniques of Combinatorial Synthesis; 1.3.1 Synthetic Strategies Towards Combinatorial Libraries; 1.3.1.1 Split-Pool Synthesis Towards Combinatorial Libraries; 1.3.1.2 Parallel Synthesis Towards Combinatorial Libraries; 1.3.1.3 Reagent Mixture Synthesis Towards Combinatorial Libraries; 1.3.2 Synthetic Methodology for Organic Library Construction; 1.3.2.1 Solid-Phase Organic Synthesis; 1.3.2.2 Synthesis in Solution and Liquid-Phase Synthesis
1.4 Characterization of Combinatorial Libraries1.4.1 Analytical Characterization; 1.4.1.1 Analytical Characterization of Compound Mixtures; 1.4.1.2 Analytical Characterization of Single Substances; 1.4.2 Hit Identification in Combinatorial Libraries by High-Throughput Screening; 1.4.2.1 Strategies for Libraries of Compound Mixtures; 1.4.2.2 Strategies for Libraries of Separate Single Compounds; 1.5 Automation and Data Processing; 1.5.1 Synthesis Automation and Data Processing; 1.5.2 Automated Purification; 1.6 Library Design and Diversity Assessment 1.6.1 Diversity Assessment for Selection of Building Blocks or Compounds1.6.2 Iterative Optimization Methods; 1.7 Economic Aspects; 1.8 Acknowledgements; 1.9 References; 2. Survey of Solid-Phase Organic Reactions; 2.1 Introduction; 2.2 Observed Trends; 2.2.1 The Synthetic Repertoire; 2.2.1.1 Robust, Reliable Solid-Phase Reactions; 2.2.1.2 Emerging Solid-Phase Reactions; 2.2.2 Linkers and Cleavage Step; 2.2.3 Reaction-Monitoring; 2.2.4 Highlights; 2.3 Conclusions; 2.4 Reaction Tables; 2.4.1 Substitution Nucleophilic and Electrophilic Type of Reaction: Amide Bond Formation and Related Reactions 2.4.1.1 Sulphonamide2.4.1.2 (Thio)urea; 2.4.1.3 Carbonate; 2.4.1.4 Urethane; 2.4.1.5 Guanidine; 2.4.1.6 Imide; 2.4.1.7 Amide; 2.4.1.8 Lactam; 2.4.2 Type of Reaction: Aromatic Substitution; Electrophilic Carbon-Carbon Bond Formation; 2.4.2.1 Suzuki; 2.4.2.2. Stille; 2.4.2.3 Heck; 2.4.2.4 Other; 2.4.3 Type of Reaction: Aromatic Substitution; Nucleophilic (N-Arylation); 2.4.4 Type of Reaction: Cleavage; 2.4.4.1 Cyclative Cleavage; 2.4.4.2 Functional Group: None (traceless); 2.4.4.3 Functional Group: Halogens; 2.4.4.4 Functional Group: Alkenes; 2.4.4.5 Functional Group: Alcohols, Phenols 2.4.4.6 Functional Group: Primary Amine2.4.4.7 Functional Group: sec-Amine; 2.4.4.8 Functional Group: tert-Amine; 2.4.4.9 Functional Group: Aldehyde/Ketone; 2.4.4.10 Functional Group: Hydroxamic Acid; 2.4.4.11 Functional Group: Amidine; 2.4.4.12 Functional Group: Guanidine; 2.4.4.13 Functional Group: sec Amideltert Amide/Sulfonamide; 2.4.5 Type of Reaction: Condensation; 2.4.6 Type of Reaction: Cycloaddition; 2.4.6.1 [2+2] Cycloaddition; 2.4.6.2 [3+2] Cycloaddition; 2.4.6.3 [4+2] Cycloaddition; 2.4.7 Type of Reaction: Grignard and Related Reactions 2.4.8 Type of Reaction: Heterocycle Formation |
| Record Nr. | UNINA-9910877873003321 |
| Weinheim ; ; New York, : Wiley-VCH, 2001, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Combinatorial peptide and nonpeptide libraries : a handbook / / edited by Günther Jung
| Combinatorial peptide and nonpeptide libraries : a handbook / / edited by Günther Jung |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : VCH, , 1996 |
| Descrizione fisica | 1 online resource (574 p.) |
| Disciplina | 547.756 |
| Soggetto topico | Combinatorial chemistry |
| ISBN |
1-281-84264-8
9786611842642 3-527-61491-5 3-527-61490-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Combinatorial Peptide and Nonpeptide Libraries; Preface; Contents; List of Contributors; List of Abbreviations; 1 Natural Peptide Libraries of Microbial and Mammalian Origin; 1.1 Introduction; 1.2 Natural Peptide Libraries of Microbial Origin; 1.2.1 Microbial Polypeptide Antibiotics by Multienzymatic Thiotemplate Synthesis; 1.2.2 Polypeptide Antibiotics by Ribosomal Precursor Protein Synthesis and Posttranslational Modifications; 1.2.3 Combinatorial Biosynthesis and Biological Diversity of Polyketids; 1.3 Natural Peptide Libraries of Mammalian Origin
1.3.1 Self-peptide Libraries Isolated from MHC-Class I Molecules1.3.2 Self-peptide Libraries Isolated from MHC-Class II Molecules; 1.4 From Natural to Synthetic Peptide Libraries; 1.4.1 Synthetic Methods and the Variety of Peptide and Oligomer Libraries; 1.4.2 Analysis of Synthetic Peptide Libraries; 1.4.3 Selected Applications of Synthetic Peptide Libraries; References; 2 Polymer Supported Organic Synthesis: A Review; 2.1 Introduction; 2.2 Solid-Phase Organic Synthesis and Analytics; 2.2.1 Advantages of Solid-Phase Synthesis in Organic Reactions and Product Work-Up 2.2.2 Supports and Anchors2.2.3 Multiple, Parallel Syntheses; 2.2.4 Analytics and Monitoring of Solid-Phase Reactions; 2.3 Examples of Solid-Phase Syntheses of Small Molecules; 2.3.1 Immobilization and Reactions with Hydroxy Compounds; 2.3.1.1 Derivatization of Hydroxy Compounds by Mitsunobu Reaction; 2.3.2 Immobilization and Derivatization of Aldehydes and Ketones; 2.3.3 Immobilization and Derivatization of Dicarboxylic Acids and Their Derivatives; 2.3.4 Ring Closure Reactions; 2.3.5 Heterocyclic Compounds: Benzodiazepines, Hydantoins and Thiazolidines 2.3.6 Further Ring Closures on Solid Support2.3.7 Palladium Catalyzed C-C Attachments; 2.3.8 Further Reactions on Polymeric Support; 2.4 Oligomer Synthesis; 2.4.1 Peptoids; 2.4.2 Oligocarbamates; 2.4.3 Peptide-Nucleic Acids (PNA); 2.4.4 Oligoureas; 2.5 Outlook; Acknowledgments; References; 3 From Multiple Peptide Synthesis to Peptide Libraries; 3.1 Introduction; 3.2 Simultaneous Multiple Peptide Synthesis (SMPS); 3.2.1 Tea-Bag Synthesis; 3.2.2 Cellulose as Support in Multiple Syntheses; 3.2.3 Polystyrene-Grafted Polyethylene (PS-PE) Film, a New Resin? 3.2.4 Automated Multiple Peptide Synthesizers3.2.5 Synthesis of Polymer-Bound Peptides; 3.2.6 Spot Synthesis; 3.2.7 Spatially Addressed Synthesis of Thousands of Peptides; 3.2.8 Microstructured Peptide-Gold Electrode; 3.2.9 Peptide Functionalized Surface by Electrochemical Polymerization; 3.3 Peptide Libraries; 3.3.1 Mixotopes; 3.3.2 Mimotopes; 3.3.3 Phage Libraries and Biopanning; 3.3.4 Random Libraries; 3.3.5 Modified Peptide Libraries; 3.3.6 Identification of the Active Compounds; 3.4 Conclusions; References; 4 Chemical Synthesis of Peptide Libraries; 4.1 The Portioning-Mixing Method 4.1.1 Principles and Realization |
| Record Nr. | UNINA-9910144281103321 |
| Weinheim, [Germany] : , : VCH, , 1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Combinatorial peptide and nonpeptide libraries : a handbook / / edited by Günther Jung
| Combinatorial peptide and nonpeptide libraries : a handbook / / edited by Günther Jung |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : VCH, , 1996 |
| Descrizione fisica | 1 online resource (574 p.) |
| Disciplina | 547.756 |
| Soggetto topico | Combinatorial chemistry |
| ISBN |
1-281-84264-8
9786611842642 3-527-61491-5 3-527-61490-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Combinatorial Peptide and Nonpeptide Libraries; Preface; Contents; List of Contributors; List of Abbreviations; 1 Natural Peptide Libraries of Microbial and Mammalian Origin; 1.1 Introduction; 1.2 Natural Peptide Libraries of Microbial Origin; 1.2.1 Microbial Polypeptide Antibiotics by Multienzymatic Thiotemplate Synthesis; 1.2.2 Polypeptide Antibiotics by Ribosomal Precursor Protein Synthesis and Posttranslational Modifications; 1.2.3 Combinatorial Biosynthesis and Biological Diversity of Polyketids; 1.3 Natural Peptide Libraries of Mammalian Origin
1.3.1 Self-peptide Libraries Isolated from MHC-Class I Molecules1.3.2 Self-peptide Libraries Isolated from MHC-Class II Molecules; 1.4 From Natural to Synthetic Peptide Libraries; 1.4.1 Synthetic Methods and the Variety of Peptide and Oligomer Libraries; 1.4.2 Analysis of Synthetic Peptide Libraries; 1.4.3 Selected Applications of Synthetic Peptide Libraries; References; 2 Polymer Supported Organic Synthesis: A Review; 2.1 Introduction; 2.2 Solid-Phase Organic Synthesis and Analytics; 2.2.1 Advantages of Solid-Phase Synthesis in Organic Reactions and Product Work-Up 2.2.2 Supports and Anchors2.2.3 Multiple, Parallel Syntheses; 2.2.4 Analytics and Monitoring of Solid-Phase Reactions; 2.3 Examples of Solid-Phase Syntheses of Small Molecules; 2.3.1 Immobilization and Reactions with Hydroxy Compounds; 2.3.1.1 Derivatization of Hydroxy Compounds by Mitsunobu Reaction; 2.3.2 Immobilization and Derivatization of Aldehydes and Ketones; 2.3.3 Immobilization and Derivatization of Dicarboxylic Acids and Their Derivatives; 2.3.4 Ring Closure Reactions; 2.3.5 Heterocyclic Compounds: Benzodiazepines, Hydantoins and Thiazolidines 2.3.6 Further Ring Closures on Solid Support2.3.7 Palladium Catalyzed C-C Attachments; 2.3.8 Further Reactions on Polymeric Support; 2.4 Oligomer Synthesis; 2.4.1 Peptoids; 2.4.2 Oligocarbamates; 2.4.3 Peptide-Nucleic Acids (PNA); 2.4.4 Oligoureas; 2.5 Outlook; Acknowledgments; References; 3 From Multiple Peptide Synthesis to Peptide Libraries; 3.1 Introduction; 3.2 Simultaneous Multiple Peptide Synthesis (SMPS); 3.2.1 Tea-Bag Synthesis; 3.2.2 Cellulose as Support in Multiple Syntheses; 3.2.3 Polystyrene-Grafted Polyethylene (PS-PE) Film, a New Resin? 3.2.4 Automated Multiple Peptide Synthesizers3.2.5 Synthesis of Polymer-Bound Peptides; 3.2.6 Spot Synthesis; 3.2.7 Spatially Addressed Synthesis of Thousands of Peptides; 3.2.8 Microstructured Peptide-Gold Electrode; 3.2.9 Peptide Functionalized Surface by Electrochemical Polymerization; 3.3 Peptide Libraries; 3.3.1 Mixotopes; 3.3.2 Mimotopes; 3.3.3 Phage Libraries and Biopanning; 3.3.4 Random Libraries; 3.3.5 Modified Peptide Libraries; 3.3.6 Identification of the Active Compounds; 3.4 Conclusions; References; 4 Chemical Synthesis of Peptide Libraries; 4.1 The Portioning-Mixing Method 4.1.1 Principles and Realization |
| Record Nr. | UNISA-996202138703316 |
| Weinheim, [Germany] : , : VCH, , 1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Combinatorial peptide and nonpeptide libraries : a handbook / / edited by Günther Jung
| Combinatorial peptide and nonpeptide libraries : a handbook / / edited by Günther Jung |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : VCH, , 1996 |
| Descrizione fisica | 1 online resource (574 p.) |
| Disciplina | 547.756 |
| Soggetto topico | Combinatorial chemistry |
| ISBN |
1-281-84264-8
9786611842642 3-527-61491-5 3-527-61490-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Combinatorial Peptide and Nonpeptide Libraries; Preface; Contents; List of Contributors; List of Abbreviations; 1 Natural Peptide Libraries of Microbial and Mammalian Origin; 1.1 Introduction; 1.2 Natural Peptide Libraries of Microbial Origin; 1.2.1 Microbial Polypeptide Antibiotics by Multienzymatic Thiotemplate Synthesis; 1.2.2 Polypeptide Antibiotics by Ribosomal Precursor Protein Synthesis and Posttranslational Modifications; 1.2.3 Combinatorial Biosynthesis and Biological Diversity of Polyketids; 1.3 Natural Peptide Libraries of Mammalian Origin
1.3.1 Self-peptide Libraries Isolated from MHC-Class I Molecules1.3.2 Self-peptide Libraries Isolated from MHC-Class II Molecules; 1.4 From Natural to Synthetic Peptide Libraries; 1.4.1 Synthetic Methods and the Variety of Peptide and Oligomer Libraries; 1.4.2 Analysis of Synthetic Peptide Libraries; 1.4.3 Selected Applications of Synthetic Peptide Libraries; References; 2 Polymer Supported Organic Synthesis: A Review; 2.1 Introduction; 2.2 Solid-Phase Organic Synthesis and Analytics; 2.2.1 Advantages of Solid-Phase Synthesis in Organic Reactions and Product Work-Up 2.2.2 Supports and Anchors2.2.3 Multiple, Parallel Syntheses; 2.2.4 Analytics and Monitoring of Solid-Phase Reactions; 2.3 Examples of Solid-Phase Syntheses of Small Molecules; 2.3.1 Immobilization and Reactions with Hydroxy Compounds; 2.3.1.1 Derivatization of Hydroxy Compounds by Mitsunobu Reaction; 2.3.2 Immobilization and Derivatization of Aldehydes and Ketones; 2.3.3 Immobilization and Derivatization of Dicarboxylic Acids and Their Derivatives; 2.3.4 Ring Closure Reactions; 2.3.5 Heterocyclic Compounds: Benzodiazepines, Hydantoins and Thiazolidines 2.3.6 Further Ring Closures on Solid Support2.3.7 Palladium Catalyzed C-C Attachments; 2.3.8 Further Reactions on Polymeric Support; 2.4 Oligomer Synthesis; 2.4.1 Peptoids; 2.4.2 Oligocarbamates; 2.4.3 Peptide-Nucleic Acids (PNA); 2.4.4 Oligoureas; 2.5 Outlook; Acknowledgments; References; 3 From Multiple Peptide Synthesis to Peptide Libraries; 3.1 Introduction; 3.2 Simultaneous Multiple Peptide Synthesis (SMPS); 3.2.1 Tea-Bag Synthesis; 3.2.2 Cellulose as Support in Multiple Syntheses; 3.2.3 Polystyrene-Grafted Polyethylene (PS-PE) Film, a New Resin? 3.2.4 Automated Multiple Peptide Synthesizers3.2.5 Synthesis of Polymer-Bound Peptides; 3.2.6 Spot Synthesis; 3.2.7 Spatially Addressed Synthesis of Thousands of Peptides; 3.2.8 Microstructured Peptide-Gold Electrode; 3.2.9 Peptide Functionalized Surface by Electrochemical Polymerization; 3.3 Peptide Libraries; 3.3.1 Mixotopes; 3.3.2 Mimotopes; 3.3.3 Phage Libraries and Biopanning; 3.3.4 Random Libraries; 3.3.5 Modified Peptide Libraries; 3.3.6 Identification of the Active Compounds; 3.4 Conclusions; References; 4 Chemical Synthesis of Peptide Libraries; 4.1 The Portioning-Mixing Method 4.1.1 Principles and Realization |
| Record Nr. | UNINA-9910830528103321 |
| Weinheim, [Germany] : , : VCH, , 1996 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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