Edizione	[2nd ed. 2022.]
Pubbl/distr/stampa	Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
Descrizione fisica	1 online resource (562 pages)
Disciplina	572.86 572.792
Collana	Advances in Experimental Medicine and Biology
Soggetto topico	Cytology Epigenetics Medical genetics Enzymology Cell Biology Medical Genetics
ISBN	3-031-11454-X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Chapter 1. Mechanisms and biological roles of DNA methyltransferases and DNA methylation – from past achievements to future challenges -- Chapter 2.Bacterial DNA Methylation and Methylomes -- Chapter 3. ChapterDomain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases -- Chapter 4. Enzymology of Mammalian DNA Methyltransferases -- Chapter 5. Genetic Studies on Mammalian DNA Methyltransferase -- Chapter 6. Structure and Mechanism of Plant DNA Methyltransferases -- Chapter 7. DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics -- Chapter 8. N6-Methyladenine: A Conserved and Dynamic DNA Mark -- Chapter 9. Pathways of DNA Demethylation -- Chapter 10. Structure and Function of TET Enzymes -- Chapter 11.Proteins That Read DNA Methylation -- Chapter 12. Recent advances on DNA base flipping – a general mechanism for writing, reading, and erasing DNA modifications.-Chapter 13. The Role of DNA Methylation in Cancer -- Chapter 14. DNMTs and DNA damage -- Chapter 15. Role of DNMTs in brain -- Chapter 16. Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.-Chapter 17. Inhibitors of DNA methylation -- Chapter 18. Rewriting DNA Methylation Signatures at Will: The Curable Genome Within Reach? -- Chapter 19. DNA Labeling Using DNA Methyltransferases.
Record Nr.	UNINA-9910629285803321

Edizione	[1st ed. 2016.]
Pubbl/distr/stampa	Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Descrizione fisica	1 online resource (VIII, 535 p. 61 illus., 57 illus. in color.)
Disciplina	572.86
Collana	Advances in Experimental Medicine and Biology
Soggetto topico	Cytology Gene expression Cytogenetics Cell Biology Gene Expression
ISBN	3-319-43624-4
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Mechanisms and biological roles of DNA methylation and DNA methyltransferases – from past achievements to future challenges -- DNA and RNA pyrimidine nucleobase alkylation at the carbon-5 position -- Bacterial DNA methylation and methylomes -- Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases -- Enzymology of mammalian DNA methyltransferases -- Genetic studies on mammalian DNA methyltransferases -- The role of DNA methylation in cancer -- Structure and mechanism of plant DNA methyltransferases -- DNA methylation and gene regulation in honey bees: from genome-wide analyses to obligatory epi-alleles -- N6-methyladenine: a conserved and dynamic DNA mark -- Pathways of DNA demethylation -- Structure and function of TET enzymes -- Proteins that read DNA methylation -- DNA base flipping – a general mechanism for writing, reading, and erasing DNA modifications -- Current and emerging technologies for the analysis of the genome-wide and locus-specific DNA methylation patterns -- DNA methyltransferase inhibitors – development and applications -- Rewriting DNA methylation signatures at will: the curable genome within reach? -- Engineering and directed evolution of DNA methyltransferases -- DNA labeling using DNA methyltransferases.
Record Nr.	UNINA-9910150454903321

Pubbl/distr/stampa	Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2020
Descrizione fisica	1 online resource (150 pages) : illustrations
Disciplina	574.1
Soggetto topico	Enzymes
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-9910673902503321

Autore	Jeltsch Albert
Pubbl/distr/stampa	Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022
Descrizione fisica	1 online resource (292 p.)
Soggetto topico	Biochemistry Biology, life sciences Research & information: general
Soggetto non controllato	actin actin cytoskeleton AML arginine methylation cancer cardiovascular disease cell proliferation cell signaling chromatin regulation congenital heart diseases cytoskeleton dendritic spine diabetes disease DNA damage repair dystonia eEF1A EHMT1 EHMT2 enteroviruses enzyme regulation enzyme specificity epigenetics G9a GLP GTPase H3K36 H3K36me2 H3K4me3 H3K9 methylation H3R2me2a H4R3 methylation heterochromatin histone Hsmar1 Huntington's disease immunity inflammation inflammatory bowel disease lysine methylation lysine-specific methyltransferase (PKMT) methyltransferase Metnase METTL13 MLL2 N-terminal methylation n/a neurodegenerative diseases neuron NHEJ non-homologous end joining repair NSD1 NSD3 NUP98-NSD1 oncogenesis PKMT pluripotency polymerization post translational modification post-translational modification post-translational protein modification posttranslational modifications Prader-Willi syndrome PRMT1 PRMT2 PRMT5 PRMT6 PRMT7 protein arginine methylation protein histidine methylation protein lysine methylation protein post-translational modification Rett syndrome schizophrenia SET7/9 SETD3 SETD7 SETDB1 SETMAR SH3 SOTOS stress response structure structure and function synapse transcriptional regulation translation transposable elements transposase WHSC1L1
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-9910566479603321