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Autore: |
Jankowski Marek
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Titolo: |
Interleukin-27: Biological Properties and Clinical Application / / by Marek Jankowski, Tomasz Wandtke
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Pubblicazione: | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
Edizione: | 1st ed. 2016. |
Descrizione fisica: | 1 online resource (91 p.) |
Disciplina: | 616.994071 |
Soggetto topico: | Immunology |
Cytokines | |
Growth factors | |
Cytokines and Growth Factors | |
Persona (resp. second.): | WandtkeTomasz |
Note generali: | Description based upon print version of record. |
Nota di bibliografia: | Includes bibliographical references at the end of each chapters. |
Nota di contenuto: | IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease. |
Sommario/riassunto: | This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike. |
Titolo autorizzato: | Interleukin-27: Biological Properties and Clinical Application ![]() |
ISBN: | 3-319-39664-1 |
Formato: | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910253870803321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |