Interleukin-27: Biological Properties and Clinical Application / / by Marek Jankowski, Tomasz Wandtke
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| Autore: |
Jankowski Marek
|
| Titolo: |
Interleukin-27: Biological Properties and Clinical Application / / by Marek Jankowski, Tomasz Wandtke
|
| Pubblicazione: | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Edizione: | 1st ed. 2016. |
| Descrizione fisica: | 1 online resource (91 p.) |
| Disciplina: | 616.994071 |
| Soggetto topico: | Immunology |
| Cytokines | |
| Growth factors | |
| Cytokines and Growth Factors | |
| Persona (resp. second.): | WandtkeTomasz |
| Note generali: | Description based upon print version of record. |
| Nota di bibliografia: | Includes bibliographical references at the end of each chapters. |
| Nota di contenuto: | IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease. |
| Sommario/riassunto: | This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike. |
| Titolo autorizzato: | Interleukin-27: Biological Properties and Clinical Application |
| ISBN: | 3-319-39664-1 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910253870803321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
SpringerBriefs in Immunology, . 2194-2773