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Molecular genetics of mycobacteria / / edited by Graham F. Hatfull and William R. Jacobs, Jr
| Molecular genetics of mycobacteria / / edited by Graham F. Hatfull and William R. Jacobs, Jr |
| Edizione | [2nd edition.] |
| Pubbl/distr/stampa | Washington, District of Columbia : , : ASM Press, , 2014 |
| Descrizione fisica | 1 online resource (xviii, 805 pages) : illustrations (some color) |
| Disciplina | 579.374135 |
| Soggetto topico |
Mycobacteria
Bacterial genetics Tuberculosis - Genetic aspects |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-68367-342-5
1-68367-100-7 1-55581-884-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Half Title; Title Page; Copyright; Contents; Contributors; Preface; I. Genomes, Genomics, and Genetic Exchange; Chapter 1: Gene Transfer in Mycobacterium tuberculosis: Shuttle Phasmids to Enlightenment; OVERVIEW OF KEY MUTATIONS THAT FACILITATED GENE TRANSFER IN M. TUBERCULOSIS; GENE TRANSMISSION ESTABLISHED PHENOTYPE CAUSALITY; ELUCIDATING THE MECHANISMS OFDRUG KILLING: THE STREPTOMYCIN EXAMPLE; TRANSFER OF GENES FROM PATHOGENIC MYCOBACTERIA INTO THE SURROGATE HOST E. COLI: GREAT PROMISE WITH LIMITATIONS
INTRODUCTION OF FOREIGN DNA INTO MYCOBACTERIA: SHUTTLE PHASMIDS AND THE DEVELOPMENT OF A PLASMID TRANSFORMATION SYSTEM FOR M. SMEGMATISSECOND GENERATION SHUTTLE PHASMIDS: REPORTER MYCOBACTERIOPHAGES, TRANSPOSON DELIVERY, AND SPECIALIZED TRANSDUCTION; HIGH-THROUGHPUT SPECIALIZED TRANSDUCTION; IMAGINING A WORLD WITHOUT TB; Chapter 2: Mycobacterial Pathogenomics and Evolution; INTRODUCTION; MYCOBACTERIAL GENOMICS; INSIGHTS INTO THE MACROEVOLUTION OF M. TUBERCULOSIS BASED ON COMPARISON WITH M. MARINUM AND MYCOBACTERIUM KANSASII; MICROEVOLUTIONARY GENOMICS OF THE TUBERCLE BACILLI MYCOBACTERIAL SYSTEMS DISCOVERED BY GENOMICS THAT ARE INVOLVED IN PATHOGENICITYCONCLUSIONS AND PERSPECTIVES; Chapter 3: BCG Vaccines; HISTORY OF BCG SUBSTRAINS; BCG AS AN ATTENUATED MEMBER OF THE M. TUBERCULOSIS COMPLEX; MOLECULAR EVOLUTION AND THE DERIVATION OF BCG SUBSTRAINS; MOLECULAR EVOLUTION AND THE PROPAGATION OF BCG SUBSTRAINS; CONCLUSION AND PERSPECTIVES: ATTENUATION OF VIRULENCE AND PROTECTIVE EFFICACY; REFERENCES; Chapter 4: Distributive Conjugal Transfer: New Insights into Horizontal Gene Transfer and Genetic Exchange in Mycobacteria CLASSICAL oriT-MEDIATED CONJUGATION: A BRIEF OVERVIEWMYCOBACTERIAL CONJUGATION; DISTRIBUTIVE CONJUGAL TRANSFER; DCT AS AN ENGINE FOR MYCOBACTERIAL EVOLUTION; DCT AS A GENETIC MAPPING TOOL; SUMMARY AND FUTURE PROSPECTSFOR DCT; Chapter 5: Molecular Genetics of Mycobacteriophages; GENERAL ASPECTS OF MYCOBACTERIOPHAGES; MYCOBACTERIOPHAGE GENOMICS; MYCOBACTERIOPHAGE-HOST INTERACTIONS; INTEGRATION SYSTEMS; MYCOBACTERIOPHAGE GENE EXPRESSIONAND ITS REGULATION; GENETIC MANIPULATION OF MYCOBACTERIOPHAGES; APPLICATIONS FOR MYCOBACTERIAL GENETICS; PERSPECTIVES: PAST, PRESENT, AND FUTURE Chapter 6: Genetics of Phage LysisTHE LYSIS PLAYERS; MYCOBACTERIOPHAGE-MEDIATED LYSIS; APPLICATIONS OF THE LYSIS PROPERTIES; CONCLUDING REMARKS; II. Gene Expression and Regulation; Chapter 7: Sigma Factors: Key Molecules in Mycobacterium tuberculosis Physiology and Virulence; THE σ FACTORS OF MYCOBACTERIUM TUBERCULOSIS ; Chapter 8: Transcription Factor Binding Site Mapping Using ChIP-Seq; ChIP-Seq METHOD AND PROTOCOL; DATA ANALYSIS; COMPREHENSIVE MAPPING OF TF BINDING SITES IN M. TUBERCULOSIS; VALIDATION OF THE ChIP-Seq SYSTEM; THE DIVERSITY OF TF BINDING IN PROKARYOTES NONPROMOTER TF BINDING |
| Record Nr. | UNINA-9910555144203321 |
| Washington, District of Columbia : , : ASM Press, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular genetics of mycobacteria / / edited by Graham F. Hatfull and William R. Jacobs, Jr
| Molecular genetics of mycobacteria / / edited by Graham F. Hatfull and William R. Jacobs, Jr |
| Edizione | [2nd edition.] |
| Pubbl/distr/stampa | Washington, District of Columbia : , : ASM Press, , 2014 |
| Descrizione fisica | 1 online resource (xviii, 805 pages) : illustrations (some color) |
| Disciplina | 579.374135 |
| Soggetto topico |
Mycobacteria
Bacterial genetics Tuberculosis - Genetic aspects |
| ISBN |
1-68367-342-5
1-68367-100-7 1-55581-884-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Half Title; Title Page; Copyright; Contents; Contributors; Preface; I. Genomes, Genomics, and Genetic Exchange; Chapter 1: Gene Transfer in Mycobacterium tuberculosis: Shuttle Phasmids to Enlightenment; OVERVIEW OF KEY MUTATIONS THAT FACILITATED GENE TRANSFER IN M. TUBERCULOSIS; GENE TRANSMISSION ESTABLISHED PHENOTYPE CAUSALITY; ELUCIDATING THE MECHANISMS OFDRUG KILLING: THE STREPTOMYCIN EXAMPLE; TRANSFER OF GENES FROM PATHOGENIC MYCOBACTERIA INTO THE SURROGATE HOST E. COLI: GREAT PROMISE WITH LIMITATIONS
INTRODUCTION OF FOREIGN DNA INTO MYCOBACTERIA: SHUTTLE PHASMIDS AND THE DEVELOPMENT OF A PLASMID TRANSFORMATION SYSTEM FOR M. SMEGMATISSECOND GENERATION SHUTTLE PHASMIDS: REPORTER MYCOBACTERIOPHAGES, TRANSPOSON DELIVERY, AND SPECIALIZED TRANSDUCTION; HIGH-THROUGHPUT SPECIALIZED TRANSDUCTION; IMAGINING A WORLD WITHOUT TB; Chapter 2: Mycobacterial Pathogenomics and Evolution; INTRODUCTION; MYCOBACTERIAL GENOMICS; INSIGHTS INTO THE MACROEVOLUTION OF M. TUBERCULOSIS BASED ON COMPARISON WITH M. MARINUM AND MYCOBACTERIUM KANSASII; MICROEVOLUTIONARY GENOMICS OF THE TUBERCLE BACILLI MYCOBACTERIAL SYSTEMS DISCOVERED BY GENOMICS THAT ARE INVOLVED IN PATHOGENICITYCONCLUSIONS AND PERSPECTIVES; Chapter 3: BCG Vaccines; HISTORY OF BCG SUBSTRAINS; BCG AS AN ATTENUATED MEMBER OF THE M. TUBERCULOSIS COMPLEX; MOLECULAR EVOLUTION AND THE DERIVATION OF BCG SUBSTRAINS; MOLECULAR EVOLUTION AND THE PROPAGATION OF BCG SUBSTRAINS; CONCLUSION AND PERSPECTIVES: ATTENUATION OF VIRULENCE AND PROTECTIVE EFFICACY; REFERENCES; Chapter 4: Distributive Conjugal Transfer: New Insights into Horizontal Gene Transfer and Genetic Exchange in Mycobacteria CLASSICAL oriT-MEDIATED CONJUGATION: A BRIEF OVERVIEWMYCOBACTERIAL CONJUGATION; DISTRIBUTIVE CONJUGAL TRANSFER; DCT AS AN ENGINE FOR MYCOBACTERIAL EVOLUTION; DCT AS A GENETIC MAPPING TOOL; SUMMARY AND FUTURE PROSPECTSFOR DCT; Chapter 5: Molecular Genetics of Mycobacteriophages; GENERAL ASPECTS OF MYCOBACTERIOPHAGES; MYCOBACTERIOPHAGE GENOMICS; MYCOBACTERIOPHAGE-HOST INTERACTIONS; INTEGRATION SYSTEMS; MYCOBACTERIOPHAGE GENE EXPRESSIONAND ITS REGULATION; GENETIC MANIPULATION OF MYCOBACTERIOPHAGES; APPLICATIONS FOR MYCOBACTERIAL GENETICS; PERSPECTIVES: PAST, PRESENT, AND FUTURE Chapter 6: Genetics of Phage LysisTHE LYSIS PLAYERS; MYCOBACTERIOPHAGE-MEDIATED LYSIS; APPLICATIONS OF THE LYSIS PROPERTIES; CONCLUDING REMARKS; II. Gene Expression and Regulation; Chapter 7: Sigma Factors: Key Molecules in Mycobacterium tuberculosis Physiology and Virulence; THE σ FACTORS OF MYCOBACTERIUM TUBERCULOSIS ; Chapter 8: Transcription Factor Binding Site Mapping Using ChIP-Seq; ChIP-Seq METHOD AND PROTOCOL; DATA ANALYSIS; COMPREHENSIVE MAPPING OF TF BINDING SITES IN M. TUBERCULOSIS; VALIDATION OF THE ChIP-Seq SYSTEM; THE DIVERSITY OF TF BINDING IN PROKARYOTES NONPROMOTER TF BINDING |
| Record Nr. | UNINA-9910830420003321 |
| Washington, District of Columbia : , : ASM Press, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Tuberculosis and the tubercle bacillus / / edited by William R. Jacobs, Jr. [and three others]
| Tuberculosis and the tubercle bacillus / / edited by William R. Jacobs, Jr. [and three others] |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Washington, District of Columbia : , : American Society For Microbiology, , 2018 |
| Descrizione fisica | 1 online resource (726 pages) : illustrations (some color), tables |
| Disciplina | 614.5/42 |
| Soggetto topico | Tuberculosis |
| ISBN |
1-68367-305-0
1-68367-083-3 1-55581-956-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910554839803321 |
| Washington, District of Columbia : , : American Society For Microbiology, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Tuberculosis and the tubercle bacillus / / edited by William R. Jacobs, Jr. [and three others]
| Tuberculosis and the tubercle bacillus / / edited by William R. Jacobs, Jr. [and three others] |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Washington, District of Columbia : , : American Society For Microbiology, , 2018 |
| Descrizione fisica | 1 online resource (726 pages) : illustrations (some color), tables |
| Disciplina | 614.5/42 |
| Soggetto topico | Tuberculosis |
| ISBN |
1-68367-305-0
1-68367-083-3 1-55581-956-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910677339003321 |
| Washington, District of Columbia : , : American Society For Microbiology, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||