Novel drug targets with traditional herbal medicines : scientific and clinical evidence / / edited by Fatma Tugce Guragac Dereli, Mert Ilhan, and Tarun Belwal

• Pubblicazione: Cham, Switzerland : , : Springer, , [2022]; ©2022
• Descrizione fisica: 1 online resource (579 pages)
• Disciplina: 615.7
• Soggetto topico: Medicinal plants; Traditional medicine; Drug targeting; Phytotherapy; Plants, Medicinal; Medicine, Traditional; Ethnopharmacology
• Persona (resp. second.): IlhanMert; BelwalTarun; Guragac DereliFatma Tugce
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- Preface -- Contents -- About the Editors -- 1: Achillea biebersteinii Afan. -- 1.1 Introduction -- 1.2 Distribution and Status of Species -- 1.3 Comparison of Traditional/Ethnomedicinal/Local Uses -- 1.4 Bioactive/Nutraceutical and Nutritional Composition and Available Extraction Techniques -- 1.5 Scientific Evidences: Pharmacological Activities -- 1.5.1 Antioxidant Activity -- 1.5.2 Antinociceptive and Analgesic Activity -- 1.5.3 Wound Healing Activity -- 1.5.4 Central Nervous System Activity -- 1.5.5 Anticancer Activity -- 1.5.6 Insecticidal Activity -- 1.5.7 Antidiabetic Activity -- 1.5.8 Antimicrobial, Antifungal, and Antiprotozoal Activity -- 1.5.9 Protective of the Liver and Kidney -- 1.5.10 Other Activities -- 1.6 Clinical Studies -- 1.7 Toxicological Studies -- 1.8 Available Commercial Formulations/Products, Uses, Administration Methods, and Pharmacokinetic Studies -- 1.9 Gap Between Ethnomedicinal and Scientific/Clinical Evidences -- 1.10 Challenges and Future Recommendations as Potential Drug Candidate -- References -- 2: Aesculus hippocastanum L. -- 2.1 Introduction -- 2.1.1 Description of Aesculus hippocastanum L. -- 2.1.2 Synonyms -- 2.1.3 Local Names -- 2.1.4 Occurrence/Habitat -- 2.1.5 Registered Pharmacopoeias and Monographs -- 2.1.6 Importance -- 2.1.7 Objective of This Chapter -- 2.2 Distribution and Status of Species -- 2.3 Comparison of Traditional/Ethnomedicinal/Local Uses: In Turkey and Throughout the World (Asia and Europe) -- 2.4 Bioactive/Nutraceutical and Nutritional Composition and Available Extraction Techniques (Classification and Structures of Few Representatives) -- 2.5 Scientific Evidences: Pharmacological Activities (All Major Therapeutic Activity with In Vitro and In Vivo Studies, Mechanism of Action) -- 2.5.1 In Vitro Assays -- Anti-inflammatory Activity. ; Antioxidant Activity -- Antibacterial Activity -- Antifungal Activity -- Antiviral Activity -- Cytotoxic Activity -- Vasoactive Effects -- 2.5.2 In Vivo Assays -- Anti-Obesity Activity -- Antioxidant Activity -- Anti-inflammatory Activity -- Antidiabetic Activity -- Antidiabetic Neuropathy Activity -- Hepatoprotective Activity -- Anticancer Activity -- 2.6 Clinical Studies (Ongoing, Proposed, and Completed Studies) -- 2.6.1 Anti-inflammatory Activity -- 2.6.2 Anticoagulant Activity -- 2.6.3 Anticancer Activity -- 2.6.4 Antihematoma Activity -- 2.6.5 Anti-Infertility Activity -- 2.6.6 Gastroprotective Effect -- 2.7 Toxicological Studies (Dose and Safety Profile, Acute, Chronic, and Mutagenicity Studies to Demonstrate Broad Spectrum Safety, GARS Status) -- 2.7.1 Dose and Safety Profile -- Internal Usage -- External Usage -- Mode of Administration and Dosage -- Side Effects -- Contraindications -- Pregnancy and Lactation -- Warnings -- Drug Interactions and Other Interactions -- 2.7.2 Acute, Chronic, and Mutagenicity Studies to Demonstrate Broad Spectrum Safety -- Acute Toxicity -- Subacute Toxicity -- Chronic Toxicity -- Mutagenicity and Teratogenicity -- 2.7.3 GRAS Status -- 2.8 Available Commercial Formulations/Products, Uses, Administration Methods, and Pharmacokinetic Studies (with Special Focus on Bioavailability and Metabolism of Active Constituents) -- 2.8.1 Commercial Formulations/Products -- 2.8.2 Pharmacokinetic Studies -- 2.8.3 Clinical Safety -- 2.9 Gap Between Ethnomedicinal and Scientific/Clinical Evidences -- 2.10 Challenges and Future Recommendations as a Potential Drug Candidate -- References -- 3: Berberis crataegina DC. -- 3.1 Introduction -- 3.2 Distribution and Status of Species -- 3.3 Traditional/Ethnomedical/Local Uses -- 3.4 Bioactive Composition -- 3.4.1 Phenolics, Organic Acid, and Mineral Components. ; 3.4.2 Alkaloid Content of B. crataegina -- 3.5 Pharmacological Activities -- 3.5.1 Anti-Inflammatory, Analgesic, and Antipyretic Activities -- 3.5.2 Antioxidant Activity -- 3.5.3 Antimicrobial Activity -- 3.5.4 Use of Diabetes Treatment -- 3.6 Toxicological Studies -- 3.6.1 In Vitro, Genotoxicity, and Cytotoxicity -- 3.6.2 Acute Toxicity -- 3.6.3 Sub-Acute Toxicity -- 3.6.4 Sub-Chronic Toxicity -- 3.6.5 Chronic Toxicity -- 3.6.6 Clinical Toxicity -- 3.7 Pharmacokinetic Studies -- 3.8 Conclusion -- References -- 4: Calendula officinalis L. -- 4.1 Introduction -- 4.2 Distribution and Status of Species -- 4.3 Comparison of Traditional/Ethnomedicinal/Local Uses -- 4.4 Bioactive/Nutraceutical and Nutritional Composition and Available Extraction Techniques -- 4.4.1 Triterpene Saponosides -- 4.4.2 Triterpene Alcohol and Esters -- 4.4.3 Phenolic Components -- 4.4.4 Carotenoids -- 4.4.5 Volatile Components -- 4.4.6 Other Components -- 4.5 Scientific Evidences -- 4.5.1 In Vivo and In Vitro Studies -- 4.5.2 Antimicrobial -- 4.5.3 Antiviral -- 4.5.4 Antioxidant -- 4.5.5 Immunomodulatory -- 4.5.6 Cytotoxic -- 4.5.7 Antitumor -- 4.5.8 Wound Healing -- 4.5.9 Analgesic -- 4.5.10 Anti-inflammatory -- 4.5.11 Hepatoprotective and Renoprotective -- 4.5.12 Antigenotoxic -- 4.5.13 Cytoprotective -- 4.6 Clinical Studies -- 4.6.1 Wound Healing -- 4.6.2 Antioxidant -- 4.6.3 Anticandidal -- 4.6.4 Cosmetic -- 4.7 Toxicological Studies -- 4.7.1 Acute Toxicity -- 4.7.2 Chronic Toxicity -- 4.7.3 Mutagenicity and Teratogenicity -- 4.7.4 Pregnancy Toxicity -- 4.7.5 Reproductive Toxicity -- 4.8 Available Commercial Formulations/Products, Uses, Administration Methods, and Pharmacokinetic Studies -- 4.9 Gap Between Ethnomedicinal and Scientific/Clinical Evidences. ; 4.10 Challenges and Future Recommendations as Potential Drug Candidate -- References -- 5: Camellia sinensis (L.) Kuntze -- 5.1 Introduction -- 5.1.1 Origin, Distribution, and Cultivation -- 5.1.2 Economic Importance -- 5.1.3 Chemical Components -- 5.1.4 Biological Activities -- 5.1.5 Traditional Uses -- 5.1.6 Medicinal Uses -- 5.2 Effect of Camellia sinensis on Reproduction -- 5.3 Conclusion and Recommendation for Future Research -- References -- 6: Capsella bursa-pastoris (L.) Medik. -- 6.1 Introduction -- 6.2 Distribution and Status of the Species -- 6.3 Traditional/Ethnomedicinal Uses -- 6.4 Composition -- 6.5 Pharmacological Activities -- 6.5.1 Acetylcholinesterase Inhibitory Activity -- 6.5.2 Antibacterial Activity -- 6.5.3 Anticancer Activity -- 6.5.4 Antihemorrhoidal Activity -- 6.5.5 Anti-inflammatory Activity -- 6.5.6 Antioxidant Activity -- 6.5.7 Antihemorrhagic Activity -- 6.5.8 Cholesterol-Lowering Activity -- 6.5.9 Hepatoprotective Activity -- 6.5.10 Neuroprotective Activity -- 6.5.11 Sexual Function -- 6.5.12 Other Activities/Usages -- 6.6 Side Effects -- 6.7 Toxicity -- 6.8 Commercial Formulations -- 6.8.1 Commercial Preparations Related to Well-being -- 6.8.2 Cosmetic Preparations -- 6.9 Gap between Ethnomedicinal and Scientific/Clinical Evidences -- 6.10 Challenges and Future Recommendation -- References -- 7: Capsicum annuum L. -- 7.1 Introduction -- 7.1.1 Description of Capsicum annuum L. -- 7.1.2 Taxonomical Aspect with Photograph -- 7.1.3 Synonyms -- 7.1.4 Local Names -- 7.1.5 Occurrence/Habitat -- 7.1.6 Importance -- 7.1.7 Objective of This Chapter -- 7.2 Distribution and Status of Species -- 7.3 Comparison of Traditional/Ethnomedicinal/Local Uses: In Turkey and Throughout the World (Asia and Europe). ; 7.4 Bioactive/Nutraceutical and Nutritional Composition and Available Extraction Techniques (Classification and Structures of Few Representatives) -- 7.5 Scientific Evidences: Pharmacological Activities (All Major Therapeutic Activity with In Vitro and In Vivo Studies and Mechanism of Action) -- 7.5.1 In Vitro Studies -- Antioxidant Activity -- Antibacterial Activity -- Antiviral Activity -- Antiproliferative Activity -- Anti-Adipogenic Activity -- Antimutagenic Activity -- Enzyme Inhibitory Activity -- 7.5.2 In Vivo Studies -- Anti-inflammatory Activity -- Hepatoprotective Activity -- Antidiabetic Activity -- Renoprotective Activity -- Hypocholesterolemic Activity -- Antitumor Activity -- Anti-Obesity Activity -- Analgesic Activity -- Gastric Acid Secretory Activity -- 7.6 Clinical Studies (Ongoing, Proposed, and Completed) -- 7.6.1 Food Craving Activity -- 7.6.2 Anti-Reflux Activity -- 7.6.3 UV-Induced Skin Damage Suppression Activity -- 7.6.4 Anti-Obesity Activity -- 7.7 Toxicological Studies (Dose and Safety Profile -- Acute, Chronic, and Mutagenicity Studies to Demonstrate Broad Spectrum Safety -- GRAS Status) -- 7.7.1 Dose and Safety Profile -- Internal Usage -- External Usage -- Method of Administration -- Contraindications -- Interactions with Other Medications -- Pregnancy and Lactation -- Works that Required Attention -- Overdose -- Duration of Use -- 7.7.2 Acute, Chronic, and Mutagenicity Studies to Demonstrate Broad Spectrum Safety -- Acute Toxicity -- Chronic Toxicity -- Mutagenicity and Teratogenicity -- 7.7.3 GRAS Status -- 7.8 Available Commercial Formulations/Products, Uses, Administration Methods, and Pharmacokinetic Studies (with Special Focus on Bioavailability and Metabolism of Active Constituents) -- 7.8.1 Commercial Formulations/Products -- 7.8.2 Pharmacokinetic Studies. ; 7.9 Gap Between Ethnomedicinal and Scientific/Clinical Evidences.
• Titolo autorizzato: Novel Drug Targets with Traditional Herbal Medicines
• ISBN: 3-031-07753-9
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910616210603321
• Lo trovi qui: Univ. Federico II