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Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance [[electronic resource] /] / edited by Peter Igaz
| Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance [[electronic resource] /] / edited by Peter Igaz |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Basel : , : Springer Basel : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (292 p.) |
| Disciplina | 572.88 |
| Collana | Experientia Supplementum |
| Soggetto topico |
Gene expression
Nucleic acids Medical biochemistry Gene Expression Nucleic Acid Chemistry Medical Biochemistry |
| ISBN | 3-0348-0955-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I: General features and technical issues related to circulating microRNA -- 1. Introduction to microRNAs: biogenesis, action, relevance of tissue microRNAs in disease pathogenesis, diagnosis and therapy. The concept of circulating microRNAs -- 2. Extracellular microRNAs in membrane vesicles and non-vesicular carriers -- 3. Technical aspects related to the analysis of circulating microRNAs -- Part II: Diagnostic relevance of circulating microRNAs -- 4. Circulating blood-borne microRNAs as biomarkers in solid tumors -- 5. Circulating microRNA as biomarkers in hematological malignancies -- 6 Circulating microRNAs as biomarkers in cardiovascular diseases -- 7 Circulating microRNAs in neurodegenerative diseases -- 8 Circulating extracellular microRNA in systemic autoimmunity -- 9. Circulating microRNAs in inflammatory bowel diseases -- 10. Circulating microRNAs in diabetes progression: discovery, validation and research translation -- 11. Diagnostic relevance of microRNAs in other body fluids including urine, feces and saliva -- Part III: Potential biological relevance of circulating microRNA -- 12 Circulating microRNAs as hormones – intercellular and inter-organ conveyors of epigenetic information? -- 13. Are circulating microRNAs involved in tumor surveillance? -- 14.-Hypothetic interindividual and interspecies relevance of microRNAs released in body fluids. |
| Record Nr. | UNINA-9910298268103321 |
| Basel : , : Springer Basel : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Genetics of Endocrine Diseases and Syndromes [[electronic resource] /] / edited by Peter Igaz, Attila Patócs
| Genetics of Endocrine Diseases and Syndromes [[electronic resource] /] / edited by Peter Igaz, Attila Patócs |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (XIX, 473 p. 72 illus., 51 illus. in color.) |
| Disciplina | 611.01816 |
| Collana | Experientia Supplementum |
| Soggetto topico |
Molecular biology
Human genetics Molecular Medicine Human Genetics |
| ISBN | 3-030-25905-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part 1: Basics of Genetics -- Chapter 1. Basic concepts ofgenetics -- Chapter 2. Brief description of inheritance patterns -- Chapter 3. Family screening and genetic counseling -- Chapter 4. Brief summary of the most important molecular genetic methods (PCR, qPCR, microarray, next generation sequencing etc.) -- Part 2: Endocrine diseases inherited as monogenic traits: Alterations of hormones and hormone receptors -- Chapter 5. Syndromes of resistance to thyroid hormone action -- Chapter 6. Glucocorticoid resistance.-Part 3: Endocrine diseases inherited as monogenic traits: Hereditary diseases predisposing to endocrine tumors -- Chapter 7. Overview of genetically determined diseases/multiple endocrine neoplasia syndromes predisposing to endocrine tumors -- Chapter 8. Hereditary diseases predisposing to pheochromocytoma (VHL, NF-1, paraganglioma syndromes and novel genes) -- Chapter 9. Diseases predisposing to adrenocortical malignancy (Li-Fraumeni syndrome, Beckwith-Wiedemann-syndrome, Carney-complex) -- Chapter 10. Genetics of pituitary tumors -- Chapter 11. Timeline of advances in genetics of primary aldosteronism -- Chapter 12. Congenital adrenal hyperplasia -- Part 4: Endocrine diseases inherited as monogenic traits: Monogenic diseases predisposing to hormone deficiency, infertility and diabetes mellitus -- Chapter 13. Pituitary transcription factor mutations leading to hypopituitarism -- Chapter 14. Hereditary neurohypophyseal diabetes insipidus -- Chapter 15. Nephrogenic diabetes insipidus -- Chapter 16. Monogenic forms of male infertility (including androgen resistance) -- Chapter 17. Genetic causes of female infertility -- Chapter 18. Monogenicforms of diabetes mellitus -- Part 5: Example of a multifactorial disease and chromosomal alterations in endocrine diseases -- Chapter 19. Genetics of obesity -- Chapter 20. Chromosomal aberrations with endocrine relevance (Turner-syndrome, Klinefelter-syndrome, Prader-Willi syndrome). |
| Record Nr. | UNINA-9910349441603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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New Insights in the Genetics and Genomics of Adrenocortical Tumors and Pheochromocytomas
| New Insights in the Genetics and Genomics of Adrenocortical Tumors and Pheochromocytomas |
| Autore | Igaz Peter |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (272 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
pheochromocytoma
paraganglioma genetics non-coding RNA malignancy biomarker treatment adaptive metabolism adrenal gland conn adenoma fatty acid metabolism ferroptosis hyperaldosteronism metabolic reprogramming β-oxidation PPARα tumor microenvironment Next Generation Sequencing hereditary cancer endocrine tumor syndrome KCNJ5 somatic mutation pulse wave velocity aldosterone-producing adenoma adrenalectomy propensity score matching arterial stiffness pheochromocytomas paragangliomas mutations susceptibility genes driver mutations hereditary germline somatic environment variants tumor suppressor genes metastatic RNAseq next generation sequencing adrenocortical carcinoma in silico analysis machine learning bioinformatic clustering biomarker prediction aldosterone producing adenoma ATP2B3 K416-F418delinsN mutation primary aldosteronism PPGL telomeres TERT ATRX NOP10 prognostic biomarker ALT phaeochromocytoma cancer mitochondrial complex II zebrafish therapy drug discovery redox balance pathway Vitamin C mitotane H295 strains microRNA aldosterone circulating adrenocortical transcriptomics epigenetics metabolomics epidemiology genetic analysis mortality surveillance TP53 R337H genetic testing adrenocortical tumor neonatal screening screening adenoma adrenal tissue artificial intelligence neural network |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557609003321 |
Igaz Peter
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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