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Molecular diagnostics : current research and applications / / edited by Jim F. Huggett and Justin O'Grady
| Molecular diagnostics : current research and applications / / edited by Jim F. Huggett and Justin O'Grady |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 616.0756 |
| Soggetto topico |
Molecular diagnosis
Cancer - Molecular diagnosis Communicable diseases - Molecular diagnosis |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-908230-64-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Current books of interest; Foreword; Biographies; 1: Molecular Diagnostics: An Introduction; Part I: Molecular Diagnostics in Cancer: Research and Development of Biomarkers; 2: Transcriptome-based Biomarkers: A Road Map Exemplified for Peripheral Blood-based Biomarker Discovery, Development and Clinical Use; Introduction; Defining biomarker classes as a prerequisite for successful biomarker development; Focus on peripheral blood-based biomarkers as an example; Blood transcriptomics started in leukaemia research
Is there a role for blood transcriptomics in other diseases?Is there a role of blood transcriptomics for early detection of disease?; General guidance towards successful biomarker development; Importance of technical and organizational aspects during biomarker development; Requirements for bioinformatics analysis during biomarker development; The next decade of blood transcriptomics; 3: Development of Methylation Biomarkers for Clinical Applications and Methylation-sensitive High-resolution Melting Technology; DNA methylation; Methylation-based in vitro diagnostic tests Fields of applications of in vitro diagnostic testsChallenges of methylation biomarker development process; Methylation biomarker development workflow; PCR amplification and melting analyses in methylation studies; Development of methylation-sensitive high-resolution melting (MS-HRM); Characteristics of the MS-HRM protocol; Final remarks; 4: Genetic and Epigenetic Biomarkers of Colorectal Cancer ; Introduction; Biomarkers; Biomarker location; Practical limitations; Conclusions and outlook; Part II: Molecular Diagnostics of Infectious Diseases: Past, Present and Future 5: Molecular Diagnosis in Medical Microbiology: The Horizon Draws NearIntroduction; Enhancing diagnosis; Molecular typing in control of infection; Molecular tools in screening/high-throughput analysis; Considerations in selecting a molecular tool; Conclusion; 6: Viral Diagnostics and qPCR-based Methodologies; Introduction; PCR-based methods; Non-PCR-based methods; Perspectives; Validation/standardization/harmonization; Conclusions; 7: XMRV: A Cautionary Tale; Introduction; Discovery of XMRV; Reports of XMRV in prostate cancer and chronic fatigue syndrome Mounting negative evidence ignites XMRV controversyHuman pathogen or laboratory contaminant?; The recombinant origin of XMRV; Dénouement and conclusions; Note added in proof; 8: Ancient DNA and the Fingerprints of Disease: Retrieving Human Pathogen Genomic Sequences from Archaeological Remains Using Real-time Quantitative Polymerase Chain Reaction; Introduction; aDNA breakdown after deposition; Why study aDNA and what can it tell us?; Sampling and measures to avoid cross-contamination; PCR; Validation of PCR findings; Conclusions; Part III: From Bench to Bedside 9: Point-of-care Nucleic Acid Testing: User Requirements, Regulatory Affairs and Quality Assurance |
| Record Nr. | UNINA-9910463988103321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular diagnostics : current research and applications / / edited by Jim F. Huggett and Justin O'Grady
| Molecular diagnostics : current research and applications / / edited by Jim F. Huggett and Justin O'Grady |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 616.0756 |
| Soggetto topico |
Molecular diagnosis
Cancer - Molecular diagnosis Communicable diseases - Molecular diagnosis |
| ISBN | 1-908230-64-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Current books of interest; Foreword; Biographies; 1: Molecular Diagnostics: An Introduction; Part I: Molecular Diagnostics in Cancer: Research and Development of Biomarkers; 2: Transcriptome-based Biomarkers: A Road Map Exemplified for Peripheral Blood-based Biomarker Discovery, Development and Clinical Use; Introduction; Defining biomarker classes as a prerequisite for successful biomarker development; Focus on peripheral blood-based biomarkers as an example; Blood transcriptomics started in leukaemia research
Is there a role for blood transcriptomics in other diseases?Is there a role of blood transcriptomics for early detection of disease?; General guidance towards successful biomarker development; Importance of technical and organizational aspects during biomarker development; Requirements for bioinformatics analysis during biomarker development; The next decade of blood transcriptomics; 3: Development of Methylation Biomarkers for Clinical Applications and Methylation-sensitive High-resolution Melting Technology; DNA methylation; Methylation-based in vitro diagnostic tests Fields of applications of in vitro diagnostic testsChallenges of methylation biomarker development process; Methylation biomarker development workflow; PCR amplification and melting analyses in methylation studies; Development of methylation-sensitive high-resolution melting (MS-HRM); Characteristics of the MS-HRM protocol; Final remarks; 4: Genetic and Epigenetic Biomarkers of Colorectal Cancer ; Introduction; Biomarkers; Biomarker location; Practical limitations; Conclusions and outlook; Part II: Molecular Diagnostics of Infectious Diseases: Past, Present and Future 5: Molecular Diagnosis in Medical Microbiology: The Horizon Draws NearIntroduction; Enhancing diagnosis; Molecular typing in control of infection; Molecular tools in screening/high-throughput analysis; Considerations in selecting a molecular tool; Conclusion; 6: Viral Diagnostics and qPCR-based Methodologies; Introduction; PCR-based methods; Non-PCR-based methods; Perspectives; Validation/standardization/harmonization; Conclusions; 7: XMRV: A Cautionary Tale; Introduction; Discovery of XMRV; Reports of XMRV in prostate cancer and chronic fatigue syndrome Mounting negative evidence ignites XMRV controversyHuman pathogen or laboratory contaminant?; The recombinant origin of XMRV; Dénouement and conclusions; Note added in proof; 8: Ancient DNA and the Fingerprints of Disease: Retrieving Human Pathogen Genomic Sequences from Archaeological Remains Using Real-time Quantitative Polymerase Chain Reaction; Introduction; aDNA breakdown after deposition; Why study aDNA and what can it tell us?; Sampling and measures to avoid cross-contamination; PCR; Validation of PCR findings; Conclusions; Part III: From Bench to Bedside 9: Point-of-care Nucleic Acid Testing: User Requirements, Regulatory Affairs and Quality Assurance |
| Record Nr. | UNINA-9910787832703321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular diagnostics : current research and applications / / edited by Jim F. Huggett and Justin O'Grady
| Molecular diagnostics : current research and applications / / edited by Jim F. Huggett and Justin O'Grady |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 616.0756 |
| Soggetto topico |
Molecular diagnosis
Cancer - Molecular diagnosis Communicable diseases - Molecular diagnosis |
| ISBN | 1-908230-64-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Current books of interest; Foreword; Biographies; 1: Molecular Diagnostics: An Introduction; Part I: Molecular Diagnostics in Cancer: Research and Development of Biomarkers; 2: Transcriptome-based Biomarkers: A Road Map Exemplified for Peripheral Blood-based Biomarker Discovery, Development and Clinical Use; Introduction; Defining biomarker classes as a prerequisite for successful biomarker development; Focus on peripheral blood-based biomarkers as an example; Blood transcriptomics started in leukaemia research
Is there a role for blood transcriptomics in other diseases?Is there a role of blood transcriptomics for early detection of disease?; General guidance towards successful biomarker development; Importance of technical and organizational aspects during biomarker development; Requirements for bioinformatics analysis during biomarker development; The next decade of blood transcriptomics; 3: Development of Methylation Biomarkers for Clinical Applications and Methylation-sensitive High-resolution Melting Technology; DNA methylation; Methylation-based in vitro diagnostic tests Fields of applications of in vitro diagnostic testsChallenges of methylation biomarker development process; Methylation biomarker development workflow; PCR amplification and melting analyses in methylation studies; Development of methylation-sensitive high-resolution melting (MS-HRM); Characteristics of the MS-HRM protocol; Final remarks; 4: Genetic and Epigenetic Biomarkers of Colorectal Cancer ; Introduction; Biomarkers; Biomarker location; Practical limitations; Conclusions and outlook; Part II: Molecular Diagnostics of Infectious Diseases: Past, Present and Future 5: Molecular Diagnosis in Medical Microbiology: The Horizon Draws NearIntroduction; Enhancing diagnosis; Molecular typing in control of infection; Molecular tools in screening/high-throughput analysis; Considerations in selecting a molecular tool; Conclusion; 6: Viral Diagnostics and qPCR-based Methodologies; Introduction; PCR-based methods; Non-PCR-based methods; Perspectives; Validation/standardization/harmonization; Conclusions; 7: XMRV: A Cautionary Tale; Introduction; Discovery of XMRV; Reports of XMRV in prostate cancer and chronic fatigue syndrome Mounting negative evidence ignites XMRV controversyHuman pathogen or laboratory contaminant?; The recombinant origin of XMRV; Dénouement and conclusions; Note added in proof; 8: Ancient DNA and the Fingerprints of Disease: Retrieving Human Pathogen Genomic Sequences from Archaeological Remains Using Real-time Quantitative Polymerase Chain Reaction; Introduction; aDNA breakdown after deposition; Why study aDNA and what can it tell us?; Sampling and measures to avoid cross-contamination; PCR; Validation of PCR findings; Conclusions; Part III: From Bench to Bedside 9: Point-of-care Nucleic Acid Testing: User Requirements, Regulatory Affairs and Quality Assurance |
| Record Nr. | UNINA-9910822510503321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||