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Biomedical informatics in translational research / / Hai Hu, Richard J. Mural, Michael N. Liebman, editors
| Biomedical informatics in translational research / / Hai Hu, Richard J. Mural, Michael N. Liebman, editors |
| Pubbl/distr/stampa | Boston : , : Artech House, , ©2008 |
| Descrizione fisica | xiv, 264 p. : ill |
| Disciplina | 610.285 |
| Altri autori (Persone) |
HuHai
MuralRichard J LiebmanMichael N. <1947-> |
| Collana | Artech House series bioinformatics & biomedical imaging |
| Soggetto topico |
Medical informatics
Bioinformatics |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-59693-039-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biomedical Informatics in Translational Research; Contents; Preface; Chapter 1 Biomedical Informatics in TranslationalResearch; 1.1 Evolution of Terminology; 1.1.1 Translational Research; 1.1.2 Systems Biology; 1.1.3 Personalized Medicine; References; Chapter 2 The Clinical Perspective; 2.1 Introduction; 2.2 Ethics in Clinical Research; 2.3 Regulatory Policies for Protecting a Research Subject's Privacy; 2.4 Informed Consent; 2.5 Collecting Clinical Data: Developing and Administering Survey Instruments; 2.6 Issues Important to Biomedical Informatics; 2.6.1 Data Tracking and Centralization.
2.6.2 Deidentifying Data2.6.3 Quality Assurance; 2.6.4 Data Transfer from the Health Care Clinic to the Research Setting; 2.7 Standard Operating Procedures; 2.8 Developing and Implementing a Research Protocol; 2.8.1 Developing a Research Protocol; 2.8.2 Implementing the Research Protocol; 2.9 Summary; References; Chapter 3 Tissue Banking: Collection, Processing, and Pathologic Characterization of Biospecimens for Research; 3.1 Introduction; 3.1.1 A Biorepository's Mandate; 3.1.2 Overview of Current Tissue Banking Practices; 3.2 Consenting and Clinical Data Acquisition. 3.3 Blood Collection, Processing, and Storage3.4 Tissue Collection, Processing, Archiving, and Annotation; 3.4.1 Tissue Collection; 3.4.2 Tissue Processing; 3.4.3 Tissue Archiving and Storage; 3.4.4 Pathologic Characterization of Tissue Samples; 3.5 Conclusion; References; Chapter 4 Biological Perspective; 4.1 Background for "Omics" Technologies; 4.2 Basic Biology and Definitions; 4.2.1 A Historical Perspective; 4.2.2 Biological Processes; 4.2.3 Some Definitions; 4.3 Very Basic Biochemistry; 4.3.1 DNA; 4.3.2 RNA; 4.3.3 Proteins; 4.4 Summary; References; Chapter 5 Genomics Studies. 5.1 Introduction5.2 Genomic Technologies Used for DNA Analysis; 5.2.1 DNA Sequencing; 5.2.1.2 Biomedical Informatics Requirements; 5.2.1.3 Future Directions; 5.2.2 Genotyping; 5.2.2.1 Array Technologies; 5.2.2.2 Technological Assessment of Genotyping; 5.2.2.3 Affymetrix Genotyping SNP Assay Workflow; 5.2.2.4 QA/SOP Issues; 5.2.2.5 Biomedical Informatics Requirements; 5.2.2.6 Future Directions; 5.2.3 Array-Based Comparative Genomic Hybridization; 5.2.3.1 Technological Assessment of Chromosomal Rearrangements; 5.2.3.2 Example Platform; 5.2.3.3 QA/SOP Issues. 5.2.3.4 Biomedical Informatics Requirements5.2.3.5 Oligo-Based aCGH Platform; 5.3 Genomic Technology Used for RNA Analysis; 5.3.1 Real-Time PCR; 5.3.1.1 Data Analysis Methods; 5.3.1.2 Biomedical Informatics Requirements; 5.3.1.3 Future Directions; 5.3.2 Microarrays; 5.3.2.1 Array Technologies; 5.3.2.2 Example Platform; 5.3.2.3 QA/SOP Issues; 5.3.2.4 MIAME Checklist and Platform Comparison; 5.3.2.5 Data Analysis Issues; 5.3.2.6 Biomedical Informatics Requirements; 5.3.2.7 Future Directions; 5.3.3 Chips for Alternative Splicing Analysis (GeneChip Exon); 5.3.3.1 Array Technology. |
| Record Nr. | UNINA-9910455456703321 |
| Boston : , : Artech House, , ©2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biomedical informatics in translational research / / Hai Hu, Richard J. Mural, Michael N. Liebman, editors
| Biomedical informatics in translational research / / Hai Hu, Richard J. Mural, Michael N. Liebman, editors |
| Pubbl/distr/stampa | Boston : , : Artech House, , ©2008 |
| Descrizione fisica | xiv, 264 p. : ill |
| Disciplina | 610.285 |
| Altri autori (Persone) |
HuHai
MuralRichard J LiebmanMichael N. <1947-> |
| Collana | Artech House series bioinformatics & biomedical imaging |
| Soggetto topico |
Medical informatics
Bioinformatics |
| ISBN | 1-59693-039-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biomedical Informatics in Translational Research; Contents; Preface; Chapter 1 Biomedical Informatics in TranslationalResearch; 1.1 Evolution of Terminology; 1.1.1 Translational Research; 1.1.2 Systems Biology; 1.1.3 Personalized Medicine; References; Chapter 2 The Clinical Perspective; 2.1 Introduction; 2.2 Ethics in Clinical Research; 2.3 Regulatory Policies for Protecting a Research Subject's Privacy; 2.4 Informed Consent; 2.5 Collecting Clinical Data: Developing and Administering Survey Instruments; 2.6 Issues Important to Biomedical Informatics; 2.6.1 Data Tracking and Centralization.
2.6.2 Deidentifying Data2.6.3 Quality Assurance; 2.6.4 Data Transfer from the Health Care Clinic to the Research Setting; 2.7 Standard Operating Procedures; 2.8 Developing and Implementing a Research Protocol; 2.8.1 Developing a Research Protocol; 2.8.2 Implementing the Research Protocol; 2.9 Summary; References; Chapter 3 Tissue Banking: Collection, Processing, and Pathologic Characterization of Biospecimens for Research; 3.1 Introduction; 3.1.1 A Biorepository's Mandate; 3.1.2 Overview of Current Tissue Banking Practices; 3.2 Consenting and Clinical Data Acquisition. 3.3 Blood Collection, Processing, and Storage3.4 Tissue Collection, Processing, Archiving, and Annotation; 3.4.1 Tissue Collection; 3.4.2 Tissue Processing; 3.4.3 Tissue Archiving and Storage; 3.4.4 Pathologic Characterization of Tissue Samples; 3.5 Conclusion; References; Chapter 4 Biological Perspective; 4.1 Background for "Omics" Technologies; 4.2 Basic Biology and Definitions; 4.2.1 A Historical Perspective; 4.2.2 Biological Processes; 4.2.3 Some Definitions; 4.3 Very Basic Biochemistry; 4.3.1 DNA; 4.3.2 RNA; 4.3.3 Proteins; 4.4 Summary; References; Chapter 5 Genomics Studies. 5.1 Introduction5.2 Genomic Technologies Used for DNA Analysis; 5.2.1 DNA Sequencing; 5.2.1.2 Biomedical Informatics Requirements; 5.2.1.3 Future Directions; 5.2.2 Genotyping; 5.2.2.1 Array Technologies; 5.2.2.2 Technological Assessment of Genotyping; 5.2.2.3 Affymetrix Genotyping SNP Assay Workflow; 5.2.2.4 QA/SOP Issues; 5.2.2.5 Biomedical Informatics Requirements; 5.2.2.6 Future Directions; 5.2.3 Array-Based Comparative Genomic Hybridization; 5.2.3.1 Technological Assessment of Chromosomal Rearrangements; 5.2.3.2 Example Platform; 5.2.3.3 QA/SOP Issues. 5.2.3.4 Biomedical Informatics Requirements5.2.3.5 Oligo-Based aCGH Platform; 5.3 Genomic Technology Used for RNA Analysis; 5.3.1 Real-Time PCR; 5.3.1.1 Data Analysis Methods; 5.3.1.2 Biomedical Informatics Requirements; 5.3.1.3 Future Directions; 5.3.2 Microarrays; 5.3.2.1 Array Technologies; 5.3.2.2 Example Platform; 5.3.2.3 QA/SOP Issues; 5.3.2.4 MIAME Checklist and Platform Comparison; 5.3.2.5 Data Analysis Issues; 5.3.2.6 Biomedical Informatics Requirements; 5.3.2.7 Future Directions; 5.3.3 Chips for Alternative Splicing Analysis (GeneChip Exon); 5.3.3.1 Array Technology. |
| Record Nr. | UNINA-9910778299503321 |
| Boston : , : Artech House, , ©2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biomedical informatics in translational research / / Hai Hu, Richard J. Mural, Michael N. Liebman, editors
| Biomedical informatics in translational research / / Hai Hu, Richard J. Mural, Michael N. Liebman, editors |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Boston, : Artech House, c2008 |
| Descrizione fisica | xiv, 264 p. : ill |
| Disciplina | 610.285 |
| Altri autori (Persone) |
HuHai
MuralRichard J LiebmanMichael N. <1947-> |
| Collana | Artech House series bioinformatics & biomedical imaging |
| Soggetto topico |
Medical informatics
Bioinformatics |
| ISBN | 1-59693-039-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biomedical Informatics in Translational Research; Contents; Preface; Chapter 1 Biomedical Informatics in TranslationalResearch; 1.1 Evolution of Terminology; 1.1.1 Translational Research; 1.1.2 Systems Biology; 1.1.3 Personalized Medicine; References; Chapter 2 The Clinical Perspective; 2.1 Introduction; 2.2 Ethics in Clinical Research; 2.3 Regulatory Policies for Protecting a Research Subject's Privacy; 2.4 Informed Consent; 2.5 Collecting Clinical Data: Developing and Administering Survey Instruments; 2.6 Issues Important to Biomedical Informatics; 2.6.1 Data Tracking and Centralization.
2.6.2 Deidentifying Data2.6.3 Quality Assurance; 2.6.4 Data Transfer from the Health Care Clinic to the Research Setting; 2.7 Standard Operating Procedures; 2.8 Developing and Implementing a Research Protocol; 2.8.1 Developing a Research Protocol; 2.8.2 Implementing the Research Protocol; 2.9 Summary; References; Chapter 3 Tissue Banking: Collection, Processing, and Pathologic Characterization of Biospecimens for Research; 3.1 Introduction; 3.1.1 A Biorepository's Mandate; 3.1.2 Overview of Current Tissue Banking Practices; 3.2 Consenting and Clinical Data Acquisition. 3.3 Blood Collection, Processing, and Storage3.4 Tissue Collection, Processing, Archiving, and Annotation; 3.4.1 Tissue Collection; 3.4.2 Tissue Processing; 3.4.3 Tissue Archiving and Storage; 3.4.4 Pathologic Characterization of Tissue Samples; 3.5 Conclusion; References; Chapter 4 Biological Perspective; 4.1 Background for "Omics" Technologies; 4.2 Basic Biology and Definitions; 4.2.1 A Historical Perspective; 4.2.2 Biological Processes; 4.2.3 Some Definitions; 4.3 Very Basic Biochemistry; 4.3.1 DNA; 4.3.2 RNA; 4.3.3 Proteins; 4.4 Summary; References; Chapter 5 Genomics Studies. 5.1 Introduction5.2 Genomic Technologies Used for DNA Analysis; 5.2.1 DNA Sequencing; 5.2.1.2 Biomedical Informatics Requirements; 5.2.1.3 Future Directions; 5.2.2 Genotyping; 5.2.2.1 Array Technologies; 5.2.2.2 Technological Assessment of Genotyping; 5.2.2.3 Affymetrix Genotyping SNP Assay Workflow; 5.2.2.4 QA/SOP Issues; 5.2.2.5 Biomedical Informatics Requirements; 5.2.2.6 Future Directions; 5.2.3 Array-Based Comparative Genomic Hybridization; 5.2.3.1 Technological Assessment of Chromosomal Rearrangements; 5.2.3.2 Example Platform; 5.2.3.3 QA/SOP Issues. 5.2.3.4 Biomedical Informatics Requirements5.2.3.5 Oligo-Based aCGH Platform; 5.3 Genomic Technology Used for RNA Analysis; 5.3.1 Real-Time PCR; 5.3.1.1 Data Analysis Methods; 5.3.1.2 Biomedical Informatics Requirements; 5.3.1.3 Future Directions; 5.3.2 Microarrays; 5.3.2.1 Array Technologies; 5.3.2.2 Example Platform; 5.3.2.3 QA/SOP Issues; 5.3.2.4 MIAME Checklist and Platform Comparison; 5.3.2.5 Data Analysis Issues; 5.3.2.6 Biomedical Informatics Requirements; 5.3.2.7 Future Directions; 5.3.3 Chips for Alternative Splicing Analysis (GeneChip Exon); 5.3.3.1 Array Technology. |
| Record Nr. | UNINA-9910820757003321 |
| Boston, : Artech House, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Translational Research in Breast Cancer : Biomarker Diagnosis, Targeted Therapies and Approaches to Precision Medicine / / edited by Erwei Song, Hai Hu
| Translational Research in Breast Cancer : Biomarker Diagnosis, Targeted Therapies and Approaches to Precision Medicine / / edited by Erwei Song, Hai Hu |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (VIII, 418 p. 15 illus. in color.) |
| Disciplina | 614.5999 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Cancer
Cytology Cancer Biology Cell Biology |
| ISBN | 981-10-6020-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chap. 1 The Dawning of Translational Breast Cancer: from Bench to Bedside -- Chap. 2 Biomarker Studies in Early Detection and Prognosis of Breast Cancer -- Chap. 3 The Preventive Intervention of Hereditary Breast Cancer -- Chap. 4 Predicting and Overcoming Chemotherapeutic Resistance for Breast Cancer -- Chap. 5 Studies on DNA Damage Repair and Precision Radiotherapy for Breast Cancer -- Chap. 6 Targeted Therapies against Growth Factor Signaling in Breast Cancer -- Chap. 7 Targeting Stemness: Implications for Precision Medicine in Breast Cancer -- Chap. 8 Disrupting Tumor Angiogenesis and “the Hunger Games” for Breast Cancer -- Chap. 9 Key Factors in Breast Cancer Dissemination and Establishment at the Bone: Past, Present and Future Perspectives -- Chap. 10 Perspectives of Reprogramming Breast Cancer Metabolism -- Chap. 11 Metabolic Changes during Cancer Cachexia Pathogenesis -- Chap. 12 Cell Cycle Regulation in Treatment of Breast Cancer -- Chap. 13 BRCA Gene Mutations and Poly (ADP-ribose) Polymerase Inhibitors in Triple-negative Breast Cancer -- Chap. 14 Targeting the Epigenome as a Novel Therapeutic Approach for Breast Cancer -- Chap. 15 Progress in Vaccine Therapies for Breast Cancer -- Chap. 16 Tumor Associated Macrophages as Therapeutic Targets for Breast Cancer -- Chap 17 New Approaches in CAR-T Cell Immunotherapy for Breast Cancer -- Chap 18 Immune Checkpoint Blockade in Breast Cancer Therapy. |
| Record Nr. | UNINA-9910253944203321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||