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Hemodynamics and mechanobiology of endothelium [[electronic resource] /] / editors, Tzung K. Hsiai, Brett Blackman, Hanjoong Jo
| Hemodynamics and mechanobiology of endothelium [[electronic resource] /] / editors, Tzung K. Hsiai, Brett Blackman, Hanjoong Jo |
| Autore | Hsiai Tzung K |
| Pubbl/distr/stampa | Hackensack, N.J., : World Scientific, c2010 |
| Descrizione fisica | 1 online resource (380 p.) |
| Disciplina | 612.13 |
| Altri autori (Persone) |
HsiaiTzung K
BlackmanBrett JoHanjoong |
| Soggetto topico |
Hemodynamics
Oxidative stress |
| ISBN |
1-283-14379-8
9786613143792 981-4280-42-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PREFACE; CONTENTS; Chapter 1 FLOW AND ATHEROSCLEROSIS; 1. Overview and Clinical Significance; 1.1. Composition and Progression of Atherosclerotic Plaques; 1.1.1. Early Lesions; 1.1.2. Advanced Lesions; 1.1.3. Outward Remodeling and Plaque Stenosis; 2. Methods for Studying the Role of Flow in the Pathogenesis of Atherosclerosis; 2.1. Tools for Studying Biological Responses to Mechanical Stimuli in Vitro; 2.2. Animal Models of Atherosclerosis and Relation to Flow; 2.2.1. Genetically-manipulated Mouse Models; 2.2.2. Mechanical Induction of Stenosis in Animals
2.2.3. Larger Animal Models of Atherosclerosis2.3. Flow in Humans and Its Role in Atherosclerosis; 2.4. Computational Fluid Dynamics; 2.4.1. Imaging Data for Lesion-specific Geometry; 2.4.2. Modeling Assumptions; 3. Wall Shear Stress is a Potent Modulator of Plaque Formation and Localization; 3.1. Low and Oscillatory Wall Shear Stress Promote Atherosclerotic Plaque Formation; 3.2. High Wall Shear Stress Protects Arteries from Atherosclerosis; 3.3. Hemodynamic Parameters Related to Plaque Formation; 3.4. Wall Shear Stress and Plaque Rupture 4. Flow is Not the Only Biomechanical Determinant of Plaque Formation and Disruption4.1. Solid Wall Mechanics and Atherosclerotic Responses to Stretch; 4.2. Plaque Composition Influences Solid Wall Mechanics and Risk for Rupture; 4.3. Fluid-solid Interaction Provides Additional Biomechanical Insight into Atherosclerosis; 5. Current Dilemmas and Future Directions for Atherosclerotic Research; 5.1. Need for Better Understanding of Plaque Disruption Events; 5.2. How Do Flow-mediated Mechanisms of Atherogenesis Occur on Human Timescales? 5.3. How Much Does Directionality of Flow Contribute to Atherosclerosis?6. Conclusion; References; Chapter 2 SHEAR STRESS-MEDIATED SIGNAL TRANSDUCTION; 1. Introduction; 2. Mechanosignal Transduction: From Molecular Sensors to Cellular Responses; 3. The Role of Mechanotransduction in Cardiovascular Health and Disease; 4. The Unique Role of PECAM-1 in Mechanosensing; 4.1. Forced-induced PECAM-1 Phosphorylation and Mechano-signaling; 4.2. PECAM-1 as a Mechanosensor; 4.3. PECAM-1 Kinase in Mechanotransduction; 5. S-flow-mediated Redox Regulation and Inflammation 5.1. TRX and TRX-interacting Protein (TXNIP)5.2. Thiol Regulation and Glutaredoxin; 6. S-flow Inhibits TNF-α Signaling by Multiple Mechanisms; 6.1. MAP Kinases in Response to s-flow and TNF-α; 6.2. S-flow Inhibits PKCζ Signaling in ECs; 6.3. S-flow Inhibits TNF-α-mediated SHP-2 Phosphatase Activity and MEKK3 Signaling; 6.4. ERK5 Inhibits TNF-α-mediated JNK Activation; 7. ERK5 and Shear Stress; 7.1. s-flow Mediated ERK5 Activation; 7.2. ERK5 in Diabetes: ERK5-SUMOylation; 7.2.1. SUMOylation; 7.2.2. ERK5-SUMOylation; Acknowledgments; References Chapter 3 ENDOTHELIAL GLYCOCALYX STRUCTURE AND ROLE IN MECHANOTRANSDUCTION |
| Record Nr. | UNINA-9910789404503321 |
Hsiai Tzung K
|
||
| Hackensack, N.J., : World Scientific, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hemodynamics and mechanobiology of endothelium / / editors, Tzung K. Hsiai, Brett Blackman, Hanjoong Jo
| Hemodynamics and mechanobiology of endothelium / / editors, Tzung K. Hsiai, Brett Blackman, Hanjoong Jo |
| Autore | Hsiai Tzung K |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hackensack, N.J., : World Scientific, c2010 |
| Descrizione fisica | 1 online resource (380 p.) |
| Disciplina | 612.13 |
| Altri autori (Persone) |
HsiaiTzung K
BlackmanBrett JoHanjoong |
| Soggetto topico |
Hemodynamics
Oxidative stress |
| ISBN |
1-283-14379-8
9786613143792 981-4280-42-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PREFACE; CONTENTS; Chapter 1 FLOW AND ATHEROSCLEROSIS; 1. Overview and Clinical Significance; 1.1. Composition and Progression of Atherosclerotic Plaques; 1.1.1. Early Lesions; 1.1.2. Advanced Lesions; 1.1.3. Outward Remodeling and Plaque Stenosis; 2. Methods for Studying the Role of Flow in the Pathogenesis of Atherosclerosis; 2.1. Tools for Studying Biological Responses to Mechanical Stimuli in Vitro; 2.2. Animal Models of Atherosclerosis and Relation to Flow; 2.2.1. Genetically-manipulated Mouse Models; 2.2.2. Mechanical Induction of Stenosis in Animals
2.2.3. Larger Animal Models of Atherosclerosis2.3. Flow in Humans and Its Role in Atherosclerosis; 2.4. Computational Fluid Dynamics; 2.4.1. Imaging Data for Lesion-specific Geometry; 2.4.2. Modeling Assumptions; 3. Wall Shear Stress is a Potent Modulator of Plaque Formation and Localization; 3.1. Low and Oscillatory Wall Shear Stress Promote Atherosclerotic Plaque Formation; 3.2. High Wall Shear Stress Protects Arteries from Atherosclerosis; 3.3. Hemodynamic Parameters Related to Plaque Formation; 3.4. Wall Shear Stress and Plaque Rupture 4. Flow is Not the Only Biomechanical Determinant of Plaque Formation and Disruption4.1. Solid Wall Mechanics and Atherosclerotic Responses to Stretch; 4.2. Plaque Composition Influences Solid Wall Mechanics and Risk for Rupture; 4.3. Fluid-solid Interaction Provides Additional Biomechanical Insight into Atherosclerosis; 5. Current Dilemmas and Future Directions for Atherosclerotic Research; 5.1. Need for Better Understanding of Plaque Disruption Events; 5.2. How Do Flow-mediated Mechanisms of Atherogenesis Occur on Human Timescales? 5.3. How Much Does Directionality of Flow Contribute to Atherosclerosis?6. Conclusion; References; Chapter 2 SHEAR STRESS-MEDIATED SIGNAL TRANSDUCTION; 1. Introduction; 2. Mechanosignal Transduction: From Molecular Sensors to Cellular Responses; 3. The Role of Mechanotransduction in Cardiovascular Health and Disease; 4. The Unique Role of PECAM-1 in Mechanosensing; 4.1. Forced-induced PECAM-1 Phosphorylation and Mechano-signaling; 4.2. PECAM-1 as a Mechanosensor; 4.3. PECAM-1 Kinase in Mechanotransduction; 5. S-flow-mediated Redox Regulation and Inflammation 5.1. TRX and TRX-interacting Protein (TXNIP)5.2. Thiol Regulation and Glutaredoxin; 6. S-flow Inhibits TNF-α Signaling by Multiple Mechanisms; 6.1. MAP Kinases in Response to s-flow and TNF-α; 6.2. S-flow Inhibits PKCζ Signaling in ECs; 6.3. S-flow Inhibits TNF-α-mediated SHP-2 Phosphatase Activity and MEKK3 Signaling; 6.4. ERK5 Inhibits TNF-α-mediated JNK Activation; 7. ERK5 and Shear Stress; 7.1. s-flow Mediated ERK5 Activation; 7.2. ERK5 in Diabetes: ERK5-SUMOylation; 7.2.1. SUMOylation; 7.2.2. ERK5-SUMOylation; Acknowledgments; References Chapter 3 ENDOTHELIAL GLYCOCALYX STRUCTURE AND ROLE IN MECHANOTRANSDUCTION |
| Record Nr. | UNINA-9910820106103321 |
|
Hsiai Tzung K
|
||
| Hackensack, N.J., : World Scientific, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Hemodynamics and mechanobiology of endothelium [[electronic resource] /] / editors, Tzung K. Hsiai, Brett Blackman, Hanjoong Jo
| Hemodynamics and mechanobiology of endothelium [[electronic resource] /] / editors, Tzung K. Hsiai, Brett Blackman, Hanjoong Jo |
| Pubbl/distr/stampa | Hackensack, N.J., : World Scientific, c2010 |
| Descrizione fisica | 1 online resource (380 p.) |
| Disciplina | 612.13 |
| Altri autori (Persone) |
HsiaiTzung K
BlackmanBrett JoHanjoong |
| Soggetto topico |
Hemodynamics
Oxidative stress |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-14379-8
9786613143792 981-4280-42-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PREFACE; CONTENTS; Chapter 1 FLOW AND ATHEROSCLEROSIS; 1. Overview and Clinical Significance; 1.1. Composition and Progression of Atherosclerotic Plaques; 1.1.1. Early Lesions; 1.1.2. Advanced Lesions; 1.1.3. Outward Remodeling and Plaque Stenosis; 2. Methods for Studying the Role of Flow in the Pathogenesis of Atherosclerosis; 2.1. Tools for Studying Biological Responses to Mechanical Stimuli in Vitro; 2.2. Animal Models of Atherosclerosis and Relation to Flow; 2.2.1. Genetically-manipulated Mouse Models; 2.2.2. Mechanical Induction of Stenosis in Animals
2.2.3. Larger Animal Models of Atherosclerosis2.3. Flow in Humans and Its Role in Atherosclerosis; 2.4. Computational Fluid Dynamics; 2.4.1. Imaging Data for Lesion-specific Geometry; 2.4.2. Modeling Assumptions; 3. Wall Shear Stress is a Potent Modulator of Plaque Formation and Localization; 3.1. Low and Oscillatory Wall Shear Stress Promote Atherosclerotic Plaque Formation; 3.2. High Wall Shear Stress Protects Arteries from Atherosclerosis; 3.3. Hemodynamic Parameters Related to Plaque Formation; 3.4. Wall Shear Stress and Plaque Rupture 4. Flow is Not the Only Biomechanical Determinant of Plaque Formation and Disruption4.1. Solid Wall Mechanics and Atherosclerotic Responses to Stretch; 4.2. Plaque Composition Influences Solid Wall Mechanics and Risk for Rupture; 4.3. Fluid-solid Interaction Provides Additional Biomechanical Insight into Atherosclerosis; 5. Current Dilemmas and Future Directions for Atherosclerotic Research; 5.1. Need for Better Understanding of Plaque Disruption Events; 5.2. How Do Flow-mediated Mechanisms of Atherogenesis Occur on Human Timescales? 5.3. How Much Does Directionality of Flow Contribute to Atherosclerosis?6. Conclusion; References; Chapter 2 SHEAR STRESS-MEDIATED SIGNAL TRANSDUCTION; 1. Introduction; 2. Mechanosignal Transduction: From Molecular Sensors to Cellular Responses; 3. The Role of Mechanotransduction in Cardiovascular Health and Disease; 4. The Unique Role of PECAM-1 in Mechanosensing; 4.1. Forced-induced PECAM-1 Phosphorylation and Mechano-signaling; 4.2. PECAM-1 as a Mechanosensor; 4.3. PECAM-1 Kinase in Mechanotransduction; 5. S-flow-mediated Redox Regulation and Inflammation 5.1. TRX and TRX-interacting Protein (TXNIP)5.2. Thiol Regulation and Glutaredoxin; 6. S-flow Inhibits TNF-α Signaling by Multiple Mechanisms; 6.1. MAP Kinases in Response to s-flow and TNF-α; 6.2. S-flow Inhibits PKCζ Signaling in ECs; 6.3. S-flow Inhibits TNF-α-mediated SHP-2 Phosphatase Activity and MEKK3 Signaling; 6.4. ERK5 Inhibits TNF-α-mediated JNK Activation; 7. ERK5 and Shear Stress; 7.1. s-flow Mediated ERK5 Activation; 7.2. ERK5 in Diabetes: ERK5-SUMOylation; 7.2.1. SUMOylation; 7.2.2. ERK5-SUMOylation; Acknowledgments; References Chapter 3 ENDOTHELIAL GLYCOCALYX STRUCTURE AND ROLE IN MECHANOTRANSDUCTION |
| Record Nr. | UNINA-9910461615903321 |
| Hackensack, N.J., : World Scientific, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Interfacing Bioelectronics and Biomedical Sensing / / edited by Hung Cao, Todd Coleman, Tzung K. Hsiai, Ali Khademhosseini
| Interfacing Bioelectronics and Biomedical Sensing / / edited by Hung Cao, Todd Coleman, Tzung K. Hsiai, Ali Khademhosseini |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (VIII, 234 p. 69 illus., 60 illus. in color.) |
| Disciplina | 571.45 |
| Soggetto topico |
Biomedical engineering
Biomedical materials Electronic circuits Nanotechnology Biomedical Engineering and Bioengineering Biomaterials Circuits and Systems Nanotechnology and Microengineering Biomedical Engineering/Biotechnology |
| ISBN | 3-030-34467-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Challenges in the Design of Large-Scale, High-Density, Wireless Stimulation and Recording Interface -- Chapter 2. Advances in Bioresorbable Electronics and Uses in Biomedical Sensing -- Chapter 3. Inorganic Dissolvable Bioelectronics -- Chapter 4. Wirelessly Powered Medical Implants Via Radio Frequency Electromagnetic Radiation -- Chapter 5. Electrocardiogram: Acquisition and Analysis for Biological Investigations and Health Monitoring -- Chapter 6. Flexible Intravascular EIS Sensors for Detecting Metabolically Active Plaque -- Chapter 7. Epidermal EIT Electrode Arrays for Detecting Fatty Liver Infiltration -- Chapter 8. High-Frequency Ultrasonic Transducers to Uncover Cardiac Dynamics -- Chapter 9. Minimally Invasive Technologies for Biosensing. |
| Record Nr. | UNINA-9910377823703321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||