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Drug Discovery and Evaluation: Methods in Clinical Pharmacology [[electronic resource] /] / edited by Franz J. Hock, Michael R. Gralinski
| Drug Discovery and Evaluation: Methods in Clinical Pharmacology [[electronic resource] /] / edited by Franz J. Hock, Michael R. Gralinski |
| Edizione | [2nd ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (249 illus., 179 illus. in color. eReference.) |
| Disciplina | 615.19 |
| Collana | Springer reference |
| Soggetto topico |
Pharmacology
Medical biochemistry Pharmacotherapy Pharmacology/Toxicology Medical Biochemistry Farmacologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-319-68864-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910416109203321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug Discovery and Evaluation: Methods in Clinical Pharmacology [[electronic resource] /] / edited by Franz J. Hock, Michael R. Gralinski
| Drug Discovery and Evaluation: Methods in Clinical Pharmacology [[electronic resource] /] / edited by Franz J. Hock, Michael R. Gralinski |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Disciplina | 615 |
| Soggetto topico |
Pharmacology
Medical biochemistry Pharmacotherapy Pharmacology/Toxicology Medical Biochemistry |
| ISBN | 3-319-56637-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910736497403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug Discovery and Evaluation: Pharmacological Assays [[electronic resource] /] / edited by Franz J. Hock
| Drug Discovery and Evaluation: Pharmacological Assays [[electronic resource] /] / edited by Franz J. Hock |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (LVIII, 2071 p. 5 illus.) |
| Disciplina | 615 |
| Soggetto topico |
Pharmacology
Pharmacy Biochemistry Pharmacology/Toxicology Biochemistry, general |
| ISBN | 3-642-27728-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910349295803321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug Discovery and Evaluation: Pharmacological Assays [[electronic resource] /] / edited by Franz J. Hock
| Drug Discovery and Evaluation: Pharmacological Assays [[electronic resource] /] / edited by Franz J. Hock |
| Edizione | [4th ed. 2016.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
| Descrizione fisica | 1 online resource (32 illus., 20 illus. in color. eReference.) |
| Disciplina | 610 |
| Collana | Springer Reference |
| Soggetto topico |
Medicine
Pharmacology Pharmacy Biomedicine, general Pharmacology/Toxicology Drug Safety and Pharmacovigilance |
| ISBN | 3-319-05392-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface to the Fourth Edition -- Contents -- About the Editor -- Contributors -- Part I: Cardiovascular Activity -- Studies in Isolated Organs -- α-Sympatholytic Activity in Isolated Vascular Smooth Muscle -- Purpose and Rationale -- Procedure -- Experimental Course -- Evaluation -- Modifications of the Method -- α-Sympatholytic Activity in the Isolated Guinea Pig Seminal Vesicle -- Purpose and Rationale -- Procedure -- Evaluation -- Modification of the Method -- α-Sympatholytic Activity in the Isolated Vas Deferens of the Rat -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- α-Sympatholytic Activity in the Isolated Rat Spleen -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- α-Sympatholytic Activity in the Isolated Rat Anococcygeus Muscle -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- beta1-Sympatholytic Activity in Isolated Guinea Pig Atria -- Purpose and Rationale -- Procedure -- Right Atrium -- Left Atrium -- Evaluation -- Modifications of the Method -- beta2-Sympatholytic Activity in the Isolated Tracheal Chain -- Purpose and Rationale -- Procedure -- Experimental Course -- Evaluation -- Modifications of the Method -- Angiotensin-Converting Enzyme Inhibition in the Isolated Guinea Pig Ileum -- Purpose and Rationale -- Procedure -- Angiotensin I Antagonism -- Bradykinin Potentiation -- Evaluation -- Angiotensin I Antagonism -- Bradykinin Potentiation -- Modification of the Method -- Contractile and Relaxing Activity on Isolated Blood Vessels Including Effects of Potassium-Channel Openers -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Isolated Guinea Pig Ureter -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method.
Isolated Corpus Cavernosum -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- References and Further Reading -- α-Sympatholytic Activity in Isolated Vascular Smooth Muscle -- α-Sympatholytic Activity in the Isolated Guinea Pig Seminal Vesicle -- α-Sympatholytic Activity in the Isolated Vas Deferens of the Rat -- α-Sympatholytic Activity in the Isolated Rat Spleen -- α-Sympatholytic Activity in the Isolated Rat Anococcygeus Muscle -- beta1-Sympatholytic Activity in Isolated Guinea Pig Atria -- beta2-Sympatholytic Activity in the Isolated Tracheal Chain -- Angiotensin Converting Enzyme Inhibition in the Isolated Guinea Pig Ileum -- Contractile and Relaxing Activity on Isolated Blood Vessels Including Effects of Potassium-Channel Openers -- Isolated Guinea Pig Ureter -- Isolated Corpus Cavernosum -- Cardiovascular Analysis In Vivo -- Hemodynamic Screening in Anesthetized Rats -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Blood Pressure in Pithed Rats -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Antihypertensive Vasodilator Activity in Ganglion-Blocked, Angiotensin II-Supported Rats -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Blood Pressure in Conscious Hypertensive Rats (Tail-Cuff Method) -- Purpose and Rationale -- Procedure -- Surgical Procedure to Induce Renal Hypertension -- Test Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Direct Measurement of Blood Pressure in Conscious Rats with Indwelling Catheter -- Purpose and Rationale -- Procedure -- Preparation of Cannulae -- Implantation of Cannulae -- Measurement of Blood Pressure -- Evaluation. Critical Assessment of the Method -- Modifications of the Method -- Cannulation Techniques in Rodents -- Purpose and Rationale -- Permanent Cannulation of the Jugular Vein in Rats -- Purpose and Rationale -- Procedure -- Modifications of the Method -- Permanent Cannulation of the Renal Vein in Rats -- Purpose and Rationale -- Procedure -- Permanent Cannulation of the Portal Vein in Rats -- Purpose and Rationale -- Procedure -- Permanent Cannulation of the Thoracic Duct in Rats -- Purpose and Rationale -- Procedure -- Portacaval Anastomosis in Rats -- Purpose and Rationale -- Procedure -- Cardiovascular Analysis in Anesthetized Mice -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Blood Pressure in Anesthetized Cats -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Cardiovascular Drug Challenging Experiments in Anesthetized Dogs -- Purpose and Rationale -- Procedure -- Evaluation -- Hemodynamic Analysis in Anesthetized Dogs -- Purpose and Rationale -- Procedure -- Preparation for Hemodynamic Measurements -- Experimental Course -- Calculation of Results and Evaluation -- Modifications of the Method -- Hemodynamic Measurements in Conscious Dogs -- Purpose and Rationale -- Procedure -- Experimental Protocol -- Evaluation -- Modifications of the Method -- Hemodynamic Studies in Monkeys -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Measurement of Cardiac Output and Regional Blood Flow with Microspheres -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Carotid Artery Loop Technique -- Purpose and Rationale -- Procedure -- Critical Assessment of the Method -- Modifications of the Method. Measurement of Heart Dimensions in Anesthetized Dogs -- Purpose and Rationale -- Procedure -- Implantation of Ultrasonic Transducers -- Preparation for Hemodynamic Measurements -- Experimental Course -- Evaluation -- Modifications of the Method -- Telemetric Monitoring of Cardiovascular Parameters in Rats -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Cardiovascular Effects After Intracerebroventricular Administration -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Influence on Orthostatic Hypotension -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Bezold-Jarisch Reflex -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Endotoxin-Induced Shock -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Hemorrhagic Shock -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Tourniquet Shock -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Evaluation of the Method -- Modifications of the Method -- Heatstroke -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- α- and beta-Adrenoreceptors in the Mouse Iris -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- α2-Adrenoreceptor Blockade Measured In Vivo by Clonidine-Induced Sleep in Chicks -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Activity at beta1- and beta2-Adrenoreceptors in the Rat -- Purpose and Rationale -- Procedure -- Evaluation of Agonists -- Evaluation of Antagonists -- Critical Assessment of the Method -- Modifications of the Method -- beta1- and beta2-Sympatholytic Activity in Dogs -- Purpose and Rationale -- Procedure. Preparation for Hemodynamic Measurements -- Screening for beta-Blocking Effects in Anesthetized Dogs -- Testing for beta1- and beta2-Blocking Effects: Determination of ED50 -- Evaluation -- Intrinsic beta-Sympathomimetic Activity in Reserpine-Pretreated Dogs -- Purpose and Rationale -- Procedure -- Preparation for Hemodynamic Measurements -- Experimental Course -- Evaluation -- Cat Nictitating Membrane Preparation (Ganglion-Blocking Activity) -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Assessment of Ganglion-Blocking Activity in the Isolated Bovine Retractor Penis Muscle -- Purpose and Rationale -- Procedure -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Angiotensin II Antagonism -- Purpose and Rationale -- Procedure -- Intrinsic Agonistic Activity -- Antagonistic Activity -- Duration of Activity -- Evaluation -- Intrinsic Agonistic Activity -- Antagonistic Activity -- Critical Assessment of the Method -- Modifications of the Method -- ACE Inhibition Measured In Vivo in the Rat -- Purpose and Rationale -- Procedure -- Inhibition of Angiotensin I Cleavage -- Potentiation of Bradykinin-Induced Vasodepression -- Evaluation -- Inhibition of Angiotensin I Cleavage -- Potentiation of Bradykinin-Induced Vasodepression -- Critical Assessment of the Method -- Modifications of the Method -- Evaluation of Renin Inhibitors in Dogs -- Purpose and Rationale -- Procedure -- Animal Experiment -- Analytical Procedures -- Evaluation -- Critical Assessment of the Method -- Modifications of the Method -- Evaluation of Renin Inhibitors in Monkeys -- Purpose and Rationale -- Procedure -- Evaluation -- Modifications of the Method -- Critical Assessment of the Method -- Penile Erection in Rabbits -- Purpose and Rationale -- Procedure -- Evaluation. Modifications of the Method. |
| Record Nr. | UNINA-9910253870903321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays [[electronic resource] /] / edited by H. Gerhard Vogel, Jochen Maas, Franz J. Hock, Dieter Mayer
| Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays [[electronic resource] /] / edited by H. Gerhard Vogel, Jochen Maas, Franz J. Hock, Dieter Mayer |
| Edizione | [2nd ed. 2013.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2013 |
| Descrizione fisica | 1 online resource (XXIV, 1404 p. 243 illus. eReference.) |
| Disciplina | 615 |
| Soggetto topico |
Pharmacology
Pharmacology/Toxicology |
| ISBN | 3-642-25240-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | From the contents: General Introduction: Safety Pharmacology -- Safety Pharmacokinetics -- Safety Toxicology. |
| Record Nr. | UNINA-9910437845803321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays [[electronic resource] /] / edited by H. Gerhard Vogel, Franz J. Hock, Jochen Maas, Dieter Mayer
| Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays [[electronic resource] /] / edited by H. Gerhard Vogel, Franz J. Hock, Jochen Maas, Dieter Mayer |
| Edizione | [1st ed. 2006.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2006 |
| Descrizione fisica | 1 online resource (896 p.) |
| Disciplina | 615.7 |
| Collana | Springer reference |
| Soggetto topico |
Pharmacology
Pharmacology/Toxicology |
| ISBN | 3-540-29804-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | From the contents General Introduction: Safety Pharmacology -- Safety Pharmacokinetics -- Safety Toxicology. |
| Record Nr. | UNINA-9910484811203321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||