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Strategies and tactics in organic synthesis . Volume 13 / / edited by Michael Harmata
| Strategies and tactics in organic synthesis . Volume 13 / / edited by Michael Harmata |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2017 |
| Descrizione fisica | 1 online resource (266 pages) : illustrations (some color), graphs |
| Disciplina | 547.2 |
| Soggetto topico | Organic compounds - Synthesis |
| ISBN |
0-12-811791-5
0-12-811790-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910736999303321 |
| London, England : , : Academic Press, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Strategies and tactics in organic synthesis / / edited by Michael Harmata
| Strategies and tactics in organic synthesis / / edited by Michael Harmata |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier Academic Press, 2005 |
| Descrizione fisica | 1 online resource (501 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) | HarmataMichael |
| Collana | Strategies and tactics in organic synthesis |
| Soggetto topico |
Organic compounds - Synthesis
Chemistry, Organic |
| ISBN |
1-280-63068-X
9786610630684 0-08-045884-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COVER; STRATEGIES AND TACTICS IN ORGANIC SYNTHESIS; Copyright Page; CONTENTS; CONTRIBUTORS; Foreword; Preface; Dedication; CHAPTER 1. THE TOTAL SYNTHESIS OF LUZOPEPTINS; I. Introduction; II. Background; III. Synthesis of Quinaldic Acid and gly-sar-mhv Tripeptide Fragments; IV. Synthesis and Chemistry of the Piperazic Acid Fragment; V. Initial Cyclization Experiments; VI. The Total Synthesis; VII. Epilogue; VIII. Acknowledgements; References and Footnotes; CHAPTER 2. SYNTHESIS OF GELDANAMYCIN USING GLYCOLATE ALDOL REACTIONS; I. Introduction; II. Retrosynthetic Analysis
III. Ansamycin Antitumor AntibioticsIV. Synthesis of the C12-C21 Quinone Precursor Portion using Evans Asymmetric Alkylation; V. Development of Anti-Selective Glycolate Aldol Methodology Based on the 2,3-Diary1 1,4-Dioxan-5-one Template; VI. Installation of the C11-12 Hydroxy Methoxy Functionality; VII. Difficulties Associated with the C10 methyl and the C8-9 Trisubstituted Alkene; VIII. Syn Glycolate Aldol Methodology Based on the Masamune Norephedrine Auxiliary; IX. Construction of the C2-5 Diene and Macrolactamization; X. Unsuccessful RCM-Based Convergent Approach XI. Unanticipated Problematic Para-Quinone FormationXII. Successful Strategy for Para-Quinone formation Using a 1,4-Di-Protected Hydroquinone Precursor; XIII. Conclusions; References and Footnotes; CHAPTER 3. FROM METHYLENE BRIDGED GLYCOLURIL DIMERS TO CUCURBIT[N]URIL ANALOGS WITH SOME DETOURS ALONG THE WAY; I. Introduction; II. Retrosynthetic Analysis of the Cucurbit[n]uril Family; III. A Few Lucky Breaks Lead to C- and S-Shaped Methylene Bridged Glycoluril Dimers; IV. The Hard Work; V. Three Related Synthetic Procedures Lead to S- and C-shaped Methylene Bridged Glycoluril Dimers VI. Interlude. Molecular Clips Capable of Enantiomeric Self-Recognition, Heterochiral Recognition, and Self-SortingVII. Implications for the Mechanism of CB[n] Formation and the Synthesis of Cucurbit[n]uril Derivatives; VIII. Mechanism of the S- to C-Shaped Interconversion and Implications for the Synthesis of Cucurbit[n]uril Derivatives; IX. Methylene Bridged Glycoluril Oligomers; X. Phthalhydrazides are Nucleophilic Glycoluril Surrogates; XI. Cucurbit[n]uril Analogs; XII. Conclusions; References and Footnotes CHAPTER 4. APPLICATION OF SILICON-ASSISTED INTRAMOLECULAR CROSS-COUPLING IN TOTAL SYNTHESIS OF (+)-BRASILENYNEI. Introduction and Background; II. Preliminary Studies; III. Synthetic Strategies; IV. Synthesis of (+)-Brasilenyne; V. Conformational Analysis; VI. Summary; References and Footnotes; CHAPTER 5. SAMARIUM(II) PROMOTED KETYL OLEFIN CYCLIZATIONS APPLIED TO THE TOTAL SYNTHESES OF (-)-STEGANONE AND (+)-ISOSCHIZANDRIN; I. Introduction; II. Samarium(II) Promoted Ketyl-Olefin Cyclizations; III. Total Synthesis of (-)-Steganone; IV. Total Synthesis of (+)-Isoschizandrin; V. Conclusion References and Footnotes |
| Record Nr. | UNINA-9910812298003321 |
| Amsterdam, : Elsevier Academic Press, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||