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Protein kinases as drug targets [[electronic resource] /] / edited by Bert Klebl, Gerhard Müller, and Michael Hamacher
| Protein kinases as drug targets [[electronic resource] /] / edited by Bert Klebl, Gerhard Müller, and Michael Hamacher |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2011 |
| Descrizione fisica | 1 online resource (398 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
MüllerGerhard
KleblBert HamacherMichael |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Protein kinases
Drugs - Design |
| Soggetto genere / forma | Electronic books. |
| ISBN |
3-527-63349-9
1-283-28324-7 9786613283245 3-527-63347-2 3-527-63348-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Hit finding and profiling for protein kinases : assay development and screening, libraries -- pt. 2. Medicinal chemistry -- pt. 3. Application of kinase inhibitors to therapeutic indication areas. |
| Record Nr. | UNINA-9910139601103321 |
| Weinheim, Germany, : Wiley-VCH, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein kinases as drug targets [[electronic resource] /] / edited by Bert Klebl, Gerhard Müller, and Michael Hamacher
| Protein kinases as drug targets [[electronic resource] /] / edited by Bert Klebl, Gerhard Müller, and Michael Hamacher |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2011 |
| Descrizione fisica | 1 online resource (398 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
MüllerGerhard
KleblBert HamacherMichael |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Protein kinases
Drugs - Design |
| ISBN |
3-527-63349-9
1-283-28324-7 9786613283245 3-527-63347-2 3-527-63348-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Hit finding and profiling for protein kinases : assay development and screening, libraries -- pt. 2. Medicinal chemistry -- pt. 3. Application of kinase inhibitors to therapeutic indication areas. |
| Record Nr. | UNINA-9910829935103321 |
| Weinheim, Germany, : Wiley-VCH, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein kinases as drug targets / / edited by Bert Klebl, Gerhard Muller, and Michael Hamacher
| Protein kinases as drug targets / / edited by Bert Klebl, Gerhard Muller, and Michael Hamacher |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, 2011 |
| Descrizione fisica | 1 online resource (398 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
MullerGerhard
KleblBert HamacherMichael |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Protein kinases
Drugs - Design |
| ISBN |
3-527-63349-9
1-283-28324-7 9786613283245 3-527-63347-2 3-527-63348-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Hit finding and profiling for protein kinases : assay development and screening, libraries -- pt. 2. Medicinal chemistry -- pt. 3. Application of kinase inhibitors to therapeutic indication areas. |
| Record Nr. | UNINA-9910877284803321 |
| Weinheim, Germany, : Wiley-VCH, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Proteomics in drug research [[electronic resource] /] / edited by Michael Hamacher ... [et al.]
| Proteomics in drug research [[electronic resource] /] / edited by Michael Hamacher ... [et al.] |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (386 p.) |
| Disciplina | 572.6 |
| Altri autori (Persone) | HamacherMichael |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Proteomics
Drugs - Research |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-72343-2
9786610723430 3-527-60823-0 3-527-60794-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Proteomics in Drug Research; Contents; A Personal Foreword; Preface; List of Contributors; I Introduction; 1 Administrative Optimization of Proteomics Networks for Drug Development; 1.1 Introduction; 1.2 Tasks and Aims of Administration; 1.3 Networking; 1.4 Evaluation of Biomarkers; 1.5 A Network for Proteomics in Drug Development; 1.6 Realization of Administrative Networking: the Brain Proteome Projects; 1.6.1 National Genome Research Network: the Human Brain Proteome Project; 1.6.2 Human Proteome Organisation: the Brain Proteome Project; 1.6.2.1 The Pilot Phase; References
2 Proteomic Data Standardization, Deposition and Exchange2.1 Introduction; 2.2 Protein Analysis Tools; 2.2.1 UniProt; 2.2.2 InterPro; 2.2.3 Proteome Analysis; 2.2.4 International Protein Index (IPI); 2.2.5 Reactome; 2.3 Data Storage and Retrieval; 2.4 The Proteome Standards Initiative; 2.5 General Proteomics Standards (GPS); 2.6 Mass Spectrometry; 2.7 Molecular Interactions; 2.8 Summary; References; II Proteomic Technologies; 3 Difference Gel Electrophoresis (DIGE): the Next Generation of Two-Dimensional Gel Electrophoresis for Clinical Research; 3.1 Introduction 3.2 Difference Gel Electrophoresis: Next Generation of Protein Detection in 2-DE3.2.1 Application of CyDye DIGE Minimal Fluors (Minimal Labeling with CyDye DIGE Minimal Fluors); 3.2.1.1 General Procedure; 3.2.1.2 Example of Use: Identification of Kinetic Proteome Changes upon Ligand Activation of Trk-Receptors; 3.2.2 Application of Saturation Labeling with CyDye DIGE Saturation Fluors; 3.2.2.1 General Procedure; 3.2.2.2 Example of Use: Analysis of 1000 Microdissected Cells from PanIN Grades for the Identification of a New Molecular Tumor Marker Using CyDye DIGE Saturation Fluors 3.2.3 Statistical Aspects of Applying DIGE Proteome Analysis3.2.3.1 Calibration and Normalization of Protein Expression Data; 3.2.3.2 Detection of Differentially Expressed Proteins; 3.2.3.3 Sample Size Determination; 3.2.3.4 Further Applications; References; 4 Biological Mass Spectrometry: Basics and Drug Discovery Related Approaches; 4.1 Introduction; 4.2 Ionization Principles; 4.2.1 Matrix-Assisted Laser Desorption/Ionization (MALDI); 4.2.2 Electrospray Ionization; 4.3 Mass Spectrometric Instrumentation; 4.4 Protein Identification Strategies 4.5 Quantitative Mass Spectrometry for Comparative and Functional Proteomics4.6 Metabolic Labeling Approaches; 4.6.1 (15)N Labeling; 4.6.2 Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC); 4.7 Chemical Labeling Approaches; 4.7.1 Chemical Isotope Labeling at the Protein Level; 4.7.2 Stable Isotope Labeling at the Peptide Level; 4.8 Quantitative MS for Deciphering Protein-Protein Interactions; 4.9 Conclusions; References; 5 Multidimensional Column Liquid Chromatography (LC) in Proteomics - Where Are We Now?; 5.1 Introduction; 5.2 Why Do We Need MD-LC/MS Methods? 5.3 Basic Aspects of Developing a MD-LC/MS Method |
| Record Nr. | UNINA-9910144561003321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Proteomics in drug research [[electronic resource] /] / edited by Michael Hamacher ... [et al.]
| Proteomics in drug research [[electronic resource] /] / edited by Michael Hamacher ... [et al.] |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (386 p.) |
| Disciplina | 572.6 |
| Altri autori (Persone) | HamacherMichael |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Proteomics
Drugs - Research |
| ISBN |
1-280-72343-2
9786610723430 3-527-60823-0 3-527-60794-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Proteomics in Drug Research; Contents; A Personal Foreword; Preface; List of Contributors; I Introduction; 1 Administrative Optimization of Proteomics Networks for Drug Development; 1.1 Introduction; 1.2 Tasks and Aims of Administration; 1.3 Networking; 1.4 Evaluation of Biomarkers; 1.5 A Network for Proteomics in Drug Development; 1.6 Realization of Administrative Networking: the Brain Proteome Projects; 1.6.1 National Genome Research Network: the Human Brain Proteome Project; 1.6.2 Human Proteome Organisation: the Brain Proteome Project; 1.6.2.1 The Pilot Phase; References
2 Proteomic Data Standardization, Deposition and Exchange2.1 Introduction; 2.2 Protein Analysis Tools; 2.2.1 UniProt; 2.2.2 InterPro; 2.2.3 Proteome Analysis; 2.2.4 International Protein Index (IPI); 2.2.5 Reactome; 2.3 Data Storage and Retrieval; 2.4 The Proteome Standards Initiative; 2.5 General Proteomics Standards (GPS); 2.6 Mass Spectrometry; 2.7 Molecular Interactions; 2.8 Summary; References; II Proteomic Technologies; 3 Difference Gel Electrophoresis (DIGE): the Next Generation of Two-Dimensional Gel Electrophoresis for Clinical Research; 3.1 Introduction 3.2 Difference Gel Electrophoresis: Next Generation of Protein Detection in 2-DE3.2.1 Application of CyDye DIGE Minimal Fluors (Minimal Labeling with CyDye DIGE Minimal Fluors); 3.2.1.1 General Procedure; 3.2.1.2 Example of Use: Identification of Kinetic Proteome Changes upon Ligand Activation of Trk-Receptors; 3.2.2 Application of Saturation Labeling with CyDye DIGE Saturation Fluors; 3.2.2.1 General Procedure; 3.2.2.2 Example of Use: Analysis of 1000 Microdissected Cells from PanIN Grades for the Identification of a New Molecular Tumor Marker Using CyDye DIGE Saturation Fluors 3.2.3 Statistical Aspects of Applying DIGE Proteome Analysis3.2.3.1 Calibration and Normalization of Protein Expression Data; 3.2.3.2 Detection of Differentially Expressed Proteins; 3.2.3.3 Sample Size Determination; 3.2.3.4 Further Applications; References; 4 Biological Mass Spectrometry: Basics and Drug Discovery Related Approaches; 4.1 Introduction; 4.2 Ionization Principles; 4.2.1 Matrix-Assisted Laser Desorption/Ionization (MALDI); 4.2.2 Electrospray Ionization; 4.3 Mass Spectrometric Instrumentation; 4.4 Protein Identification Strategies 4.5 Quantitative Mass Spectrometry for Comparative and Functional Proteomics4.6 Metabolic Labeling Approaches; 4.6.1 (15)N Labeling; 4.6.2 Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC); 4.7 Chemical Labeling Approaches; 4.7.1 Chemical Isotope Labeling at the Protein Level; 4.7.2 Stable Isotope Labeling at the Peptide Level; 4.8 Quantitative MS for Deciphering Protein-Protein Interactions; 4.9 Conclusions; References; 5 Multidimensional Column Liquid Chromatography (LC) in Proteomics - Where Are We Now?; 5.1 Introduction; 5.2 Why Do We Need MD-LC/MS Methods? 5.3 Basic Aspects of Developing a MD-LC/MS Method |
| Record Nr. | UNINA-9910830978603321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Proteomics in drug research / / edited by Michael Hamacher ... [et al.]
| Proteomics in drug research / / edited by Michael Hamacher ... [et al.] |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (386 p.) |
| Disciplina | 572.6 |
| Altri autori (Persone) | HamacherMichael |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Proteomics
Drugs - Research |
| ISBN |
1-280-72343-2
9786610723430 3-527-60823-0 3-527-60794-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Proteomics in Drug Research; Contents; A Personal Foreword; Preface; List of Contributors; I Introduction; 1 Administrative Optimization of Proteomics Networks for Drug Development; 1.1 Introduction; 1.2 Tasks and Aims of Administration; 1.3 Networking; 1.4 Evaluation of Biomarkers; 1.5 A Network for Proteomics in Drug Development; 1.6 Realization of Administrative Networking: the Brain Proteome Projects; 1.6.1 National Genome Research Network: the Human Brain Proteome Project; 1.6.2 Human Proteome Organisation: the Brain Proteome Project; 1.6.2.1 The Pilot Phase; References
2 Proteomic Data Standardization, Deposition and Exchange2.1 Introduction; 2.2 Protein Analysis Tools; 2.2.1 UniProt; 2.2.2 InterPro; 2.2.3 Proteome Analysis; 2.2.4 International Protein Index (IPI); 2.2.5 Reactome; 2.3 Data Storage and Retrieval; 2.4 The Proteome Standards Initiative; 2.5 General Proteomics Standards (GPS); 2.6 Mass Spectrometry; 2.7 Molecular Interactions; 2.8 Summary; References; II Proteomic Technologies; 3 Difference Gel Electrophoresis (DIGE): the Next Generation of Two-Dimensional Gel Electrophoresis for Clinical Research; 3.1 Introduction 3.2 Difference Gel Electrophoresis: Next Generation of Protein Detection in 2-DE3.2.1 Application of CyDye DIGE Minimal Fluors (Minimal Labeling with CyDye DIGE Minimal Fluors); 3.2.1.1 General Procedure; 3.2.1.2 Example of Use: Identification of Kinetic Proteome Changes upon Ligand Activation of Trk-Receptors; 3.2.2 Application of Saturation Labeling with CyDye DIGE Saturation Fluors; 3.2.2.1 General Procedure; 3.2.2.2 Example of Use: Analysis of 1000 Microdissected Cells from PanIN Grades for the Identification of a New Molecular Tumor Marker Using CyDye DIGE Saturation Fluors 3.2.3 Statistical Aspects of Applying DIGE Proteome Analysis3.2.3.1 Calibration and Normalization of Protein Expression Data; 3.2.3.2 Detection of Differentially Expressed Proteins; 3.2.3.3 Sample Size Determination; 3.2.3.4 Further Applications; References; 4 Biological Mass Spectrometry: Basics and Drug Discovery Related Approaches; 4.1 Introduction; 4.2 Ionization Principles; 4.2.1 Matrix-Assisted Laser Desorption/Ionization (MALDI); 4.2.2 Electrospray Ionization; 4.3 Mass Spectrometric Instrumentation; 4.4 Protein Identification Strategies 4.5 Quantitative Mass Spectrometry for Comparative and Functional Proteomics4.6 Metabolic Labeling Approaches; 4.6.1 (15)N Labeling; 4.6.2 Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC); 4.7 Chemical Labeling Approaches; 4.7.1 Chemical Isotope Labeling at the Protein Level; 4.7.2 Stable Isotope Labeling at the Peptide Level; 4.8 Quantitative MS for Deciphering Protein-Protein Interactions; 4.9 Conclusions; References; 5 Multidimensional Column Liquid Chromatography (LC) in Proteomics - Where Are We Now?; 5.1 Introduction; 5.2 Why Do We Need MD-LC/MS Methods? 5.3 Basic Aspects of Developing a MD-LC/MS Method |
| Record Nr. | UNINA-9910877521503321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||