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Arrestins - Pharmacology and Therapeutic Potential [[electronic resource] /] / edited by Vsevolod V. Gurevich
| Arrestins - Pharmacology and Therapeutic Potential [[electronic resource] /] / edited by Vsevolod V. Gurevich |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (441 p.) |
| Disciplina | 572.696 |
| Collana | Handbook of Experimental Pharmacology |
| Soggetto topico |
Pharmacology
Biochemistry Proteins Gene therapy Cell physiology Pharmacology/Toxicology Biochemistry, general Protein Structure Gene Therapy Cell Physiology Receptors |
| ISBN | 3-642-41199-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia. |
| Record Nr. | UNINA-9910298309403321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The Structural Basis of Arrestin Functions [[electronic resource] /] / edited by Vsevolod V. Gurevich
| The Structural Basis of Arrestin Functions [[electronic resource] /] / edited by Vsevolod V. Gurevich |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (IX, 304 p. 53 illus., 51 illus. in color.) |
| Disciplina | 573.44 |
| Soggetto topico |
Biochemistry
Proteins Animal Biochemistry Protein Science Protein Structure |
| ISBN | 3-319-57553-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Arrestins: discovery of the family and functional role of conformational flexibility -- Overview of arrestin-mediated signaling with receptors and non-receptor binding partners -- Initial crystallographic studies of visual arrestin: insights and perspectives -- Structural basis for b-arrestins in GPCR trafficking -- Arrestin-3: the structural basis of lower receptor selectivity -- Phosphate sensor and construction of phosphorylation-independent arrestins -- Comprehensive analysis of the role of arrestin residues in receptor binding -- How arrestin recognizes and binds active GPCRs -- Localization of conformational dynamics of arrestins by HDX-MS -- GPCR footprint on arrestins and manipulation of receptor specificity -- The structure of the polar core mutant R175E and its functional implications -- Active conformations of arrestins: expected and unexpected changes -- The arrestin-receptor complex: exciting answers and new questions -- Scaffolding c-Jun N-terminal kinase cascades: mechanistic insights from the reconstituted arrestin-JNK cascades -- Arrestin-dependent ERK activation and its disruption -- The functional role of the conformational changes in arrestin upon activation -- Is signaling specificity encoded in arrestin conformation? -- Monofunctional elements of multi-functional arrestin proteins -- Arrestins in cell death. |
| Record Nr. | UNINA-9910253915103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||