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Peptidomimetics in organic and medicinal chemistry / / Andrea Trabocchi and Antonio Guarna
| Peptidomimetics in organic and medicinal chemistry / / Andrea Trabocchi and Antonio Guarna |
| Autore | Guarna Antonio |
| Pubbl/distr/stampa | Chichester, West Sussex, United Kingdom : , : John Wiley & Sons, , 2014 |
| Descrizione fisica | 1 online resource (320 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Peptide drugs
Proteins - Therapeutic use Drugs - Design |
| ISBN |
1-118-68314-5
1-118-68303-X 1-118-68384-6 |
| Classificazione | SCI013050 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Preface; Abbreviations; Part I The Basics of Peptidomimetics; Chapter 1 The Basics of Peptidomimetics; 1.1 Introduction; 1.2 Definition and Classification; 1.3 Strategic Approaches to Peptidomimetic Design; 1.3.1 Modification of Amino Acids; 1.3.2 Compounds with Global Restrictions; 1.3.3 Molecular Scaffolds Mimicking the Peptidic Backbone; 1.4 Successful Examples of Peptidomimetic Drugs; 1.4.1 ACE Inhibitors; 1.4.2 Thrombin Inhibitors; 1.5 Conclusion; References; Chapter 2 Synthetic Approaches towards Peptidomimetic Design; 2.1 Introduction
2.2 Local Modifications2.2.1 Single Amino Acid Modifications; 2.2.2 Dipeptide Isosteres; 2.2.3 Retro-inverso Peptides; 2.2.4 N-Methylation of Peptides; 2.2.5 Azapeptides; 2.2.6 Peptoids; 2.3 Global Restrictions through Cyclic Peptidomimetics; 2.4 Peptidomimetic Scaffolds; 2.5 Conclusions; References; Part II Synthetic Methods and Molecules; Chapter 3 Peptidomimetic Bioisosteres; 3.1 Introduction; 3.2 Peptide Bond Isosteres; 3.2.1 Thioamides; 3.2.2 Esters; 3.2.3 Alkenes and Fluoroalkenes; 3.2.4 Transition-State Isosteres; 3.3 Side-Chain Isosteres 3.3.1 Guanidine Isosteres in Arginine Peptidomimetics3.3.2 Isosteres of Aspartic Acid and Glutamic Acid; 3.3.3 Tethered α-Amino Acids: Constraining the x-Space; 3.4 Dipeptide Isosteres; 3.4.1 δ-Amino Acids; 3.5 Tripeptide Isosteres; 3.6 Conclusion; References; Chapter 4 Solid-Phase Synthesis and Combinatorial Approaches to Peptidomimetics; 4.1 Introduction; 4.2 Solid-Phase Synthesis of Peptidomimetics; 4.2.1 Scaffolds from α-Amino Acids; 4.2.2 Scaffolds from Amino Aldehyde Intermediates; 4.2.3 Pyrrolidine-Containing Scaffolds; 4.3 Conclusion; References Chapter 5 Click Chemistry: The Triazole Ring as a Privileged Peptidomimetic Scaffold5.1 Introduction; 5.1.1 CuAAC Reaction; 5.1.2 Triazole Ring as a Peptidomimetic Isostere; 5.2 Triazole-Containing Peptidomimetics Elaborated through `Click Chemistry'; 5.2.1 Macrocycles; 5.2.2 Oligomers and Foldamers; 5.3 Relevant Applications in Drug Discovery; 5.3.1 AChE Inhibitors; 5.3.2 HIV Protease Inhibitors; 5.3.3 MMP Inhibitors; 5.3.4 Integrin Ligands; 5.4 Conclusions; Acknowledgements; References; Chapter 6 Peptoids; 6.1 Introduction and Basics of Peptoids; 6.2 Synthetic Methods 6.3 Macrocyclic Peptoids6.4 Conformational Analysis of Folded Peptoids; 6.5 Application of Peptoids as Antimicrobial Peptidomimetics; 6.6 Conclusions; References; Chapter 7 Sugar Amino Acids; 7.1 Introduction; 7.2 α-SAAs; 7.2.1 Furanoid α-SAAs; 7.2.2 Pyranoid α-SAAs; 7.3 β-SAAs; 7.3.1 Furanoid β-SAAs; 7.3.2 Pyranoid β-SAAs; 7.4 r-SAAs1; 7.5 δ-SAAs; 7.5.1 Furanoid δ-SAAs; 7.5.2 Pyranoid δ-SAAs; 7.6 Representative Applications in Medicinal Chemistry; 7.7 Conclusions; References; Chapter 8 Cyclic α-Amino Acids as Proline Mimetics; 8.1 Introduction; 8.2 Cyclic α-Amino Acids 8.2.1 3-Substituted Proline Derivatives |
| Record Nr. | UNINA-9910140270003321 |
Guarna Antonio
|
||
| Chichester, West Sussex, United Kingdom : , : John Wiley & Sons, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptidomimetics in organic and medicinal chemistry / / Andrea Trabocchi and Antonio Guarna
| Peptidomimetics in organic and medicinal chemistry / / Andrea Trabocchi and Antonio Guarna |
| Autore | Guarna Antonio |
| Pubbl/distr/stampa | Chichester, West Sussex, United Kingdom : , : John Wiley & Sons, , 2014 |
| Descrizione fisica | 1 online resource (320 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Peptide drugs
Proteins - Therapeutic use Drugs - Design |
| ISBN |
1-118-68314-5
1-118-68303-X 1-118-68384-6 |
| Classificazione | SCI013050 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Preface; Abbreviations; Part I The Basics of Peptidomimetics; Chapter 1 The Basics of Peptidomimetics; 1.1 Introduction; 1.2 Definition and Classification; 1.3 Strategic Approaches to Peptidomimetic Design; 1.3.1 Modification of Amino Acids; 1.3.2 Compounds with Global Restrictions; 1.3.3 Molecular Scaffolds Mimicking the Peptidic Backbone; 1.4 Successful Examples of Peptidomimetic Drugs; 1.4.1 ACE Inhibitors; 1.4.2 Thrombin Inhibitors; 1.5 Conclusion; References; Chapter 2 Synthetic Approaches towards Peptidomimetic Design; 2.1 Introduction
2.2 Local Modifications2.2.1 Single Amino Acid Modifications; 2.2.2 Dipeptide Isosteres; 2.2.3 Retro-inverso Peptides; 2.2.4 N-Methylation of Peptides; 2.2.5 Azapeptides; 2.2.6 Peptoids; 2.3 Global Restrictions through Cyclic Peptidomimetics; 2.4 Peptidomimetic Scaffolds; 2.5 Conclusions; References; Part II Synthetic Methods and Molecules; Chapter 3 Peptidomimetic Bioisosteres; 3.1 Introduction; 3.2 Peptide Bond Isosteres; 3.2.1 Thioamides; 3.2.2 Esters; 3.2.3 Alkenes and Fluoroalkenes; 3.2.4 Transition-State Isosteres; 3.3 Side-Chain Isosteres 3.3.1 Guanidine Isosteres in Arginine Peptidomimetics3.3.2 Isosteres of Aspartic Acid and Glutamic Acid; 3.3.3 Tethered α-Amino Acids: Constraining the x-Space; 3.4 Dipeptide Isosteres; 3.4.1 δ-Amino Acids; 3.5 Tripeptide Isosteres; 3.6 Conclusion; References; Chapter 4 Solid-Phase Synthesis and Combinatorial Approaches to Peptidomimetics; 4.1 Introduction; 4.2 Solid-Phase Synthesis of Peptidomimetics; 4.2.1 Scaffolds from α-Amino Acids; 4.2.2 Scaffolds from Amino Aldehyde Intermediates; 4.2.3 Pyrrolidine-Containing Scaffolds; 4.3 Conclusion; References Chapter 5 Click Chemistry: The Triazole Ring as a Privileged Peptidomimetic Scaffold5.1 Introduction; 5.1.1 CuAAC Reaction; 5.1.2 Triazole Ring as a Peptidomimetic Isostere; 5.2 Triazole-Containing Peptidomimetics Elaborated through `Click Chemistry'; 5.2.1 Macrocycles; 5.2.2 Oligomers and Foldamers; 5.3 Relevant Applications in Drug Discovery; 5.3.1 AChE Inhibitors; 5.3.2 HIV Protease Inhibitors; 5.3.3 MMP Inhibitors; 5.3.4 Integrin Ligands; 5.4 Conclusions; Acknowledgements; References; Chapter 6 Peptoids; 6.1 Introduction and Basics of Peptoids; 6.2 Synthetic Methods 6.3 Macrocyclic Peptoids6.4 Conformational Analysis of Folded Peptoids; 6.5 Application of Peptoids as Antimicrobial Peptidomimetics; 6.6 Conclusions; References; Chapter 7 Sugar Amino Acids; 7.1 Introduction; 7.2 α-SAAs; 7.2.1 Furanoid α-SAAs; 7.2.2 Pyranoid α-SAAs; 7.3 β-SAAs; 7.3.1 Furanoid β-SAAs; 7.3.2 Pyranoid β-SAAs; 7.4 r-SAAs1; 7.5 δ-SAAs; 7.5.1 Furanoid δ-SAAs; 7.5.2 Pyranoid δ-SAAs; 7.6 Representative Applications in Medicinal Chemistry; 7.7 Conclusions; References; Chapter 8 Cyclic α-Amino Acids as Proline Mimetics; 8.1 Introduction; 8.2 Cyclic α-Amino Acids 8.2.1 3-Substituted Proline Derivatives |
| Record Nr. | UNINA-9910821269603321 |
|
Guarna Antonio
|
||
| Chichester, West Sussex, United Kingdom : , : John Wiley & Sons, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||