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Genomics, proteomics, and vaccines [[electronic resource] /] / editor, Guido Grandi
| Genomics, proteomics, and vaccines [[electronic resource] /] / editor, Guido Grandi |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, NJ, : Wiley, c2004 |
| Descrizione fisica | 1 online resource (345 p.) |
| Disciplina | 572.8/6 |
| Altri autori (Persone) | GrandiGuido |
| Soggetto topico |
Genomics
Vaccines - Biotechnology Proteomics |
| ISBN |
1-280-26948-0
9786610269488 0-470-09392-7 0-470-01253-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Genomics, Proteomics and Vaccines -- Contents -- Preface -- List of contributors -- PART 1: INTRODUCTION -- 1 Vaccination: Past, Present and Future -- 1.1 Introduction -- 1.2 Vaccination: the past -- 1.3 Vaccination: the present -- 1.4 Vaccination: the future -- 1.5 Conclusion: the intangible value of vaccination -- 2 Bioinformatics, DNA Microarrays and Proteomics in Vaccine Discovery: Competing or Complementary Technologies? -- 2.1 Introduction -- 2.2 From genome sequence to vaccine discovery -- 2.3 A case study: the anti-meningococcus B vaccine -- 2.4 Comparison of the three approaches -- 2.5 Conclusions: a 'nomics' approach to vaccine discovery -- PART 2: TECHNOLOGIES -- 3 Genome Sequencing and Analysis -- 3.1 Introduction -- 3.2 Genome sequencing -- 3.3 Genome analysis -- 3.4 Conclusion -- 4 Understanding DNA Microarrays: Sources and Magnitudes of Variances in DNA Microarray Data Sets -- 4.1 Introduction -- 4.2 DNA array formats -- 4.3 Data analysis methods -- 4.4 Sources and magnitudes of noise in DNA microarray experiments -- 4.5 Conclusions -- Acknowledgements -- 5 The Proteome, Anno Domini Two Zero Zero Three -- 5.1 Introduction -- 5.2 Some definitions -- 5.3 What methods exist to tackle the proteome complexity?5.4 Quantitative proteomics -- 5.5 Pre-fractionation in proteome analysis -- 5.6 Multi-dimensional chromatography -- 5.7 Protein chip arrays -- 5.8 Imaging mass spectrometry -- Acknowledgements -- 6 Mass Spectrometry in Proteomics -- 6.1 Introduction -- 6.2 MS technology -- 6.3 Principle of protein identification based on MS data -- 6.4 Proteomics workflows -- 7 High Throughput Cloning, Expression and Purification Technologies -- 7.1 Introduction -- 7.2 Gene cloning -- 7.3 Protein expression -- 7.4 High-throughput protein purification -- 7.5 Validation of the pipeline and outlook7.6 Conclusion -- PART 3: APPLICATIONS -- 8 Meningococcus B: from Genome to Vaccine -- 8.1 Meningococcus, a major cause of bacterial meningitis -- 8.2 Group B meningococcus as an example of reverse vaccinology -- 8.3 Conclusions -- 9 Vaccines Against Pathogenic Streptococci -- 9.1 Introduction -- 9.2 Comparative genomics of streptococci -- 9.3 A vaccine against group B streptococcus -- 9.4 A vaccine against group A streptococcus -- 9.5 Conclusions -- 10 Identification of the 'Antigenome' - a Novel Tool for Design and Development of Subunit Vaccines Against Bacterial Pathogens -- 10.1 Introduction -- 10.2 Small DNA insert libraries - a tool to cover a pathogen's 'antigenome' -- 10.3 Proper display platforms -- 10.4 Selected human sera to provide imprints of pathogen encounters -- 10.5 Cognate antibodies reveal the 'antigenome' of a pathogen -- 10.6 How to retrieve from the 'antigenome' the candidate antigens for vaccine development -- 10.7 Summary and discussion -- 11 Searching the Chlamydia Genomes for New Vaccine Candidates -- 11.1 Old problems and new perspectives for chlamydial vaccines. |
| Record Nr. | UNINA-9910145752603321 |
| Chichester ; ; Hoboken, NJ, : Wiley, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics, proteomics, and vaccines [[electronic resource] /] / editor, Guido Grandi
| Genomics, proteomics, and vaccines [[electronic resource] /] / editor, Guido Grandi |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, NJ, : Wiley, c2004 |
| Descrizione fisica | 1 online resource (345 p.) |
| Disciplina | 572.8/6 |
| Altri autori (Persone) | GrandiGuido |
| Soggetto topico |
Genomics
Vaccines - Biotechnology Proteomics |
| ISBN |
1-280-26948-0
9786610269488 0-470-09392-7 0-470-01253-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Genomics, Proteomics and Vaccines -- Contents -- Preface -- List of contributors -- PART 1: INTRODUCTION -- 1 Vaccination: Past, Present and Future -- 1.1 Introduction -- 1.2 Vaccination: the past -- 1.3 Vaccination: the present -- 1.4 Vaccination: the future -- 1.5 Conclusion: the intangible value of vaccination -- 2 Bioinformatics, DNA Microarrays and Proteomics in Vaccine Discovery: Competing or Complementary Technologies? -- 2.1 Introduction -- 2.2 From genome sequence to vaccine discovery -- 2.3 A case study: the anti-meningococcus B vaccine -- 2.4 Comparison of the three approaches -- 2.5 Conclusions: a 'nomics' approach to vaccine discovery -- PART 2: TECHNOLOGIES -- 3 Genome Sequencing and Analysis -- 3.1 Introduction -- 3.2 Genome sequencing -- 3.3 Genome analysis -- 3.4 Conclusion -- 4 Understanding DNA Microarrays: Sources and Magnitudes of Variances in DNA Microarray Data Sets -- 4.1 Introduction -- 4.2 DNA array formats -- 4.3 Data analysis methods -- 4.4 Sources and magnitudes of noise in DNA microarray experiments -- 4.5 Conclusions -- Acknowledgements -- 5 The Proteome, Anno Domini Two Zero Zero Three -- 5.1 Introduction -- 5.2 Some definitions -- 5.3 What methods exist to tackle the proteome complexity?5.4 Quantitative proteomics -- 5.5 Pre-fractionation in proteome analysis -- 5.6 Multi-dimensional chromatography -- 5.7 Protein chip arrays -- 5.8 Imaging mass spectrometry -- Acknowledgements -- 6 Mass Spectrometry in Proteomics -- 6.1 Introduction -- 6.2 MS technology -- 6.3 Principle of protein identification based on MS data -- 6.4 Proteomics workflows -- 7 High Throughput Cloning, Expression and Purification Technologies -- 7.1 Introduction -- 7.2 Gene cloning -- 7.3 Protein expression -- 7.4 High-throughput protein purification -- 7.5 Validation of the pipeline and outlook7.6 Conclusion -- PART 3: APPLICATIONS -- 8 Meningococcus B: from Genome to Vaccine -- 8.1 Meningococcus, a major cause of bacterial meningitis -- 8.2 Group B meningococcus as an example of reverse vaccinology -- 8.3 Conclusions -- 9 Vaccines Against Pathogenic Streptococci -- 9.1 Introduction -- 9.2 Comparative genomics of streptococci -- 9.3 A vaccine against group B streptococcus -- 9.4 A vaccine against group A streptococcus -- 9.5 Conclusions -- 10 Identification of the 'Antigenome' - a Novel Tool for Design and Development of Subunit Vaccines Against Bacterial Pathogens -- 10.1 Introduction -- 10.2 Small DNA insert libraries - a tool to cover a pathogen's 'antigenome' -- 10.3 Proper display platforms -- 10.4 Selected human sera to provide imprints of pathogen encounters -- 10.5 Cognate antibodies reveal the 'antigenome' of a pathogen -- 10.6 How to retrieve from the 'antigenome' the candidate antigens for vaccine development -- 10.7 Summary and discussion -- 11 Searching the Chlamydia Genomes for New Vaccine Candidates -- 11.1 Old problems and new perspectives for chlamydial vaccines. |
| Record Nr. | UNINA-9910828470503321 |
| Chichester ; ; Hoboken, NJ, : Wiley, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Staphylococcus aureus [[electronic resource] ] : Microbiology, Pathology, Immunology, Therapy and Prophylaxis / / edited by Fabio Bagnoli, Rino Rappuoli, Guido Grandi
| Staphylococcus aureus [[electronic resource] ] : Microbiology, Pathology, Immunology, Therapy and Prophylaxis / / edited by Fabio Bagnoli, Rino Rappuoli, Guido Grandi |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (XII, 540 p.) |
| Disciplina | 616.01 |
| Collana | Current Topics in Microbiology and Immunology |
| Soggetto topico |
Immunology
Infectious diseases Vaccines Infectious Diseases Vaccine |
| ISBN | 3-319-72063-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Clinical microbiology, transmission and carriage of Staphylococcus aureus -- Worldwide Epidemiology and antibiotic resistance of Staphylococcus aureus -- Structure and function of surface polysaccharides of Staphylococcus aureus -- Structure and function of surface proteins of Staphylococcus aureus -- Staphylococcus aureus pore-forming toxins.-Regulation of Staphylococcus aureus genes -- Staphylococcus aureus-associated Skin and Soft Tissue Infections.- Staphylococcus aureus-associated Musculoskeletal Infections -- Bacteremia, Sepsis, and Infective Endocarditis associated to Staphylococcus aureus -- Staphylococcus aureus as a zoonotic pathogen -- Antibiotic therapy of Staphylococcus aureus -- Innate immune responses against Staphylococcus aureus -- Adaptive immune responses against Staphylococcus aureus -- Immunevasion mechanisms of Staphylococcus aureus -- Vaccines and target populations for Staphylococcus aureus -- Bacteriophage and lysine therapy of Staphylococcus aureus. |
| Record Nr. | UNINA-9910255451503321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||